The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments

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The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments is …
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scholarly articleQ13442814

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P356DOI10.1007/S13311-014-0266-1
P932PMC publication ID3996125
P698PubMed publication ID24671870

P2093author name stringMichael A Rogawski
Henrik Klitgaard
Rafal M Kaminski
P2860cites workDo selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trialsQ24546221
Progress report on new antiepileptic drugs: a summary of the Eleventh Eilat Conference (EILAT XI)Q26825591
Cyclooxygenase-2 in epilepsy.Q26827095
Mitochondrial involvement and oxidative stress in temporal lobe epilepsyQ26865259
Anti-epileptogenic clinical trial designs in epilepsy: issues and optionsQ27027689
Rapamycin attenuates the development of posttraumatic epilepsy in a mouse model of traumatic brain injuryQ27319659
A systems level, functional genomics analysis of chronic epilepsyQ27335505
Modern antiepileptic drug development has failed to deliver: ways out of the current dilemmaQ27693823
The mechanisms of action of PPARsQ28216953
Natalizumab treatment for multiple sclerosis: updated recommendations for patient selection and monitoringQ28243804
Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A.Q28281249
Fenofibrate, a peroxisome proliferator-activated receptor-alpha agonist, exerts anticonvulsive propertiesQ28302788
Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotectionQ28396785
The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsyQ28579751
Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independentQ28584148
Growing roles for the mTOR pathwayQ29616212
Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogenQ29616224
Epilepsy biomarkers.Q30411290
A role for leukocyte-endothelial adhesion mechanisms in epilepsyQ30488791
Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsyQ30496223
Hippocampal FGF-2 and BDNF overexpression attenuates epileptogenesis-associated neuroinflammation and reduces spontaneous recurrent seizures.Q30497503
Interleukin-1β biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in miceQ30500480
Lovastatin corrects excess protein synthesis and prevents epileptogenesis in a mouse model of fragile X syndromeQ30537599
Transient inhibition of TrkB kinase after status epilepticus prevents development of temporal lobe epilepsyQ30542932
Searching for the ideal antiepileptogenic agent in experimental models: single treatment versus combinatorial treatment strategiesQ30576762
Neuroserpin mutation S52R causes neuroserpin accumulation in neurons and is associated with progressive myoclonus epilepsyQ30622871
Effects of a single dose of erythropoietin on subsequent seizure susceptibility in rats exposed to acute hypoxia at P10.Q33269936
Administration of simvastatin after kainic acid-induced status epilepticus restrains chronic temporal lobe epilepsyQ34031703
Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2.Q34155940
Oxidative stress in health and disease: the therapeutic potential of Nrf2 activationQ34226575
Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatmentsQ34282066
Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticusQ48484426
Ameliorative effect of pioglitazone on seizure responses in genetically epilepsy-susceptible EL miceQ48485327
Post-treatment with rapamycin does not prevent epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy.Q48722531
The PPARγ agonist rosiglitazone prevents cognitive impairment by inhibiting astrocyte activation and oxidative stress following pilocarpine-induced status epilepticusQ48901148
Atorvastatin treatment during epileptogenesis in a rat model for temporal lobe epilepsyQ49090389
Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator.Q52051559
Loss of fibrinogen rescues mice from the pleiotropic effects of plasminogen deficiency.Q52198955
Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy.Q52609125
Levetiracetam may favorably affect seizure outcome after temporal lobectomy.Q53168417
Vascular endothelial growth factor up-regulation in the mouse hippocampus and its role in the control of epileptiform activity.Q54394455
Fumarates Promote Cytoprotection of Central Nervous System Cells against Oxidative Stress via the Nuclear Factor (Erythroid-Derived 2)-Like 2 PathwayQ59344888
The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulatorsQ61415555
Bumetanide reduces seizure frequency in patients with temporal lobe epilepsyQ61676480
