Autologous transplantation of genetically modified iris pigment epithelial cells: a promising concept for the treatment of age-related macular degeneration and other disorders of the eye.

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Autologous transplantation of genetically modified iris pigment epithelial cells: a promising concept for the treatment of age-related macular degeneration and other disorders of the eye. is …
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scholarly articleQ13442814

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P819ADS bibcode2002PNAS...9913090S
P356DOI10.1073/PNAS.202486199
P932PMC publication ID130591
P698PubMed publication ID12239351
P5875ResearchGate publication ID11152148

P2093author name stringFlorian Kreppel
Stefan Kochanek
Irina Semkova
Ulrich Schraermeyer
Thomas Luther
Hanna Janicki
Gerhard Welsandt
Jolanta Kozlowski
P2860cites workSenescent WI-38 cells fail to express EPC-1, a gene induced in young cells upon entry into the G0 stateQ24324353
Enhancement of endothelial cell migration and in vitro tube formation by TAP20, a novel beta 5 integrin-modulating, PKC theta-dependent proteinQ24681057
Oxygen-induced retinopathy in the mouseQ71608431
Expression, secretion, and age-related downregulation of pigment epithelium-derived factor, a serpin with neurotrophic activityQ71923963
Retinal pigment epithelial cells from dystrophic rats form normal tight junctions in vitroQ73013101
Iris pigment epithelial cell translocation in exudative age-related macular degeneration. A pilot study in patientsQ73021388
Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerationsQ73277924
Iris pigment epithelial cells of long evans rats demonstrate phagocytic activityQ73545781
The mRNA expression of cytokines and their receptors in cultured iris pigment epithelial cells: a comparison with retinal pigment epithelial cellsQ77228444
Rescue effects of IPE transplants in RCS rats: short-term resultsQ77845338
Pigment epithelium-derived factor: a potent inhibitor of angiogenesisQ28139159
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Localization of pigment epithelium derived factor (PEDF) in developing and adult human ocular tissuesQ28204811
Comparison of long-term transgene expression after non-viral and adenoviral gene transfer into primary articular chondrocytesQ30695640
Long-term transgene expression in the RPE after gene transfer with a high-capacity adenoviral vectorQ31064383
AAV-mediated gene transfer of pigment epithelium-derived factor inhibits choroidal neovascularizationQ31064406
Transplantation of autologous iris pigment epithelium after removal of choroidal neovascular membranesQ33181246
High-capacity adenoviral vectors for gene transfer and somatic gene therapyQ33763916
Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factorQ34477473
Adenovirus-mediated regulable target gene expression in vivoQ34807993
Photoreceptor rescue in the dystrophic retina by transplantation of retinal pigment epitheliumQ35549539
A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signalQ35915922
Gene expression of the neurotrophic pigment epithelium-derived factor in the human ciliary epithelium. Synthesis and secretion into the aqueous humor.Q36839791
Quantification of the ionising radiation effect over angiogenesis in the chick embryo and its chorioallantoic membrane by computerised analysis of angiographic imagesQ39567138
Isolation and cultivation of human iris pigment epitheliumQ42462050
Clinicopathological correlation of primary and recurrent choroidal neovascularisation following surgical excision in age related macular degenerationQ42930723
Long-term rescue of photoreceptor cells in the retinas of RCS dystrophic rats by RPE transplantsQ44827122
Rapid isolation of choriocapillary endothelial cells by Lycopersicon esculentum-coated DynabeadsQ46244764
Pigment epithelium-derived factor protects cultured retinal neurons against hydrogen peroxide-induced cell deathQ48124300
Porcine iris pigment epithelial cells can take up retinal outer segmentsQ48648604
Optimal methods for preparation and immunostaining of iris, ciliary body, and choroidal wholemountsQ59400530
Uptake, processing and release of retinoids by cultured human retinal pigment epitheliumQ62937512
P433issue20
P407language of work or nameEnglishQ1860
P921main subjectmacular degenerationQ27429789
P304page(s)13090-13095
P577publication date2002-09-18
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleAutologous transplantation of genetically modified iris pigment epithelial cells: a promising concept for the treatment of age-related macular degeneration and other disorders of the eye.
P478volume99

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cites work (P2860)
Q35126780Age-Related Macular Degeneration: Etiology, Pathogenesis, and Therapeutic Strategies
Q36369034Antiangiogenic and Neurogenic Activities of Sleeping Beauty-Mediated PEDF-Transfected RPE Cells In Vitro and In Vivo
Q33291323Autologous translocation of the choroid and RPE in age-related macular degeneration: 1-year follow-up in 30 patients and recommendations for patient selection.
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Q90952575Developing Cell-Based Therapies for RPE-Associated Degenerative Eye Diseases
Q28277560Gutless adenovirus: last-generation adenovirus for gene therapy
Q43278788High efficiency non-viral transfection of retinal and iris pigment epithelial cells with pigment epithelium-derived factor
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Q36086191Immunological factors in the pathogenesis and treatment of age-related macular degeneration
Q28252870Inhibition of glioma invasion by overexpression of pigment epithelium-derived factor
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Q28191537PEDF: a multifaceted neurotrophic factor
Q64376171Persistent expression of PEDF in the eye using high-capacity adenovectors
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Q80428018[Transplantation of iris pigment epithelium]

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