Immunization with a peptide surrogate for double-stranded DNA (dsDNA) induces autoantibody production and renal immunoglobulin deposition

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Immunization with a peptide surrogate for double-stranded DNA (dsDNA) induces autoantibody production and renal immunoglobulin deposition is …
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scholarly articleQ13442814

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P356DOI10.1084/JEM.188.1.29
P932PMC publication ID2525538
P698PubMed publication ID9653081
P5875ResearchGate publication ID13631867

P2093author name stringDiamond B
Putterman C
P2860cites workThe double edged sword of the immune response: mutational analysis of a murine anti-pneumococcal, anti-DNA antibodyQ28378842
Discovering peptide ligands using epitope librariesQ31171121
Immunoglobulin epitope spreading and autoimmune disease after peptide immunization: Sm B/B'-derived PPPGMRPP and PPPGIRGP induce spliceosome autoimmunityQ33488126
Induction of a systemic lupus erythematosus-like disease in mice by a common human anti-DNA idiotypeQ33563988
Synthetic peptide vaccine design: synthesis and properties of a high-density multiple antigenic peptide systemQ33634544
Peptide mimicry of the meningococcal group C capsular polysaccharideQ34404304
Intra- and intermolecular spreading of autoimmunity involving the nuclear self-antigens La (SS-B) and Ro (SS-A).Q34744384
Selection of immunoglobulin variable regions in autoimmunity to DNAQ35499782
Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA.Q35554410
The role of bcl-2 in lymphoid differentiation and neoplastic transformationQ35663137
Antibodies elicited by pneumococcal antigens bear an anti-DNA--associated idiotypeQ35819277
Peptide inhibition of glomerular deposition of an anti-DNA antibodyQ36029509
The role of somatic mutation in the pathogenic anti-DNA responseQ36135271
A novel class of anti-DNA antibodies identified in BALB/c miceQ36229881
Genetic control of the antibody response in inbred mice. Transfer of response by spleen cells and linkage to the major histocompatibility (H-2) locusQ36269229
Mimicking of discontinuous epitopes by phage-displayed peptides, II. Selection of clones recognized by a protective monoclonal antibody against the Bordetella pertussis toxin from phage peptide libraries.Q36696069
Peptide libraries define the fine specificity of anti-polysaccharide antibodies to Cryptococcus neoformans.Q36814109
Peptides isolated from random peptide libraries on phage elicit a neutralizing anti-HIV-1 response: analysis of immunological mimicryQ36844406
Pathogenic autoantibodies are routinely generated during the response to foreign antigen: a paradigm for autoimmune diseaseQ37708458
Major histocompatibility complex genes in systemic lupus erythematosus, Sjögren's syndrome, and polymyositisQ38195561
Experimental expression in mice and spontaneous expression in human SLE of polyomavirus T-antigen. A molecular basis for induction of antibodies to DNA and eukaryotic transcription factorsQ39783214
Genetic and structural evidence for antigen selection of anti-DNA antibodies.Q40661152
Nephritogenic autoantibodies in systemic lupus erythematosus: immunochemical properties, mechanisms of immune deposition, and genetic originsQ40782682
Mechanism for induction of anti-DNA antibodies by bacterial lipopolysaccharides in mice. I. Anti-DNA induction by LPS without significant release of DNA in circulating bloodQ40821032
Recent advances in multiple antigen peptidesQ41139581
A millipore filter assay for antibodies to native dna in sera of patients with systemic lupus erythematosusQ44041151
Comparison of pathogenic and non-pathogenic murine antibodies to DNA: antigen binding and structural characteristicsQ46466571
Major histocompatibility complex genes and susceptibility to systemic lupus erythematosusQ46935576
Cross-reactive antibodies have both protective and pathogenic potentialQ48072132
Relationships among antinuclear antibodies from autoimmune MRL mice reacting with histone H2A-H2B dimers and DNA.Q48122923
Changes in immunoglobulin class and subclass of anti-DNA antibodies with increasing age in N/ZBW F1 hybrid miceQ50539039
Induction of anti-DNA antibodies in non autoimmune mice by immunization with a DNA-DNAase I complexQ64389624
The sera of patients with Klebsiella infections contain a common anti-DNA idiotype (16/6) Id and anti-polynucleotide activityQ68170246
A role for immunogenic DNA in the pathogenesis of systemic lupus erythematosusQ68931131
Anti-DNA antibodies bind directly to renal antigens and induce kidney dysfunction in the isolated perfused rat kidneyQ69737615
Specificity and idiotypic analysis of a monoclonal anti-Sm antibody with anti-DNA activityQ69875752
Antigen-specific induction of antibodies against native mammalian DNA in nonautoimmune miceQ70466622
Induction of various autoantibodies by mutant gene lpr in several strains of miceQ71008570
Immunization with short peptides from the sequence of the systemic lupus erythematosus-associated 60-kDa Ro autoantigen results in anti-Ro ribonucleoprotein autoimmunityQ71059510
Responsiveness of autoimmune and normal mice to nucleic acid antigensQ71251892
Human polyomavirus BK and immunogenicity of mammalian DNA: a conceptual frameworkQ71960247
Rat anti-T15 monoclonal antibodies with specificity for VH- and VH-VL epitopesQ72751315
DNA and the immune systemQ73006020
A model of peptide-induced lupus autoimmune B cell epitope spreading is strain specific and is not H-2 restricted in miceQ74463717
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectautoantibodyQ785022
immunizationQ1415366
P304page(s)29-38
P577publication date1998-07-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleImmunization with a peptide surrogate for double-stranded DNA (dsDNA) induces autoantibody production and renal immunoglobulin deposition
P478volume188

