A Splice Variant of E2–2 Basic Helix-Loop-Helix Protein Represses the Brain-specific Fibroblast Growth Factor 1 Promoter through the Binding to an Imperfect E-box

scientific article published on July 24, 1998

A Splice Variant of E2–2 Basic Helix-Loop-Helix Protein Represses the Brain-specific Fibroblast Growth Factor 1 Promoter through the Binding to an Imperfect E-box is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.273.30.19269
P953full work available online athttp://www.jbc.org/article/S0021925818802666/pdf
https://api.elsevier.com/content/article/PII:S0021925818802666?httpAccept=text/plain
https://api.elsevier.com/content/article/PII:S0021925818802666?httpAccept=text/xml
https://syndication.highwire.org/content/doi/10.1074/jbc.273.30.19269
P698PubMed publication ID9668116

P2093author name stringY. Liu
V. Luntz-Leybman
X. Q. Yang
S. K. Ray
I. M. Chiu
P2860cites workHelix-loop-helix transcriptional activators bind to a sequence in glucocorticoid response elements of retrovirus enhancersQ24295135
Multiple nuclear factors interact with the immunoglobulin enhancer sequencesQ24296245
Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motifQ24305878
Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system developmentQ24320072
Molecular characterization of NSCL, a gene encoding a helix-loop-helix protein expressed in the developing nervous systemQ24563496
Human fibroblast growth factor 1 gene expression in vascular smooth muscle cells is modulated via an alternate promoter in response to serum and phorbol esterQ24630121
Cloning of the gene coding for human class 1 heparin-binding growth factor and its expression in fetal tissuesQ24634413
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferaseQ27860571
Molecular cloning of the olfactory neuronal transcription factor Olf-1 by genetic selection in yeastQ28260090
Tissue-specific in vitro transcription from the mouse albumin promoterQ28304622
Cellular distribution, subcellular localization and possible functions of basic and acidic fibroblast growth factorsQ28579924
How eukaryotic transcriptional activators workQ29618289
Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix proteinQ29618504
Molecular cloning of an enhancer binding protein: isolation by screening of an expression library with a recognition site DNAQ29620537
Gene expression of fibroblast growth factors in human gliomas and meningiomas: demonstration of cellular source of basic fibroblast growth factor mRNA and peptide in tumor tissuesQ33713058
Acidic fibroblast growth factor mRNA is expressed by cardiac myocytes in culture and the protein is localized to the extracellular matrixQ33850198
atonal is a proneural gene that directs chordotonal organ formation in the Drosophila peripheral nervous systemQ34350799
Cloning of two novel forms of human acidic fibroblast growth factor (aFGF) mRNAQ34965915
The FGF family of growth factors and oncogenesQ35335377
E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteinsQ36686388
A splice variant of the ITF-2 transcript encodes a transcription factor that inhibits MyoD activityQ36799176
Characterization of the 1B promoter of fibroblast growth factor 1 and its expression in the adult and developing mouse brainQ36835011
Expression of acidic and basic fibroblast growth factors in the substantia nigra of rat, monkey, and humanQ37622562
Functional characterization of the brain-specific FGF-1 promoter, FGF-1.B.Q38296700
Single Primer-Mediated Polymerase Chain Reaction: Application in Cloning of Two Different 5′-Untranslated Sequences of Acidic Fibroblast Growth Factor mRNAQ38332056
Transcriptional activation of fibroblast growth factor 1.B promoter is mediated through an 18-base pair cis-acting elementQ41120948
Calcium/calmodulin inhibition of basic-helix-loop-helix transcription factor domainsQ41473345
Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursorsQ41724441
Elevation of acidic fibroblast growth factor mRNA in lesioned rat brainQ45859457
A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous systemQ48074513
Localization of acidic fibroblast growth factor in specific subcortical neuronal populationsQ48405166
Expression of acidic fibroblast growth factor mRNA in the developing and adult rat brainQ48788949
Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibilityQ70343054
Novel expression of the tyrosine hydroxylase gene requires both acidic fibroblast growth factor and an activatorQ71662665
Acidic fibroblast growth factor-like immunoreactivity in rat brain following cerebral infarctionQ71681851
P433issue30
P407language of work or nameEnglishQ1860
P921main subjectpromoterQ224093
alternative mRNA splicing, via spliceosomeQ21114084
Helix-Loop-Helix motifsQ70683285
P304page(s)19269-19276
P577publication date1998-07-01
1998-07-24
P1433published inJournal of Biological ChemistryQ867727
P1476titleA splice variant of E2-2 basic helix-loop-helix protein represses the brain-specific fibroblast growth factor 1 promoter through the binding to an imperfect E-box
A Splice Variant of E2–2 Basic Helix-Loop-Helix Protein Represses the Brain-specific Fibroblast Growth Factor 1 Promoter through the Binding to an Imperfect E-box
P478volume273

Reverse relations

cites work (P2860)
Q33614236Alternative splicing is frequent during early embryonic development in mouse
Q33470019Characterization of sequences in human TWIST required for nuclear localization
Q31271108Characterization of the entire transcription unit of the mouse fibroblast growth factor 1 (FGF-1) gene. Tissue-specific expression of the FGF-1.A mRNA.
Q77110319Cloning and characterization of a novel form of mouse fibroblast growth factor-1 (FGF-1) mRNA, FGF-1.G: differential expression of FGF-1 and FGF-1.G mRNAs during embryonic development and in postnatal tissues
Q35816788Common variants at VRK2 and TCF4 conferring risk of schizophrenia
Q45036364Functional analysis of TCF4 missense mutations that cause Pitt-Hopkins syndrome.
Q33971308Functional diversity of human basic helix-loop-helix transcription factor TCF4 isoforms generated by alternative 5' exon usage and splicing.
Q22254644HASH-1 and E2-2 are expressed in human neuroblastoma cells and form a functional complex
Q24682812Haploinsufficiency of TCF4 causes syndromal mental retardation with intermittent hyperventilation (Pitt-Hopkins syndrome)
Q43057948High expression of transcription factor 4 (TCF4) is an independent adverse prognostic factor in acute myeloid leukemia that could guide treatment decisions
Q53389043ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation
Q53307808Id1 modulates endothelial progenitor cells function through relieving the E2-2-mediated repression of FGFR1 and VEGFR2 in vitro
Q38300331Involvement of ITF2 in the transcriptional regulation of melanogenic genes
Q34994221Knockdown of human TCF4 affects multiple signaling pathways involved in cell survival, epithelial to mesenchymal transition and neuronal differentiation
Q34408043Multiple controlling mechanisms of FGF1 gene expression through multiple tissue-specific promoters
Q24801814Neuroblastoma and pre-B lymphoma cells share expression of key transcription factors but display tissue restricted target gene expression
Q35618374SRY induced TCF21 genome-wide targets and cascade of bHLH factors during Sertoli cell differentiation and male sex determination in rats
Q48179338Severe mental retardation with breathing abnormalities (Pitt-Hopkins syndrome) is caused by haploinsufficiency of the neuronal bHLH transcription factor TCF4.
Q38057999TCF4 (e2-2; ITF2): a schizophrenia-associated gene with pleiotropic effects on human disease
Q91012368The subcellular localization of bHLH transcription factor TCF4 is mediated by multiple nuclear localization and nuclear export signals
Q104794996Transcription factor 4 and its association with psychiatric disorders
Q49031514Tumorigenesis in transgenic mice in which the SV40 T antigen is driven by the brain-specific FGF1 promoter
Q30928632What is the impact of genome-wide supported risk variants for schizophrenia and bipolar disorder on brain structure and function? A systematic review

Search more.