scholarly article | Q13442814 |
P50 | author | Alexander Kabanov | Q4206547 |
Dongfen Yuan | Q55965618 | ||
William A Banks | Q96067584 | ||
Chi-Duen Poon | Q125190479 | ||
P2093 | author name string | Xiang Yi | |
Susan A Farr | |||
P2860 | cites work | Positional cloning of the mouse obese gene and its human homologue | Q22251285 |
A comparison of mineral affinity of bisphosphonate-protein conjugates constructed with disulfide and thioether linkages | Q46627598 | ||
Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial | Q47254016 | ||
Decreased blood-brain leptin transfer in an ovine model of obesity and weight loss: resolving the cause of leptin resistance | Q47446156 | ||
Passage of leptin across the blood-testis barrier | Q48191237 | ||
Impaired transport of leptin across the blood-brain barrier in obesity is acquired and reversible | Q48373485 | ||
Combined use of carboxyl-directed protein pegylation and vector-mediated blood-brain barrier drug delivery system optimizes brain uptake of brain-derived neurotrophic factor following intravenous administration | Q48469485 | ||
Polyethylene glycol-conjugated superoxide dismutase fails to augment brain superoxide dismutase activity in piglets | Q48725134 | ||
Phenotype of the obese Koletsky (f) rat due to Tyr763Stop mutation in the extracellular domain of the leptin receptor (Lepr): evidence for deficient plasma-to-CSF transport of leptin in both the Zucker and Koletsky obese rat. | Q48794663 | ||
Changing the chemokine gradient: CINC1 crosses the blood-brain barrier | Q48931548 | ||
Engineering a pharmacologically superior form of leptin for the treatment of obesity. | Q51521643 | ||
Poly(ethylene glycol) modification of beta-glucuronidase-antibody conjugates for solid-tumor therapy by targeted activation of glucuronide prodrugs. | Q54560803 | ||
Characterization of the heterogeneity of polyethylene glycol-modified superoxide dismutase by chromatographic and electrophoretic techniques | Q68185064 | ||
Transport of alpha-aminoisobutyric acid across brain capillary and cellular membranes | Q71654240 | ||
Biologic response to peripheral and central administration of recombinant human leptin in dogs | Q73211131 | ||
Sensitive measurement of polyethylene glycol-modified proteins | Q73575039 | ||
The effect of pegylated recombinant human leptin (PEG-OB) on weight loss and inflammatory status in obese subjects | Q74329593 | ||
Accelerated clearance of polyethylene glycol-modified proteins by anti-polyethylene glycol IgM | Q77807340 | ||
Effect of dietary restraint during and following pegylated recombinant leptin (PEG-OB) treatment of overweight men | Q79317975 | ||
Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies | Q24650977 | ||
Therapeutic antibody targeting of individual Notch receptors | Q27660544 | ||
Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody | Q27677963 | ||
The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy | Q27933717 | ||
Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data | Q28274520 | ||
Central nervous system control of food intake | Q29547439 | ||
Universal sample preparation method for proteome analysis | Q29615662 | ||
Leptin and the regulation of body weight in mammals | Q29615976 | ||
DICHROWEB, an online server for protein secondary structure analyses from circular dichroism spectroscopic data | Q29617363 | ||
Protein secondary structure analyses from circular dichroism spectroscopy: methods and reference databases | Q29617578 | ||
Role of leptin in the neuroendocrine response to fasting | Q29618866 | ||
The utilization of pathogen-like cellular trafficking by single chain block copolymer | Q30499330 | ||
Transport across the blood-brain barrier of pluronic leptin. | Q33755265 | ||
Endocytosis of nanomedicines. | Q33987301 | ||
CNS delivery via adsorptive transcytosis | Q34013526 | ||
Pluronic-modified superoxide dismutase 1 attenuates angiotensin II-induced increase in intracellular superoxide in neurons | Q34390003 | ||
Peptide drug modifications to enhance bioavailability and blood-brain barrier permeability. | Q34489836 | ||
