Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions

scientific article

Distinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/IAI.73.8.4823-4833.2005
P8608Fatcat IDrelease_lgfmrnwkbjgmrn6mkg3usu3zru
P932PMC publication ID1201278
P698PubMed publication ID16040996

P50authorTomas GanzQ15059118
P2093author name stringPeter A Rice
Alison J Quayle
Sunita Gulati
Gill Diamond
Heriberto Lima
Edith Porter
Huixia Yang
Gloria C Preza
Sheila Greene
Marcia Klein-Patel
Sujata Yavagal
Laily Mahoozi
Omar Murillo
P2860cites workProcessing of seminal plasma hCAP-18 to ALL-38 by gastricsin: a novel mechanism of generating antimicrobial peptides in vaginaQ24302168
Neutrophil elastase enzymatically antagonizes the in vitro action of G-CSF: implications for the regulation of granulopoiesisQ24312190
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Human beta-defensin-1: an antimicrobial peptide of urogenital tissuesQ24564659
Susceptibility of Chlamydia trachomatis to protegrins and defensinsQ24672117
Localization of human intestinal defensin 5 in Paneth cell granulesQ24674859
Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tractQ24678044
Epithelial antimicrobial peptides in host defense against infectionQ24791605
Defensins: antimicrobial peptides of innate immunityQ28204453
Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattractionQ28204611
Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteriaQ28204776
More than destructive: neutrophil-derived serine proteases in cytokine bioactivity controlQ28207037
Posttranslational processing of defensins in immature human myeloid cellsQ28213705
A peptide antibiotic from human skinQ28242199
Differential expression and antibacterial activity of epididymis protein 2 isoforms in the male reproductive tract of human and rhesus monkey (Macaca mulatta)Q28269664
Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional propertiesQ28277523
Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophilsQ28277848
Expression and characterization of trypsinogen produced in the human male genital tractQ28345000
Rat neutrophil defensins. Precursor structures and expression during neutrophilic myelopoiesisQ28578008
Paneth cells of the human small intestine express an antimicrobial peptide geneQ41099931
Expression and regulation of the human beta-defensins hBD-1 and hBD-2 in intestinal epithelium.Q41705704
Characterization of luminal paneth cell alpha-defensins in mouse small intestine. Attenuated antimicrobial activities of peptides with truncated amino terminiQ41755550
Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2.Q42453950
Antimicrobial peptides initiate IL-1 beta posttranslational processing: a novel role beyond innate immunityQ43909503
Cationic defensins arise from charge-neutralized propeptides: a mechanism for avoiding leukocyte autocytotoxicity?Q44352837
Proteolytic cleavage by neutrophil elastase converts inactive storage proforms to antibacterial bactenecinsQ44426223
From pro defensins to defensins: synthesis and characterization of human neutrophil pro alpha-defensin-1 and its mature domainQ44489334
Isolation of human intestinal defensins from ileal neobladder urineQ46081367
Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiationQ46167434
Microbial lipopeptides stimulate dendritic cell maturation via Toll-like receptor 2.Q46685036
Neutrophil defensins: purification, characterization, and antimicrobial testingQ46771245
Neutrophil tissue inhibitor of matrix metalloproteinases-1 occurs in novel vesicles that do not fuse with the phagosomeQ46910092
Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers alpha-defensin productionQ47422836
Neutrophil elastase cleavage of human factor IX generates an activated factor IX-like product devoid of coagulant functionQ47725246
Purification, identification, and characterization of elastase on erythrocyte membrane as factor IX-activating enzymeQ47994639
Rhinovirus increases human beta-defensin-2 and -3 mRNA expression in cultured bronchial epithelial cells.Q51660498
Isolation of human polymorphonuclear leukocyte elastase by chromatography on immobilized benzamidine.Q52515544
Expression of antimicrobial defensins in the male reproductive tract of rats, mice, and humans.Q54799327
