BMP-9 induced endothelial cell tubule formation and inhibition of migration involves Smad1 driven endothelin-1 production

scientific article

BMP-9 induced endothelial cell tubule formation and inhibition of migration involves Smad1 driven endothelin-1 production is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2012PLoSO...730075P
P356DOI10.1371/JOURNAL.PONE.0030075
P932PMC publication ID3267722
P698PubMed publication ID22299030
P5875ResearchGate publication ID239785274

P50authorNicholas W MorrellQ60960702
Ian M. AdcockQ38803002
P2093author name stringPaul D Upton
Mark J D Griffiths
Stephen J Wort
Rachel J Davies
Dongmin Shao
John E S Park
Patricia Desouza
P2860cites workBMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivoQ24307458
Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cellsQ24309588
Gene expression fingerprinting for human hereditary hemorrhagic telangiectasiaQ64045883
Plasma endothelin concentrations in patients with pulmonary hypertension associated with congenital heart defects. Evidence for increased production of endothelin in pulmonary circulationQ68069838
Bosentan therapy for pulmonary arterial hypertensionQ77801473
Signaling by ALK5 mediates TGF-beta-induced ET-1 expression in endothelial cells: a role for migration and proliferationQ80005826
Localization of endothelin receptors in bleomycin-induced pulmonary fibrosis in the ratQ80852841
Transforming growth factor-beta induces endothelin-1 expression through activation of the Smad signaling pathwayQ81663164
Endothelin receptor expression in idiopathic pulmonary arterial hypertension: effect of bosentan and epoprostenol treatmentQ83619736
The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways.Q42823613
Primary pulmonary hypertension is associated with reduced pulmonary vascular expression of type II bone morphogenetic protein receptorQ43952396
Signaling molecules in nonfamilial pulmonary hypertensionQ44305028
Signaling molecules in overcirculation-induced pulmonary hypertension in piglets: effects of sildenafil therapyQ45091702
Endothelin-1 enhances cell migration via matrix metalloproteinase-9 up-regulation in brain astrocytesQ48258310
Proliferative stimulation of the vascular Endothelin-1 axis in vitro and ex vivo by infection with Chlamydia pneumoniae.Q52596124
p38 mitogen-activated protein kinase inhibition ameliorates angiotensin II-induced target organ damage.Q52927963
Bone morphogenic protein-9 stimulates endothelin-1 release from human pulmonary microvascular endothelial cells: a potential mechanism for elevated ET-1 levels in pulmonary arterial hypertension.Q54665302
Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertensionQ55670914
Deletion of Endothelial Cell Endothelin B Receptors Does Not Affect Blood Pressure or Sensitivity to SaltQ56987910
Dysfunctional Smad Signaling Contributes to Abnormal Smooth Muscle Cell Proliferation in Familial Pulmonary Arterial HypertensionQ57149168
Endothelin-1 in the lungs of patients with pulmonary hypertensionQ58622178
Dexamethasone reverses monocrotaline-induced pulmonary arterial hypertension in ratsQ61712109
Casein kinase 2beta as a novel enhancer of activin-like receptor-1 signalingQ24313348
BMP4 induces HO-1 via a Smad-independent, p38MAPK-dependent pathway in pulmonary artery myocytesQ24315830
Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cellsQ24315838
The selectivity of protein kinase inhibitors: a further updateQ24654622
Bone morphogenetic protein-9 is a circulating vascular quiescence factorQ24657942
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6Q28140674
Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathwayQ28243967
BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesisQ28289169
Downregulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertensionQ28572271
The specificities of protein kinase inhibitors: an updateQ30014834
ALK1 signalling analysis identifies angiogenesis related genes and reveals disparity between TGF-beta and constitutively active receptor induced gene expressionQ30811602
BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertensionQ34043809
BMPR2 mutation alters the lung macrophage endothelin-1 cascade in a mouse model and patients with heritable pulmonary artery hypertensionQ34180789
Atherogenic phospholipids attenuate osteogenic signaling by BMP-2 and parathyroid hormone in osteoblasts.Q34402832
Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-beta familyQ35559673
Role of endothelin-1 in neovascularization of ovarian carcinomaQ35829525
Evidence for the presence of endothelin ETA receptors in endothelial cells in situ on the aortic side of porcine aortic valveQ35872700
IKKalpha is a critical coregulator of a Smad4-independent TGFbeta-Smad2/3 signaling pathway that controls keratinocyte differentiationQ36497326
Drug Insight: endothelin-receptor antagonists for pulmonary arterial hypertension in systemic rheumatic diseasesQ36577383
Pulmonary hypertension due to BMPR2 mutation: a new paradigm for tissue remodeling?Q36634716
Endothelin receptor antagonism and cancerQ37428046
Synergistic induction of endothelin-1 by tumor necrosis factor alpha and interferon gamma is due to enhanced NF-kappaB binding and histone acetylation at specific kappaB sitesQ37433354
Controlling of bone morphogenetic protein signalingQ37671293
The role of endothelin-1 in the pathogenesis of pulmonary arterial hypertensionQ37854945
ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motifQ38855307
Role of p38 MAPK pathway in BMP4-mediated Smad-dependent premature senescence in lung cancer cellsQ39635816
Endothelin-1 induces pulmonary but not aortic smooth muscle cell migration by activating ERK1/2 MAP kinaseQ39665350
Functional implication of BMP4 expression on angiogenesis in malignant melanomaQ40195197
Genetic ablation of the BMPR2 gene in pulmonary endothelium is sufficient to predispose to pulmonary arterial hypertension.Q41946175
Differential effects of BMP signaling on parvalbumin and somatostatin interneuron differentiationQ42040440
Endothelin-1 promotes migration of endothelial cells through the activation of ARF6 and the regulation of FAK activityQ42442261
Functional characterization of bone morphogenetic protein binding sites and Smad1/5 activation in human vascular cellsQ42820799
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
P304page(s)e30075
P577publication date2012-01-27
P1433published inPLOS OneQ564954
P1476titleBMP-9 induced endothelial cell tubule formation and inhibition of migration involves Smad1 driven endothelin-1 production
P478volume7

