Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis

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Alpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.0901404
P932PMC publication ID3999618
P698PubMed publication ID20483748
P5875ResearchGate publication ID44612568

P50authorBritta EngelhardtQ43814115
Robert RottapelQ51814787
P2093author name stringPooja Jain
Caroline Coisne
Gaby Enzmann
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Intra-articular fms-like tyrosine kinase 3 ligand expression is a driving force in induction and progression of arthritisQ33382375
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Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAEQ82810101
Intracerebral dendritic cells critically modulate encephalitogenic versus regulatory immune responses in the CNS.Q34140567
Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitisQ35829642
p150/95 (CD11c/CD18) expression is required for the development of experimental autoimmune encephalomyelitisQ35855614
Dendritic cell transmigration through brain microvessel endothelium is regulated by MIP-1alpha chemokine and matrix metalloproteinasesQ35946021
Alpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvesselsQ36168394
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Regulation of immune cell entry into the central nervous systemQ36636302
Antigen presentation in the CNS by myeloid dendritic cells drives progression of relapsing experimental autoimmune encephalomyelitisQ36766158
Dendritic cell behaviour in vivo: lessons learned from intravital two-photon microscopy.Q37145830
Circulating Ly-6C+ myeloid precursors migrate to the CNS and play a pathogenic role during autoimmune demyelinating disease.Q37151168
Perivascular spaces and the two steps to neuroinflammationQ37329042
P-selectin glycoprotein ligand 1 is not required for the development of experimental autoimmune encephalomyelitis in SJL and C57BL/6 miceQ40400365
Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis.Q40453661
Immature mouse dendritic cells enter inflamed tissue, a process that requires E- and P-selectin, but not P-selectin glycoprotein ligand 1.Q43863938
Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.Q46007698
CD163-positive perivascular macrophages in the human CNS express molecules for antigen recognition and presentation.Q46450925
L-selectin function is required for beta 2-integrin-mediated neutrophil adhesion at physiological shear rates in vivo.Q46901209
Cutting edge: Natalizumab blocks adhesion but not initial contact of human T cells to the blood-brain barrier in vivo in an animal model of multiple sclerosisQ47884689
Detection of endothelial/lymphocyte interaction in spinal cord microvasculature by intravital videomicroscopyQ48206326
Dendritic cells in multiple sclerosis lesions: maturation stage, myelin uptake, and interaction with proliferating T cellsQ48660181
Brain endothelium lack one of two pathways of P-selectin-mediated neutrophil adhesion.Q48829755
Decrease in the numbers of dendritic cells and CD4+ T cells in cerebral perivascular spaces due to natalizumabQ48882820
The potential role of dendritic cells in immune-mediated inflammatory diseases in the central nervous systemQ48932592
Two subsets of dendritic cells are present in human cerebrospinal fluidQ48974990
Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis.Q49014751
The blood-central nervous system barriers actively control immune cell entry into the central nervous systemQ49018946
Cutting edge: generation of splenic CD8+ and CD8- dendritic cell equivalents in Fms-like tyrosine kinase 3 ligand bone marrow cultures.Q52049353
CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ T(H)-17 cells in relapsing EAE.Q53015646
Endothelial, not hemodynamic, differences are responsible for preferential leukocyte rolling in rat mesenteric venules.Q53028508
Immune surveillance in multiple sclerosis patients treated with natalizumab.Q54606407
Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesionsQ59070288
The blood-brain barrier induces differentiation of migrating monocytes into Th17-polarizing dendritic cellsQ60446151
Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow culturesQ73119250
Is the pial microvessel a good model for blood-brain barrier studies?Q73535651
E- and P-selectin are not required for the development of experimental autoimmune encephalomyelitis in C57BL/6 and SJL miceQ80139592
Cutting edge: CNS CD11c+ cells from mice with encephalomyelitis polarize Th17 cells and support CD25+CD4+ T cell-mediated immunosuppression, suggesting dual roles in the disease processQ80358422
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectexperimental autoimmune encephalomyelitisQ494066
dendritic cellQ506253
blood–brain barrierQ221694
P304page(s)7196-7206
P577publication date2010-05-17
P1433published inJournal of ImmunologyQ3521441
P1476titleAlpha4beta1 integrin mediates the recruitment of immature dendritic cells across the blood-brain barrier during experimental autoimmune encephalomyelitis
P478volume184

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