Development and screening of a polyketide virtual library for drug leads against a motilide pharmacophore

scientific article

Development and screening of a polyketide virtual library for drug leads against a motilide pharmacophore is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S1093-3263(00)00070-X
P698PubMed publication ID11143565

P2093author name stringKuntz ID
Skillman AG
Santi DV
Siani MA
Carreras CW
Ashley G
P2860cites workSynthesis of 9-deoxo-4''-deoxy-6,9-epoxyerythromycin derivatives: novel and acid-stable motilidesQ77158427
Engineering of modular polyketide synthases to produce novel polyketidesQ77343517
Identification of the motilide pharmacophores using quantitative structure activity relationshipsQ77614032
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Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products.Q30650504
Synthesis and Applications of Small Molecule LibrariesQ30814137
Motilides, macrolides with gastrointestinal motor stimulating activity. I. O-substituted and tertiary N-substituted derivatives of 8,9-anhydroerythromycin A 6,9-hemiacetalQ30977205
Applications of genetic algorithms in molecular diversityQ32044976
Microbial polyketide synthases: more and more prolificQ33546208
Novel macrolides through genetic engineeringQ33771935
Motilin, a Gastric Motor Activity Stimulating Polypeptide: The Complete Amino Acid SequenceQ34216976
The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine libraryQ35271840
"Diversomers": an approach to nonpeptide, nonoligomeric chemical diversityQ36439632
An erythromycin analog produced by reprogramming of polyketide synthesisQ36451359
Measuring diversity: experimental design of combinatorial libraries for drug discoveryQ36702676
Discovery of nanomolar ligands for 7-transmembrane G-protein-coupled receptors from a diverse N-(substituted)glycine peptoid libraryQ36737683
Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial librariesQ36749429
Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directionsQ36749967
Enhancing the diversity of a corporate database using chemical database clustering and analysisQ36794962
Designing combinatorial library mixtures using a genetic algorithmQ36873770
D-amino acid and alanine scans of the bioactive portion of porcine motilinQ44922712
CHUCKLES: a method for representing and searching peptide and peptoid sequences on both monomer and atomic levelsQ46555683
CHORTLES: a method for representing oligomeric and template-based mixturesQ46833015
Effects of a new motilide, ABT-229, on gastric emptying and postprandial antroduodenal motility in healthy volunteersQ47847767
Conformational analysis. 130. MM2. A hydrocarbon force field utilizing V1 and V2 torsional termsQ55878541
Three-Dimensional Structure and Position of Porcine Motilin in Sodium Dodecyl Sulfate Micelles Determined by1H NMR†Q58486533
The erythromycin derivative EM-523 is a potent motilin agonist in man and in rabbitQ68878378
Macrolides with gastrointestinal motor stimulating activityQ69427002
Motilin receptors in rabbit stomach and small intestineQ69674877
Bioactive metabolites of EM574 and EM523, erythromycin derivatives having strong gastrointestinal motor stimulating activityQ71572442
Structure-function studies of motilin analoguesQ72154437
Synthesis of 4"-deoxy motilides: identification of a potent and orally active prokinetic drug candidateQ72241518
Effects of LY267108, an erythromycin analogue derivative, on lower esophageal sphincter function in the catQ72271501
P433issue4-5
P921main subjectdrug screeningQ10505555
P304page(s)497-511, 539-40
P577publication date2000-08-01
P1433published inJournal of Molecular Graphics & ModellingQ3186928
P1476titleDevelopment and screening of a polyketide virtual library for drug leads against a motilide pharmacophore
P478volume18

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cites work (P2860)
Q35100294New developments in the treatment of functional dyspepsia
Q35669824Progress with novel pharmacological strategies for gastro-oesophageal reflux disease.
Q34421482Review article: the pharmacological treatment of acute colonic pseudo-obstruction

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