Alpha 2-adrenoceptor agonist, dexmedetomidine, protects against kainic acid-induced convulsions and neuronal damageQ71128803
Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsyQ74138296
Increased expression of erythropoietin receptor on blood vessels in the human epileptogenic hippocampus with sclerosisQ75351318
Topiramate promotes neurological recovery in a new model of traumatic brain injury in ratsQ83876444
Neuroprotective effects of recombinant human erythropoietin in the developing brain of rat after lithium-pilocarpine induced status epilepticusQ84159649
Levetiracetam: the first SV2A ligand for the treatment of epilepsyQ86363817
Rapamycin has a beneficial effect on controlling epilepsy in children with tuberous sclerosis complex: results of 7 children from a cohort of 86Q86910950
Erythropoietin pretreatment suppresses seizures and prevents the increase in inflammatory mediators during pentylenetetrazole-induced generalized seizuresQ87047234
Lovastatin modulates glycogen synthase kinase-3β pathway and inhibits mossy fiber sprouting after pilocarpine-induced status epilepticusQ34325797
VEGF receptor-2 (Flk-1) overexpression in mice counteracts focal epileptic seizuresQ34342111
The mechanism of neuroprotection by topiramate in an animal model of epilepsy.Q34372245
Prevention or Modification of Epileptogenesis after Brain Insults: Experimental Approaches and Translational ResearchQ34458158
Depression of synaptic transmission by vascular endothelial growth factor in adult rat hippocampus and evidence for increased efficacy after chronic seizures.Q34482995
Use of nonsteroidal antiinflammatory drugs: an update for clinicians: a scientific statement from the American Heart AssociationQ34576407
Statins: mechanism of action and effects.Q34687736
Early treatment suppresses the development of spike-wave epilepsy in a rat modelQ34723299
The role of catecholamines in seizure susceptibility: new results using genetically engineered miceQ34734993
Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsyQ34778218
Therapeutic role of mammalian target of rapamycin (mTOR) inhibition in preventing epileptogenesisQ35028378
Promise of resveratrol for easing status epilepticus and epilepsyQ35097960
How do statins control neuroinflammation?Q35547770
The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions.Q35824087
Vascular endothelial growth factor (VEGF) in seizures: a double-edged swordQ35834542
Peroxisome proliferator-activated receptors γ/mitochondrial uncoupling protein 2 signaling protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus.Q36241486
The tissue plasminogen activator (tPA)/plasmin extracellular proteolytic system regulates seizure-induced hippocampal mossy fiber outgrowth through a proteoglycan substrateQ36326299
Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampusQ36402077
Neuronal death in the central nervous system demonstrates a non-fibrin substrate for plasminQ36574727
Role of oxidative stress in refractory epilepsy: evidence in patients and experimental modelsQ36590070
Age-dependent effects of topiramate on the acquisition and the retention of rapid kindling.Q36647742
Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammationQ36653830
Neuroprotective and antiepileptogenic effects of combination of anti-inflammatory drugs in the immature brain.Q36690609
Results of phase 2 safety and feasibility study of treatment with levetiracetam for prevention of posttraumatic epilepsy.Q36703584
Mammalian target of rapamycin: master regulator of cell growth in the nervous systemQ36822152
Development of new antiepileptic drugs: challenges, incentives, and recent advancesQ36913503
Results of phase II levetiracetam trial following acute head injury in children at risk for posttraumatic epilepsyQ37161340
Finding a better drug for epilepsy: antiepileptogenesis targets.Q37232240
Statin inhibits kainic acid-induced seizure and associated inflammation and hippocampal cell deathQ37243450
BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells.Q37306648
Bumetanide inhibits rapid kindling in neonatal ratsQ37320851
Preventing and treating posttraumatic seizures: the human experienceQ37383515
Posttraumatic epilepsy: the challenge of translating discoveries in the laboratory to pathways to a cureQ37383526
Single application of a CB1 receptor antagonist rapidly following head injury prevents long-term hyperexcitability in a rat modelQ37399998
Evaluation of the innate and adaptive immunity in type I and type II focal cortical dysplasiasQ43117316
