Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer: a pooled analysis of two randomised trials

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Stereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer: a pooled analysis of two randomised trials is …
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scholarly articleQ13442814

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P356DOI10.1016/S1470-2045(15)70168-3
P932PMC publication ID4489408
P698PubMed publication ID25981812
P5875ResearchGate publication ID278652545

P50authorSuresh SenanQ37830477
Joachim WidderQ41085060
Ritsuko KomakiQ64585410
Harry J M GroenQ86505093
Mark F MunsellQ90326364
P2093author name stringLei Feng
Donald A Berry
Jack A Roth
Egbert F Smit
Reza J Mehran
Joe Y Chang
Alexander V Louie
Anne-Marie Dingemans
Ben E E M van den Borne
Ben J Slotman
Coen Hurkmans
Cornelis J A Haasbeek
Erik van Werkhoven
John J Kresl
Katrien De Jaeger
Larry S Carpenter
Marinus A Paul
Omar Dawood
Peter Balter
Stephen E McRae
P2860cites workLobectomy, sublobar resection, and stereotactic ablative radiotherapy for early-stage non-small cell lung cancers in the elderlyQ30640824
Data from The Society of Thoracic Surgeons General Thoracic Surgery database: the surgical management of primary lung tumorsQ31145126
Stereotactic body radiation therapy for inoperable early stage lung cancerQ34010065
Randomized trial of lobectomy versus limited resection for T1 N0 non-small cell lung cancer. Lung Cancer Study GroupQ34721402
Clinical outcome and predictors of survival and pneumonitis after stereotactic ablative radiotherapy for stage I non-small cell lung cancerQ36241457
Positron emission tomography for assessing local failure after stereotactic body radiotherapy for non-small-cell lung cancerQ36327908
Surgery for early-stage non-small cell lung cancer: a systematic review of the video-assisted thoracoscopic surgery versus thoracotomy approaches to lobectomyQ37330615
Comparison of the effectiveness of radiotherapy with photons, protons and carbon-ions for non-small cell lung cancer: a meta-analysisQ37592621
Stereotactic body radiotherapy (SBRT) for operable stage I non-small-cell lung cancer: can SBRT be comparable to surgery?Q37773607
Mediastinal staging of lung cancer: novel conceptsQ38007233
Outcomes after lobectomy using thoracoscopy vs thoracotomy: a comparative effectiveness analysis utilizing the Nationwide Inpatient Sample databaseQ40051115
Morbidity and mortality of major pulmonary resections in patients with early-stage lung cancer: initial results of the randomized, prospective ACOSOG Z0030 trial.Q40349654
Stereotactic body radiotherapy for medically inoperable lung cancer: prospective, single-center study of 108 consecutive patients.Q44017103
Impact of introducing stereotactic lung radiotherapy for elderly patients with stage I non-small-cell lung cancer: a population-based time-trend analysisQ44592987
Treatment of stage I NSCLC in elderly patients: a population-based matched-pair comparison of stereotactic radiotherapy versus surgeryQ45395354
Ninety-day mortality after resection for lung cancer is nearly double 30-day mortalityQ46157366
Patterns of recurrence and second primary lung cancer in early-stage lung cancer survivors followed with routine computed tomography surveillance.Q53134171
Stereotactic body radiation therapy versus surgical resection for stage I non-small cell lung cancer.Q53299557
Stage I–II non-small-cell lung cancer treated using either stereotactic ablative radiotherapy (SABR) or lobectomy by video-assisted thoracoscopic surgery (VATS): outcomes of a propensity score-matched analysisQ59587327
Developments in early-stage NSCLC: advances in radiotherapyQ59587387
Outcomes of Stereotactic Ablative Radiotherapy in Patients With Potentially Operable Stage I Non-Small Cell Lung CancerQ59587407
Outcomes of Risk-Adapted Fractionated Stereotactic Radiotherapy for Stage I Non–Small-Cell Lung CancerQ59587541
Stereotactic hypofractionated high-dose irradiation for stage I nonsmall cell lung carcinoma: clinical outcomes in 245 subjects in a Japanese multiinstitutional studyQ80587769
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectlung cancerQ47912
adaptive radiation therapyQ180507
P304page(s)630-637
P577publication date2015-05-13
P1433published inLancet Oncology CommissionQ13747613
P1476titleStereotactic ablative radiotherapy versus lobectomy for operable stage I non-small-cell lung cancer: a pooled analysis of two randomised trials
P478volume16

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Q39181674Ratio of C-reactive protein to albumin is a prognostic factor for operable non-small-cell lung cancer in elderly patients.
