NAD+ and SIRT3 control microtubule dynamics and reduce susceptibility to antimicrotubule agents

scientific article

NAD+ and SIRT3 control microtubule dynamics and reduce susceptibility to antimicrotubule agents is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PNAS..111E2443H
P356DOI10.1073/PNAS.1404269111
P8608Fatcat IDrelease_jvect7jf7zg6rag2hct3ciknr4
P932PMC publication ID4066477
P698PubMed publication ID24889606
P5875ResearchGate publication ID262846288

P2093author name stringParaskevi Giannakakou
Samie R Jaffrey
Kevin D Brown
Ananda K Ghosh
Alexandre Matov
William T Harkcom
Matthew S Sung
P2860cites workMolecular cloning, chromosomal localization, tissue mRNA levels, bacterial expression, and enzymatic properties of human NMN adenylyltransferaseQ24290390
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylaseQ24296766
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylaseQ24296836
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cellsQ24301843
Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferaseQ24338198
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survivalQ24612868
Inhibition of cell migration and cell division correlates with distinct effects of microtubule inhibiting drugsQ24633520
A local mechanism mediates NAD-dependent protection of axon degenerationQ24679199
Fiji: an open-source platform for biological-image analysisQ27860912
Biochemistry and molecular cell biology of diabetic complicationsQ28131781
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1Q28237795
Microtubules as a target for anticancer drugsQ28253993
Microtubule polymerization dynamicsQ28259930
The Sir2 family of protein deacetylasesQ28266179
New functions of a long-known molecule. Emerging roles of NAD in cellular signalingQ28372946
Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesisQ28510836
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylationQ28586153
Axon degeneration: Molecular mechanisms of a self-destruction pathwayQ29013985
Signal transduction by reactive oxygen speciesQ29615230
Sirtuins in mammals: insights into their biological functionQ29615248
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degenerationQ29616075
A third-generation lentivirus vector with a conditional packaging systemQ29616120
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activationQ29617458
Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1Q29619241
Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric RestrictionQ29619949
Organization and dynamics of growing microtubule plus ends during early mitosisQ30477651
Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injuryQ30513561
Multiparametric analysis of CLASP-interacting protein functions during interphase microtubule dynamicsQ30538764
Life cycle of MTs: persistent growth in the cell interior, asymmetric transition frequencies and effects of the cell boundaryQ31100715
The WldS gene delays axonal but not somatic degeneration in a rat glaucoma modelQ33368412
Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published dataQ33386435
A new splice variant of the mouse SIRT3 gene encodes the mitochondrial precursor proteinQ33424485
Protecting axonal degeneration by increasing nicotinamide adenine dinucleotide levels in experimental autoimmune encephalomyelitis models.Q33999656
Wallerian degeneration of injured axons and synapses is delayed by a Ube4b/Nmnat chimeric gene.Q34107309
Mechanism of action of antitumor drugs that interact with microtubules and tubulinQ34188643
Local translation of RhoA regulates growth cone collapseQ34231454
The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO SignalingQ34358623
Vinblastine suppresses dynamics of individual microtubules in living interphase cellsQ34451612
Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.Q34510395
Analysis of microtubule dynamic instability using a plus-end growth markerQ34547668
Quantitative image analysis identifies pVHL as a key regulator of microtubule dynamic instabilityQ35005618
A microfluidic culture platform for CNS axonal injury, regeneration and transportQ35014942
SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS productionQ35100923
Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotideQ35182446
The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylaseQ35774565
EB1-recruited microtubule +TIP complexes coordinate protrusion dynamics during 3D epithelial remodeling.Q35953923
APC is a component of an organizing template for cortical microtubule networksQ36012265
Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrationsQ36598611
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesityQ36739590
Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylomeQ36991517
Axonal elongation triggered by stimulus-induced local translation of a polarity complex proteinQ37298382
The SirT3 divining rod points to oxidative stressQ37887129
Mitochondrial sirtuins: regulators of protein acylation and metabolismQ38035693
Microtubule-destabilizing agents: structural and mechanistic insights from the interaction of colchicine and vinblastine with tubulin.Q38096825
Medicinal chemistry of nicotinamide phosphoribosyltransferase (NAMPT) inhibitorsQ38107280
Expression patterns of nicotinamide phosphoribosyltransferase and nicotinic acid phosphoribosyltransferase in human malignant lymphomas.Q39558774
NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress responseQ39642626
The Wlds transgene reduces axon loss in a Charcot-Marie-Tooth disease 1A rat model and nicotinamide delays post-traumatic axonal degenerationQ39804153
The human SIRT3 protein deacetylase is exclusively mitochondrialQ40021465
Inhibition of nicotinamide phosphoribosyltransferase: cellular bioenergetics reveals a mitochondrial insensitive NAD poolQ42009559
Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activationQ42497877
Activation of delta-isoform of protein kinase C is required for oxidant-induced disruption of both the microtubule cytoskeleton and permeability barrier of intestinal epitheliaQ42526036
Poly(ADP-ribose) polymerase-1-mediated cell death in astrocytes requires NAD+ depletion and mitochondrial permeability transitionQ44762646
NAD+ acts on mitochondrial SirT3 to prevent axonal caspase activation and axonal degenerationQ46147123
Structural basis for the regulation of tubulin by vinblastineQ46511115
Mechanism of inhibition of cell proliferation by Vinca alkaloids.Q46826837
Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3-green fluorescent protein).Q48342203
Disorganized microtubules underlie the formation of retraction bulbs and the failure of axonal regeneration.Q50668696
New functions of a long-known moleculeQ55952691
Implicating PARP and NAD+ depletion in type I diabetesQ60192401
Pharmacological Effects of Exogenous NAD on Mitochondrial Bioenergetics, DNA Repair, and ApoptosisQ60338061
The WldS gene modestly prolongs survival in the SOD1G93A fALS mouseQ81662125
Metabolomic Analysis of Livers and Serum from High-Fat Diet Induced Obese MiceQ82292576
Taxol facilitates axon regeneration in the mature CNSQ83421222
P433issue24
P407language of work or nameEnglishQ1860
P304page(s)E2443-52
P577publication date2014-06-02
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleNAD+ and SIRT3 control microtubule dynamics and reduce susceptibility to antimicrotubule agents
P478volume111

Reverse relations

cites work (P2860)
Q27312652Alterations of mitochondrial dynamics allow retrograde propagation of locally initiated axonal insults
Q47773202Human mesenchymal stromal cells transplanted into mice stimulate renal tubular cells and enhance mitochondrial function
Q39145655Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria
Q92536133Microtubules Stabilization by Mutant Spastin Affects ER Morphology and Ca2+ Handling
Q90675094Neuronal Growth Cone Size-Dependent and -Independent Parameters of Microtubule Polymerization
Q92498490Nicotinamide adenine dinucleotides and their precursor NMN have no direct effect on microtubule dynamics in purified brain tubulin
Q60044549Oxidative stress-induced structural changes in the microtubule-associated flavoenzyme Irc15p from Saccharomyces cerevisiae
Q36371538Poly(ADP-ribose) polymerase 1 is a novel target to promote axonal regeneration
Q46280873ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS).
Q59798260Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes
Q92598154SIRT3, PP2A and TTP protein stability in the presence of TNF-α on vincristine-induced apoptosis of leukaemia cells
Q52592887SIRT3: A New Regulator of Cardiovascular Diseases.
Q100512240Synthetic lethality of RB1 and aurora A is driven by stathmin-mediated disruption of microtubule dynamics

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