Paradoxical effect of increased diastolic Ca(2+) release and decreased sinoatrial node activity in a mouse model of catecholaminergic polymorphic ventricular tachycardia.

scientific article

Paradoxical effect of increased diastolic Ca(2+) release and decreased sinoatrial node activity in a mouse model of catecholaminergic polymorphic ventricular tachycardia. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1161/CIRCULATIONAHA.111.075382
P932PMC publication ID3434373
P698PubMed publication ID22711277

P50authorMatteo E. MangoniQ42439630
Carlo NapolitanoQ57067294
Jean-Pierre BenitahQ57337524
Pietro MesircaQ63928589
Angelo TorrenteQ83620981
P2093author name stringSilvia G Priori
Sylvain Richard
Nian Liu
Ana María Gómez
Esther Zorio
Patricia Neco
P2860cites workLoss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafnessQ24311948
Catecholaminergic polymorphic ventricular tachycardia: electrocardiographic characteristics and optimal therapeutic strategies to prevent sudden deathQ24674590
Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardiaQ28201561
Calcium sparks: elementary events underlying excitation-contraction coupling in heart muscleQ28256108
Catecholaminergic polymorphic ventricular tachycardiaQ28287523
Functional role of L-type Cav1.3 Ca2+ channels in cardiac pacemaker activityQ28593156
Bidirectional ventricular tachycardia and fibrillation elicited in a knock-in mouse model carrier of a mutation in the cardiac ryanodine receptor.Q33152686
Sudden death in a young man with catecholaminergic polymorphic ventricular tachycardia and paroxysmal atrial fibrillationQ33156361
Catecholaminergic polymorphic ventricular tachycardia from bedside to bench and beyondQ33156900
Catecholaminergic polymorphic ventricular tachycardia in children. A 7-year follow-up of 21 patientsQ33173888
Increased Ca2+ sensitivity of the ryanodine receptor mutant RyR2R4496C underlies catecholaminergic polymorphic ventricular tachycardiaQ33551271
A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker.Q33722486
The role of the funny current in pacemaker activity.Q34099619
Orphaned ryanodine receptors in the failing heart.Q34573114
New insights into pacemaker activity: promoting understanding of sick sinus syndromeQ34617500
Flecainide therapy reduces exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardiaQ34629553
What keeps us ticking: a funny current, a calcium clock, or both?Q36010630
Genesis and regulation of the heart automaticity.Q37216067
Catecholaminergic polymorphic ventricular tachycardia: A paradigm to understand mechanisms of arrhythmias associated to impaired Ca(2+) regulationQ37625277
Efficacy and potency of class I antiarrhythmic drugs for suppression of Ca2+ waves in permeabilized myocytes lacking calsequestrin.Q38602828
Phenotypic screening for heart rate variability in the mouseQ40754804
Catecholaminergic polymorphic ventricular tachycardia: RYR2 mutations, bradycardia, and follow up of the patients.Q43073409
Mechanisms of automaticity in subsidiary pacemakers from cat right atriumQ43444149
Left-to-right gradient of atrial frequencies during acute atrial fibrillation in the isolated sheep heartQ43624016
Sinoatrial nodal cell ryanodine receptor and Na(+)-Ca(2+) exchanger: molecular partners in pacemaker regulationQ43649137
A rapidly activating delayed rectifier K+ current regulates pacemaker activity in adult mouse sinoatrial node cellsQ44704953
What determines the initiation of the heartbeat?Q46981862
Association of atrial arrhythmia and sinus node dysfunction in patients with catecholaminergic polymorphic ventricular tachycardiaQ46981935
Sudden cardiac death despite an implantable cardioverter-defibrillator in a young female with catecholaminergic ventricular tachycardia.Q51094959
Positive and negative chronotropic effects of caffeine in spontaneously beating rabbit sino-atrial node cells.Q51657013
Caffeine depression of spontaneous activity in rabbit sino-atrial node cellsQ72093935
Defective excitation-contraction coupling in experimental cardiac hypertrophy and heart failureQ73257762
Intracellular calcium and Na+-Ca2+ exchange current in isolated toad pacemaker cellsQ74271245
Contribution of L-type Ca2+ current to electrical activity in sinoatrial nodal myocytes of rabbitsQ74591134
P433issue4
P407language of work or nameEnglishQ1860
P921main subjecttachycardiaQ209583
diastoleQ492905
catecholaminergic polymorphic ventricular tachycardiaQ1649897
P304page(s)392-401
P577publication date2012-06-18
P1433published inCirculationQ578091
P1476titleParadoxical effect of increased diastolic Ca(2+) release and decreased sinoatrial node activity in a mouse model of catecholaminergic polymorphic ventricular tachycardia
P478volume126

