Pluronic modified leptin with increased systemic circulation, brain uptake and efficacy for treatment of obesity

scientific article

Pluronic modified leptin with increased systemic circulation, brain uptake and efficacy for treatment of obesity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JCONREL.2014.05.044
P932PMC publication ID4197010
P698PubMed publication ID24881856

P50authorAlexander KabanovQ4206547
Dongfen YuanQ55965618
William A BanksQ96067584
Chi-Duen PoonQ125190479
P2093author name stringXiang Yi
Susan A Farr
P2860cites workPositional cloning of the mouse obese gene and its human homologueQ22251285
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Polyethylene glycol-conjugated superoxide dismutase fails to augment brain superoxide dismutase activity in pigletsQ48725134
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Effect of dietary restraint during and following pegylated recombinant leptin (PEG-OB) treatment of overweight menQ79317975
Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studiesQ24650977
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Role of leptin in the neuroendocrine response to fastingQ29618866
The utilization of pathogen-like cellular trafficking by single chain block copolymerQ30499330
Transport across the blood-brain barrier of pluronic leptin.Q33755265
Endocytosis of nanomedicines.Q33987301
CNS delivery via adsorptive transcytosisQ34013526
Pluronic-modified superoxide dismutase 1 attenuates angiotensin II-induced increase in intracellular superoxide in neuronsQ34390003
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Is obesity a disease of the blood-brain barrier? Physiological, pathological, and evolutionary considerationsQ35100987
Physiological response to long-term peripheral and central leptin infusion in lean and obese miceQ36564953
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Pegylated leptin antagonist is a potent orexigenic agent: preparation and mechanism of activityQ37244706
Diet-induced obese mice develop peripheral, but not central, resistance to leptinQ37362925
Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapyQ37368085
Leptin and neuropeptide Y (NPY) modulate nitric oxide synthase: further evidence for a role of nitric oxide in feedingQ38321157
Chronic administration of OB protein decreases food intake by selectively reducing meal size in male rats.Q38334882
Leptin enters the brain by a saturable system independent of insulinQ38363314
Synthesis and biological evaluation of disulfide-linked HPMA copolymer-mesochlorin e6 conjugatesQ40021505
Large-scale preparation of biologically active mouse and rat leptins and their L39A/D40A/F41A muteins which act as potent antagonistsQ40350799
Monoclonal antibody-based quantitation of poly(ethylene glycol)-derivatized proteins, liposomes, and nanoparticlesQ40371074
Effects of cell-type specific leptin receptor mutation on leptin transport across the BBB.Q42489044
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Leptin-based glycopeptide induces weight loss and simultaneously restores fertility in animal modelsQ43087494
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Obesity-prone rats have normal blood-brain barrier transport but defective central leptin signaling before obesity onsetQ44575170
BiaCore analysis of leptin-leptin receptor interaction: evidence for 1:1 stoichiometryQ44820224
P407language of work or nameEnglishQ1860
P921main subjectobesityQ12174
P304page(s)34-46
P577publication date2014-06-02
P1433published inJournal of Controlled ReleaseQ6295046
P1476titlePluronic modified leptin with increased systemic circulation, brain uptake and efficacy for treatment of obesity
P478volume191

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