Testin interacts with vangl2 genetically to regulate inner ear sensory cell orientation and the normal development of the female reproductive tract in mice

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Testin interacts with vangl2 genetically to regulate inner ear sensory cell orientation and the normal development of the female reproductive tract in mice is …
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scholarly articleQ13442814

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P356DOI10.1002/DVDY.24042
P932PMC publication ID3999664
P698PubMed publication ID23996638

P2093author name stringPing Chen
Michael Kelly
Cynthia Mary Grimsley-Myers
Dong-Dong Ren
Fang-Lu Chi
Sun Myoung Kim
P2860cites workBasal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndromeQ24296493
A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5)Q24318611
AlphaII-spectrin interacts with Tes and EVL, two actin-binding proteins located at cell contactsQ24529006
Knockout mice reveal a tumor suppressor function for TestinQ24534385
The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesionsQ24675213
Tes, a specific Mena interacting partner, breaks the rules for EVH1 bindingQ27649424
Mutation of Celsr1 disrupts planar polarity of inner ear hair cells and causes severe neural tube defects in the mouseQ28184694
Identification and characterization of human PRICKLE1 and PRICKLE2 genes as well as mouse Prickle1 and Prickle2 genes homologous to Drosophila tissue polarity gene prickleQ28202925
TES is a novel focal adhesion protein with a role in cell spreadingQ28207842
Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled bindingQ28254777
Wnt5a is required for proper epithelial-mesenchymal interactions in the uterusQ28255597
Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled familyQ28285378
Fuz controls the morphogenesis and differentiation of hair follicles through the formation of primary ciliaQ28505257
Planar cell polarity effector gene Fuzzy regulates cilia formation and Hedgehog signal transduction in mouseQ28505727
Wnt5a functions in planar cell polarity regulation in miceQ28505898
Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closureQ28507430
Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathwayQ28509023
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube developmentQ28511382
Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter releaseQ28513362
Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair folliclesQ28513824
p27(Kip1) links cell proliferation to morphogenesis in the developing organ of CortiQ28585281
The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear.Q28585297
Ciliary proteins link basal body polarization to planar cell polarity regulationQ28585995
Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tractQ28587502
PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebratesQ28587777
Rack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activityQ28587927
Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner earQ28587932
Frizzled3 is required for neurogenesis and target innervation during sympathetic nervous system developmentQ28588216
Severe neural tube defects in the loop-tail mouse result from mutation of Lpp1, a novel gene involved in floor plate specificationQ28591062
The small GTPase Rac1 regulates auditory hair cell morphogenesisQ28591364
Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammalsQ28591957
Identification of Vangl2 and Scrb1 as planar polarity genes in mammalsQ28593071
The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cellsQ28593180
Prickle mediates feedback amplification to generate asymmetric planar cell polarity signalingQ28613827
Cilia-driven fluid flow in the zebrafish pronephros, brain and Kupffer's vesicle is required for normal organogenesisQ29614824
Kif3a regulates planar polarization of auditory hair cells through both ciliary and non-ciliary mechanismsQ30425548
Planar cell polarity signalling couples cell division and morphogenesis during neurulation.Q30477078
Non-canonical Wnt signaling regulates cell polarity in female reproductive tract development via van gogh-like 2.Q30487286
A novel role for MuSK and non-canonical Wnt signaling during segmental neural crest cell migration.Q30502383
Shaping the mammalian auditory sensory organ by the planar cell polarity pathwayQ34154050
Planar polarity: A new player in both lung development and diseaseQ35624649
Planar cell polarity signaling in craniofacial developmentQ35693873
Van Gogh-like2 (Strabismus) and its role in planar cell polarity and convergent extension in vertebratesQ35913686
Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signalingQ36065784
Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos.Q36381456
Wnt/PCP signaling: a veritable polar star in establishing patterns of polarity in embryonic tissuesQ36502375
Primary cilia in planar cell polarity regulation of the inner earQ37369343
Planar cell polarity signaling in neural development.Q37765741
Getting to the heart of planar cell polarity signaling.Q37871547
Planar cell polarity and the developmental control of cell behavior in vertebrate embryosQ38035934
Ascidian prickle regulates both mediolateral and anterior-posterior cell polarity of notochord cellsQ38330834
Prickle 1 regulates cell movements during gastrulation and neuronal migration in zebrafishQ38352359
Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements.Q38520593
Seven-pass transmembrane cadherins: roles and emerging mechanisms in axonal and dendritic patterning.Q39568264
Vangl2 promotes Wnt/planar cell polarity-like signaling by antagonizing Dvl1-mediated feedback inhibition in growth cone guidanceQ39726927
The frizzled extracellular domain is a ligand for Van Gogh/Stbm during nonautonomous planar cell polarity signalingQ39937859
Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signalingQ42491186
Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tailQ42653433
Testin is a tumor suppressor and prognostic marker in breast cancerQ42831001
Embryonic expression of three mouse genes with homology to the Drosophila melanogaster prickle geneQ48185409
LIM domain protein TES changes its conformational states in different cellular compartments.Q51951109
Tes regulates neural crest migration and axial elongation in Xenopus.Q52022681
Diego interacts with Prickle and Strabismus/Van Gogh to localize planar cell polarity complexes.Q52088144
The Wnt5/planar cell polarity pathway regulates axonal development of the Drosophila mushroom body neuron.Q52718124
Circletail, a new mouse mutant with severe neural tube defects: chromosomal localization and interaction with the loop-tail mutationQ77165546
RNAi knockdown of the focal adhesion protein TES reveals its role in actin stress fibre organisationQ81302016
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)1454-1465
P577publication date2013-10-02
P1433published inDevelopmental DynamicsQ59752
P1476titleTestin interacts with vangl2 genetically to regulate inner ear sensory cell orientation and the normal development of the female reproductive tract in mice
P478volume242