A novel role of the organizer gene Goosecoid as an inhibitor of Wnt/PCP-mediated convergent extension in Xenopus and mouse

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A novel role of the organizer gene Goosecoid as an inhibitor of Wnt/PCP-mediated convergent extension in Xenopus and mouse is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1083852535
P356DOI10.1038/SREP43010
P932PMC publication ID5318956
P698PubMed publication ID28220837

P50authorMark LewandoskiQ86143620
Thomas ThumbergerQ42360796
P2093author name stringAxel Schweickert
Martin Blum
Abraham Fainsod
Herbert Steinbeißer
Marina Campione
Philipp Andre
Bärbel Ulmer
Dina Mönch
Melanie Tingler
Sabrina Kurz
Markus Maerker
Kirsten Deißler
P2860cites workThe amphioxus genome and the evolution of the chordate karyotypeQ22122227
Neural Crest and the Origin of Vertebrates: A New HeadQ22337060
SAMS, a syndrome of short stature, auditory-canal atresia, mandibular hypoplasia, and skeletal abnormalities is a unique neurocristopathy caused by mutations in GoosecoidQ24310673
The Spemann organizer gene, Goosecoid, promotes tumor metastasisQ24678045
Microinjection of recombinant p21rho induces rapid changes in cell morphologyQ24678787
A positional Toll receptor code directs convergent extension in DrosophilaQ27317080
The forces that shape embryos: physical aspects of convergent extension by cell intercalationQ28276123
Wnt5a functions in planar cell polarity regulation in miceQ28505898
Targeted mutation of the murine goosecoid gene results in craniofacial defects and neonatal deathQ28506088
Goosecoid is not an essential component of the mouse gastrula organizer but is required for craniofacial and rib developmentQ28509785
Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrulaQ28587138
Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closureQ28588549
Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathwaysQ28616373
Negative autoregulation of the organizer-specific homeobox gene goosecoidQ28771519
A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cellsQ29614542
Dishevelled controls cell polarity during Xenopus gastrulationQ29619295
The planar cell polarity gene strabismus regulates convergence and extension and neural fold closure in XenopusQ30309547
WNT5A/JNK and FGF/MAPK pathways regulate the cellular events shaping the vertebrate limb bud.Q30497597
TGF-β Signaling Regulates the Differentiation of Motile CiliaQ30651183
Xenbase, the Xenopus model organism database; new virtualized system, data types and genomesQ30860115
Emerging systems: between vertebrates and arthropods, the LophotrochozoaQ31151112
Organizer-Specific Homeobox Genes in Xenopus laevis EmbryosQ33246706
The animal cap assayQ33741757
Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway.Q33898502
Goosecoid promotes head organizer activity by direct repression of Xwnt8 in Spemann's organizerQ34088948
Shaping the mammalian auditory sensory organ by the planar cell polarity pathwayQ34154050
Gastrulation in the mouse: the role of the homeobox gene goosecoidQ34243254
The role of gsc and BMP-4 in dorsal-ventral patterning of the marginal zone in Xenopus: a loss-of-function study using antisense RNA.Q34289453
The homeobox gene goosecoid controls cell migration in Xenopus embryosQ34334613
A functional homologue of goosecoid in DrosophilaQ34378695
Conditional control of gene expression in the mouseQ34389488
Expression patterns of fork head and goosecoid homologues in the mollusc Patella vulgata supports the ancestry of the anterior mesendoderm across BilateriaQ78595889
Ciliation and gene expression distinguish between node and posterior notochord in the mammalian embryoQ79815333
Xenopus laevis Keller ExplantsQ83489419
Expression of zebrafish goosecoid and no tail gene products in wild-type and mutant no tail embryosQ47073431
FoxA3 and goosecoid promote anterior neural fate through inhibition of Wnt8a activity before the onset of gastrulationQ47073533
Short- and long-range functions of Goosecoid in zebrafish axis formation are independent of Chordin, Noggin 1 and Follistatin-like 1b.Q47074062
A role for the homeobox gene Xvex-1 as part of the BMP-4 ventral signaling pathwayQ47938281
Subcellular localization and signaling properties of dishevelled in developing vertebrate embryos.Q50336929
Control of gastrula cell motility by the Goosecoid/Mix.1/ Siamois network: basic patterns and paradoxical effects.Q51959707
Role of Goosecoid, Xnot and Wnt antagonists in the maintenance of the notochord genetic programme in Xenopus gastrulae.Q52128892
The Xvex-1 antimorph reveals the temporal competence for organizer formation and an early role for ventral homeobox genes.Q52172698
Interference with brachyury function inhibits convergent extension, causes apoptosis, and reveals separate requirements in the FGF and activin signalling pathways.Q52175020
Distinct regulatory control of the Brachyury gene in axial and non-axial mesoderm suggests separation of mesoderm lineages early in mouse gastrulation.Q52201668
über Induktion von Embryonalanlagen durch Implantation artfremder OrganisatorenQ55893763
Antero-posterior tissue polarity links mesoderm convergent extension to axial patterningQ59052036
