Therapeutic modification of the L-arginine-eNOS pathway in cardiovascular diseases

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Therapeutic modification of the L-arginine-eNOS pathway in cardiovascular diseases is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0021-9150(00)00736-X
P698PubMed publication ID11166757
P5875ResearchGate publication ID12162982

P2093author name stringStefanadis C
Toutouzas P
Tousoulis D
Tentolouris C
Goumas G
P2860cites workRole of endothelium-derived nitric oxide in the regulation of blood pressureQ28242958
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Vascular endothelial cells synthesize nitric oxide from L-arginineQ28291036
Randomized, double-blind, placebo-controlled study of supplemental oral L-arginine in patients with heart failureQ28297273
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factorQ28299224
The effect of arginine and nitric oxide on resistance blood vessels of the perfused rat kidneyQ28359320
The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholineQ29547539
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxideQ29619956
NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxideQ33575382
An L-arginine/nitric oxide pathway present in human platelets regulates aggregationQ33674149
Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolaseQ33865641
The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginineQ33882001
Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertensionQ34170380
L-arginine abrogates salt-sensitive hypertension in Dahl/Rapp ratsQ34208507
Interactions between L-arginine and L-glutamine change endothelial NO production. An effect independent of NO synthase substrate availability.Q34223377
Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humansQ34256239
L-arginine infusion has no effect on systemic haemodynamics in normal volunteers, or systemic and pulmonary haemodynamics in patients with elevated pulmonary vascular resistanceQ34345457
Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cellsQ34573717
Effects of L-arginine on lower limb vasodilator reserve and exercise capacity in patients with chronic heart failureQ35371877
Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects.Q35532246
Short-term pulmonary vasodilation with L-arginine in pulmonary hypertension.Q54162413
Contribution of endothelium-derived nitric oxide to exercise-induced vasodilation.Q54189353
L-arginine infusion decreases peripheral arterial resistance and inhibits platelet aggregation in healthy subjects.Q54195872
Effects of L-arginine on impaired acetylcholine-induced and ischemic vasodilation of the forearm in patients with heart failure.Q54198187
Role of nitric oxide synthesis in salt-sensitive hypertension in Dahl/Rapp rats.Q54225996
Effect of increased availability of endothelium-derived nitric oxide precursor on endothelium-dependent vascular relaxation in normal subjects and in patients with essential hypertension.Q54240963
Effect of antihypertensive treatment on endothelium-dependent vascular relaxation in patients with essential hypertension.Q54243794
Effects of L-arginine on forearm vessels and responses to acetylcholineQ54261202
L-Arginine as an Antihypertensive AgentQ54282687
Dilator actions of arginine in human peripheral vasculatureQ54286330
L-arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits.Q54310603
Role of endothelium-derived nitric oxide in the regulation of tonus in large-bore arterial resistance vessels, arterioles and veins in cat skeletal muscle.Q54313178
Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo. Blunted response in essential hypertension.Q54322623
NG-methylarginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: does nitric oxide regulate blood pressure in vivo?Q54355366
Dietary supplementation with L-arginine fails to restore endothelial function in forearm resistance arteries of patients with severe heart failure.Q55066434
Vascular function in the forearm of hypercholesterolaemic patients off and on lipid-lowering medicationQ57791545
Dietary l-arginine and α-tocopherol reduce vascular oxidative stress and preserve endothelial function in hypercholesterolemic rabbits via different mechanismsQ60723135
Dietary l -Arginine Reduces the Progression of Atherosclerosis in Cholesterol-Fed RabbitsQ60723154
Supplementation of hypercholesterolaemic rabbits with L-arginine reduces the vascular release of superoxide anions and restores NO productionQ60723170
A Caveolar Complex between the Cationic Amino Acid Transporter 1 and Endothelial Nitric-oxide Synthase May Explain the “Arginine Paradox”Q61940316
Chronic dietary supplementation with ?-arginine inhibits platelet aggregation and thromboxane A2 synthesis in hypercholesterolaemic rabbits in vivoQ63184879
