Current neuroimaging techniques in Alzheimer's disease and applications in animal models

scientific article

Current neuroimaging techniques in Alzheimer's disease and applications in animal models is …
instance of (P31):
scholarly articleQ13442814

External links are
P932PMC publication ID3477739
P698PubMed publication ID23133824

P50authorRaymond Chuen-Chung ChangQ41932816
P2093author name stringLinda Zhang
Henry Ka-Fung Mak
Leung-Wing Chu
P2860cites workCorrelative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic MiceQ22242267
Cholinesterase inhibitors for Alzheimer's diseaseQ22252975
Long-term course and effectiveness of combination therapy in Alzheimer diseaseQ24642161
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memoryQ24645499
MRI patterns of atrophy associated with progression to AD in amnestic mild cognitive impairmentQ24645655
11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairmentQ24648319
Cingulate cortex hypoperfusion predicts Alzheimer's disease in mild cognitive impairmentQ24804621
Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1Q28118975
Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunizationQ28185520
Skeletal and CNS defects in Presenilin-1-deficient miceQ28238795
Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic miceQ28300764
Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesodermQ28585594
Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor proteinQ28592893
beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activityQ28593175
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-BQ29012704
Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairmentQ29547294
The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's diseaseQ29547554
Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS-ADRDA criteriaQ29614408
Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brainsQ29616293
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouseQ29619237
Amyloid deposition as the central event in the aetiology of Alzheimer's diseaseQ29619450
Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trialQ44735780
Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursorQ44777442
Effects of memantine on cognition in patients with moderate to severe Alzheimer's disease: post-hoc analyses of ADAS-cog and SIB total and single-item scores from six randomized, double-blind, placebo-controlled studiesQ44820313
Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profileQ44906525
Regional metabolic changes in the hippocampus and posterior cingulate area detected with 3-Tesla magnetic resonance spectroscopy in patients with mild cognitive impairment and Alzheimer diseaseQ44940013
Dynamics of gray matter loss in Alzheimer's disease.Q46191030
Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer diseaseQ46388486
PET imaging of brain with the beta-amyloid probe, [11C]6-OH-BTA-1, in a transgenic mouse model of Alzheimer's disease.Q46404881
Conversion of MCI to dementia: Role of proton magnetic resonance spectroscopyQ46528864
Detection of amyloid plaques in mouse models of Alzheimer's disease by magnetic resonance imagingQ46764922
Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition.Q47230871
Reduced size of right hippocampus in 39- to 80-year-old normal subjects carrying the apolipoprotein E epsilon4 alleleQ47298772
Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenesQ47583031
A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's diseaseQ47583762
Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer's diseaseQ47671587
Diffusion tensor imaging detects age-dependent white matter changes in a transgenic mouse model with amyloid depositionQ47844222
Diffusion-weighted and magnetization transfer imaging of the corpus callosum in Alzheimer's diseaseQ48104476
Characterization of in vivo MRI detectable thalamic amyloid plaques from APP/PS1 miceQ48127495
PET imaging of amyloid deposition in patients with mild cognitive impairmentQ48169392
Memantine in moderate to severe Alzheimer's disease: a meta-analysis of randomised clinical trialsQ48171083
Primate learning tasks reveal strong impairments in patients with presenile or senile dementia of the Alzheimer typeQ48198165
Longitudinal assessment of Alzheimer's beta-amyloid plaque development in transgenic mice monitored by in vivo magnetic resonance microimagingQ48453447
Imaging markers of mild cognitive impairment: multivariate analysis of CBF SPECT.Q48477449
Quantitative assessment of cerebral hemodynamic parameters by QUASAR arterial spin labeling in Alzheimer's disease and cognitively normal Elderly adults at 3-teslaQ48567726
Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteinsQ48601563
Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease modelQ48635943
Simultaneous measurement of arterial transit time, arterial blood volume, and cerebral blood flow using arterial spin-labeling in patients with Alzheimer diseaseQ48675651
Volumetric MRI and MRS provide sensitive measures of Alzheimer's disease neuropathology in inducible Tau transgenic mice (rTg4510)Q43594370
Memantine in moderate-to-severe Alzheimer's diseaseQ44388745
Mild cognitive impairment: Can FDG-PET predict who is to rapidly convert to Alzheimer's disease?Q44411562
Limbic hypometabolism in Alzheimer's disease and mild cognitive impairmentQ44571913
Apolipoprotein E protects against oxidative stress in mixed neuronal-glial cell cultures by reducing glutamate toxicityQ44583358
