scholarly article | Q13442814 |
P2093 | author name string | Michael A Rogawski | |
Henrik Klitgaard | |||
Rafal M Kaminski | |||
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Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A. | Q28281249 | ||
Fenofibrate, a peroxisome proliferator-activated receptor-alpha agonist, exerts anticonvulsive properties | Q28302788 | ||
Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection | Q28396785 | ||
The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy | Q28579751 | ||
Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent | Q28584148 | ||
Growing roles for the mTOR pathway | Q29616212 | ||
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen | Q29616224 | ||
Epilepsy biomarkers. | Q30411290 | ||
A role for leukocyte-endothelial adhesion mechanisms in epilepsy | Q30488791 | ||
Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy | Q30496223 | ||
Hippocampal FGF-2 and BDNF overexpression attenuates epileptogenesis-associated neuroinflammation and reduces spontaneous recurrent seizures. | Q30497503 | ||
Interleukin-1β biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice | Q30500480 | ||
Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndrome | Q30537599 | ||
Transient inhibition of TrkB kinase after status epilepticus prevents development of temporal lobe epilepsy | Q30542932 | ||
Searching for the ideal antiepileptogenic agent in experimental models: single treatment versus combinatorial treatment strategies | Q30576762 | ||
Neuroserpin mutation S52R causes neuroserpin accumulation in neurons and is associated with progressive myoclonus epilepsy | Q30622871 | ||
Effects of a single dose of erythropoietin on subsequent seizure susceptibility in rats exposed to acute hypoxia at P10. | Q33269936 | ||
Administration of simvastatin after kainic acid-induced status epilepticus restrains chronic temporal lobe epilepsy | Q34031703 | ||
Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2. | Q34155940 | ||
Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation | Q34226575 | ||
Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments | Q34282066 | ||
Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus | Q48484426 | ||
Ameliorative effect of pioglitazone on seizure responses in genetically epilepsy-susceptible EL mice | Q48485327 | ||
Post-treatment with rapamycin does not prevent epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy. | Q48722531 | ||
The PPARγ agonist rosiglitazone prevents cognitive impairment by inhibiting astrocyte activation and oxidative stress following pilocarpine-induced status epilepticus | Q48901148 | ||
Atorvastatin treatment during epileptogenesis in a rat model for temporal lobe epilepsy | Q49090389 | ||
Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator. | Q52051559 | ||
Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency. | Q52198955 | ||
Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy. | Q52609125 | ||
Levetiracetam may favorably affect seizure outcome after temporal lobectomy. | Q53168417 | ||
Vascular endothelial growth factor up-regulation in the mouse hippocampus and its role in the control of epileptiform activity. | Q54394455 | ||
Fumarates Promote Cytoprotection of Central Nervous System Cells against Oxidative Stress via the Nuclear Factor (Erythroid-Derived 2)-Like 2 Pathway | Q59344888 | ||
The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators | Q61415555 | ||
Bumetanide reduces seizure frequency in patients with temporal lobe epilepsy | Q61676480 | ||
Alpha 2-adrenoceptor agonist, dexmedetomidine, protects against kainic acid-induced convulsions and neuronal damage | Q71128803 | ||
Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy | Q74138296 | ||
Increased expression of erythropoietin receptor on blood vessels in the human epileptogenic hippocampus with sclerosis | Q75351318 | ||
Topiramate promotes neurological recovery in a new model of traumatic brain injury in rats | Q83876444 | ||
Neuroprotective effects of recombinant human erythropoietin in the developing brain of rat after lithium-pilocarpine induced status epilepticus | Q84159649 | ||
Levetiracetam: the first SV2A ligand for the treatment of epilepsy | Q86363817 | ||
Rapamycin has a beneficial effect on controlling epilepsy in children with tuberous sclerosis complex: results of 7 children from a cohort of 86 | Q86910950 | ||
