| scholarly article | Q13442814 |
| P356 | DOI | 10.1016/S0021-9673(03)00506-5 |
| P698 | PubMed publication ID | 12877182 |
| P2093 | author name string | Niessen WM | |
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| Mixed-mode anion-cation exchange/hydrophilic interaction liquid chromatography-electrospray mass spectrometry as an alternative to reversed phase for small molecule drug discovery | Q73070180 | ||
| Microfabricated polymer devices for automated sample delivery of peptides for analysis by electrospray ionization tandem mass spectrometry | Q73144883 | ||
| Mechanistic investigation of ionization suppression in electrospray ionization | Q73176706 | ||
| Application of a non-indexed dual sprayer pneumatically assisted electrospray source to the high throughput quantitation of target compounds in biological fluids | Q73207857 | ||
| Liquid chromatography-mass spectrometry with on-line solid-phase extraction by a restricted-access C18 precolumn for direct plasma and urine injection | Q73213952 | ||
| Factors to consider in the development of generic bioanalytical high-performance liquid chromatographic-mass spectrometric methods to support drug discovery | Q73226683 | ||
| An interface with a linear quadrupole ion guide for an electrospray-ion trap mass spectrometer system | Q73255368 | ||
| High-throughput screening of tocopherols in natural extracts | Q73291184 | ||
| Ternary-column system for high-throughput direct-injection bioanalysis by liquid chromatography/tandem mass spectrometry | Q73330580 | ||
| Automated sample preparation using membrane microtiter extraction for bioanalytical mass spectrometry | Q73469508 | ||
| Electron capture dissociation for structural characterization of multiply charged protein cations | Q73493699 | ||
| Chromatographic aspects in high throughput liquid chromatography/mass spectrometry | Q73504623 | ||
| Higher throughput bioanalysis by automation of a protein precipitation assay using a 96-well format with detection by LC-MS/MS | Q73597435 | ||
| A microfabricated device for rapid protein identification by microelectrospray ion trap mass spectrometry | Q73626145 | ||
| Determination of (R)- and (S)-ketoprofen in human plasma by liquid chromatography/tandem mass spectrometry following automated solid-phase extraction in the 96-well format | Q73748289 | ||
| Microfabricated PDMS multichannel emitter for electrospray ionization mass spectrometry | Q73805639 | ||
| Liquid chromatography/electrospray tandem mass spectrometry method for the quantitation of fosinoprilat in human serum using automated 96-well solid-phase extraction for sample preparation | Q73912265 | ||
| Combination of matrix solid-phase dispersion extraction and direct on-line liquid chromatography-nuclear magnetic resonance spectroscopy-tandem mass spectrometry as a new efficient approach for the rapid screening of natural products: application to | Q74013241 | ||
| Quantitative liquid chromatographic-tandem mass spectrometric determination of reserpine in FVB/N mouse plasma using a "chelating" agent (disodium EDTA) for releasing protein-bound analytes during 96-well liquid-liquid extraction | Q74019216 | ||
| Accurate mass liquid chromatography/mass spectrometry on orthogonal acceleration time-of-flight mass analyzers using switching between separate sample and reference sprays. 1. Proof of concept | Q74226823 | ||
| Bioanalytical applications of 'fast chromatography' to high-throughput liquid chromatography/tandem mass spectrometric quantitation | Q74234629 | ||
| Immunoaffinity chromatography combined on-line with high-performance liquid chromatography-mass spectrometry for the determination of corticosteroids | Q74275618 | ||
| Matrix effect in quantitative LC/MS/MS analyses of biological fluids: a method for determination of finasteride in human plasma at picogram per milliliter concentrations | Q74341658 | ||
| Continuous-flow, on-line monitoring of biospecific interactions using electrospray mass spectrometry | Q74457738 | ||
| Screening and identification of unknown contaminants in water with liquid chromatography and quadrupole-orthogonal acceleration-time-of-flight tandem mass spectrometry | Q74607054 | ||
| Effect of the sample matrix on the determination of indinavir in human urine by HPLC with turbo ion spray tandem mass spectrometric detection | Q74651774 | ||
| Use of generic fast gradient liquid chromatography-tandem mass spectroscopy in quantitative bioanalysis | Q74764476 | ||
