Species-specific differences in the expression of the HNF1A, HNF1B and HNF4A genes

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Species-specific differences in the expression of the HNF1A, HNF1B and HNF4A genes is …
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scholarly articleQ13442814

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P819ADS bibcode2009PLoSO...4.7855H
P356DOI10.1371/JOURNAL.PONE.0007855
P932PMC publication ID2773013
P698PubMed publication ID19924231
P5875ResearchGate publication ID38099962

P50authorAnna GloynQ21254068
P2093author name stringLorna W Harries
James E Brown
P2860cites workIsomers of the TCF1 gene encoding hepatocyte nuclear factor-1 alpha show differential expression in the pancreas and define the relationship between mutation position and clinical phenotype in monogenic diabetes.Q52015720
The diabetic phenotype in HNF4A mutation carriers is moderated by the expression of HNF4A isoforms from the P1 promoter during fetal development.Q54541119
Mutations in the genes encoding the transcription factors hepatocyte nuclear factor 1 alpha (HNF1A) and 4 alpha (HNF4A) in maturity-onset diabetes of the youngQ57916579
Genotype/phenotype relationships in HNF-4alpha/MODY1: haploinsufficiency is associated with reduced apolipoprotein (AII), apolipoprotein (CIII), lipoprotein(a), and triglyceride levelsQ74034127
Liver and kidney function in Japanese patients with maturity-onset diabetes of the youngQ77634805
Expression of HNF4alpha variants in pancreatic islets and Ins-1 beta cellsQ81473356
HNF1alpha controls renal glucose reabsorption in mouse and man.Q24290983
Evidence for haploinsufficiency of the human HNF1alpha gene revealed by functional characterization of MODY3-associated mutationsQ24292735
More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processingQ24564329
The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolismQ24654815
Expression patterns of vHNF1 and HNF1 homeoproteins in early postimplantation embryos suggest distinct and sequential developmental rolesQ28506623
An alternative splice variant of the tissue specific transcription factor HNF4alpha predominates in undifferentiated murine cell typesQ28585077
Selective deletion of the Hnf1beta (MODY5) gene in beta-cells leads to altered gene expression and defective insulin releaseQ28586448
Defective pancreatic beta-cell glycolytic signaling in hepatocyte nuclear factor-1alpha-deficient miceQ28588297
Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasisQ28591211
Identification and analysis of alternative splicing events conserved in human and mouseQ33841124
Maturity-onset diabetes of the young: from clinical description to molecular genetic characterizationQ34367981
A genetic switch in pancreatic beta-cells: implications for differentiation and haploinsufficiency.Q34764918
Messenger RNA transcripts of the hepatocyte nuclear factor-1alpha gene containing premature termination codons are subject to nonsense-mediated decayQ38345455
Conditional expression of hepatocyte nuclear factor-1beta, the maturity-onset diabetes of the young-5 gene product, influences the viability and functional competence of pancreatic beta-cellsQ40256281
Mutations in hepatocyte nuclear factor-1beta and their related phenotypesQ43167987
Contrasting diabetes phenotypes associated with hepatocyte nuclear factor-1alpha and -1beta mutationsQ44865625
Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated with MODY.Q48041792
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)e7855
P577publication date2009-11-16
P1433published inPLOS OneQ564954
P1476titleSpecies-specific differences in the expression of the HNF1A, HNF1B and HNF4A genes
P478volume4

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cites work (P2860)
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