Purification and characterization of a human neutrophil lipocalin (HNL) from the secondary granules of human neutrophils.Q55065798
Responses to estradiol in a human endometrial adenocarcinoma cell line (Ishikawa)Q69496595
Isolation and sequence determination of 6- and 8-kDa precursors of human neutrophil peptides from bone marrow, plasma and peripheral blood neutrophilsQ71840000
Structural analysis of human beta-defensin-1 and its significance in urinary tract infectionQ73694483
Proteolysis of factor V by cathepsin G and elastase indicates that cleavage at Arg1545 optimizes cofactor function by facilitating factor Xa bindingQ77153299
Characterization of defensin precursors in mature human neutrophilsQ28612183
Posttranslational processing and targeting of transgenic human defensin in murine granulocyte, macrophage, fibroblast, and pituitary adenoma cell linesQ28613010
Detection of beta-defensins secreted by human oral epithelial cells.Q30702619
Activation of Paneth cell alpha-defensins in mouse small intestineQ30717364
Antimicrobial defences in Drosophila: the story so far.Q33339525
Chlamydia trachomatis infections: progress and problemsQ33542366
The human cationic antimicrobial protein (hCAP-18) is expressed in the epithelium of human epididymis, is present in seminal plasma at high concentrations, and is attached to spermatozoaQ33598978
The role of protegrins and other elastase-activated polypeptides in the bactericidal properties of porcine inflammatory fluids.Q33757436
Defensins of vertebrate animalsQ34109303
Paneth cell trypsin is the processing enzyme for human defensin-5.Q34129474
Neutrophil-derived elastases and their inhibitors: potential role in the pathogenesis of lung diseaseQ34349350
Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowelQ34359011
Protease-induced leukocyte chemotaxis and activation: roles in host defense and inflammation.Q34428937
Novel roles of protease inhibitors in infection and inflammationQ34649754
Neutrophil elastase inhibitors as treatment for COPD.Q34706998
Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump familyQ34745204
Chlamydia and its effect on reproductionQ34911527
Cellular immunity and Chlamydia genital infection: induction, recruitment, and effector mechanismsQ35113092
Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel diseaseQ35362664
Antimicrobial peptides in innate immunity of the human intestineQ35541235
Porcine polymorphonuclear leukocytes generate extracellular microbicidal activity by elastase-mediated activation of secreted proprotegrinsQ35544155
Recognition of bacterial peptidoglycan by the innate immune systemQ35549169
Urogenital infection and sperm motilityQ35554957
Antimicrobial peptides in defence of the oral and respiratory tractsQ35563978
Regulation of expression of β-defensins: endogenous enteric peptide antibioticsQ35563983
Innate immunity in the lung: how epithelial cells fight against respiratory pathogensQ35673699
Protease-activated receptors: contribution to physiology and diseaseQ35715253
The molecular mechanisms used by Neisseria gonorrhoeae to initiate infection differ between men and womenQ35920654
Glucose metabolism in Neisseria gonorrhoeaeQ36760653
Monoclonal antibody against a genus-specific antigen of Chlamydia species: location of the epitope on chlamydial lipopolysaccharideQ37082240
Inflammatory-associated obstructions of the male reproductive tractQ37868434
Association between elevated neutrophil defensin levels and endometritisQ37871340
Approach to men with urethritis and urologic complications of sexually transmitted diseasesQ37895914
Degranulation of paneth cells via toll-like receptor 9.Q38338466
Intramolecular inhibition of human defensin HNP-1 by its propieceQ39762806
Innate immune response of oral and foreskin keratinocytes: utilization of different signaling pathways by various bacterial speciesQ40582522
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectChlamydia trachomatisQ131065
Neisseria gonorrhoeaeQ131129
urethritisQ1122485
Chlamydia trachomatis urethritisQ18967710
P304page(s)4823-4833
P577publication date2005-08-01
P1433published inInfection and ImmunityQ6029193
P1476titleDistinct defensin profiles in Neisseria gonorrhoeae and Chlamydia trachomatis urethritis reveal novel epithelial cell-neutrophil interactions
P478volume73

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