Dietary l-arginine decreases myointimal cell proliferation and vascular monocyte accumulation in cholesterol-fed rabbitsQ63184881
Restoring vascular nitric oxide formation by l-arginine improves the symptoms of intermittent claudication in patients with peripheral arterial occlusive diseaseQ63184884
Elevatedl-Arginine/Dimethylarginine Ratio Contributes to Enhanced Systemic NO Production by Dietaryl-Arginine in Hypercholesterolemic RabbitsQ63184888
Effects of oral administration of L-arginine on renal function in patients with heart failureQ73491823
Endocrine and lipid effects of oral L-arginine treatment in healthy postmenopausal womenQ73535751
Serum cholesterol level, cigarette smoking, and vasomotor responses to L-arginine in narrowed epicardial coronary arteriesQ73574912
Coronary stenosis dilatation induced by L-arginineQ73620129
Oral L-arginine in patients with coronary artery disease on medical managementQ73762604
Effect of L-arginine on human coronary endothelium-dependent and physiologic vasodilationQ73832085
Coronary artery responses to physiological stimuli are improved by deferoxamine but not by L-arginine in non-insulin-dependent diabetic patients with angiographically normal coronary arteries and no other risk factorsQ74302884
Endothelial function of internal mammary artery in patients with coronary artery disease and in cardiac transplant recipientsQ74322955
Lack of effect of vitamin E on L-arginine-responsive endothelial dysfunction in patients with mild hypercholesterolaemia and coronary artery diseaseQ74426928
Selective stimulation of L-arginine uptake contributes to shear stress-induced formation of nitric oxideQ74589838
Regression of atherosclerosis: role of nitric oxide and apoptosisQ74590428
Continuous perivascular L-arginine delivery increases total vessel area and reduces neointimal thickening after experimental balloon dilatationQ74598510
Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humansQ74645901
Arginine consumption in coronary diseaseQ74747771
Elevation of an endogenous inhibitor of nitric oxide synthesis in experimental congestive heart failureQ74768966
Effect of atherosclerosis on endothelium-dependent inhibition of platelet activation in humansQ74779487
L-arginine: effect on reperfusion injury after heart transplantationQ74797647
Endothelium-dependent and -independent perfusion reserve and the effect of L-arginine on myocardial perfusion in patients with syndrome XQ77312958
A large blood pressure-raising effect of nitric oxide synthase inhibition in humansQ77330674
Decreased activity of the L-arginine-nitric oxide metabolic pathway in patients with congestive heart failureQ77367253
Nitric oxide synthesis in atherosclerosisQ77575511
Clinical and inflammatory effects of dietary L-arginine in patients with intractable angina pectorisQ77769400
Superoxide production, risk factors, and endothelium-dependent relaxations in human internal mammary arteriesQ77781924
L-arginine reduces right heart hypertrophy in hypoxia-induced pulmonary hypertensionQ77911595
Acute effect of nitric oxide on Raynaud's phenomenon in sclerodermaQ78213020
L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humansQ35606367
Hypercholesterolemia increases endothelial superoxide anion productionQ35610616
Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbitQ35822869
Oral L-arginine improves endothelium-dependent dilation in hypercholesterolemic young adults.Q37354435
The vascular effects of L-Arginine in humans. The role of endogenous insulinQ37363072
Nitric oxide: an endogenous modulator of leukocyte adhesionQ37519420
Long-term oral administration of L-arginine reduces intimal thickening and enhances neoendothelium-dependent acetylcholine-induced relaxation after arterial injury.Q39397341
L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbitsQ40340324
Nitric oxide: mediator, murderer, and medicineQ40622626
Endothelial function in congestive heart failureQ40841227
Diminished vascular response to inhibition of endothelium-derived nitric oxide and enhanced vasoconstriction to exogenously administered endothelin-1 in clinically healthy smokersQ41027238
Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginineQ41469396
Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxidesQ41640232
Bradykinin and ATP stimulate L-arginine uptake and nitric oxide release in vascular endothelial cellsQ41660144
Improvement of cardiac performance by intravenous infusion of l-arginine in patients with moderate congestive heart failureQ41673266
Effects of L-arginine on atherogenesis and endothelial dysfunction due to secondhand smokeQ41679296
Nitric oxide-generating vasodilators inhibit mitogenesis and proliferation of BALB/C 3T3 fibroblasts by a cyclic GMP-independent mechanismQ41724429
Effects of infusion of L-arginine into the left anterior descending coronary artery on acetylcholine-induced vasoconstriction of human atheromatous coronary arteriesQ41853016