Erythropoietin pretreatment suppresses seizures and prevents the increase in inflammatory mediators during pentylenetetrazole-induced generalized seizures | Q87047234 | ||
Lovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticus | Q34325797 | ||
VEGF receptor-2 (Flk-1) overexpression in mice counteracts focal epileptic seizures | Q34342111 | ||
The mechanism of neuroprotection by topiramate in an animal model of epilepsy. | Q34372245 | ||
Prevention or Modification of Epileptogenesis after Brain Insults: Experimental Approaches and Translational Research | Q34458158 | ||
Depression of synaptic transmission by vascular endothelial growth factor in adult rat hippocampus and evidence for increased efficacy after chronic seizures. | Q34482995 | ||
Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association | Q34576407 | ||
Statins: mechanism of action and effects. | Q34687736 | ||
Early treatment suppresses the development of spike-wave epilepsy in a rat model | Q34723299 | ||
The role of catecholamines in seizure susceptibility: new results using genetically engineered mice | Q34734993 | ||
Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy | Q34778218 | ||
Therapeutic role of mammalian target of rapamycin (mTOR) inhibition in preventing epileptogenesis | Q35028378 | ||
Promise of resveratrol for easing status epilepticus and epilepsy | Q35097960 | ||
How do statins control neuroinflammation? | Q35547770 | ||
The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions. | Q35824087 | ||
Vascular endothelial growth factor (VEGF) in seizures: a double-edged sword | Q35834542 | ||
Peroxisome proliferator-activated receptors γ/mitochondrial uncoupling protein 2 signaling protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus. | Q36241486 | ||
The tissue plasminogen activator (tPA)/plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrate | Q36326299 | ||
Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus | Q36402077 | ||
Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasmin | Q36574727 | ||
Role of oxidative stress in refractory epilepsy: evidence in patients and experimental models | Q36590070 | ||
Age-dependent effects of topiramate on the acquisition and the retention of rapid kindling. | Q36647742 | ||
Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation | Q36653830 | ||
Neuroprotective and antiepileptogenic effects of combination of anti-inflammatory drugs in the immature brain. | Q36690609 | ||
Results of phase 2 safety and feasibility study of treatment with levetiracetam for prevention of posttraumatic epilepsy. | Q36703584 | ||
Mammalian target of rapamycin: master regulator of cell growth in the nervous system | Q36822152 | ||
Development of new antiepileptic drugs: challenges, incentives, and recent advances | Q36913503 | ||
Results of phase II levetiracetam trial following acute head injury in children at risk for posttraumatic epilepsy | Q37161340 | ||
Finding a better drug for epilepsy: antiepileptogenesis targets. | Q37232240 | ||
Statin inhibits kainic acid-induced seizure and associated inflammation and hippocampal cell death | Q37243450 | ||
BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells. | Q37306648 | ||
Bumetanide inhibits rapid kindling in neonatal rats | Q37320851 | ||
Preventing and treating posttraumatic seizures: the human experience | Q37383515 | ||
Posttraumatic epilepsy: the challenge of translating discoveries in the laboratory to pathways to a cure | Q37383526 | ||
Single application of a CB1 receptor antagonist rapidly following head injury prevents long-term hyperexcitability in a rat model | Q37399998 | ||
Evaluation of the innate and adaptive immunity in type I and type II focal cortical dysplasias | Q43117316 | ||
Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsy | Q43240417 | ||
Prospective, randomized, single-blinded comparative trial of intravenous levetiracetam versus phenytoin for seizure prophylaxis | Q43245957 | ||
Effect of topiramate following recurrent and prolonged seizures during early development | Q44193568 | ||
The PPARγ agonist rosiglitazone prevents neuronal loss and attenuates development of spontaneous recurrent seizures through BDNF/TrkB signaling following pilocarpine-induced status epilepticus | Q44196643 | ||
