| scholarly article | Q13442814 |
| P356 | DOI | 10.1002/PATH.4654 |
| P698 | PubMed publication ID | 26446984 |
| P50 | author | Yonglun Luo | Q68703561 |
| P2093 | author name string | Aage Kristian Olsen Alstrup | |
| Ida E Holm | |||
| P2860 | cites work | Therapeutic approaches to Alzheimer's disease | Q22242932 |
| Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease | Q22251067 | ||
| Clinical features of Alzheimer's disease | Q22252702 | ||
| Huntington's disease genetics | Q22305906 | ||
| A single ataxia telangiectasia gene with a product similar to PI-3 kinase | Q24323579 | ||
| Pigs in sequence space: a 0.66X coverage pig genome survey based on shotgun sequencing | Q24529105 | ||
| Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease | Q24595802 | ||
| RNA-guided human genome engineering via Cas9 | Q24598394 | ||
| Multiple Aspects of Gene Dysregulation in Huntington's Disease | Q24605880 | ||
| Multiplex genome engineering using CRISPR/Cas systems | Q24609428 | ||
| Towards a transgenic model of Huntington's disease in a non-human primate | Q24644013 | ||
| A positive modifier of spinal muscular atrophy in the SMN2 gene | Q24646149 | ||
| Influence of species differences on the neuropathology of transgenic Huntington's disease animal models | Q38022914 | ||
| Anaesthesia for positron emission tomography scanning of animal brains | Q38076701 | ||
| Genetically modified pig models for human diseases | Q38084522 | ||
| The appropriateness of the mouse model for ataxia-telangiectasia: neurological defects but no neurodegeneration | Q38111512 | ||
| Genetically modified pigs to model human diseases | Q38162792 | ||
| Characterization of the porcine ATM gene: towards the generation of a novel non-murine animal model for Ataxia-Telangiectasia. | Q38297378 | ||
| In vivo imaging of human acetylcholinesterase density in peripheral organs using 11C-donepezil: dosimetry, biodistribution, and kinetic analyses | Q39111709 | ||
| Huntington's disease. Pathogenesis and management | Q39460676 | ||
| Environmental risk factors in Parkinson's disease | Q39523776 | ||
| Preventing Alzheimer's disease | Q39549596 | ||
| Characterization and expression analysis in the developing embryonic brain of the porcine FET family: FUS, EWS, and TAF15. | Q39679052 | ||
| First inducible transgene expression in porcine large animal models | Q39679941 | ||
| Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation | Q39834753 | ||
| Generation of pig induced pluripotent stem cells with a drug-inducible system | Q39841807 | ||
| Pig transgenesis by Sleeping Beauty DNA transposition | Q39843018 | ||
| The anatomy of the Göttingen minipig hypothalamus | Q39913222 | ||
| Piglets born from handmade cloning, an innovative cloning method without micromanipulation | Q40077453 | ||
| Permanent neonatal diabetes in INS(C94Y) transgenic pigs. | Q40124315 | ||
| Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function | Q40132400 | ||
| Epigenetic silencing and tissue independent expression of a novel tetracycline inducible system in double-transgenic pigs. | Q40282041 | ||
| Replicative fidelity of lentiviral vectors produced by transient transfection | Q40318505 | ||
| Natural history in proximal spinal muscular atrophy. Clinical analysis of 445 patients and suggestions for a modification of existing classifications | Q40986555 | ||
| Cholecystokinin‐, enkephalin‐, and substance P‐like immunoreactivity in the dentate area, hippocampus, and subiculum of the domestic pig | Q41079281 | ||
| Somatostatin- and neuropeptide Y-like immunoreactivity in the dentate area, hippocampus, and subiculum of the domestic pig | Q41110146 | ||
| Neuropathology of ALS: an overview | Q41152629 | ||
| RETRACTED ARTICLE: Rescue of the spinal muscular atrophy phenotype in a mouse model by early postnatal delivery of SMN | Q41275236 | ||
| Inheritance of frontotemporal dementia | Q41679025 | ||
| Three- and four-repeat Tau coassemble into heterogeneous filaments: an implication for Alzheimer disease | Q41713209 | ||