Apolipoprotein E e4 allele in the normal elderly: neuropsychologic and brain MRI correlatesQ48868567
Neuronal activity and early neurofibrillary tangles in Alzheimer's diseaseQ48935126
A new experimental approach and signal processing scheme for the detection and quantitation of ³¹P brain neurochemicals from in vivo MRS studies using dual tuned (¹H/³¹P) head coilQ48960744
Noninvasive in vivo MRI detection of neuritic plaques associated with iron in APP[V717I] transgenic mice, a model for Alzheimer's disease.Q49028511
Parkinson disease: diagnostic utility of diffusion kurtosis imagingQ49031391
Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease. Alzheimer's Disease Centers Consortium on Apolipoprotein E and Alzheimer's Disease.Q50907793
The vascular hypothesis of Alzheimer's disease: bench to bedside and beyond.Q51855473
Whole-brain atrophy rate in Alzheimer disease: identifying fast progressors.Q51891117
Donepezil in patients with severe Alzheimer's disease: double-blind, parallel-group, placebo-controlled study.Q51919586
Model-free arterial spin labeling quantification approach for perfusion MRI.Q51955793
Potential role of diffusion tensor MRI in the differential diagnosis of mild cognitive impairment and Alzheimer's disease.Q51965306
Assessment of cerebral blood flow in Alzheimer's disease by spin-labeled magnetic resonance imaging.Q51978363
Volumes of hippocampus, amygdala and frontal lobe in Alzheimer patients with different apolipoprotein E genotypes.Q52052697
Brain iron and ferritin in Parkinson's and Alzheimer's diseases.Q53184175
Quantitative 1H and 31P MRS of PCA extracts of postmortem Alzheimer's disease brain.Q53212464
Vascular involvement in cognitive decline and dementia. Epidemiologic evidence from the Rotterdam Study and the Rotterdam Scan Study.Q53235144
Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation.Q53338394
Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model.Q53341374
Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment.Q53350823
Ultrastructural hippocampal and white matter alterations in mild cognitive impairment: a diffusion tensor imaging study.Q53364124
Cerebral perfusion correlates of conversion to Alzheimer's disease in amnestic mild cognitive impairment.Q53454566
Hopes remain for an Alzheimer's vaccineQ59068383
Dosing in phase II trial of Alzheimer's vaccine suspendedQ73632329
Risk factors for cerebral hypoperfusion, mild cognitive impairment, and dementiaQ73924763
Do white matter changes contribute to the subsequent development of dementia in patients with mild cognitive impairment? A longitudinal studyQ74309189
Single photon emission computed tomography perfusion differences in mild cognitive impairmentQ36226953
Medial temporal structures relate to memory impairment in Alzheimer's disease: an MRI volumetric studyQ36316973
Major decrease in the volume of the entorhinal cortex in patients with Alzheimer's disease carrying the apolipoprotein E epsilon4 alleleQ36318674
31P nuclear magnetic resonance (NMR) spectroscopy of brain in aging and Alzheimer's disease.Q36447528
Detection of neuritic plaques in Alzheimer's disease by magnetic resonance microscopyQ36707869
Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathologyQ36724967
The projected effect of risk factor reduction on Alzheimer's disease prevalenceQ36825862
Proton magnetic resonance spectroscopy can differentiate Alzheimer's disease from normal agingQ36871035
Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer's disease, and other dementiasQ36990181
Anti-amyloid-beta immunotherapy in Alzheimer's disease: relevance of transgenic mouse studies to clinical trials.Q37041524
The value of incomplete mouse models of Alzheimer's diseaseQ37083271
Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's diseaseQ37118356
MRI and histological analysis of beta-amyloid plaques in both human Alzheimer's disease and APP/PS1 transgenic miceQ37295234
PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET.Q37351230
Animal models of Alzheimer's disease: therapeutic implications.Q37354734
Modeling Tauopathy in the fruit fly Drosophila melanogasterQ37354741
The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP.Q37354744
The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches.Q37354760
Estimation of working memory in macaques for studying drugs for the treatment of cognitive disordersQ37354764
Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's diseaseQ37398634
Donepezil in severe Alzheimer's diseaseQ37402181
Regional metabolic patterns in mild cognitive impairment and Alzheimer's disease: A 1H MRS studyQ37407266
Effects of injected Alzheimer beta-amyloid cores in rat brain.Q37596908
Vascular risk factor detection and control may prevent Alzheimer's diseaseQ37729423
Magnetic resonance imaging of amyloid plaques in transgenic mouse models of Alzheimer's diseaseQ37866098
Visualization of beta-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagentsQ38394981
Cerebrospinal fluid biomarkers in the differential diagnosis of Alzheimer's disease from other cortical dementiasQ38500630
Limitations of small animal PET imaging with [18F]FDDNP and FDG for quantitative studies in a transgenic mouse model of Alzheimer's diseaseQ39873732
In vivo measurement of plaque burden in a mouse model of Alzheimer's diseaseQ40171019
The gene defects responsible for familial Alzheimer's diseaseQ41288332
