Dendrimers as drugs: discovery and preclinical and clinical development of dendrimer-based microbicides for HIV and STI prevention

scientific article

Dendrimers as drugs: discovery and preclinical and clinical development of dendrimer-based microbicides for HIV and STI prevention is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1021/MP050023Q
P698PubMed publication ID16053334
P5875ResearchGate publication ID7693153

P2093author name stringJeremy R A Paull
Tom D McCarthy
Peter Karellas
Scott A Henderson
George Holan
Barry R Matthews
David F O'Keefe
Graham Heery
Michael Giannis
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectpreventionQ1717246
prevention of HIV/AIDSQ7242372
P304page(s)312-318
P577publication date2005-07-01
P1433published inMolecular PharmaceuticsQ3011140
P1476titleDendrimers as drugs: discovery and preclinical and clinical development of dendrimer-based microbicides for HIV and STI prevention
P478volume2

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cites work (P2860)
Q39152233"Fusion and binding inhibition" key target for HIV-1 treatment and pre-exposure prophylaxis: targets, drug delivery and nanotechnology approaches.
Q94512129A phase 2, double-blind, multicenter, randomized, placebo-controlled, dose‑ranging study of the efficacy and safety of Astodrimer Gel for the treatment of bacterial vaginosis
Q37187788A randomized controlled trial of the safety of candidate microbicide SPL7013 gel when applied to the penis
Q30431343A review of nanotechnological approaches for the prophylaxis of HIV/AIDS.
Q38864932Aminolevulinic acid dendrimers in photodynamic treatment of cancer and atheromatous disease
Q37208310An Electrochemical DNA Biosensor Developed on a Nanocomposite Platform of Gold and Poly(propyleneimine) Dendrimer
Q57380327Applications of Dendrimers in Drug Delivery Agents, Diagnosis, Therapy, and Detection
Q38722141Bioactive clusters promoting cell penetration and nucleic acid complexation for drug and gene delivery applications: from designed to self-assembled and responsive systems.
Q36988348Biodegradable, polymeric nanoparticle delivery systems for cancer therapy
Q30356032Candidate polyanion microbicides inhibit HIV-1 infection and dissemination pathways in human cervical explants.
Q30355939Clinical Translation of Nanomedicine.
Q36803970Comparative evaluation of virus transmission inhibition by dual-acting pyrimidinedione microbicides using the microbicide transmission and sterilization assay
Q33367952Complex Amphiphilic Hyperbranched Fluoropolymers by Atom Transfer Radical Self-Condensing Vinyl (Co)polymerization
Q37368022Crucial functionalizations of carbon nanotubes for improved drug delivery: a valuable option?
Q37984498Current and future microbicide approaches aimed at preventing HIV infection in women.
Q47352518Dendrimer-induced leukocyte procoagulant activity depends on particle size and surface charge
Q38755622Dendrimer-mediated approaches for the treatment of brain tumor.
Q57079901Dendrimeric based microbicides against sexual transmitted infections associated to heparan sulfate
Q55563721Dendrimeric systems and their applications in ocular drug delivery.
Q38123954Dendrimers as potential therapeutic tools in HIV inhibition.
Q37585659Dendrimers as therapeutic agents: a systematic review.
Q57079961Dendrimers as topical microbicides with activity against HIV
Q37279284Dendrimers for enhanced drug solubilization.
Q38196447Dendrimers for gene delivery--a potential approach for ocular therapy?
Q38542021Dendrimers for theranostic applications
Q26782404Designing Dendrimer and Miktoarm Polymer Based Multi-Tasking Nanocarriers for Efficient Medical Therapy
Q37823446Designing dendrimers for drug delivery and imaging: pharmacokinetic considerations
Q36593791Development of a comprehensive human immunodeficiency virus type 1 screening algorithm for discovery and preclinical testing of topical microbicides.
Q37809880Drug delivery using multifunctional dendrimers and hyperbranched polymers
Q33819656Emerging nanotechnology approaches for HIV/AIDS treatment and prevention
Q33613788Evaluation of WLBU2 peptide and 3-O-octyl-sn-glycerol lipid as active ingredients for a topical microbicide formulation targeting Chlamydia trachomatis
Q58869727Evaluation of a new dendrimeric structure as prospective drugs carrier for intravenous administration of antichagasic active compounds
Q39885075Evaluation of the synthesis of sialic acid-PAMAM glycodendrimers without the use of sugar protecting groups, and the anti-HIV-1 properties of these compounds