| Loss of PINK1 enhances neurodegeneration in a mouse model of Parkinson's disease triggered by mitochondrial stress. | Q41846921 | ||
| One-step generation of knockout pigs by zygote injection of CRISPR/Cas system | Q42419006 | ||
| Sequence conservation between porcine and human LRRK2. | Q42636181 | ||
| Piglets cloned from induced pluripotent stem cells | Q42636975 | ||
| HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia | Q42722993 | ||
| Amyloid beta 1-42 deposits do not lead to Alzheimer's neuritic plaques in aged dogs. | Q42980695 | ||
| Generation of minipigs with targeted transgene insertion by recombinase-mediated cassette exchange (RMCE) and somatic cell nuclear transfer (SCNT). | Q43090780 | ||
| The substantia nigra pars compacta of the Göttingen minipig: an anatomical and stereological study | Q43286588 | ||
| Imaging dopamine release with Positron Emission Tomography (PET) and (11)C-raclopride in freely moving animals | Q43539395 | ||
| Normalization of markers for dopamine innervation in striatum of MPTP-lesioned miniature pigs with intrastriatal grafts. | Q43591772 | ||
| Production of transgenic miniature pigs by pronuclear microinjection | Q43870699 | ||
| Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells | Q44189907 | ||
| Characterization of the porcine FBX07 gene: the first step towards generation of a pig model for Parkinsonian pyramidal syndrome | Q44402345 | ||
| Histochemical demonstration of zinc in the hippocampal region of the domestic pig: III. The dentate area | Q44454716 | ||
| Kinetics of the uptake and distribution of the dopamine D(2,3) agonist (R)-N-[1-(11)C]n-propylnorapomorphine in brain of healthy and MPTP-treated Göttingen miniature pigs | Q44494957 | ||
| The progression of beta-amyloid deposition in the frontal cortex of the aged canine | Q44810115 | ||
| High overall in vitro efficiency of porcine handmade cloning (HMC) combining partial zona digestion and oocyte trisection with sequential culture | Q44863419 | ||
| Tyrosine hydroxylase and acetylcholinesterase in the domestic pig mesencephalon: an immunocytochemical and histochemical study | Q44964869 | ||
| Genetics of Parkinson's disease | Q26827825 | ||
| Genetically engineered mouse models of Parkinson's disease | Q26852964 | ||
| Genetics and neuropathology of Huntington's disease | Q27023050 | ||
| The genetics of Alzheimer disease | Q27026166 | ||
| A large animal model of spinal muscular atrophy and correction of phenotype | Q27340106 | ||
| APP processing in Alzheimer's disease | Q27694738 | ||
| RNA-programmed genome editing in human cells | Q28044562 | ||
| Olfaction and Aging: A Mini-Review | Q28082742 | ||
| Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis | Q28131805 | ||
| Phenylbutyrate increases SMN expression in vitro: relevance for treatment of spinal muscular atrophy | Q28177632 | ||
| Huntingtin aggregation and toxicity in Huntington's disease | Q28204163 | ||
| Aclarubicin treatment restores SMN levels to cells derived from type I spinal muscular atrophy patients | Q28209134 | ||
| Use of the CRISPR/Cas9 system to produce genetically engineered pigs from in vitro-derived oocytes and embryos | Q28245450 | ||
| Trafficking and proteolytic processing of APP | Q28265871 | ||
| Production of CFTR-null and CFTR-DeltaF508 heterozygous pigs by adeno-associated virus-mediated gene targeting and somatic cell nuclear transfer | Q28271767 | ||
| Correction of SMN2 Pre-mRNA splicing by antisense U7 small nuclear RNAs | Q28277159 | ||
| Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database | Q28280965 | ||
| Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes | Q28302701 | ||
| Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue | Q28506834 | ||
| Inactivation of the mouse Huntington's disease gene homolog Hdh | Q28509662 | ||
| Amino-terminal fragments of mutant huntingtin show selective accumulation in striatal neurons and synaptic toxicity | Q28513938 | ||
| Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice | Q28594828 | ||
| Parkinson's disease: mechanisms and models | Q29547424 | ||
| Identification and characterization of a spinal muscular atrophy-determining gene | Q29547495 | ||
| Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation | Q29547561 | ||
| Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction | Q29547778 | ||
| Association between early-onset Parkinson's disease and mutations in the parkin gene | Q29615733 | ||
| Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptoms | Q30492587 | ||
| Alzheimer disease models and human neuropathology: similarities and differences | Q30499574 | ||
| Factors influencing the efficiency of generating genetically engineered pigs by nuclear transfer: multi-factorial analysis of a large data set. | Q30628854 | ||
| The basics of preclinical drug development for neurodegenerative disease indications | Q33469825 | ||
| The influx of neutral amino acids into the porcine brain during development: a positron emission tomography study | Q45047151 | ||
| Animal models of neurodegenerative diseases. | Q45293452 | ||
| ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. | Q46135324 | ||
| Neuroimaging of the vesicular acetylcholine transporter by a novel 4-[18F]fluoro-benzoyl derivative of 7-hydroxy-6-(4-phenyl-piperidin-1-yl)-octahydro-benzo[1,4]oxazines. | Q46139745 | ||
| Synthesis and cerebral uptake of 1-(1-[(11)C]methyl-1H-pyrrol-2-yl)-2-phenyl-2-(1-pyrrolidinyl)ethanone, a novel tracer for positron emission tomography studies of monoamine oxidase type A. | Q46728257 | ||
| Effect of monoamine oxidase inhibition on amphetamine-evoked changes in dopamine receptor availability in the living pig: a dual tracer PET study with [11C]harmine and [11C]raclopride | Q46950279 | ||
| Inverse correlation between SMN1 and SMN2 copy numbers: evidence for gene conversion from SMN2 to SMN1. | Q47996236 | ||
| Hippocampus of the domestic pig: a stereological study of subdivisional volumes and neuron numbers | Q48184432 | ||
| The use of pigs in neuroscience: modeling brain disorders | Q48195971 | ||
| Serotonergic modulation of receptor occupancy in rats treated with L-DOPA after unilateral 6-OHDA lesioning | Q48210282 | ||
| A PET study of effects of chronic 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy") on serotonin markers in Göttingen minipig brain | Q48212891 | ||
| MPTP-induced Parkinsonism in minipigs: A behavioral, biochemical, and histological study | Q48245796 | ||
| Imaging imidazoline-I2 binding sites in porcine brain using 11C-BU99008. | Q48261312 | ||
| Statistical mapping of effects of middle cerebral artery occlusion (MCAO) on blood flow and oxygen consumption in porcine brain | Q48356823 | ||
| In vivo estimation of cerebral blood flow, oxygen consumption and glucose metabolism in the pig by [15O]water injection, [15O]oxygen inhalation and dual injections of [18F]fluorodeoxyglucose. | Q48518620 | ||
| Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms | Q48571996 | ||
| MR-based statistical atlas of the Göttingen minipig brain | Q48719637 | ||
| MRI protocol for in vivo visualization of the Göttingen minipig brain improves targeting in experimental functional neurosurgery | Q48772422 | ||
| Histochemical demonstration of zinc in the hippocampal region of the domestic pig: II. Subiculum and hippocampus | Q48788634 | ||
| Ataxia telangiectasia: new neurons and ATM. | Q48865724 | ||
| Object recognition as a measure of memory in 1-2 years old transgenic minipigs carrying the APPsw mutation for Alzheimer's disease. | Q50803794 | ||
| Foreword: neurodegenerative diseases: challenges and opportunities. | Q51563574 | ||
| Generation of CRISPR/Cas9-mediated gene-targeted pigs via somatic cell nuclear transfer. | Q52423182 | ||
| Targeted disruption of Ataxia-telangiectasia mutated gene in miniature pigs by somatic cell nuclear transfer. | Q52653447 | ||
| An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria | Q54965159 | ||
| Molecular analysis of spinal muscular atrophy and modification of the phenotype by SMN2. | Q55035683 | ||
| Juvenile Huntington's disease: does a dosage-effect pathogenic mechanism differ from the classical adult disease? | Q36308082 | ||
| Efficient TALEN-mediated gene knockout in livestock | Q36378266 | ||