Q99239657Reactive Oxygen Species Modulator 1 is Associated with Poor Survival in Patients with Non-Small Cell Lung Cancer After Stereotactic Fractionated Radiosurgery: A Retrospective Pilot Study
Q39223364Real-time 4D dose reconstruction for tracked dynamic MLC deliveries for lung SBRT.
Q46034873Real-time tomosynthesis for radiation therapy guidance.
Q26747020Recent Advances in Bronchoscopic Treatment of Peripheral Lung Cancers
Q47105316Recent advances in the management of non-small cell lung cancer
Q47986975Recommendations from the European Society of Thoracic Surgeons (ESTS) regarding computed tomography screening for lung cancer in Europe
Q36301196Redefining radiotherapy for early-stage breast cancer with single dose ablative treatment: a study protocol
Q40455887Reducing scan angle using adaptive prior knowledge for a limited-angle intrafraction verification (LIVE) system for conformal arc radiotherapy.
Q52450428Reirradiation of Skull Base Tumors With Advanced Highly Conformal Techniques.
Q52878867Reirradiation of recurrent node-positive non-small cell lung cancer after previous stereotactic radiotherapy for stage I disease : A multi-institutional treatment recommendation.
Q36938199Renal atrophy after stereotactic body radiotherapy for renal cell carcinoma.
Q64946137Repeat stereotactic body radiotherapy (SBRT) for local recurrence of non-small cell lung cancer and lung metastasis after first SBRT.
Q55119541Response criteria in solid tumors (PERCIST/RECIST) and SUVmax in early-stage non-small cell lung cancer patients treated with stereotactic body radiotherapy.
Q39496906Risk Factors Associated With Symptomatic Radiation Pneumonitis After Stereotactic Body Radiation Therapy for Stage I Non-Small Cell Lung Cancer
Q42590974Risk calculators are useful but....
Q48233447Risk-adapted robotic stereotactic body radiation therapy for inoperable early-stage non-small-cell lung cancer.
Q87322426SABR in early operable lung cancer: time for evidence
Q86150669SABR vs surgery for NSCLC in the media
Q38813253SABR vs. Limited Resection for Non-small Cell Lung Cancer: Are We Closer to an Answer?
Q93080685SABR-COMET: harbinger of a new cancer treatment paradigm
Q98157769SBRT combined with PD-1/PD-L1 inhibitors in NSCLC treatment: a focus on the mechanisms, advances, and future challenges
Q39135612SBRT for centrally localized NSCLC - What is too central?
Q42384628SBRT versus lobectomy in stage I NSCLC: knowns, unknowns and its interpretation
Q38863092Safety and feasibility of prolonged bronchoscopy involving diagnosis of lung cancer, systematic nodal staging, and fiducial marker placement in a high-risk population
Q90697953Salvage stereotactic body radiotherapy for post-operative oligo-recurrence of non-small cell lung cancer: A single-institution analysis of 59 patients
Q39265624Salvage surgery after high-dose radiotherapy
Q63367919Salvage surgery for local recurrence after stereotactic body radiotherapy for early stage non-small cell lung cancer: a systematic review
Q47428325Serum MicroRNA Signature Predicts Response to High-Dose Radiation Therapy in Locally Advanced Non-Small Cell Lung Cancer
Q42359042Shared decision making in the treatment of stage I non small cell lung cancer-a choice which should equally involve both sides
Q38994894Short report: interim safety results for a phase II trial measuring the integration of stereotactic ablative radiotherapy (SABR) plus surgery for early stage non-small cell lung cancer (MISSILE-NSCLC).
Q57805631Short-term outcomes and clinical efficacy of stereotactic body radiation therapy (SBRT) in treatment of adrenal gland metastases from lung cancer
Q55251778Similar results of robotic and uniportal videothoracoscopic surgery for lung cancer treatment.
Q38871523Simple Factors Associated With Radiation-Induced Lung Toxicity After Stereotactic Body Radiation Therapy of the Thorax: A Pooled Analysis of 88 Studies
Q37013991Solutions that enable ablative radiotherapy for large liver tumors: Fractionated dose painting, simultaneous integrated protection, motion management, and computed tomography image guidance
Q42384638Stage I lung cancer-to operate or to radiate? that is the question
Q40308740Stereotactic Ablative Radiation Therapy is Highly Safe and Effective for Elderly Patients With Early-stage Non-Small Cell Lung Cancer
Q52886428Stereotactic Ablative Radiotherapy Induces Peripheral T-Cell Activation in Patients with Early-Stage Lung Cancer.