Correlation of phosphorus-31 magnetic resonance spectroscopy and morphologic findings in Alzheimer's diseaseQ41399691
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer diseaseQ41753192
Alzheimer's disease through the eye of a mouse. Acceptance lecture for the 2001 Gayle A. Olson and Richard D. Olson prizeQ42165184
Rodent models of Alzheimer's disease: rat A beta infusion approaches to amyloid depositsQ42521273
In vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agentQ42556930
Cerebrovascular and brain morphologic correlates of mild cognitive impairment in the National Heart, Lung, and Blood Institute Twin StudyQ43570563
Structural magnetic resonance imaging in the practical assessment of dementia: beyond exclusionQ30810310
Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialecticsQ30908064
Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experienceQ30983673
The role of quantitative structural imaging in the early diagnosis of Alzheimer's diseaseQ31030916
Molecular mechanisms for Alzheimer's disease: implications for neuroimaging and therapeuticsQ31047131
Magnetic resonance imaging of Alzheimer's pathology in the brains of living transgenic mice: a new tool in Alzheimer's disease researchQ31093609
White matter damage in Alzheimer disease and mild cognitive impairment: assessment with diffusion-tensor MR imaging and parallel imaging techniquesQ31110382
Non-mono-exponential attenuation of water and N-acetyl aspartate signals due to diffusion in brain tissueQ32071895
Proteomic analysis for protein carbonyl as an indicator of oxidative damage in senescence-accelerated miceQ33260812
A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's diseaseQ33292093
Alzheimer's disease: clinical trials and drug developmentQ33349401
Age-related non-Gaussian diffusion patterns in the prefrontal brainQ33386359
Magnetic resonance spectroscopy of the brain: review of metabolites and clinical applicationsQ33391815
Transgenic animals relevant to Alzheimer's diseaseQ33588638
MR diffusion kurtosis imaging for neural tissue characterization.Q33630700
Conversion of amyloid positive and negative MCI to AD over 3 years: an 11C-PIB PET study.Q33697980
SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E epsilon 4 alleleQ33735332
Monitoring disease progression in transgenic mouse models of Alzheimer's disease with proton magnetic resonance spectroscopyQ33920295
Aβ oligomers inhibit synapse remodelling necessary for memory consolidationQ33936929
Critically attained threshold of cerebral hypoperfusion: the CATCH hypothesis of Alzheimer's pathogenesisQ33950420
Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivoQ34063772
Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenesQ34452028
Alzheimer disease as a vascular disorder: nosological evidenceQ34589057
Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's diseaseQ34589414
Preclinical properties of 18F-AV-45: a PET agent for Abeta plaques in the brainQ34725521
Amyloid-beta: a vascular sealant that protects against hemorrhage?Q34976258
(99m)Tc hexamethyl-propylene-aminoxime single-photon emission computed tomography prediction of conversion from mild cognitive impairment to Alzheimer diseaseQ35010269
Alzheimer's disease: how does it start?Q35039914
Dying for a cause: invertebrate genetics takes on human neurodegenerationQ35074847
White matter damage in Alzheimer's disease assessed in vivo using diffusion tensor magnetic resonance imagingQ35467884
Looking Backward to Move Forward: Early Detection of Neurodegenerative DisordersQ35573431
Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer's diseaseQ35607811
Amyloid vs FDG-PET in the differential diagnosis of AD and FTLD.Q35609244
Toward modeling hemorrhagic and encephalitic complications of Alzheimer amyloid-beta vaccination in nonhuman primatesQ35876784
P433issue3
P921main subjectAlzheimer's diseaseQ11081
neuroimagingQ551875
P304page(s)386-404
P577publication date2012-07-10
P1433published inAmerican journal of nuclear medicine and molecular imagingQ27723780
P1476titleCurrent neuroimaging techniques in Alzheimer's disease and applications in animal models
P478volume2

Reverse relations

cites work (P2860)
Q34571189A review of neuroimaging biomarkers of Alzheimer's disease
Q37590895Design and synthesis of curcumin analogues for in vivo fluorescence imaging and inhibiting copper-induced cross-linking of amyloid beta species in Alzheimer's disease
Q28537832Hemodynamic and neuropathological analysis in rats with aluminum trichloride-induced Alzheimer's disease
Q26765945Insight into the Molecular Imaging of Alzheimer's Disease
Q37110373Molecular imaging strategies for in vivo tracking of microRNAs: a comprehensive review
Q38112726Multimodality imaging of RNA interference
Q35946092Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer's disease
Q38430889Neuroimaging Feature Terminology: A Controlled Terminology for the Annotation of Brain Imaging Features
Q28388580Pharmacokinetic issues of imaging with nanoparticles: focusing on carbon nanotubes and quantum dots
Q36746567Positron emission tomography imaging of vascular endothelial growth factor receptor expression with (61)Cu-labeled lysine-tagged VEGF121.
Q37337213Quantum dot-based nanoprobes for in vivo targeted imaging
Q37649861Synthesis and biomedical applications of copper sulfide nanoparticles: from sensors to theranostics

Search more.