| Current approaches to the treatment of Parkinson's disease | Q36876438 | ||
| Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs | Q36944556 | ||
| Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis | Q37165188 | ||
| Effects of anesthesia and species on the uptake or binding of radioligands in vivo in the Göttingen minipig | Q37191041 | ||
| Rodent genetic models of Huntington disease | Q37220633 | ||
| Derivation of induced pluripotent stem cells from pig somatic cells | Q37233718 | ||
| Generation of induced pluripotent stem cell lines from Tibetan miniature pig. | Q37285271 | ||
| PiB Fails to Map Amyloid Deposits in Cerebral Cortex of Aged Dogs with Canine Cognitive Dysfunction | Q37417915 | ||
| ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects | Q37609639 | ||
| Perspectives and diagnostic considerations in spinal muscular atrophy | Q37670613 | ||
| Species-dependent neuropathology in transgenic SOD1 pigs | Q37684257 | ||
| Genetic animal models of Parkinson's disease | Q37765030 | ||
| Cognitive testing of pigs (Sus scrofa) in translational biobehavioral research | Q37765677 | ||
| The association between infectious burden and Parkinson's disease: A case-control study. | Q37840384 | ||
| TAL effectors: customizable proteins for DNA targeting | Q37940951 | ||
| Recent rodent models for Alzheimer's disease: clinical implications and basic research | Q37956513 | ||
| Genetically modified pigs for biomedical research. | Q37997627 | ||
| Therapeutic interventions targeting Beta amyloid pathogenesis in an aging dog model | Q38015346 | ||
| Three repeat isoforms of tau inhibit assembly of four repeat tau filaments | Q33593147 | ||
| Analysis of triplet repeats in the huntingtin gene in Japanese families affected with Huntington's disease | Q33682442 | ||
| Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick? | Q33785933 | ||
| An ovine transgenic Huntington's disease model | Q33815561 | ||
| Phylogenetic diversity of the expression of the microtubule-associated protein tau: implications for neurodegenerative disorders | Q33861704 | ||
| Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). | Q34010341 | ||
| Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model | Q34030144 | ||
| Comparison of gene expression and genome-wide DNA methylation profiling between phenotypically normal cloned pigs and conventionally bred controls | Q34055767 | ||
| Juvenile onset Huntington's disease--clinical and research perspectives. | Q34091006 | ||
| A good practice guide to the administration of substances and removal of blood, including routes and volumes | Q34141695 | ||
| Determination of Odor Detection Threshold in the Gottingen Minipig | Q34145250 | ||
| Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs | Q34163091 | ||
| A humanized Smn gene containing the SMN2 nucleotide alteration in exon 7 mimics SMN2 splicing and the SMA disease phenotype | Q34184793 | ||
| Proposed Motor Scoring System in a Porcine Model of Parkinson's Disease induced by Chronic Subcutaneous Injection of MPTP. | Q34241599 | ||
| A polymorphic DNA marker genetically linked to Huntington's disease | Q34255139 | ||
| Neuropathology of amyotrophic lateral sclerosis with extra-motor system degeneration: characteristics and differences in the molecular pathology between ALS with dementia and Guamanian ALS. | Q34315764 | ||
| Efficient bi-allelic gene knockout and site-specific knock-in mediated by TALENs in pigs | Q34452907 | ||
| Genetically engineered mouse models of neurodegenerative diseases | Q34708236 | ||
| Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis | Q34718757 | ||
| Transgenic mouse models of neurodegenerative disease: opportunities for therapeutic development | Q34778122 | ||
| Hemizygous minipigs produced by random gene insertion and handmade cloning express the Alzheimer's disease-causing dominant mutation APPsw | Q34934330 | ||
| The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs | Q35056880 | ||
| Long-term accumulation of amyloid-beta, beta-secretase, presenilin-1, and caspase-3 in damaged axons following brain trauma | Q35103035 | ||