Neuroprotection with noninvasive neurotrophin delivery to the brain | Q34802946 | ||
Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities | Q35058921 | ||
Is obesity a disease of the blood-brain barrier? Physiological, pathological, and evolutionary considerations | Q35100987 | ||
Physiological response to long-term peripheral and central leptin infusion in lean and obese mice | Q36564953 | ||
Protein conjugation with amphiphilic block copolymers for enhanced cellular delivery. | Q36944967 | ||
Pegylated leptin antagonist is a potent orexigenic agent: preparation and mechanism of activity | Q37244706 | ||
Diet-induced obese mice develop peripheral, but not central, resistance to leptin | Q37362925 | ||
Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy | Q37368085 | ||
Leptin and neuropeptide Y (NPY) modulate nitric oxide synthase: further evidence for a role of nitric oxide in feeding | Q38321157 | ||
Chronic administration of OB protein decreases food intake by selectively reducing meal size in male rats. | Q38334882 | ||
Leptin enters the brain by a saturable system independent of insulin | Q38363314 | ||
Synthesis and biological evaluation of disulfide-linked HPMA copolymer-mesochlorin e6 conjugates | Q40021505 | ||
Large-scale preparation of biologically active mouse and rat leptins and their L39A/D40A/F41A muteins which act as potent antagonists | Q40350799 | ||
Monoclonal antibody-based quantitation of poly(ethylene glycol)-derivatized proteins, liposomes, and nanoparticles | Q40371074 | ||
Effects of cell-type specific leptin receptor mutation on leptin transport across the BBB. | Q42489044 | ||
Measurement of poly(ethylene glycol) by cell-based anti-poly(ethylene glycol) ELISA. | Q42829191 | ||
Leptin-based glycopeptide induces weight loss and simultaneously restores fertility in animal models | Q43087494 | ||
Enhanced leptin transport across the blood-brain barrier by alpha 1-adrenergic agents | Q43581368 | ||
Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onset | Q44575170 | ||
BiaCore analysis of leptin-leptin receptor interaction: evidence for 1:1 stoichiometry | Q44820224 | ||
P407 | language of work or name | English | Q1860 |
P921 | main subject | obesity | Q12174 |
P304 | page(s) | 34-46 | |
P577 | publication date | 2014-06-02 | |
P1433 | published in | Journal of Controlled Release | Q6295046 |
P1476 | title | Pluronic modified leptin with increased systemic circulation, brain uptake and efficacy for treatment of obesity | |
P478 | volume | 191 |
Q34079647 | Agile delivery of protein therapeutics to CNS |
Q42036645 | Blood-Brain Barriers in Obesity. |
Q92918920 | Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis |
Q37474214 | Brain signaling systems in the Type 2 diabetes and metabolic syndrome: promising target to treat and prevent these diseases |
Q47433079 | Drug Delivery to the Brain across the Blood-Brain Barrier Using Nanomaterials |
Q28550452 | In Vivo Biodistribution and Anti-Tumor Efficacy Evaluation of Doxorubicin and Paclitaxel-Loaded Pluronic Micelles Decorated with c(RGDyK) Peptide |
Q57469998 | Intranasal Leptin Relieves Sleep Disordered Breathing in Mice with Diet Induced Obesity |
Q47933830 | Intranasal delivery of N-terminal modified leptin-pluronic conjugate for treatment of obesity |
Q38475978 | Latest approaches for the treatment of obesity. |
Q28087233 | Leptin applications in 2015: what have we learned about leptin and obesity? |
Q38366277 | Leptin signaling as a therapeutic target of obesity |
Q47824357 | Macrophage exosomes as natural nanocarriers for protein delivery to inflamed brain. |
Q42841340 | Nano-particle delivery of brain derived neurotrophic factor after focal cerebral ischemia reduces tissue injury and enhances behavioral recovery. |
Q34330557 | New pharmacological perspectives for the leptin receptor in the treatment of obesity |
Q38767147 | Short peptides interfering with signaling pathways as new therapeutic tools for cancer treatment |
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