Ibandronate in osteoporosis: preclinical data and rationale for intermittent dosing.

scientific article

Ibandronate in osteoporosis: preclinical data and rationale for intermittent dosing. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/S00198-004-1612-7
P698PubMed publication ID15205712

P50authorRobert Graham G RussellQ67903135
P2093author name stringFrieder Bauss
P2860cites workAssessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study GroupQ28239579
Ibandronate treatment decreases the effects of tumor-associated lesions on bone density and strength in the rat.Q31034846
Bisphosphonates: from the laboratory to the clinic and back againQ33697467
Bisphosphonates: pharmacology, mechanisms of action and clinical usesQ33753698
Characteristics of an ovariectomized osteopenic rat modelQ69606670
A one year follow-up study of the distribution of 14C-clodronate in mice and ratsQ70051344
Effects of long-term infusion of physiologic doses of 1-34 PTH on boneQ70302121
The bisphosphonate ibandronate, given daily as well as discontinuously, decreases bone resorption and increases calcium retention as assessed by 45Ca kinetics in the intact ratQ71249878
Structural requirements for bisphosphonate actions in vitroQ72582036
A new bisphosphonate, BM 21.0955, prevents bone loss associated with cessation of ovarian function in experimental dogsQ72671390
Continuous alendronate treatment throughout growth, maturation, and aging in the rat results in increases in bone mass and mechanical propertiesQ72691856
Effects of the bisphosphonate tiludronate on bone resorption, calcium balance, and bone mineral densityQ72763627
Decreased bone mass and strength in ovariectomized cynomolgus monkeys (Macaca fascicularis)Q73153006
Disuse bone loss in hindquarter suspended rats: partial weightbearing, exercise and ibandronate treatment as countermeasuresQ73275540
Treatment with ibandronate preserves bone in experimental tumour-induced bone lossQ73498674
Short-term administration of the bisphosphonate ibandronate increases bone volume and prevents hyperparathyroid bone changes in mild experimental renal failureQ74160170
Bisphosphonates: mechanisms of actionQ74291014
Treatment of postmenopausal osteoporosisQ74332861
Importance of preclinical studies in the development of drugs for treatment of osteoporosis: a review related to the 1998 WHO guidelinesQ33767974
Dosing regimens and main adverse events of bisphosphonatesQ34090289
Intravenous zoledronic acid in postmenopausal women with low bone mineral densityQ34116443
Pathogenesis of bone fragility in women and men.Q34131375
Chemical and biological prerequisites for novel bisphosphonate molecules: results of comparative preclinical studiesQ34247899
How often is medication taken as prescribed? A novel assessment techniqueQ34525872
The ovariectomized rat model of postmenopausal bone lossQ34669140
Epidemiology and outcomes of osteoporotic fracturesQ34671295
Effect of daily and intermittent use of ibandronate on bone mass and bone turnover in postmenopausal osteoporosis: a review of three phase II studiesQ35085359
On the rat model of human osteopenias and osteoporosesQ35365332
Intravenous ibandronate injections given every three months: a new treatment option to prevent bone loss in postmenopausal womenQ35552068
Measuring compliance with inhaled medication in asthmaQ35627983
Dose-response study of ibandronate in the treatment of cancer-associated hypercalcaemiaQ36115924
Three-monthly ibandronate bolus injection offers favourable tolerability and sustained efficacy advantage over two years in established corticosteroid-induced osteoporosisQ39395362
Overview of patient compliance with medication dosing: a literature reviewQ40186921
Administration of the bisphosphonate ibandronate (BM 21.0955) by intravenous bolus injectionQ40668608
Basic biomechanical measurements of bone: a tutorialQ40797364
Remodeling and the repair of fatigue damageQ40798061
Preclinical pharmacology of alendronateQ40809403
The crippling consequences of fractures and their impact on quality of lifeQ41597014
The socioeconomic burden of fractures: today and in the 21st centuryQ41597021
Compliance with sulfonylureas in a health maintenance organization: a pharmacy record-based studyQ41645618
Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: report from the National Osteoporosis FoundationQ43583991
Ibandronate: a comparison of oral daily dosing versus intermittent dosing in postmenopausal osteoporosisQ43755577
Total administered dose of ibandronate determines its effects on bone mass and architecture in ovariectomized aged ratsQ44001436
The efficacy and tolerability of risedronate once a week for the treatment of postmenopausal osteoporosisQ44042152
Effects of treatment with ibandronate on bone mass, architecture, biomechanical properties, and bone concentration of ibandronate in ovariectomized aged ratsQ44176120
Bisphosphonates inhibit angiogenesis in vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats.Q44220762
Patient preference for once-weekly alendronate 70 mg versus once-daily alendronate 10 mg: a multicenter, randomized, open-label, crossover studyQ44261951
Intermittent intravenous administration of the bisphosphonate ibandronate prevents bone loss and maintains bone strength and quality in ovariectomized cynomolgus monkeysQ44313218
Intravenous ibandronate reduces the incidence of skeletal complications in patients with breast cancer and bone metastasesQ44572717
Effects of dose, sex, and age on the disposition of alendronate, a potent antiosteolytic bisphosphonate, in ratsQ44730464
New model for simulation of fracture repair in full-grown beagle dogs: model characterization and results from a long-term study with ibandronateQ44963511
The long-term effect of ovariectomy on the quality and quantity of cortical bone in the young cynomolgus monkey: a comparison of density fractionation and histomorphometric techniquesQ46296322
The relationship between three-dimensional connectivity and the elastic properties of trabecular boneQ46771532
Lifelong administration of high doses of ibandronate increases bone mass and maintains bone quality of lumbar vertebrae in rats.Q50876185
Inhibition of bone resorption by the bisphosphonate BM 21.0955 is not associated with an alteration of the renal handling of calcium in rats infused with parathyroid hormone-related proteinQ51607813
Therapeutic equivalence of alendronate 70 mg once-weekly and alendronate 10 mg daily in the treatment of osteoporosis. Alendronate Once-Weekly Study GroupQ58971879
Intermittent and Continuous Administration of the Bisphosphonate Ibandronate in Ovariohysterectomized Beagle Dogs: Effects on Bone Morphometry and Mineral PropertiesQ61760388
The bone "quality" problemQ67573291
BM 21.0955, a potent new bisphosphonate to inhibit bone resorptionQ67906709
Pharmacokinetics of Clodronate after Single Intravenous, Intramuscular and Subcutaneous Injections in RatsQ67907303
The bisphosphonate alendronate (MK-217) inhibits bone loss due to ovariectomy in ratsQ67923874
Physiological disposition of alendronate, a potent anti-osteolytic bisphosphonate, in laboratory animalsQ68332689
Bone changes occurring early after cessation of ovarian function in beagle dogs: a histomorphometric study employing sequential biopsiesQ68771472
Editorial: Single daily dose of antidepressantsQ68940693
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectosteoporosisQ165328
P304page(s)423-433
P577publication date2004-03-26
P1433published inOsteoporosis InternationalQ7107640
P1476titleIbandronate in osteoporosis: preclinical data and rationale for intermittent dosing
P478volume15