| Compensatory mechanisms in genetic models of neurodegeneration: are the mice better than humans? | Q35153576 | ||
| Mutations in DJ-1 are rare in familial Parkinson disease | Q35231079 | ||
| Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's disease | Q35284971 | ||
| Huntington's disease in Chinese: a hypothesis of its origin | Q35351538 | ||
| A guide to neurotoxic animal models of Parkinson's disease | Q35603488 | ||
| Traumatic brain injury in later life increases risk for Parkinson disease | Q35661022 | ||
| Disruption of the Survival Motor Neuron (SMN) gene in pigs using ssDNA. | Q35683524 | ||
| Genetically engineered pig models for human diseases | Q35700104 | ||
| Splicing variants of porcine synphilin-1 | Q35745078 | ||
| In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9 | Q35820051 | ||
| Changing metabolic signatures of amino acids and lipids during the prediabetic period in a pig model with impaired incretin function and reduced β-cell mass | Q36109246 | ||
| P433 | issue | 2 | |
| P921 | main subject | neurodegeneration | Q1755122 |
| P304 | page(s) | 267-287 | |
| P577 | publication date | 2015-10-08 | |
| P1433 | published in | Journal of Pathology | Q400296 |
| P1476 | title | Genetically modified pig models for neurodegenerative disorders | |
| P478 | volume | 238 |
| Q52431215 | A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington's Disease. |
| Q50949714 | Animal and cellular models of human disease. |
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| Q55287163 | Biomimetic neural scaffolds: a crucial step towards optimal peripheral nerve regeneration. |
| Q38854247 | Bridging the gap: large animal models in neurodegenerative research |
| Q33914125 | CRISPR/Cas9-mediated ApoE-/- and LDLR-/- double gene knockout in pigs elevates serum LDL-C and TC levels |
| Q41062049 | Candidate SNP Markers of Familial and Sporadic Alzheimer's Diseases Are Predicted by a Significant Change in the Affinity of TATA-Binding Protein for Human Gene Promoters |
| Q64963501 | Canine Cognitive Dysfunction and Alzheimer’s Disease – Two Facets of the Same Disease? |
| Q39024182 | Clinical potential of human-induced pluripotent stem cells : Perspectives of induced pluripotent stem cells |
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| Q92383538 | Development and Genome Sequencing of a Laboratory-Inbred Miniature Pig Facilitates Study of Human Diabetic Disease |
| Q50893120 | Enhanced genome editing in mammalian cells with a modified dual-fluorescent surrogate system. |
| Q94544910 | Exploring Consumers' Interest in Choosing Sustainable Food |
| Q48562250 | Expression of the Alzheimer's Disease Mutations AβPP695sw and PSEN1M146I in Double-Transgenic Göttingen Minipigs |
| Q64074438 | Generation and characterization of a novel knockin minipig model of Hutchinson-Gilford progeria syndrome |
| Q48353805 | Generation of embryonic stem-like cells from in vivo-derived porcine blastocysts at a low concentration of basic fibroblast growth factor. |
| Q38901709 | Genome editing revolutionize the creation of genetically modified pigs for modeling human diseases |
| Q49478512 | Genome-editing applications of CRISPR-Cas9 to promote in vitro studies of Alzheimer's disease |
| Q52425293 | Golden Gate Assembly of CRISPR gRNA expression array for simultaneously targeting multiple genes. |
| Q57061818 | MRI-guided intracerebral convection-enhanced injection of gliotoxins to induce focal demyelination in swine |
| Q38783343 | Non human primate models for Alzheimer's disease-related research and drug discovery |
| Q47249282 | Production of transgenic pigs using the pGFAP-CreERT2;EGFPLoxP inducible system for central nervous system disease models |
| Q53408298 | Psychosocial Stress and Immunity-What Can We Learn From Pig Studies? |
| Q38672269 | Simple and reproducible approaches for the collection of select porcine ganglia. |
| Q48342666 | Somatic cell reprogramming-free generation of genetically modified pigs. |
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