Q39342656Stereotactic Body Radiation Therapy Delivery in a Genetically Engineered Mouse Model of Lung Cancer
Q91996939Stereotactic Body Radiation Therapy Versus Nonradiotherapeutic Ablative Procedures (Laser/Cryoablation and Electrocautery) for Early-Stage Non-Small Cell Lung Cancer
Q57764566Stereotactic Body Radiation Therapy for Patients with Pulmonary Interstitial Change: High Incidence of Fatal Radiation Pneumonitis in a Retrospective Multi-Institutional Study
Q93378567Stereotactic Body Radiotherapy for Early-Stage Multiple Primary Lung Cancers
Q49310050Stereotactic Body Radiotherapy for Early-stage Non-small-cell Lung Cancer in Patients 80 Years and Older: A Multi-center Analysis.
Q42558770Stereotactic Radiotherapy for Stage I Small Cell Lung Cancer
Q42362383Stereotactic ablative body radiation therapy or surgery for operable early non-small cell lung cancer patients: bound hand and foot to evidence.
Q41112569Stereotactic ablative radiotherapy (SABR) in operable early stage non-small cell lung cancer (NSCLC) patients: challenge to claim being undisputed gold standard
Q38828265Stereotactic ablative radiotherapy and immunotherapy combinations: turning the future into systemic therapy?
Q35783598Stereotactic ablative radiotherapy and surgery: two gold standards for early-stage non-small cell lung cancer?
Q92127930Stereotactic ablative radiotherapy and systemic treatments for extracerebral oligometastases, oligorecurrence, oligopersistence and oligoprogression from lung cancer
Q38549543Stereotactic ablative radiotherapy for early stage non-small cell lung cancer: a word of caution
Q89507738Stereotactic ablative radiotherapy of 60 Gy in eight fractions is safe for ultracentral non-small cell lung cancer
Q50096367Stereotactic ablative radiotherapy versus lobectomy for stage I non-small cell lung cancer: A systematic review
Q91631990Stereotactic ablative radiotherapy versus standard radiotherapy in stage 1 non-small-cell lung cancer (TROG 09.02 CHISEL): a phase 3, open-label, randomised controlled trial
Q57172947Stereotactic body radiation therapy (SBRT) for early stage non-small cell lung cancer (NSCLC): contemporary insights and advances
Q55282076Stereotactic body radiation therapy (SBRT) in the management of non-small-cell lung cancer: Clinical impact and patient perspectives.
Q64081395Stereotactic body radiation therapy and surgery for early lung cancer "two sides of the same coin"
Q57177641Stereotactic body radiation therapy for lung, spine and oligometastatic disease: current evidence and future directions
Q60912983Stereotactic body radiation therapy for non-small cell lung cancer: A review
Q91875040Stereotactic body radiation therapy for oligometastatic pulmonary tumors from cervical cancer
Q64228173Stereotactic body radiation therapy for pulmonary large cell neuroendocrine carcinoma: a case report
Q40073828Stereotactic body radiation therapy for small primary or recurrent hepatocellular carcinoma in 132 Chinese patients
Q64096283Stereotactic body radiation therapy in early-stage NSCLC: historical review, contemporary evidence and future implications
Q64928708Stereotactic body radiation therapy versus metastasectomy for oligometastases.
Q30992150Stereotactic body radiation therapy versus no treatment for early stage non-small cell lung cancer in medically inoperable elderly patients: A National Cancer Data Base analysis
Q64922876Stereotactic body radiation therapy versus surgery for early stage non-small cell lung cancer: clearing a path through an evolving treatment landscape.
Q55062398Stereotactic body radiation therapy vs. surgery in early-stage non-small cell lung cancer: lessons learned, current recommendations, future directions.
Q64917835Stereotactic body radiotherapy for centrally-located lung tumors with 56 Gy in seven fractions: A retrospective study.
Q90329602Stereotactic body radiotherapy for early-stage non-small cell lung cancer has low post-treatment mortality
Q38935913Stereotactic body radiotherapy for oligoprogressive cancer
Q90329595Stereotactic body radiotherapy for operable, early stage non-small cell lung cancer-let's all take a deep breath
Q38783194Stereotactic body radiotherapy for pancreatic cancer: recent progress and future directions
Q41273661Stereotactic body radiotherapy for stage I non-small-cell lung cancer using higher doses for larger tumors: results of the second study.