Reverse relations

cites work (P2860)
Q47856805ALK1 signaling in development and disease: new paradigms.
Q38140116Activin receptor-like kinase 1 as a target for anti-angiogenesis therapy.
Q34467651An atypical canonical bone morphogenetic protein (BMP) signaling pathway regulates Msh homeobox 1 (Msx1) expression during odontogenesis
Q36498604BMP signaling in mesenchymal stem cell differentiation and bone formation
Q28296361BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells
Q36796379BMP9 signaling in stem cell differentiation and osteogenesis
Q36731449BMP9-regulated angiogenic signaling plays an important role in the osteogenic differentiation of mesenchymal progenitor cells
Q37561236Bromodomain and extra-terminal protein mimic JQ1 decreases inflammation in human vascular endothelial cells: Implications for pulmonary arterial hypertension.
Q37080802Circulating Bmp10 acts through endothelial Alk1 to mediate flow-dependent arterial quiescence
Q38332401Emerging roles of BMP9 and BMP10 in hereditary hemorrhagic telangiectasia.
Q34982792Endoplasmic reticulum (ER) stress inducible factor cysteine-rich with EGF-like domains 2 (Creld2) is an important mediator of BMP9-regulated osteogenic differentiation of mesenchymal stem cells
Q33738647Endothelial follistatin-like-1 regulates the postnatal development of the pulmonary vasculature by modulating BMP/Smad signaling.
Q37671796Endothelial signaling and the molecular basis of arteriovenous malformation
Q36378875Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia.
Q38627317Morphogenic Peptides in Regeneration of Load Bearing Tissues
Q37215728Nuclear factor κ-B is activated in the pulmonary vessels of patients with end-stage idiopathic pulmonary arterial hypertension.
Q38199567Potential roles of bone morphogenetic protein (BMP)-9 in human liver diseases
Q36473791The Prodomain-Containing BMP9 Produced from a Stable Line Effectively Regulates the Differentiation of Mesenchymal Stem Cells
Q38218507The role of BMPs in endothelial cell function and dysfunction

Search more.