Inhaled anesthetic responses of recombinant receptors and knockin mice harboring α2(S270H/L277A) GABA(A) receptor subunits that are resistant to isoflurane

scientific article

Inhaled anesthetic responses of recombinant receptors and knockin mice harboring α2(S270H/L277A) GABA(A) receptor subunits that are resistant to isoflurane is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1124/JPET.110.170431
P932PMC publication ID3014300
P698PubMed publication ID20807777
P5875ResearchGate publication ID46107525

P2093author name stringR A Harris
A Swihart
C M Borghese
D F Werner
E I Eger
F Jia
G E Homanics
I Oh
J M Sonner
M L McCracken
M S Fanselow
N L Harrison
S Iyer
V Rau
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Trace fear conditioning involves hippocampal alpha5 GABA(A) receptorsQ28594296
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The alpha1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdalaQ30438111
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Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.Q33902217
Gamma-aminobutyric acid type A receptor alpha 4 subunit knockout mice are resistant to the amnestic effect of isofluraneQ33954029
Molecular and cellular mechanisms of general anaesthesiaQ34291163
Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.Q34440513
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Trace and contextual fear conditioning is enhanced in mice lacking the alpha4 subunit of the GABA(A) receptorQ37701219
Which GABAA-receptor subtypes really occur in the brain?Q41003268
Enhancement of gamma-aminobutyric acid-activated Cl- currents in cultured rat hippocampal neurones by three volatile anaestheticsQ41085686
Immobilizing doses of halothane, isoflurane or propofol, do not preferentially depress noxious heat-evoked responses of rat lumbar dorsal horn neurons with ascending projectionsQ41771683
General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit.Q44244818
Neural organization of the defensive behavior system responsible for fearQ44272854
Effect of isoflurane and other potent inhaled anesthetics on minimum alveolar concentration, learning, and the righting reflex in mice engineered to express alpha1 gamma-aminobutyric acid type A receptors unresponsive to isofluraneQ44342044
Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms.Q44588647
A gain-of-function mutation in the GABA receptor produces synaptic and behavioral abnormalities in the mouseQ45231249
Alpha 1 subunit-containing GABA type A receptors in forebrain contribute to the effect of inhaled anesthetics on conditioned fearQ46156560
Exaggerated anesthetic requirements in the preferentially anesthetized brain.Q46186108
Anesthetic potency (MAC) is independent of forebrain structures in the rat.Q46218573
An extrasynaptic GABAA receptor mediates tonic inhibition in thalamic VB neuronsQ46703347
Knockin mice with ethanol-insensitive alpha1-containing gamma-aminobutyric acid type A receptors display selective alterations in behavioral responses to ethanolQ48492906
GABA(A) receptor subunits in the rat hippocampus I: immunocytochemical distribution of 13 subunits.Q48624478
Gene knockout of the alpha6 subunit of the gamma-aminobutyric acid type A receptor: lack of effect on responses to ethanol, pentobarbital, and general anestheticsQ48746857
Potentiation of gamma-aminobutyric acid type A receptor-mediated chloride currents by novel halogenated compounds correlates with their abilities to induce general anesthesia.Q49082382
Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.Q51434685
Potentiation of gamma-aminobutyric acidA receptor Cl- current correlates with in vivo anesthetic potency.Q51626396
Anesthetic potencies of secondary alcohol enantiomers.Q51797640
Analysis of the set of GABA(A) receptor genes in the human genome.Q51994023
On biological assays involving quantal responsesQ52961674
Laminar compartmentalization of GABAA-receptor subtypes in the spinal cord: an immunohistochemical studyQ71038900
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectisofluraneQ413918
P304page(s)134-144
P577publication date2010-08-31
P1433published inJournal of Pharmacology and Experimental TherapeuticsQ1500272
P1476titleInhaled anesthetic responses of recombinant receptors and knockin mice harboring α2(S270H/L277A) GABA(A) receptor subunits that are resistant to isoflurane
P478volume336

Reverse relations

cites work (P2860)
Q37386370Alcohol Dependence and Genes Encoding α2 and γ1 GABAA Receptor Subunits: Insights from Humans and Mice.
Q34389061Altered anesthetic sensitivity of mice lacking Ndufs4, a subunit of mitochondrial complex I.
Q34071160Anesthetic agent-specific effects on synaptic inhibition
Q35924378Anxiety and depression: mouse genetics and pharmacological approaches to the role of GABA(A) receptor subtypes
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Q41710142Clinical concentrations of chemically diverse general anesthetics minimally affect lipid bilayer properties
Q38290581Effects of Gabra2 Point Mutations on Alcohol Intake: Increased Binge-Like and Blunted Chronic Drinking by Mice
Q37824834GABA(A) receptors as molecular targets of general anesthetics: identification of binding sites provides clues to allosteric modulation
Q87964129Identification of binding sites contributing to volatile anesthetic effects on GABA type A receptors
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Q35851064Isoflurane enhances both fast and slow synaptic inhibition in the hippocampus at amnestic concentrations.
Q34458650Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive α2-containing GABA(A) receptors.
Q38866827Mechanisms of the Immunological Effects of Volatile Anesthetics: A Review
Q36309696Mechanistic Insights into the Modulation of Voltage-Gated Ion Channels by Inhalational Anesthetics
Q30448542Mutations M287L and Q266I in the glycine receptor α1 subunit change sensitivity to volatile anesthetics in oocytes and neurons, but not the minimal alveolar concentration in knockin mice
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Q38014564The discovery of new anesthetics by targeting GABA(A) receptors
Q26827554The molecular pharmacology of volatile anesthetics
Q34566656Volatile anesthetics inhibit sodium channels without altering bulk lipid bilayer properties

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