Q26781806Stereotactic body radiotherapy in lung cancer: an update
Q90701467Stereotactic body radiotherapy in patients with lung tumors composed of mainly ground-glass opacity
Q33813299Stereotactic body radiotherapy or stereotactic ablative radiotherapy versus surgery for patients with T1-3N0M0 non-small cell lung cancer: a systematic review and meta-analysis
Q39769743Stereotactic body radiotherapy versus lobectomy for operable clinical stage IA lung adenocarcinoma: comparison of survival outcomes in two clinical trials with propensity score analysis (JCOG1313-A).
Q28076058Stereotactic body radiotherapy: current strategies and future development
Q35824255Stereotactic radiotherapy for early stage non-small cell lung cancer
Q48183175Stereotactic radiotherapy for primary renal cell carcinoma: time for larger-scale prospective studies
Q87273860Stereotactic radiotherapy or surgery for early-stage non-small-cell lung cancer
Q59587237Stereotactic radiotherapy or surgery for early-stage non-small-cell lung cancer – Authors' reply
Q39123715Strategies for Translating Evidence-Based Medicine in Lung Cancer into Community Practice
Q47159062Summary of the lecture given on June 1, 2017 on the occasion of the Jacob I. Fabrikant Award ceremony
Q38732479Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy
Q57864954Surgery SBRT in retrospective analyses: confounding by operability is the elephant in the room
Q90087984Surgery and stereotactic body radiotherapy for early stage non-small cell lung cancer: review of meta-analyses
Q47106372Surgery compared to stereotactic body radiation therapy for early-stage non-small cell lung cancer: better, equivalent or worse?
Q47781280Surgery or stereotactic body radiotherapy for elderly stage I lung cancer? A propensity score matching analysis.
Q42354883Surgery versus SABR for early stage non-small cell lung cancer: the moving target of equipoise
Q55012865Surgery versus SABR for resectable non-small-cell lung cancer
Q85846446Surgery versus SABR for resectable non-small-cell lung cancer
Q95419806Surgery versus SABR for resectable non-small-cell lung cancer
Q95419835Surgery versus SABR for resectable non-small-cell lung cancer
Q59587263Surgery versus SABR for resectable non-small-cell lung cancer – Authors' reply
Q52836419Surgery versus SABR for resectable non-small-cell lung cancer.
Q26748296Surgery versus stereotactic ablative radiotherapy (SABR) for early-stage non-small cell lung cancer: less is not more
Q48369218Surgery versus stereotactic body radiation therapy for stage I non-small cell lung cancer: A comprehensive review.
Q58764285Surgical Resection Versus Stereotactic Body Radiation Therapy for Stage I NSCLC: Can Randomized Trials Provide the Solution?
Q53101096Survival Outcome after Stereotactic Body Radiation Therapy and Surgery for Early Stage Non-Small Cell Lung Cancer: A Meta-Analysis.
Q90138365Survival of Primary SBRT Compared to Surgery for Operable Stage I/II Non-Small Cell Lung Cancer
Q47108053Systemic Inflammation Biomarkers Predict Survival in Patients of Early Stage Non-Small Cell Lung Cancer Treated With Stereotactic Ablative Radiotherapy - A Single Center Experience
Q91737684Tanshinone IIA Reverses Gefitinib-Resistance In Human Non-Small-Cell Lung Cancer Via Regulation Of VEGFR/Akt Pathway
Q92725532Technical Assessment of an Automated Treatment Planning on Dose Escalation of Pancreas Stereotactic Body Radiotherapy
Q64967557The Combination of Stereotactic Body Radiation Therapy and Immunotherapy in Primary Liver Tumors.