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cites work (P2860)
Q28386635A peptide mimic blocks the cross-reaction of anti-DNA antibodies with glomerular antigens
Q33300252A potential trigger of nephritogenic anti-DNA antibodies in lupus nephritis
Q33887369A single-stranded DNA-cross-reactive immunogenic epitope of human homocysteine-inducible endoplasmic reticulum protein
Q43786936A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus
Q91612706ALW peptide ameliorates lupus nephritis in MRL/lpr mice
Q38089261Advances in understanding newer autoantibodies and their role as biomarkers in systemic lupus erythematosus
Q37411836Anti-DNA antibodies cross-react with C1q
Q43786930Anti-DNA meets NMDA in neuropsychiatric lupus
Q35334977Antigen is required for maturation and activation of pathogenic anti-DNA antibodies and systemic inflammation
Q39431371Antigen-specific immunotherapies in rheumatic diseases
Q31125878Antigenic triggers and molecular targets for anti-double-stranded DNA antibodies
Q56806670Autoantibodies in SLE: Specificities, Isotypes and Receptors
Q37713384B cell epitope of human cytomegalovirus phosphoprotein 65 (HCMV pp65) induced anti-dsDNA antibody in BALB/c mice
Q36772165B cell receptor revision diminishes the autoreactive B cell response after antigen activation in mice
Q36093973B cell tolerance and positive selection in lupus
Q35553367B lymphocytes and systemic lupus erythematosus
Q28082493Biomarkers for CNS involvement in pediatric lupus
Q35458567Brain-reactive antibodies and disease.
Q33494799Characterization of structurally defined epitopes recognized by monoclonal antibodies produced by chronic lymphocytic leukemia B cells
Q36369080Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2
Q34577755Cross-reactive myelin antibody induces renal pathology.
Q60959920DNA-Mediated Interferon Signature Induction by SLE Serum Occurs in Monocytes Through Two Pathways: A Mechanism to Inhibit Both Pathways
Q37175424Depression is an early disease manifestation in lupus-prone MRL/lpr mice
Q73816096Differential effects of interleukin-4 in peptide induced autoimmunity
Q30433491Differential responses to Smith D autoantigen by mice with HLA-DR and HLA-DQ transgenes: dominant responses by HLA-DR3 transgenic mice with diversification of autoantibodies to small nuclear ribonucleoprotein, double-stranded DNA, and nuclear antige
Q35051889Discovery of biomarkers for systemic lupus erythematosus using a library of synthetic autoantigen surrogates
Q35826037Dual regulation of IRF4 function in T and B cells is required for the coordination of T-B cell interactions and the prevention of autoimmunity.
Q82641912Endogenous humoral autoreactive immune responses to apoptotic cells: Effects on phagocytic uptake, chemotactic migration and antigenic spread
Q35032627Enforced expression of the apoptosis inhibitor Bcl-2 ablates tolerance induction in DNA-reactive B cells through a novel mechanism
Q37001022Epitope spreading induced by immunization with synthetic SSB peptides
Q36021796Female mouse fetal loss mediated by maternal autoantibody
Q35840778Fragment of tegument protein pp65 of human cytomegalovirus induces autoantibodies in BALB/c mice
Q79784858Generalized multi-organ autoimmunity in CCR7-deficient mice
Q33586280Generation of gene-engineered chimeric DNA molecules for specific therapy of autoimmune diseases.
Q30424263HLA-DR3 restricted T cell epitope mimicry in induction of autoimmune response to lupus-associated antigen SmD
Q51827296Human cytomegalovirus pp65 lower matrix protein: a humoral immunogen for systemic lupus erythematosus patients and autoantibody accelerator for NZB/W F1 mice.
Q73816093IL-4 and many roads to lupuslike autoimmunity
Q35751397IL-6 contributes to an immune tolerance checkpoint in post germinal center B cells
Q36960924Identification of DNA-reactive B cells in patients with systemic lupus erythematosus
Q44265184Identification of an antigen-specific B cell population
Q35800361IgG3 deficiency extends lifespan and attenuates progression of glomerulonephritis in MRL/lpr mice
Q30442810Immune responses to Ro60 and its peptides in mice. I. The nature of the immunogen and endogenous autoantigen determine the specificities of the induced autoantibodies
Q36472054Immunity and acquired alterations in cognition and emotion: lessons from SLE.
Q34270963Immunity and behavior: antibodies alter emotion
Q33809736Immunization as a model for systemic lupus erythematosus