The N-methyl-D-aspartate antagonists aminophosphonovalerate and carboxypiperazinephosphonate retard the development and expression of kindled seizures | Q44284970 | ||
Effects of lamotrigine and levetiracetam on seizure development in a rat amygdala kindling model | Q44308125 | ||
Evaluation of topiramate neuroprotective effect in severe TBI using microdialysis | Q44508301 | ||
Nrf2 defense pathway: Experimental evidence for its protective role in epilepsy. | Q44527858 | ||
The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy | Q44572950 | ||
Interleukin-1β Enhances NMDA Receptor-Mediated Intracellular Calcium Increase through Activation of the Src Family of Kinases | Q44595357 | ||
Consequences of inhibition of bumetanide metabolism in rodents on brain penetration and effects of bumetanide in chronic models of epilepsy | Q44616602 | ||
Neuroprotective properties of topiramate in the lithium-pilocarpine model of epilepsy | Q44639225 | ||
The antiepileptic drug levetiracetam selectively modifies kindling-induced alterations in gene expression in the temporal lobe of rats | Q44729812 | ||
Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy model | Q44829751 | ||
Levetiracetam prevents changes in levels of brain-derived neurotrophic factor and neuropeptide Y mRNA and of Y1- and Y5-like receptors in the hippocampus of rats undergoing amygdala kindling: implications for antiepileptogenic and mood-stabilizing p | Q44880525 | ||
Differential effects of the anticonvulsant topiramate on neurobehavioral and histological outcomes following traumatic brain injury in rats | Q44912317 | ||
Atipamezole, an alpha(2)-adrenoceptor antagonist, has disease modifying effects on epileptogenesis in rats | Q45080312 | ||
Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilespy | Q45284051 | ||
Proepileptic phenotype of SV2A-deficient mice is associated with reduced anticonvulsant efficacy of levetiracetam. | Q45987760 | ||
Transcriptional upregulation of Cav3.2 mediates epileptogenesis in the pilocarpine model of epilepsy. | Q46082573 | ||
Treatment of experimental status epilepticus in immature rats: dissociation between anticonvulsant and antiepileptogenic effects. | Q46092465 | ||
Protective effect of resveratrol against kainate-induced temporal lobe epilepsy in rats | Q46121091 | ||
Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsy | Q46137073 | ||
Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats | Q46308837 | ||
Effect of topiramate on cognitive function and single units from hippocampal place cells following status epilepticus | Q46311109 | ||
Efficacy and tolerability of levetiracetam versus phenytoin after supratentorial neurosurgery | Q46412337 | ||
Effects of chronic treatment with levetiracetam on hippocampal field responses after pilocarpine-induced status epilepticus in rats | Q46414611 | ||
Interleukin Converting Enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1beta production | Q46480418 | ||
Erythropoietin reduces epileptogenic processes following status epilepticus | Q46596388 | ||
Separation of antiepileptogenic and antiseizure effects of levetiracetam in the spontaneously epileptic rat (SER). | Q46629490 | ||
Anticonvulsive and antiepileptogenic effects of levetiracetam in the audiogenic kindling model | Q46657489 | ||
Management of epilepsy in tuberous sclerosis complex. | Q46697537 | ||
Epigenetic modulation of seizure-induced neurogenesis and cognitive decline. | Q46729231 | ||
Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy | Q46954553 | ||
Bumetanide enhances phenobarbital efficacy in a neonatal seizure model. | Q46964954 | ||
Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy | Q47795001 | ||
Effect of levetiracetam on visual-spatial memory following status epilepticus | Q47847677 | ||
Prophylactic treatment with levetiracetam after status epilepticus: lack of effect on epileptogenesis, neuronal damage, and behavioral alterations in rats | Q48129101 | ||
Topiramate reduces neuronal injury after experimental status epilepticus | Q48144553 | ||
Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy | Q48154139 | ||
The effect of the non-NMDA receptor antagonist GYKI 52466 and NBQX and the competitive NMDA receptor antagonist D-CPPene on the development of amygdala kindling and on amygdala-kindled seizures | Q48178824 | ||