Q38792207The IR Evolution in Oncology: Tools, Treatments, and Guidelines
Q36176801The MRI-Linear Accelerator Consortium: Evidence-Based Clinical Introduction of an Innovation in Radiation Oncology Connecting Researchers, Methodology, Data Collection, Quality Assurance, and Technical Development
Q89520902The PEMBRO-RT phase II randomized trial and the evolution of therapy for metastatic non-small cell lung cancer: a historical perspective
Q92605873The Role of Local Treatment in Oligometastatic and Oligoprogressive Cancer
Q37497743The SABRTooth feasibility trial protocol: a study to determine the feasibility and acceptability of conducting a phase III randomised controlled trial comparing stereotactic ablative radiotherapy (SABR) with surgery in patients with peripheral stage
Q61804644The current and future faces of stereotactic body radiation therapy for thoracic malignancies
Q91800465The current state of randomized clinical trial evidence for prostate brachytherapy
Q96138240The debate for thermal ablation of colorectal cancer pulmonary metastases is heating up
Q38967475The development of stereotactic body radiotherapy in the past decade: a global perspective
Q41954362The evolving evidence for the efficacy and safety of charged particle therapy for hepatocellular carcinoma-a commentary
Q90175125The evolving role of radiotherapy in non-small cell lung cancer
Q38625125The evolving role of radiotherapy in treatment of oligometastatic NSCLC.
Q38751141The future of image-guided radiotherapy will be MR guided
Q50138849The great debate flashes: Surgery versus stereotactic body radiotherapy as the primary treatment of early-stage lung cancer
Q61804643The optimal treatment approaches for stage I small cell lung cancer
Q38928692The radiobiological targets of SBRT: tumor cells or endothelial cells?
Q30248748The role of local ablative therapy in oligometastatic non-small-cell lung cancer: hype or hope.
Q64080769The role of small or single-institution prospective studies in thoracic research
Q64120986The use of texture-based radiomics CT analysis to predict outcomes in early-stage non-small cell lung cancer treated with stereotactic ablative radiotherapy
Q64111832Three discipline collaborative radiation therapy (3 DCRT ) special debate: I would treat all early‐stage NSCLC patients with SBRT
Q91600204Timeliness of Lung Cancer Diagnosis and Treatment
Q38780270Treatment Burden of Medicare Beneficiaries With Stage I Non-Small-Cell Lung Cancer
Q64118469Treatment of T3N0 non-small cell lung cancer with chest wall invasion using stereotactic body radiotherapy
Q50863889Treatment outcomes and patterns of radiologic appearance after hypofractionated image-guided radiotherapy delivered with helical tomotherapy (HHT) for lung tumours.
Q47164549Treatment recommendations by clinicians in stage I non-small cell lung cancer: better work-up leads to less discussion
Q50044375Treatment selection of early stage non-small cell lung cancer: the role of the patient in clinical decision making
Q92645649Treatment strategy and decision-making for elderly surgical candidates with early lung cancer
Q58584561Treatment-Related Adverse Effects in Lung Cancer Patients after Stereotactic Ablative Radiation Therapy
Q47648038Trend Analysis for the Choice and Cost of Lung Cancer Treatment in South Korea, 2003-2013.
Q38962875Triaging early-stage lung cancer patients into non-surgical pathways: who, when, and what?
Q55012601Two lives
Q47123759Under-treatment of small cell lung cancer: the case for surgical resection
Q64355411Understanding patients' values and preferences regarding early stage lung cancer treatment decision making
Q38859683Undetected lymph node metastases in presumed early stage NSCLC SABR patients
Q47141436Unless I see, I will not believe.
Q41115829Update in Lung Cancer 2015.
Q92356100Verification of meta-analysis and propensity-matched analysis comparing stereotactic body radiation therapy versus surgery for early stage lung cancer
Q89067458Virtual Bronchoscopy-Guided Treatment Planning to Map and Mitigate Radiation-Induced Airway Injury in Lung SAbR
Q42318777What if a tumor is significantly enlarged just before stereotactic body radiation therapy? A case report and review of the literature
Q42340577What is the role of stereotactic ablative radiotherapy in the management of surgically resectable and operable stage I non-small cell lung cancer?
Q92467682Which patients benefit most from stereotactic body radiotherapy or surgery in medically operable non-small cell lung cancer? An in-depth look at patient characteristics on both sides of the debate
Q52936448Young at Heart: Is That Good Enough for Computed Tomography Screening?
Q53080274[Advances in Surgical Treatment of Early Stage Non-small Cell Lung Cancer].
Q88208674[Different mortality after surgery and stereotactic body radiotherapy for early-stage non-small-cell lung cancer]
Q57641071[Local treatment of solitary intrapulmonary, malignant nodules]
Q89921619[Minimally Invasive Therapies For Early Stage Non-Small Cell Lung Cancer]
Q53423125[Stereotactic Ablative Radiotherapy for Operable Stage I Non-small Cell Lung Cancer in Clinical Practice: How Long Way to Go?].

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