Q34474688Immunoglobulin variable-region gene usage in systemic autoimmune diseases
Q36916349Increased IL-12 inhibits B cells' differentiation to germinal center cells and promotes differentiation to short-lived plasmablasts
Q51823390Induction of pathogenic anti-dsDNA antibodies is controlled on the level of B cells in a non-lupus prone mouse strain.
Q50485131Induction of systemic lupus erythematosus-like syndrome in syngeneic mice by immunization with activated lymphocyte-derived DNA.
Q64079480Latent autoimmunity across disease-specific boundaries in at-risk first-degree relatives of SLE and RA patients
Q90371858Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory
Q38330433Lupus autoantibodies to native DNA preferentially bind DNA presented on PolIV.
Q35119826Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.
Q37216058Mapping an epitope in EBNA-1 that is recognized by monoclonal antibodies to EBNA-1 that cross-react with dsDNA
Q35156885Memantine in systemic lupus erythematosus: a randomized, double-blind placebo-controlled trial
Q26991887Mesangial cell-specific antibodies are central to the pathogenesis of lupus nephritis
Q92362492Molecular Mimicry, Autoimmunity, and Infection: The Cross-Reactive Antigens of Group A Streptococci and their Sequelae
Q34491035Molecular mimicry in the autoimmune pathogenesis of rheumatic heart disease
Q43722238Molecular mimicry: anti-DNA antibodies may arise inadvertently as a response to antibodies generated to microorganisms
Q33871737Neuronal Surface Autoantibodies in Neuropsychiatric Disorders: Are There Implications for Depression?
Q42374576Neuropsychiatric lupus and autoantibodies against ionotropic glutamate receptor (NMDAR)
Q30485404Neurotoxic autoantibodies mediate congenital cortical impairment of offspring in maternal lupus
Q46616003Oral administration of different forms of a tolerogenic peptide to define the preparations and doses that delay anti-DNA antibody production and nephritis and prolong survival in SLE-prone mice
Q29615547Pathogenesis of group A streptococcal infections
Q30923814Peptide Mimics of a Major Lupus Epitope of SmB/B′
Q34692321Peptide dendrimers: applications and synthesis
Q30649669Peptide mimicking antigenic and immunogenic epitope of double-stranded DNA in systemic lupus erythematosus
Q33458328Phenotypic characterization of autoreactive B cells--checkpoints of B cell tolerance in patients with systemic lupus erythematosus
Q33819686Receptor editing in peripheral B cell tolerance
Q34018666Regional brain metabolism in a murine systemic lupus erythematosus model.
Q33739699SLAP deficiency decreases dsDNA autoantibody production
Q28212921Selective involvement of the amygdala in systemic lupus erythematosus
Q47970761Serum and organ-associated anti-hemoglobin humoral autoreactivity: association with anti-Sm responses and inflammation
Q33992328Serum autoantibodies in pristane induced lupus are regulated by neutrophil gelatinase associated lipocalin
Q33391806Specific cross-reaction of anti-dsDNA antibody with platelet integrin GPIIIa49-66
Q43772915Strong acceleration of murine lupus by injection of the SmD1(83-119) peptide.
Q36216540Structure-function analysis of a lupus anti-DNA autoantibody: central role of the heavy chain complementarity-determining region 3 Arg in binding of double- and single-stranded DNA.
Q30736023Structure-function studies of an anti-asialo GM1 antibody obtained from a phage display library
Q30405454T cell epitope mimicry between Sjögren's syndrome Antigen A (SSA)/Ro60 and oral, gut, skin and vaginal bacteria
Q46797870Targeted silencing of DNA-specific B cells combined with partial plasma cell depletion displays additive effects on delaying disease onset in lupus-prone mice
Q38607446The Genotype and Phenotype (GaP) registry: a living biobank for the analysis of quantitative traits
Q53933125The Naive B Cell Repertoire Predisposes to Antigen-Induced Systemic Lupus Erythematosus
Q38512653The anti-DNA antibody: origin and impact, dogmas and controversies
Q38206945The pathogenesis and diagnosis of systemic lupus erythematosus: still not resolved
Q33716669The role of B cells in lupus pathogenesis
Q53892129Vaccination with carbohydrate peptide mimotopes promotes anti-tumor responses.
Q37377432XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development
Q35110970p185, an immunodominant epitope, is an autoantigen mimotope.

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