CCM1-ICAP-1 complex controls β1 integrin-dependent endothelial contractility and fibronectin remodeling

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CCM1-ICAP-1 complex controls β1 integrin-dependent endothelial contractility and fibronectin remodeling is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.201303044
P932PMC publication ID3734079
P698PubMed publication ID23918940
P5875ResearchGate publication ID255688292

P50authorClaire RomeQ57617379
Corinne Albiges-RizoQ64681294
Eva FaurobertQ68223379
Daniel BouvardQ88421789
Justyna LisowskaQ90374900
Sandra Manet-DupéQ114408106
Anne-Pascale BouinQ114408107
Gwénola BouldayQ42187601
Elisabeth Tournier-LasserveQ42187629
Jean-Luc CollQ56384222
Martial BallandQ57452281
P2093author name stringFlorence Ruggiero
Marilyne Malbouyres
Michelle Kéramidas
P2860cites workKrit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1Q24296474
CCM1 regulates vascular-lumen organization by inducing endothelial polarityQ24304408
ICAP-1, a novel beta1 integrin cytoplasmic domain-associated protein, binds to a conserved and functionally important NPXY sequence motif of beta1 integrinQ24308783
CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesisQ24309334
Disruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alphaQ24324657
Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesisQ24338343
A two-hit mechanism causes cerebral cavernous malformations: complete inactivation of CCM1, CCM2 or CCM3 in affected endothelial cellsQ24654323
Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin ActivationQ27675893
Integrins: bidirectional, allosteric signaling machinesQ27860700
Regulation of cardiovascular development and integrity by the heart of glass-cerebral cavernous malformation protein pathwayQ28116174
KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesisQ28202423
Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformationQ28210519
KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctionsQ28254336
Rho kinase inhibition rescues the endothelial cell cerebral cavernous malformation phenotypeQ28274176
Cell adaptive response to extracellular matrix density is controlled by ICAP-1-dependent beta1-integrin affinityQ28507546
Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesionsQ28575990
Cell adhesion: integrating cytoskeletal dynamics and cellular tensionQ29618066
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cellsQ29619848
Fibronectins, their fibrillogenesis, and in vivo functionsQ30421926
Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formationQ30492193
Cell-ECM traction force modulates endogenous tension at cell-cell contacts.Q30499136
The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins.Q30500836
Osteoblast mineralization requires beta1 integrin/ICAP-1-dependent fibronectin depositionQ30502880
Spatial organization of the extracellular matrix regulates cell-cell junction positioning.Q30505114
Assembly of Fibronectin Extracellular MatrixQ30538938
Unraveling ICAP-1 function: toward a new direction?Q33236980
Second harmonic generation confocal microscopy of collagen type I from rat tendon cryosectionsQ33264767
Defective osteoblast function in ICAP-1-deficient miceQ33287597
Recent insights into cerebral cavernous malformations: a complex jigsaw puzzle under constructionQ33348515
Mechanosensing in actin stress fibers revealed by a close correlation between force and protein localizationQ33436122
Control of cell adhesion dynamics by Rap1 signalingQ33740476
Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrityQ33794968
Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotypeQ33811092
Thalidomide stimulates vessel maturation and reduces epistaxis in individuals with hereditary hemorrhagic telangiectasiaQ34021937
Developmental timing of CCM2 loss influences cerebral cavernous malformations in miceQ34209951
A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease.Q34424235
Binding of soluble fibronectin to integrin alpha5 beta1 - link to focal adhesion redistribution and contractile shape.Q34793769
Contact guidance mediated three-dimensional cell migration is regulated by Rho/ROCK-dependent matrix reorganizationQ34822720
The cerebral cavernous malformation signaling pathway promotes vascular integrity via Rho GTPasesQ34924413
Conditional deletion of Ccm2 causes hemorrhage in the adult brain: a mouse model of human cerebral cavernous malformations.Q35119689
Beta1 integrin establishes endothelial cell polarity and arteriolar lumen formation via a Par3-dependent mechanismQ35227393
Ultrastructural and immunocytochemical evidence that an incompetent blood-brain barrier is related to the pathophysiology of cavernous malformationsQ35463131
Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasisQ35628173
Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation diseaseQ35693325
Alternatively-spliced extra domain A of fibronectin promotes acute inflammation and brain injury after cerebral ischemia in mice.Q35911222
Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinityQ36237442
Signaling mechanisms regulating endothelial permeabilityQ36350076
The role of extracellular matrix in vascular branching morphogenesisQ36542074
The Extra-domain A of Fibronectin Is a Vascular Marker of Solid Tumors and MetastasesQ57912086
Binding of soluble form of fibroblast surface protein, fibronectin, to collagenQ67675651
Monoclonal Antibody 9EG7 Defines a Novel β1 Integrin Epitope Induced by Soluble Ligand and Manganese, but Inhibited by CalciumQ71823689
Down regulation of talin alters cell adhesion and the processing of the alpha 5 beta 1 integrinQ71825269
A 49-residue peptide from adhesin F1 of Streptococcus pyogenes inhibits fibronectin matrix assemblyQ73807660
The matrix reorganized: extracellular matrix remodeling and integrin signalingQ36571065
Fibronectin fibrillogenesis regulates three-dimensional neovessel formationQ36585500
Balancing forces: architectural control of mechanotransductionQ36588911
Dynamic and label-free cell-based assays using the real-time cell electronic sensing systemQ36658140
Cell traction forces direct fibronectin matrix assemblyQ37277062
Adhesion signaling - crosstalk between integrins, Src and Rho.Q37429375
Permanent cell line expressing human factor VIII-related antigen established by hybridizationQ37615209
Recent insights into cerebral cavernous malformations: the molecular genetics of CCM.Q37680004
Recipient-derived EDA fibronectin promotes cardiac allograft fibrosisQ37709678
Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesisQ37780682
Cerebral cavernous malformations as a disease of vascular permeability: from bench to bedside with cautionQ37784507
Fibronectin and tenascin-C: accomplices in vascular morphogenesis during development and tumor growth.Q37902604
β1-integrin: a potential therapeutic target in the battle against cancer recurrenceQ37928830
Spatial segregation between cell-cell and cell-matrix adhesionsQ38033861
A new micropatterning method of soft substrates reveals that different tumorigenic signals can promote or reduce cell contraction levels.Q39552355
Fibronectin-dependent collagen I deposition modulates the cell response to fibronectinQ40069445
Polymerization of type I and III collagens is dependent on fibronectin and enhanced by integrins alpha 11beta 1 and alpha 2beta 1.Q40714956
Interaction of the integrin beta1 cytoplasmic domain with ICAP-1 proteinQ40985640
Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformationsQ42187240
Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forcesQ42212876
A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.Q42238933
Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice.Q42250384
Krit1 modulates beta 1-integrin-mediated endothelial cell proliferationQ45787726
Integrin beta1 subunit controls mural cell adhesion, spreading, and blood vessel wall stabilityQ46803220
Proteomic identification of the cerebral cavernous malformation signaling complexQ46978413
Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations.Q48017009
Ultrastructural pathological features of cerebrovascular malformations: a preliminary report.Q52539441
P4510describes a project that usesImageJQ1659584
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
P1104number of pages17
P304page(s)545-561
P577publication date2013-08-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleCCM1-ICAP-1 complex controls β1 integrin-dependent endothelial contractility and fibronectin remodeling
P478volume202

