Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia

scientific article published on April 1, 1992

Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/J.1460-2075.1992.TB05185.X
P953full work available at URLhttps://europepmc.org/articles/PMC556589
https://europepmc.org/articles/PMC556589?pdf=render
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/1314166/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/1314166/pdf/?tool=EBI
P932PMC publication ID556589
P698PubMed publication ID1314166

P50authorMyriam AlcalayQ58883437
P2093author name stringM. Fagioli
P. P. Pandolfi
A. Biondi
A. Rambaldi
F. Grignani
D. Diverio
F. Lo Coco
A. Mencarelli
D. Zangrilli
P2860cites workA novel cysteine-rich sequence motifQ28264720
Identification of a receptor for the morphogen retinoic acidQ28280559
Proposals for the Classification of the Acute Leukaemias French-American-British (FAB) Co-operative GroupQ28296408
The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RARQ28300893
All-trans retinoic acid as a differentiation therapy for acute promyelocytic leukemia. I. Clinical resultsQ28331693
Gene regulation by steroid hormonesQ29618291
Multiple isoforms of the mouse retinoic acid receptor alpha are generated by alternative splicing and differential induction by retinoic acidQ33332716
Translocation breakpoint of acute promyelocytic leukemia lies within the retinoic acid receptor alpha locusQ33334769
All-trans retinoic acid in acute promyelocytic leukemias. II. In vitro studies: structure-function relationship.Q34126018
Zinc fingers and other metal-binding domains. Elements for interactions between macromoleculesQ34150666
Alternative splicing: a ubiquitous mechanism for the generation of multiple protein isoforms from single genesQ34173384
Induction of differentiation of the human promyelocytic leukemia cell line (HL-60) by retinoic acidQ36390529
fra-1: a serum-inducible, cellular immediate-early gene that encodes a fos-related antigen.Q36433594
Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RAR-alpha).Q36708494
Leukemia and the disruption of normal hematopoiesisQ37625808
Nuclear receptors enhance our understanding of transcription regulationQ39324380
Zinc fingers: gilt by associationQ39601107
The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their DNA binding activityQ40817418
Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemiasQ42220357
RAR-alpha gene rearrangements as a genetic marker for diagnosis and monitoring in acute promyelocytic leukemiaQ67914638
Molecular evaluation of response to all-trans-retinoic acid therapy in patients with acute promyelocytic leukemiaQ67915178
Differentiation Therapy of Acute Promyelocytic Leukemia with Tretinoin (All-trans-Retinoic Acid)Q67915608
Structure and origin of the acute promyelocytic leukemia myl/RAR alpha cDNA and characterization of its retinoid-binding and transactivation propertiesQ68247120
A human retinoic acid receptor which belongs to the family of nuclear receptorsQ24339631
Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytesQ24555804
Characterization of a functional promoter for the human retinoic acid receptor-alpha (hRAR-alpha)Q24595994
A reappraisal of non-consensus mRNA splice sitesQ24630858
Primer-directed enzymatic amplification of DNA with a thermostable DNA polymeraseQ26778389
The steroid and thyroid hormone receptor superfamilyQ27861095
Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PMLQ28118823
The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locusQ28241824
Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17Q28255789
P433issue4
P407language of work or nameEnglishQ1860
P921main subjecthuman chromosome 17Q220677
leukemiaQ29496
proto-oncogene proteinQ66020913
neoplasm proteinQ66894191
RNA splicingQ237218
chromosomal translocationQ916504
nuclear proteinQ16860021
alternative mRNA splicing, via spliceosomeQ21114084
P304page(s)1397-1407
P577publication date1992-04-01
P1433published inThe EMBO JournalQ1278554
P1476titleGenomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia
P478volume11

Reverse relations

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