| Monolithic silica columns for high-efficiency chromatographic separations | Q74799614 | ||
| Identification of drug metabolites in biological matrices by intelligent automated liquid chromatography/tandem mass spectrometry | Q77683046 | ||
| The use of preparative high performance liquid chromatography with tandem mass spectrometric directed fraction collection for the isolation and characterisation of drug metabolites in urine by nuclear magnetic resonance spectroscopy and liquid chrom | Q77826682 | ||
| Column switching in high-performance liquid chromatography with tandem mass spectrometric detection for high-throughput preclinical pharmacokinetic studies | Q77898270 | ||
| Optimisation and routine use of generic ultra-high flow-rate liquid chromatography with mass spectrometric detection for the direct on-line analysis of pharmaceuticals in plasma | Q77898281 | ||
| Liquid-liquid extraction in the 96-well plate format with SRM LC/MS quantitative determination of methotrexate and its major metabolite in human plasma | Q77999601 | ||
| High throughput liquid chromatography/mass spectrometric analyses using a novel multiplexed electrospray interface | Q78004121 | ||
| The effects of sample preparation methods on the variability of the electrospray ionization response for model drug compounds | Q78004126 | ||
| Investigating the use of an octupole ion guide for ion storage and high-pass mass filtering to improve the quantitative performance of electrospray ion trap mass spectrometry | Q78004244 | ||
| High-throughput flow injection analysis mass spectroscopy with networked delivery of color-rendered results. 2. Three-dimensional spectral mapping of 96-well combinatorial chemistry racks | Q84283191 | ||
| Hydrophilic interaction chromatography-electrospray mass spectrometry analysis of polar compounds for natural product drug discovery | Q84283467 | ||
| Quantitation of SR 27417 in human plasma using electrospray liquid chromatography-tandem mass spectrometry: A study of ion suppression | Q86676053 | ||
| Atmospheric pressure photoionization: an ionization method for liquid chromatography-mass spectrometry | Q33422191 | ||
| Quantitative screening and matrix effect studies of drug discovery compounds in monkey plasma using fast-gradient liquid chromatography/tandem mass spectrometry | Q33424539 | ||
| Effect of eluent on the ionization efficiency of flavonoids by ion spray, atmospheric pressure chemical ionization, and atmospheric pressure photoionization mass spectrometry. | Q33424562 | ||
| Surface-assisted reduction of aniline oligomers, N-phenyl-1,4-phenylenediimine and thionin in atmospheric pressure chemical ionization and atmospheric pressure photoionization | Q33424792 | ||
| High-throughput quantification of the anti-leukemia drug STI571 (Gleevec) and its main metabolite (CGP 74588) in human plasma using liquid chromatography-tandem mass spectrometry | Q33424938 | ||
| Rapid pharmacokinetic screening for the selection of new drug discovery candidates using a generic isocratic liquid chromatography--atmospheric pressure ionization tandem mass spectrometry method | Q33425283 | ||
| Comparison of electrospray, atmospheric pressure chemical ionization, and atmospheric pressure photoionization in the identification of apomorphine, dobutamine, and entacapone phase II metabolites in biological samples | Q33425513 | ||
| Trace determination of priority pesticides in water by means of high-speed on-line solid-phase extraction-liquid chromatography-tandem mass spectrometry using turbulent-flow chromatography columns for enrichment and a short monolithic column for fas | Q33425532 | ||
| Atmospheric pressure photoionization liquid chromatographic-mass spectrometric determination of idoxifene and its metabolites in human plasma | Q33425861 | ||
| Studies on azaspiracid biotoxins. I. Ultrafast high-resolution liquid chromatography/mass spectrometry separations using monolithic columns | Q33426174 | ||
| Collisional focusing effects in radio frequency quadrupoles. | Q33459971 | ||
| Collisional activation and collision-activated dissociation of large multiply charged polypeptides and proteins produced by electrospray ionization. | Q33460014 | ||
| Sonic spray mass spectrometry | Q33486034 | ||
| Screening for Annonaceous acetogenins in bioactive plant extracts by liquid chromatography/mass spectrometry | Q33486637 | ||
| Multi-atmospheric pressure ionisation interface for liquid chromatography-mass spectrometry | Q33487362 | ||