Nitric oxide synthesized from L-arginine regulates vascular tone in the coronary circulation of the rabbitQ42133850
Amino acids dilate resistance blood vessels of the perfused rat mesenteryQ42190892
Nitric oxide modulation of neutrophil-endothelium interaction: difference between arterial and venous coronary bypass grafts.Q42453044
LDLs impair vasomotor function of the coronary microcirculation: role of superoxide anionsQ42460475
l-Arginine induces relaxation of rat aorta possibly through non-endothelial nitric oxide formationQ42560740
L-arginine and arginine analogues: effects on isolated blood vessels and cultured endothelial cellsQ42563024
Differential effects of L-arginine on the inhibition by NG-nitro-L-arginine methyl ester of basal and agonist-stimulated EDRF activityQ42713508
L-arginine improves endothelium-dependent vasorelaxation and reduces intimal hyperplasia after balloon angioplasty.Q45089990
Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosisQ45207667
L-arginine evokes both endothelium-dependent and -independent relaxations in L-arginine-depleted aortas of the rat.Q45226928
Dietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic humans.Q46024028
Arginine restores nitric oxide activity and inhibits monocyte accumulation after vascular injury in hypercholesterolemic rabbits.Q46037040
Dietary arginine prevents atherogenesis in the coronary artery of the hypercholesterolemic rabbitQ46086523
Chronic dietary L-arginine prevents endothelial dysfunction secondary to environmental tobacco smoke in normocholesterolemic rabbitsQ46087047
Effects of L-arginine and N omega-nitro-L-arginine methyl ester on cardiac perfusion and function after 1-day cold preservation of isolated heartsQ46154663
L-Arginine normalizes coronary vasomotion in long-term smokersQ46487533
Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failureQ46861533
NG-methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo. A role for nitric oxide in the central regulation of sympathetic tone?Q48519024
Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral L-arginine supplementation.Q49065954
Myocardial contractile effects of L-arginine in the human allograft.Q50621731
Depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation.Q50885317
L-arginine causes whereas L-argininosuccinic acid inhibits endothelium-dependent vascular smooth muscle relaxation.Q50887714
Role of the endothelium and arginine peptides on the vaso-motor response of porcine internal mammary artery.Q50892077
Vasodilatory properties of mono-L-arginine-containing compounds.Q50895195
Endothelium dependent vascular relaxation by arginine containing polypeptides.Q50906225
Cigarette smoking is associated with increased human monocyte adhesion to endothelial cells: reversibility with oral L-arginine but not vitamin C.Q50969660
Effects of dietary L-arginine on atherosclerosis and endothelium-dependent vasodilatation in the hypercholesterolemic rabbit. Response according to treatment duration, anatomic site, and sex.Q51016545
Oral L-arginine improves endothelium-dependent dilatation and reduces monocyte adhesion to endothelial cells in young men with coronary artery disease.Q51576241
Oral L-arginine inhibits platelet aggregation but does not enhance endothelium-dependent dilation in healthy young men.Q51585513
L-arginine and substance P reverse the pulmonary endothelial dysfunction caused by congenital heart surgery.Q54082143
Does acute improvement of endothelial dysfunction in coronary artery disease improve myocardial ischemia? A double-blind comparison of parenteral D- and L-arginine.Q54121894
Angiotensin-converting enzyme inhibition, but not calcium antagonism, improves a response of the renal vasculature to L-arginine in patients with essential hypertension.Q54130792
Contribution of nitric oxide to reactive hyperemia: impact of endothelial dysfunction.Q54130794
Early endothelial dysfunction in adults at risk from atherosclerosis: different responses to L-arginine.Q54131232
Life-threatening hyperkalemia induced by arginineQ67414278
The role of L-arginine in ameliorating reperfusion injury after myocardial ischemia in the catQ67490908
L-arginine infusion induces hypotension and diuresis/natriuresis with concomitant increased urinary excretion of nitrite/nitrate and cyclic GMP in humansQ67504169
Pathophysiological consequences of atherosclerosis extend into the coronary microcirculation. Restoration of endothelium-dependent responses by L-arginineQ68059399
L-arginine-induced hypotensionQ68095216
L-arginine-induced hypotensionQ68293600
Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginineQ68326802
Vascular activity of polycations and basic amino acids: L-arginine does not specifically elicit endothelium-dependent relaxationQ69051513