Expression of the mouse goosecoid gene during mid-embryogenesis may mark mesenchymal cell lineages in the developing head, limbs and body wallQ72225476
Distinct functions of Rho and Rac are required for convergent extension during Xenopus gastrulationQ73691283
Morpholinos: Antisense and SensibilityQ34499577
Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis.Q34666439
Wnt signaling gradients establish planar cell polarity by inducing Vangl2 phosphorylation through Ror2Q34706774
Molecular evidence for deep evolutionary roots of bilaterality in animal developmentQ34983880
The Xenopus Brachyury promoter is activated by FGF and low concentrations of activin and suppressed by high concentrations of activin and by paired-type homeodomain proteinsQ35198026
Cellular basis of amphibian gastrulationQ35483292
Tissue/planar cell polarity in vertebrates: new insights and new questionsQ36720615
Insights from the amphioxus genome on the origin of vertebrate neural crestQ36804751
Spemann organizer gene Goosecoid promotes delamination of neuroblasts from the otic vesicleQ37398239
The evolutionary origin of the vertebrate neural crest and its developmental gene regulatory network--insights from amphioxusQ37638869
Evolutionary crossroads in developmental biology: cyclostomes (lamprey and hagfish).Q38012437
Wnt signaling during cochlear development.Q38095242
Antimorphic goosecoidsQ38336467
Drosophila Goosecoid requires a conserved heptapeptide for repression of paired-class homeoprotein activators.Q38338059
Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafishQ38352359
The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos.Q38523609
Antagonistic regulation of convergent extension movements in Xenopus by Wnt/beta-catenin and Wnt/Ca2+ signaling.Q38524566
Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of XenopusQ38533172
Regional requirements for Dishevelled signaling during Xenopus gastrulation: separable effects on blastopore closure, mesendoderm internalization and archenteron formation.Q39700704
Xenopus frizzled 7 can act in canonical and non-canonical Wnt signaling pathways: implications on early patterning and morphogenesisQ39749608
Neural tube closure requires Dishevelled-dependent convergent extension of the midlineQ39750691
The prickle-related gene in vertebrates is essential for gastrulation cell movementsQ39750801
Caudalization by the amphibian organizer: brachyury, convergent extension and retinoic acid.Q40508639
On the function of BMP-4 in patterning the marginal zone of the Xenopus embryo.Q40793613
goosecoid expression represses Brachyury in embryonic stem cells and affects craniofacial development in chimeric mice.Q40873930
Leapfrogging: primordial germ cell transplantation permits recovery of CRISPR/Cas9-induced mutations in essential genesQ40975838
Morphogenesis of the murine node and notochordal plateQ41013679
Cngsc, a homologue of goosecoid, participates in the patterning of the head, and is expressed in the organizer region of Hydra.Q41701399
The Xvent-2 homeobox gene is part of the BMP-4 signalling pathway controlling [correction of controling] dorsoventral patterning of Xenopus mesodermQ41927648
Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteinsQ42078751
Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signalingQ42491186
Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoidQ42739682
The opposing homeobox genes Goosecoid and Vent1/2 self-regulate Xenopus patterningQ42743132
Goosecoid and mix.1 repress Brachyury expression and are required for head formation in Xenopus.Q42818324
Mesodermal cell migration during Xenopus gastrulationQ43735048
Dexamethasone induces proliferation and terminal differentiation of osteogenic cells in tissue cultureQ44357539
Xbra functions as a switch between cell migration and convergent extension in the Xenopus gastrulaQ44365501
FGF8 spliceforms mediate early mesoderm and posterior neural tissue formation in XenopusQ44437225
Cloning and expression of Xenopus Prickle, an orthologue of a Drosophila planar cell polarity gene.Q45935499
The epithelium of the dorsal marginal zone of Xenopus has organizer propertiesQ45992012
Induction of notochord cell intercalation behavior and differentiation by progressive signals in the gastrula of Xenopus laevisQ46063915
Mediolateral cell intercalation in the dorsal, axial mesoderm of Xenopus laevisQ46131164
Interaction of goosecoid and brachyury in Xenopus mesoderm patterningQ46892478
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P304page(s)43010
P577publication date2017-02-21
P1433published inScientific ReportsQ2261792
P1476titleA novel role of the organizer gene Goosecoid as an inhibitor of Wnt/PCP-mediated convergent extension in Xenopus and mouse
P478volume7

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cites work (P2860)
Q57093002Cellular rearrangement of the prechordal plate contributes to eye degeneration in the cavefish
Q90622915Embryogenesis of Marsupial Frogs (Hemiphractidae), and the Changes that Accompany Terrestrial Development in Frogs
Q58726345Insights into the Etiology of Mammalian Neural Tube Closure Defects from Developmental, Genetic and Evolutionary Studies

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