Comparison of the antiepileptogenic effects of an early long-term treatment with ethosuximide or levetiracetam in a genetic animal model of absence epilepsyQ43240417
Prospective, randomized, single-blinded comparative trial of intravenous levetiracetam versus phenytoin for seizure prophylaxisQ43245957
Effect of topiramate following recurrent and prolonged seizures during early developmentQ44193568
The PPARγ agonist rosiglitazone prevents neuronal loss and attenuates development of spontaneous recurrent seizures through BDNF/TrkB signaling following pilocarpine-induced status epilepticusQ44196643
The N-methyl-D-aspartate antagonists aminophosphonovalerate and carboxypiperazinephosphonate retard the development and expression of kindled seizuresQ44284970
Effects of lamotrigine and levetiracetam on seizure development in a rat amygdala kindling modelQ44308125
Evaluation of topiramate neuroprotective effect in severe TBI using microdialysisQ44508301
Nrf2 defense pathway: Experimental evidence for its protective role in epilepsy.Q44527858
The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsyQ44572950
Interleukin-1β Enhances NMDA Receptor-Mediated Intracellular Calcium Increase through Activation of the Src Family of KinasesQ44595357
Consequences of inhibition of bumetanide metabolism in rodents on brain penetration and effects of bumetanide in chronic models of epilepsyQ44616602
Neuroprotective properties of topiramate in the lithium-pilocarpine model of epilepsyQ44639225
The antiepileptic drug levetiracetam selectively modifies kindling-induced alterations in gene expression in the temporal lobe of ratsQ44729812
Effects of early long-term treatment with antiepileptic drugs on development of seizures and depressive-like behavior in a rat genetic absence epilepsy modelQ44829751
Levetiracetam prevents changes in levels of brain-derived neurotrophic factor and neuropeptide Y mRNA and of Y1- and Y5-like receptors in the hippocampus of rats undergoing amygdala kindling: implications for antiepileptogenic and mood-stabilizing pQ44880525
Differential effects of the anticonvulsant topiramate on neurobehavioral and histological outcomes following traumatic brain injury in ratsQ44912317
Atipamezole, an alpha(2)-adrenoceptor antagonist, has disease modifying effects on epileptogenesis in ratsQ45080312
Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilespyQ45284051
Proepileptic phenotype of SV2A-deficient mice is associated with reduced anticonvulsant efficacy of levetiracetam.Q45987760
Transcriptional upregulation of Cav3.2 mediates epileptogenesis in the pilocarpine model of epilepsy.Q46082573
Treatment of experimental status epilepticus in immature rats: dissociation between anticonvulsant and antiepileptogenic effects.Q46092465
Protective effect of resveratrol against kainate-induced temporal lobe epilepsy in ratsQ46121091
Effects of SC58236, a selective COX-2 inhibitor, on epileptogenesis and spontaneous seizures in a rat model for temporal lobe epilepsyQ46137073
Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in ratsQ46308837
Effect of topiramate on cognitive function and single units from hippocampal place cells following status epilepticusQ46311109
Efficacy and tolerability of levetiracetam versus phenytoin after supratentorial neurosurgeryQ46412337
Effects of chronic treatment with levetiracetam on hippocampal field responses after pilocarpine-induced status epilepticus in ratsQ46414611
Interleukin Converting Enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1beta productionQ46480418
Erythropoietin reduces epileptogenic processes following status epilepticusQ46596388
Separation of antiepileptogenic and antiseizure effects of levetiracetam in the spontaneously epileptic rat (SER).Q46629490
Anticonvulsive and antiepileptogenic effects of levetiracetam in the audiogenic kindling modelQ46657489
Management of epilepsy in tuberous sclerosis complex.Q46697537
Epigenetic modulation of seizure-induced neurogenesis and cognitive decline.Q46729231
Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsyQ46954553
Bumetanide enhances phenobarbital efficacy in a neonatal seizure model.Q46964954
Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsyQ47795001
Effect of levetiracetam on visual-spatial memory following status epilepticusQ47847677
Prophylactic treatment with levetiracetam after status epilepticus: lack of effect on epileptogenesis, neuronal damage, and behavioral alterations in ratsQ48129101
Topiramate reduces neuronal injury after experimental status epilepticusQ48144553
Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsyQ48154139
The effect of the non-NMDA receptor antagonist GYKI 52466 and NBQX and the competitive NMDA receptor antagonist D-CPPene on the development of amygdala kindling and on amygdala-kindled seizuresQ48178824
Leukocyte trafficking mechanisms in epilepsyQ48193828
Amelioration of water maze performance deficits by topiramate applied during pilocarpine-induced status epilepticus is negatively dose-dependentQ48379272
Fingolimod (FTY720) inhibits neuroinflammation and attenuates spontaneous convulsions in lithium-pilocarpine induced status epilepticus in rat modelQ48384403
Antiepileptic effects of topiramate on amygdaloid kindling in ratsQ48406834
Comparison of valproate and phenobarbital treatment after status epilepticus in ratsQ48425188
The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsyQ48431895
Neuronal sensitivity to kainic acid is dependent on the Nrf2-mediated actions of the antioxidant response elementQ48432157
Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategyQ48455854
Inhibition of VEGF receptor 2 increased cell death of dentate hilar neurons after traumatic brain injuryQ48466104
Convection-enhanced delivery in the treatment of epilepsyQ37426998
Issues related to development of new antiseizure treatmentsQ37626397
Therapeutic approaches to epileptogenesis--hope on the horizonQ37771378
Monoclonal antibodies in neuro-oncology: Getting past the blood-brain barrierQ37819809
Erythropoietin, erythropoiesis and beyondQ37904170
Mammalian target of rapamycin (mTOR) activation in focal cortical dysplasia and related focal cortical malformationsQ37947981
Inflammation and epilepsy.Q38039590
Mechanisms of action of antiseizure drugsQ38039637
Is antiepileptogenesis a realistic goal in clinical trials? Concerns and new horizons.Q38043469
Cerebrovascular remodeling and epilepsyQ38052687
Why and how to target angiogenesis in focal epilepsiesQ38058377
From resveratrol to its derivatives: new sources of natural antioxidantQ38064939
Glia and epilepsy: excitability and inflammationQ38072496
Mechanisms of drug resistance in epilepsy: relevance for antiepileptic drug discoveryQ38088316
Toward clinical application of the Keap1-Nrf2 pathwayQ38105775
Dimethyl fumarate (BG-12) for the treatment of multiple sclerosisQ38127463
New avenues for anti-epileptic drug discovery and developmentQ38139837
Anti-epileptogenesis: Electrophysiology, diffusion tensor imaging and behavior in a genetic absence model.Q38262225
Ethosuximide reduces epileptogenesis and behavioral comorbidity in the GAERS model of genetic generalized epilepsyQ39646371
Statin use and risk of epilepsy: a nested case-control studyQ39824263
Prevention of plasticity of endocannabinoid signaling inhibits persistent limbic hyperexcitability caused by developmental seizures.Q40460866
VEGF and seizures: cross-talk between endothelial and neuronal environmentsQ41772480
IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patientsQ42482233
Treatment with valproate after status epilepticus: effect on neuronal damage, epileptogenesis, and behavioral alterations in ratsQ42497528
Neuroprotective effects of erythropoietin in the rat hippocampus after pilocarpine-induced status epilepticusQ42505506
Evaluation of development-specific targets for antiepileptogenic therapy using rapid kindlingQ42654751
Lack of resveratrol neuroprotection in developing rats treated with kainic acidQ42714225
Localized overexpression of FGF-2 and BDNF in hippocampus reduces mossy fiber sprouting and spontaneous seizures up to 4 weeks after pilocarpine-induced status epilepticus.Q42754610
Tissue-plasminogen activator is induced as an immediate-early gene during seizure, kindling and long-term potentiationQ42811953
Cox-2 inhibition can lead to adverse effects in a rat model for temporal lobe epilepsyQ42965558
Levetiracetam suppresses development of spontaneous EEG seizures and aberrant neurogenesis following kainate-induced status epilepticusQ42989674
Disease-modifying effects of phenobarbital and the NKCC1 inhibitor bumetanide in the pilocarpine model of temporal lobe epilepsyQ43007324
The COX-2 inhibitor parecoxib is neuroprotective but not antiepileptogenic in the pilocarpine model of temporal lobe epilepsyQ43114554
P433issue2
P304page(s)385-400
P577publication date2014-04-01
P1433published inNeurotherapeuticsQ15716631
P1476titleThe potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments
P478volume11

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cites work (P2860)
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