Nitric oxide synthesised from L-arginine mediates endothelium dependent dilatation in human veins in vivoQ69439357
L-arginine availability determines the duration of acetylcholine-induced systemic vasodilation in vivoQ69734585
Endogenous nitric oxide inhibits human platelet adhesion to vascular endotheliumQ69908131
Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Role of scavenger receptor and endothelium-derived nitric oxideQ70168117
Crucial role of endothelium in the vasodilator response to increased flow in vivoQ70275801
Nitric oxide synthesis inhibition induces leukocyte adhesion via superoxide and mast cellsQ70495492
L-arginine inhibits balloon catheter-induced intimal hyperplasiaQ70742086
L-arginine induces nitric oxide-dependent vasodilation in patients with critical limb ischemia. A randomized, controlled studyQ71047041
L-Arginine does not restore dilatation of the basilar artery during diabetes mellitusQ71059079
Expression of inducible nitric oxide synthase in human heart failureQ71129305
Effects of L-arginine supplementation on endothelium-dependent coronary vasodilation in patients with angina pectoris and normal coronary arteriogramsQ71170633
Acute supplementation with the nitric oxide precursor L-arginine does not improve cardiovascular performance in patients with hypercholesterolemiaQ71436526
Defective L-arginine-nitric oxide pathway in offspring of essential hypertensive patientsQ71571212
Vascular and hormonal responses to arginine: provision of substrate for nitric oxide or non-specific effect?Q71731726
Basal nitric oxide production by diseased coronary arteriesQ71776455
Pressor, renal and endocrine effects of l-arginine in essential hypertensivesQ71814969
Aging-associated endothelial dysfunction in humans is reversed by L-arginineQ71879928
Discordant Effects of Dietary L-Arginine on Vascular Structure and Reactivity in Hypercholesterolemic RabbitsQ71944729
Plasma endothelin levels and vascular effects of intravenous L-arginine infusion in subjects with uncomplicated insulin-dependent diabetes mellitusQ72133348
Investigation of decreased availability of nitric oxide precursor as the mechanism responsible for impaired endothelium-dependent vasodilation in hypercholesterolemic patientsQ72238549
Attenuation of acetylcholine-induced vasoconstriction by L-arginine is related to the progression of atherosclerosisQ72248410
Amelioration by L-arginine of a dysfunctional arginine/nitric oxide pathway in diabetic endotheliumQ72285314
Effect of L-arginine on coronary endothelial function in cardiac transplant recipients. Relation to vessel wall morphologyQ72344139
Long-term administration of L-arginine, L-NAME, and the exogenous NO donor molsidomine modulates urinary nitrate and cGMP excretion in ratsQ72414928
Aging and endothelial function in normotensive subjects and patients with essential hypertensionQ72642229
Acute effects of nitric oxide on left ventricular relaxation and diastolic distensibility in humans. Assessment by bicoronary sodium nitroprusside infusionQ72677207
Sex differences in endothelial function in normal and hypercholesterolaemic subjectsQ72687147
L-arginine attenuates platelet reactivity in hypercholesterolemic rabbitsQ72696242
Effect of L-arginine on acetylcholine-induced endothelium-dependent vasodilation differs between the coronary and forearm vasculatures in humansQ72726505
Effect of inhibition of nitric oxide synthesis on epicardial coronary artery caliber and coronary blood flow in humansQ72800911
Role of nitric oxide in exercise-induced vasodilation of the forearmQ72893572
Arginine: a new therapy for atherosclerosis?Q73012571
L-arginine prevents xanthoma development and inhibits atherosclerosis in LDL receptor knockout miceQ73012628
Local L-arginine delivery after balloon angioplasty reduces monocyte binding and induces apoptosisQ73114809
Inhibition of nitric oxide synthesis in human epicardial coronary arteries and stenoses in relation to serum lipid levelQ73176757
Effects of inhibition of nitric oxide synthesis in patients with coronary artery disease and stable anginaQ73294339
Basal and flow-mediated nitric oxide production by atheromatous coronary arteriesQ73310472
Vascular effects of L-arginine: anything beyond a substrate for the NO-synthase?Q73381671
Effects of oral L-arginine on endothelium-dependent vasodilation and markers of inflammation in healthy postmenopausal womenQ73453158
Inhibition of nitric oxide synthesis during the cold pressor test in patients with coronary artery diseaseQ73456992
P433issue2
P921main subjectcardiovascular diseaseQ389735
P304page(s)255-267
P577publication date2001-02-01
P1433published inAtherosclerosisQ4813570
P1476titleTherapeutic modification of the L-arginine-eNOS pathway in cardiovascular diseases
P478volume154

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