Metagenomic analysis reveals diverse polyketide synthase gene clusters in microorganisms associated with the marine sponge Discodermia dissoluta

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Metagenomic analysis reveals diverse polyketide synthase gene clusters in microorganisms associated with the marine sponge Discodermia dissoluta is …
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scholarly articleQ13442814

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P356DOI10.1128/AEM.71.8.4840-4849.2005
P932PMC publication ID1183291
P698PubMed publication ID16085882

P50authorEdward F. DeLongQ5342553
Fadia IbrahimQ50634147
P2093author name stringChristopher D Reeves
C Richard Hutchinson
Andreas Schirmer
Rishali Gadkari
P2860cites workA polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetlesQ24540336
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Archaea in coastal marine environmentsQ24564723
Multiple sequence alignment with the Clustal series of programsQ24672842
Environmental genome shotgun sequencing of the Sargasso SeaQ27860605
The desoxyribonucleic acid content of animal cells and its evolutionary significanceQ28756221
ARB: a software environment for sequence dataQ29547354
Phylogenetic diversity of bacteria associated with the marine sponge Rhopaloeides odorabileQ30660629
Multibranched polyunsaturated and very-long-chain fatty acids of freshwater Israeli spongesQ30694457
Recombinant environmental libraries provide access to microbial diversity for drug discovery from natural productsQ30878449
Biotechnological prospects from metagenomicsQ30960118
Cloning and heterologous expression of a natural product biosynthetic gene cluster from eDNA.Q30993520
Unprecedented diversity of catalytic domains in the first four modules of the putative pederin polyketide synthaseQ31034441
Diverse microbial communities inhabit Antarctic sponges.Q31044029
Isolation of antibiotics turbomycin a and B from a metagenomic library of soil microbial DNAQ31105604
Molecular evidence for a uniform microbial community in sponges from different oceansQ31105614
Genomic analysis reveals chromosomal variation in natural populations of the uncultured psychrophilic archaeon Cenarchaeum symbiosumQ32016534
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New lessons for combinatorial biosynthesis from myxobacteria. The myxothiazol biosynthetic gene cluster of Stigmatella aurantiaca DW4/3-1.Q33883859
Marine pharmacologyQ33893559
The influence of natural products upon drug discoveryQ33908826
Evidence for the biosynthesis of bryostatins by the bacterial symbiont "Candidatus Endobugula sertula" of the bryozoan Bugula neritinaQ33990424
Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibioticQ34107244
Drugs from the seas - current status and microbiological implicationsQ34138052
Biosynthesis of nonribosomal peptides1.Q34359384
Polyketide biosynthesis: a millennium reviewQ34362914
The methyl-branched fortifications of Mycobacterium tuberculosisQ34657803
Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesisQ34867101
Lipid compounds of freshwater sponges: family Spongillidae, class DemospongiaeQ35105918
The phylogeny of the diatoms.Q35546939
Approaches to identify, clone, and express symbiont bioactive metabolite genesQ35708914
Progress in the clinical development of new marine-derived anticancer compounds.Q35730063
Antitumor polyketide biosynthesis by an uncultivated bacterial symbiont of the marine sponge Theonella swinhoeiQ37621650
Widefield deconvolution epifluorescence microscopy combined with fluorescence in situ hybridization reveals the spatial arrangement of bacteria in sponge tissueQ39530429
Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majusculaQ40541741
Evolutionary affiliations within the superfamily of ketosynthases reflect complex pathway associations.Q40597474
Promoter and exon-intron structure of the protein kinase C gene from the marine sponge Geodia cydonium: evolutionary considerations and promoter activityQ42819265
Identification and total synthesis of a novel dimethylated fatty acid from the Caribbean sponge Calyx podatypaQ43503889
A model of structure and catalysis for ketoreductase domains in modular polyketide synthasesQ44270898
Cloning and characterization of a gene cluster for geldanamycin production in Streptomyces hygroscopicus NRRL 3602.Q44314986
Bioactive marine metabolites, IV. Isolation and the amino acid composition of discodermin A, an antimicrobial peptide, from the marine sponge Discodermia kiiensisQ44625781
Targeting modular polyketide synthases with iteratively acting acyltransferases from metagenomes of uncultured bacterial consortiaQ44741060
Calyculins, potent antitumour metabolites from the marine sponge Discodermia calyx: biological activities.Q44956523
Two classes of metabolites from Theonella swinhoei are localized in distinct populations of bacterial symbionts.Q45954541
bryA: an unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritinaQ46105107
Genome size and chromosomes in marine sponges [Suberites Domuncula, Geodia Cydonium]Q47342264
Biosynthesis of the polyene antifungal antibiotic nystatin in Streptomyces noursei ATCC 11455: analysis of the gene cluster and deduction of the biosynthetic pathway.Q47849112
A general approach for identifying and cloning peptide synthetase genesQ48079590
Marine natural productsQ68770042
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectmetagenomicsQ903778
P304page(s)4840-4849
P577publication date2005-08-01
P1433published inApplied and Environmental MicrobiologyQ4781593
P1476titleMetagenomic analysis reveals diverse polyketide synthase gene clusters in microorganisms associated with the marine sponge Discodermia dissoluta
P478volume71

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