Leukocyte trafficking mechanisms in epilepsy | Q48193828 | ||
Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependent | Q48379272 | ||
Fingolimod (FTY720) inhibits neuroinflammation and attenuates spontaneous convulsions in lithium-pilocarpine induced status epilepticus in rat model | Q48384403 | ||
Antiepileptic effects of topiramate on amygdaloid kindling in rats | Q48406834 | ||
Comparison of valproate and phenobarbital treatment after status epilepticus in rats | Q48425188 | ||
The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy | Q48431895 | ||
Neuronal sensitivity to kainic acid is dependent on the Nrf2-mediated actions of the antioxidant response element | Q48432157 | ||
Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy | Q48455854 | ||
Inhibition of VEGF receptor 2 increased cell death of dentate hilar neurons after traumatic brain injury | Q48466104 | ||
Convection-enhanced delivery in the treatment of epilepsy | Q37426998 | ||
Issues related to development of new antiseizure treatments | Q37626397 | ||
Therapeutic approaches to epileptogenesis--hope on the horizon | Q37771378 | ||
Monoclonal antibodies in neuro-oncology: Getting past the blood-brain barrier | Q37819809 | ||
Erythropoietin, erythropoiesis and beyond | Q37904170 | ||
Mammalian target of rapamycin (mTOR) activation in focal cortical dysplasia and related focal cortical malformations | Q37947981 | ||
Inflammation and epilepsy. | Q38039590 | ||
Mechanisms of action of antiseizure drugs | Q38039637 | ||
Is antiepileptogenesis a realistic goal in clinical trials? Concerns and new horizons. | Q38043469 | ||
Cerebrovascular remodeling and epilepsy | Q38052687 | ||
Why and how to target angiogenesis in focal epilepsies | Q38058377 | ||
From resveratrol to its derivatives: new sources of natural antioxidant | Q38064939 | ||
Glia and epilepsy: excitability and inflammation | Q38072496 | ||
Mechanisms of drug resistance in epilepsy: relevance for antiepileptic drug discovery | Q38088316 | ||
Toward clinical application of the Keap1-Nrf2 pathway | Q38105775 | ||
Dimethyl fumarate (BG-12) for the treatment of multiple sclerosis | Q38127463 | ||
New avenues for anti-epileptic drug discovery and development | Q38139837 | ||
Anti-epileptogenesis: Electrophysiology, diffusion tensor imaging and behavior in a genetic absence model. | Q38262225 | ||
Ethosuximide reduces epileptogenesis and behavioral comorbidity in the GAERS model of genetic generalized epilepsy | Q39646371 | ||
Statin use and risk of epilepsy: a nested case-control study | Q39824263 | ||
Prevention of plasticity of endocannabinoid signaling inhibits persistent limbic hyperexcitability caused by developmental seizures. | Q40460866 | ||
VEGF and seizures: cross-talk between endothelial and neuronal environments | Q41772480 | ||
IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients | Q42482233 | ||
Treatment with valproate after status epilepticus: effect on neuronal damage, epileptogenesis, and behavioral alterations in rats | Q42497528 | ||
Neuroprotective effects of erythropoietin in the rat hippocampus after pilocarpine-induced status epilepticus | Q42505506 | ||
Evaluation of development-specific targets for antiepileptogenic therapy using rapid kindling | Q42654751 | ||
Lack of resveratrol neuroprotection in developing rats treated with kainic acid | Q42714225 | ||
Localized overexpression of FGF-2 and BDNF in hippocampus reduces mossy fiber sprouting and spontaneous seizures up to 4 weeks after pilocarpine-induced status epilepticus. | Q42754610 | ||
Tissue-plasminogen activator is induced as an immediate-early gene during seizure, kindling and long-term potentiation | Q42811953 | ||
Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsy | Q42965558 | ||
Levetiracetam suppresses development of spontaneous EEG seizures and aberrant neurogenesis following kainate-induced status epilepticus | Q42989674 | ||
Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsy | Q43007324 | ||
The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsy | Q43114554 | ||
P433 | issue | 2 | |
P304 | page(s) | 385-400 | |
P577 | publication date | 2014-04-01 | |
P1433 | published in | Neurotherapeutics | Q15716631 |
P1476 | title | The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments | |
P478 | volume | 11 |
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