| High-performance liquid chromatographic-electrospray ionization mass spectrometric analyses for the integration of natural products with modern high-throughput screening | Q33607408 | ||
| Strategies and data precision requirements for the mass spectrometric determination of structures from combinatorial mixtures | Q33921822 | ||
| Immunoaffinity Ultrafiltration with Ion Spray HPLC/MS for Screening Small-Molecule Libraries | Q33921895 | ||
| Multistage accurate mass spectrometry: a "basket in a basket" approach for structure elucidation and its application to a compound from combinatorial synthesis | Q33924172 | ||
| Infrared multiphoton dissociation of large multiply charged ions for biomolecule sequencing | Q34292844 | ||
| Analytical properties of the nanoelectrospray ion source | Q34394381 | ||
| High-performance liquid chromatography/NMR spectrometry/mass spectrometry: further advances in hyphenated technology | Q34414444 | ||
| Tandem FTMS of Large Biomolecules | Q34441864 | ||
| Screening derivatized peptide libraries for tight binding inhibitors to carbonic anhydrase II by electrospray ionization-mass spectrometry | Q36800320 | ||
| A practical ion trap mass spectrometer for the analysis of peptides by matrix-assisted laser desorption/ionization | Q36801306 | ||
| Combinatorial peptide libraries: robotic synthesis and analysis by nuclear magnetic resonance, mass spectrometry, tandem mass spectrometry, and high-performance capillary electrophoresis techniques. | Q36808633 | ||
| Isotope or mass encoding of combinatorial libraries | Q36819806 | ||
| Characterization of benzodiazepine "combinatorial" chemical libraries by on-line immunoaffinity extraction, coupled column HPLC-ion spray mass spectrometry-tandem mass spectrometry | Q36840787 | ||
| Matrix-assisted laser desorption ion trap mass spectrometry: efficient trapping and ejection of ions | Q36845809 | ||
| Matrix-assisted laser desorption ion trap mass spectrometry: efficient isolation and effective fragmentation of peptide ions | Q36845813 | ||
| Metal complexation reactions of quinolone antibiotics in a quadrupole ion trap | Q36850961 | ||
| Pulsed ultrafiltration mass spectrometry: a new method for screening combinatorial libraries. | Q36865334 | ||
| Tandem infrared multiphoton dissociation and collisionally activated dissociation techniques in a quadrupole ion trap | Q39564102 | ||
| Preparative mass spectrometry with electrospray ionization | Q41694351 | ||
| A micromachined chip-based electrospray source for mass spectrometry | Q41717502 | ||
| Structural characterization of flavonoid glycosides by collisionally activated dissociation of metal complexes | Q43605421 | ||
| Accurate mass liquid chromatography/mass spectrometry on quadrupole orthogonal acceleration time-of-flight mass analyzers using switching between separate sample and reference sprays. 2. Applications using the dual-electrospray ion source | Q43637775 | ||
| Tune compounds for electrospray ionisation/in-source collision-induced dissociation with mass spectral library searching | Q43735576 | ||
| Direct analysis of a polar pharmaceutical compound in plasma using ultra-high flow rate liquid chromatography/mass spectrometry with a mixed-mode column | Q43825915 | ||
| Analysis of a basic drug by on-line solid-phase extraction liquid chromatography/tandem mass spectrometry using a mixed mode sorbent | Q43938701 | ||
| Developing strategies for isolation of minor impurities with mass spectrometry-directed fractionation | Q44154376 | ||
| Monolithic silica liquid chromatography columns for the determination of cyclooxygenase II inhibitors in human plasma | Q44166370 | ||
| Investigation of an enhanced resolution triple quadrupole mass spectrometer for high-throughput liquid chromatography/tandem mass spectrometry assays | Q44187988 | ||
| High-throughput selected reaction monitoring liquid chromatography-mass spectrometry determination of methylphenidate and its major metabolite, ritalinic acid, in rat plasma employing monolithic columns | Q44228227 | ||
| Accurate mass measurement at enhanced mass-resolution on a triple quadrupole mass-spectrometer for the identification of a reaction impurity and collisionally-induced fragment ions of cabergoline | Q44351536 | ||
| Investigation of collisional-activation decomposition process and spectra in the transport regions of an electrospray single-quadrupole mass spectrometer | Q44412807 | ||
