Cationic residues in pathogenic anti-DNA autoantibodies arise by mutations of a germ-line gene that belongs to a large VH gene subfamily

scientific article published on March 1, 1992

Cationic residues in pathogenic anti-DNA autoantibodies arise by mutations of a germ-line gene that belongs to a large VH gene subfamily is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/EJI.1830220302
P698PubMed publication ID1547810

P2093author name stringDatta SK
Imanishi-Kari T
O'Keefe TL
P2860cites workA comprehensive set of sequence analysis programs for the VAXQ26778432
Most peripheral B cells in mice are ligand selectedQ33387224
Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segmentsQ36346092
Heavy chain variable region. Multiple gene segments encode anti-4-(hydroxy-3-nitro-phenyl)acetyl idiotypic antibodiesQ36350149
Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutationQ36350233
Induction of a cationic shift in IgG anti-DNA autoantibodies. Role of T helper cells with classical and novel phenotypes in three murine models of lupus nephritisQ36352584
Systemic autoimmune disease arises from polyclonal B cell activationQ36352692
Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable regionQ36630020
V genes encoding autoantibodies: molecular and phenotypic characteristicsQ39468473
Somatic mutations in the variable regions of a human IgG anti-double-stranded DNA autoantibody suggest a role for antigen in the induction of systemic lupus erythematosusQ41697487
Molecular basis of a mouse strain-specific anti-hapten responseQ48398632
Junctional sequences of T cell receptor gamma delta genes: implications for gamma delta T cell lineages and for a novel intermediate of V-(D)-J joining.Q52244112
Insertion of N regions into heavy-chain genes is correlated with expression of terminal deoxytransferase in B cellsQ53549666
Selective strain distribution pattern of a germline VH gene for a pathogenic anti-DNA autoantibody familyQ70248803
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectautoantibodyQ785022
immunoglobulin genesQ70688789
P304page(s)619-624
P577publication date1992-03-01
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titleCationic residues in pathogenic anti-DNA autoantibodies arise by mutations of a germ-line gene that belongs to a large VH gene subfamily
P478volume22

Reverse relations

cites work (P2860)
Q36259479Activation of natural killer T cells in NZB/W mice induces Th1-type immune responses exacerbating lupus
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Q36231704Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB x NZW)F1 mice
Q34612574Contribution of V(H) replacement products in mouse antibody repertoire
Q34287672Covalent binding antibodies suppress advanced glycation: on the innate tier of adaptive immunity.
Q42284912D-penicillamine- and quinidine-induced antinuclear antibodies in A.SW (H-2s) mice: similarities with autoantibodies in spontaneous and heavy metal-induced autoimmunity
Q36843821In vivo-activated CD103+CD4+ regulatory T cells ameliorate ongoing chronic graft-versus-host disease
Q35554410Induction of cross-reactive anti-dsDNA antibodies in preautoimmune NZB/NZW mice by immunization with bacterial DNA.
Q36714386Isolated VH4 heavy chain variable regions bind DNA characterization of a recombinant antibody heavy chain library derived from patient(s) with active SLE.
Q37353912Ligand recognition by murine anti-DNA autoantibodies. II. Genetic analysis and pathogenicity
Q81041251Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production
Q37374861Lupus-specific antibodies reveal an altered pattern of somatic mutation
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Q42799270Self Ig peptides that help anti-DNA antibody production: importance of charged residues
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Q72299564Structural properties of a subset of nephritogenic anti-DNA antibodies
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Q41362966T cells of lupus and molecular targets for immunotherapy
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