Reverse relations

cites work (P2860)
Q52580654A delayed diagnosis of catecholaminergic polymorphic ventricular tachycardia with a mutant of RYR2 at c.7580T>G for 6 years in a 9-year-old child.
Q40390266Ablation of the cardiac ryanodine receptor phospho-site Ser2808 does not alter the adrenergic response or the progression to heart failure in mice. Elimination of the genetic background as critical variable
Q36952000Abnormal Ca(2+) homeostasis, atrial arrhythmogenesis, and sinus node dysfunction in murine hearts modeling RyR2 modification
Q27312304Beat-to-Beat Variation in Periodicity of Local Calcium Releases Contributes to Intrinsic Variations of Spontaneous Cycle Length in Isolated Single Sinoatrial Node Cells
Q35701705Burst pacemaker activity of the sinoatrial node in sodium-calcium exchanger knockout mice.
Q35176492Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative fibrosis within the mouse atrial pacemaker complex1.
Q34392423Cardiac arrhythmia induced by genetic silencing of 'funny' (f) channels is rescued by GIRK4 inactivation
Q57062554Chromosome 4q25 Variant rs6817105 Bring Sinus Node Dysfunction and Left Atrial Enlargement
Q101216939Concomitant genetic ablation of L-type Cav1.3 (α1D) and T-type Cav3.1 (α1G) Ca2+ channels disrupts heart automaticity
Q49922723Conditional ablation and conditional rescue models for Casq2 elucidate the role of development and of cell type specific expression of Casq2 in the CPVT2 phenotype
Q48356846Contribution of small conductance K+ channels to sinoatrial node pacemaker activity: insights from atrial-specific Na+ /Ca2+ exchange knockout mice.
Q51312558Distinct localization and modulation of Cav1.2 and Cav1.3 L-type Ca2+ channels in mouse sinoatrial node.
Q93257610Distinct mechanisms mediate pacemaker dysfunction associated with catecholaminergic polymorphic ventricular tachycardia mutations: Insights from computational modeling
Q64375238Eliminating contraction during culture maintains global and local Ca dynamics in cultured rabbit pacemaker cells
Q35037204Functional role of voltage gated Ca(2+) channels in heart automaticity.
Q30577224Hierarchical clustering of ryanodine receptors enables emergence of a calcium clock in sinoatrial node cells
Q35915228Impaired signaling intrinsic to sinoatrial node pacemaker cells affects heart rate variability during cardiac disease
Q37088714Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity
Q51554723L-type Cav1.3 channels regulate ryanodine receptor-dependent Ca2+ release during sino-atrial node pacemaker activity.
Q39038606Murine Electrophysiological Models of Cardiac Arrhythmogenesis
Q37373390Pacemaker gene mutations, bradycardia, arrhythmias and the coupled clock theory
Q26861426Popeye domain-containing proteins and stress-mediated modulation of cardiac pacemaking
Q58582790Post-Translational Modifications and Diastolic Calcium Leak Associated to the Novel RyR2-D3638A Mutation Lead to CPVT in Patient-Specific hiPSC-Derived Cardiomyocytes
Q35110428Potential effects of intrinsic heart pacemaker cell mechanisms on dysrhythmic cardiac action potential firing
Q43115122R4496C RyR2 mutation impairs atrial and ventricular contractility
Q33168540RyR2R420Q catecholaminergic polymorphic ventricular tachycardia mutation induces bradycardia by disturbing the coupled clock pacemaker mechanism
Q37734009SK4 K+ channels are therapeutic targets for the treatment of cardiac arrhythmias
Q36179318STIM1-Ca2+ signaling modulates automaticity of the mouse sinoatrial node.
Q38350829Sick sinus syndrome and atrial fibrillation in older persons - A view from the sinoatrial nodal myocyte.
Q38191441T-type channels in the sino-atrial and atrioventricular pacemaker mechanism.
Q36402676The fractal-like complexity of heart rate variability beyond neurotransmitters and autonomic receptors: signaling intrinsic to sinoatrial node pacemaker cells
Q28085170The importance of Ca(2+)-dependent mechanisms for the initiation of the heartbeat
Q30274549The mitochondrial Na+-Ca2+ exchanger, NCLX, regulates automaticity of HL-1 cardiomyocytes.

Search more.