Q37374013Formulating a sulfonated antiviral dendrimer in a vaginal microbicidal gel having dual mechanisms of action
Q49963085Function Oriented Molecular Design: Dendrimers as Novel Antimicrobials
Q56992437Harnessing nanostructured systems for improved treatment and prevention of HIV disease
Q40050425Hyperbranched molecular structures with potential antiviral activity: derivatives of 5,6-dihydroxyindole-2-carboxylic Acid.
Q38244010In vivo studies of nanostructure-based photosensitizers for photodynamic cancer therapy
Q39541397Inhibition of herpes simplex virus type 1 and type 2 infections by peptide-derivatized dendrimers
Q38758579Inorganic dendrimers: recent advances for catalysis, nanomaterials, and nanomedicine
Q33557251Interactions and encapsulation of vitamins C, B3, and B6 with dendrimers in water
Q38925952Mechanistic Studies of Viral Entry: An Overview of Dendrimer-Based Microbicides As Entry Inhibitors Against Both HIV and HSV-2 Overlapped Infections.
Q38041060Multivalency as a chemical organization and action principle
Q34234274Nanodevices in diagnostics.
Q27022253Nanomedicine approaches for corneal diseases
Q34079533Nanoparticle-based drug delivery to the vagina: a review
Q26795444Nanoparticles as potential new generation broad spectrum antimicrobial agents
Q34655287Nanoparticles in medicine: therapeutic applications and developments
Q38250517Nanoparticulate carriers: an emerging tool for breast cancer therapy
Q26801513Nanostructures for the Inhibition of Viral Infections
Q30393980Nanotechnology and HIV: potential applications for treatment and prevention
Q38289100New Modalities for Challenging Targets in Drug Discovery
Q44460619New surface hydroxylated and internally quaternised poly(propylene imine) dendrimers as efficient biocompatible drug carriers of norfloxacin
Q35345283Non-specific microbicide product development: then and now
Q36307689One-component nanomedicine
Q33270151PAMAM dendrimers and branched polyethyleneglycol (nanoparticles) prodrugs of (-)-beta-D-(2R, 4R)-dioxolane-thymine (DOT) and their anti-HIV activity
Q33740696Peptide and glycopeptide dendrimers and analogous dendrimeric structures and their biomedical applications.
Q57815884Peptide dendrimers as "lead compounds" for the treatment of chronic lung infections by in cystic fibrosis patients: in vitro and in vivo studies
Q38079780Peptide inhibitors against herpes simplex virus infections.
Q35014689Peptide-derivatized SB105-A10 dendrimer inhibits the infectivity of R5 and X4 HIV-1 strains in primary PBMCs and cervicovaginal histocultures
Q37657468Pharmaceutical development of microbicide drug products
Q35012567Phase 1 randomized trial of the vaginal safety and acceptability of SPL7013 gel (VivaGel) in sexually active young women (MTN-004)
Q90439921Polymer-drug conjugate therapeutics: advances, insights and prospects
Q38245819Polymeric anti-HIV therapeutics
Q37975554Polypeptides and polyaminoacids in drug delivery
Q36310717Polyvalent side chain peptide-synthetic polymer conjugates as HIV-1 entry inhibitors
Q34648571Preclinical safety and efficacy assessments of dendrimer-based (SPL7013) microbicide gel formulations in a nonhuman primate model
Q30395011Progress in antiretroviral drug delivery using nanotechnology
Q38574172Protein/peptide-based entry/fusion inhibitors as anti-HIV therapies: challenges and future direction
Q38501503Recent advances in click chemistry applied to dendrimer synthesis.
Q28740364SPL7013 Gel (VivaGel®) retains potent HIV-1 and HSV-2 inhibitory activity following vaginal administration in humans
Q28749596Structure activity relationship of dendrimer microbicides with dual action antiviral activity
Q57079929Synthesis of anionic carbosilane dendrimers via “click chemistry” and their antiviral properties against HIV
Q37354233Targeted nanomedicines: effective treatment modalities for cancer, AIDS and brain disorders
Q40017027The Pharmacokinetics and Biodistribution of a 64 kDa PolyPEG Star Polymer After Subcutaneous and Pulmonary Administration to Rats
Q28087336The potential of HIV-1 nanotherapeutics: from in vitro studies to clinical trials
Q41339468Triple combination of carbosilane dendrimers, tenofovir and maraviroc as potential microbicide to prevent HIV-1 sexual transmission
Q37171165Tumour and dendrimers: a review on drug delivery aspects.
Q57340548Unexpected Biological Applications of Dendrimers and Specific Multivalency Activities
Q37059892VivaGel (SPL7013 Gel): a candidate dendrimer--microbicide for the prevention of HIV and HSV infection

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