Reverse relations

cites work (P2860)
Q35876785ANKS1B Interacts with the Cerebral Cavernous Malformation Protein-1 and Controls Endothelial Permeability but Not Sprouting Angiogenesis
Q34076187Alternative splicing of endothelial fibronectin is induced by disturbed hemodynamics and protects against hemorrhage of the vessel wall
Q38824364Beyond multiple mechanisms and a unique drug: Defective autophagy as pivotal player in cerebral cavernous malformation pathogenesis and implications for targeted therapies.
Q42615679CCM proteins control endothelial β1 integrin dependent response to shear stress
Q38203137CCM1 and the second life of proteins in adhesion complexes.
Q28650415CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation
Q37618688Ccm3, a gene associated with cerebral cavernous malformations, is required for neuronal migration
Q92853858Cerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation
Q28072671Cerebral Cavernous Malformations: Review of the Genetic and Protein-Protein Interactions Resulting in Disease Pathogenesis
Q37583343Cerebral cavernous malformation proteins at a glance.
Q57456322Cerebrovascular disorders associated with genetic lesions
Q34112722Conformational remodeling of the fibronectin matrix selectively regulates VEGF signaling
Q35047913Endothelial destabilization by angiopoietin-2 via integrin β1 activation.
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Q99211437EphrinB2-EphB4 signalling provides Rho-mediated homeostatic control of lymphatic endothelial cell junction integrity
Q38991274Essential function for PDLIM2 in cell polarization in three-dimensional cultures by feedback regulation of the β1-integrin-RhoA signaling axis.
Q64053576Fibronectin inhibitor pUR4 attenuates tumor necrosis factor α-induced endothelial hyperpermeability by modulating β1 integrin activation
Q48175918Heg1 and Ccm1/2 proteins control endocardial mechanosensitivity during zebrafish valvulogenesis.
Q30373402Impedance analysis of GPCR-mediated changes in endothelial barrier function: overview and fundamental considerations for stable and reproducible measurements
Q37351147Introduction to cerebral cavernous malformation: a brief review
Q30278010KLF4 is a key determinant in the development and progression of cerebral cavernous malformations
Q90568063KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction
Q61813848KRIT1 Loss-Of-Function Associated with Cerebral Cavernous Malformation Disease Leads to Enhanced -Glutathionylation of Distinct Structural and Regulatory Proteins
Q34552843KRIT1 protein depletion modifies endothelial cell behavior via increased vascular endothelial growth factor (VEGF) signaling
Q48127718Nuclear Localization of Integrin Cytoplasmic Domain-associated Protein-1 (ICAP1) Influences β1 Integrin Activation and Recruits Krev/Interaction Trapped-1 (KRIT1) to the Nucleus.
Q33605599Opposing effects of collagen I and vitronectin on fibronectin fibril structure and function
Q38957623Oxidative stress and inflammation in cerebral cavernous malformation disease pathogenesis: Two sides of the same coin.
Q38182363Protein conformation as a regulator of cell-matrix adhesion
Q38196358Regulation of the endothelial barrier function: a filum granum of cellular forces, Rho-GTPase signaling and microenvironment.
Q37705440STRIPAK components determine mode of cancer cell migration and metastasis.
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Q37722299Signaling pathways and the cerebral cavernous malformations proteins: lessons from structural biology.
Q28607249Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interface
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Q38717133The role of small GTPases and EPAC-Rap signaling in the regulation of the blood-brain and blood-retinal barriers
Q90319459Vis-à-vis: a focus on genetic features of cerebral cavernous malformations and brain arteriovenous malformations pathogenesis

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