| Direct analysis of plasma samples for drug discovery compounds using mixed-function column liquid chromatography tandem mass spectrometry | Q46671011 | ||
| Subattomole-Sensitivity Microchip Nanoelectrospray Source with Time-of-Flight Mass Spectrometry Detection | Q46841239 | ||
| Tandem mass spectrometry of large biomolecule ions by blackbody infrared radiative dissociation | Q46920744 | ||
| Capillary electrophoresis fourier transform ion cyclotron resonance mass spectrometry with sustained off-resonance irradiation for the characterization of protein and peptide mixtures | Q47722354 | ||
| Generic method for on-line extraction of drug substances in the presence of biological matrices using turbulent flow chromatography | Q48681956 | ||
| Novel microfabricated device for electrokinetically induced pressure flow and electrospray ionization mass spectrometry. | Q51603950 | ||
| Integration of immobilized trypsin bead beds for protein digestion within a microfluidic chip incorporating capillary electrophoresis separations and an electrospray mass spectrometry interface. | Q51604186 | ||
| Microfabricated devices for capillary electrophoresis-electrospray mass spectrometry. | Q51604851 | ||
| Multichannel microchip electrospray mass spectrometry. | Q51605930 | ||
| Liquid-liquid extraction using 96-well plate format in conjunction with liquid chromatography/tandem mass spectrometry for quantitative determination of methylphenidate (Ritalin) in human plasma. | Q52078366 | ||
| High throughput liquid chromatography/mass spectrometry bioanalysis using 96-well disk solid phase extraction plate for the sample preparation. | Q52248828 | ||
| Rapid 'de novo' peptide sequencing by a combination of nanoelectrospray, isotopic labeling and a quadrupole/time-of-flight mass spectrometer. | Q52283555 | ||
| High-throughput purity estimation and characterisation of synthetic peptides by electrospray mass spectrometry. | Q52316294 | ||
| Direct plasma sample injection in multiple-component LC-MS-MS assays for high-throughput pharmacokinetic screening. | Q52844440 | ||
| Evaluations of the stability of sheathless electrospray ionization mass spectrometry emitters using electrochemical techniques. | Q53990834 | ||
| Development of multichannel devices with an array of electrospray tips for high-throughput mass spectrometry. | Q54040878 | ||
| Small volume and low flow-rate electrospray lonization mass spectrometry of aqueous samples | Q56269193 | ||
| Electrospray and Taylor-Cone theory, Dole's beam of macromolecules at last? | Q56269194 | ||
| MASPA Program Predicting Mass Spectra of Combinatorial Libraries | Q56604062 | ||
| Crossed-beam liquid chromatoraph—mass spectrometer combination | Q56636656 | ||
| Liquid chromatography coupled to mass spectrometry and nuclear magnetic resonance spectroscopy for the screening of plant constituents | Q56686996 | ||
| Charge Capacity Limitations of Radio Frequency Ion Guides in Their Use for Improved Ion Accumulation and Trapping in Mass Spectrometry | Q58069221 | ||
| Evolution of esi–mass spectrometry and fourier transform ion cyclotron resonance for proteomics and other biological applications | Q58069226 | ||
| Characterization of an Improved Electrodynamic Ion Funnel Interface for Electrospray Ionization Mass Spectrometry | Q58069278 | ||
| An Ion Funnel Interface for Improved Ion Focusing and Sensitivity Using Electrospray Ionization Mass Spectrometry | Q58069301 | ||
| Analysis of Single Cells with Capillary Electrophoresis Electrospray Ionization Fourier Transform Ion Cycloton Resonance Mass Spectrometry | Q58069389 | ||
| Bio-affinity characterization mass spectrometry | Q58069446 | ||
| Trapping, Detection, and Mass Determination of Coliphage T4 DNA Ions by Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry | Q58069499 | ||
| P433 | issue | 1-2 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | high-throughput screening | Q626251 |
| P304 | page(s) | 413-436 | |
| P577 | publication date | 2003-06-01 | |
| P1433 | published in | Journal of Chromatography | Q902558 |
| P1476 | title | Progress in liquid chromatography-mass spectrometry instrumentation and its impact on high-throughput screening | |
| P478 | volume | 1000 |
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| Q51781323 | Fragmentation pathways and structural characterization of organophosphorus compounds related to the Chemical Weapons Convention by electron ionization and electrospray ionization tandem mass spectrometry. |
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