Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity

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Pim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity is …
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P6179Dimensions Publication ID1041128939
P356DOI10.1186/1471-2121-7-21
P932PMC publication ID1473194
P698PubMed publication ID16684349
P5875ResearchGate publication ID7097602

P2093author name stringJouko Sandholm
Päivi J Koskinen
Yoshiaki Ito
Katriina J Peltola
Teija L T Aho
P2860cites workThe Pim-1 kinase stimulates maturation of TCRbeta-deficient T cell progenitors: implications for the mechanism of Pim-1 actionQ73010730
Runx2: a novel oncogenic effector revealed by in vivo complementation and retroviral taggingQ73787472
Requirement of transcription factor AML1 in proliferation of developing thymocytesQ73881104
Amplification of AML1 gene is present in childhood acute lymphoblastic leukemia but not in adult, and is not associated with AML1 gene mutationQ74213158
Interferon-alpha activates multiple STAT proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cellsQ74587993
Enforced expression of Runx2 perturbs T cell development at a stage coincident with beta-selectionQ74754525
The pim-1 oncogene encodes two related protein-serine/threonine kinases by alternative initiation at AUG and CUGQ24311816
Subcellular localization of the alpha and beta subunits of the acute myeloid leukemia-linked transcription factor PEBP2/CBFQ24314024
The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunitQ27860669
Cutting edge: Transcriptional activity of NFATc1 is enhanced by the Pim-1 kinaseQ28217175
Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activityQ28235877
Core-binding factors in hematopoiesis and immune functionQ28262826
Pim-1 kinase and p100 cooperate to enhance c-Myb activityQ28288284
The serine/threonine kinase Pim-1Q28306071
Causal relationship between the loss of RUNX3 expression and gastric cancerQ28509530
Pim serine/threonine kinases regulate the stability of Socs-1 proteinQ28594323
Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid systemQ29620436
Runx transcription factors and the developmental balance between cell proliferation and differentiation.Q30332928
Chromosome 21 abnormalities with AML1 amplification in acute lymphoblastic leukemiaQ33182473
Molecular basis of tissue-specific gene expression mediated by the runt domain transcription factor PEBP2/CBF.Q33808389
Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer.Q34756366
The Runx genes as dominant oncogenesQ35121742
The corepressor mSin3A regulates phosphorylation-induced activation, intranuclear location, and stability of AML1.Q35544219
Phosphorylation, acetylation and ubiquitination: the molecular basis of RUNX regulationQ36329898
PIM1 reconstitutes thymus cellularity in interleukin 7- and common gamma chain-mutant mice and permits thymocyte maturation in Rag- but not CD3gamma-deficient miceQ36375419
The extracellular signal-regulated kinase pathway phosphorylates AML1, an acute myeloid leukemia gene product, and potentially regulates its transactivation abilityQ36561099
t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1Q37627380
Characterization of the nuclear and cytoplasmic components of the lymphoid-specific nuclear factor of activated T cells (NF-AT) complex.Q38321848
Intrinsic transcriptional activation-inhibition domains of the polyomavirus enhancer binding protein 2/core binding factor alpha subunit revealed in the presence of the beta subunitQ39583747
Pim-1 kinase inhibits STAT5-dependent transcription via its interactions with SOCS1 and SOCS3.Q40592274
Regulation of AML2/CBFA3 in hematopoietic cells through the retinoic acid receptor alpha-dependent signaling pathwayQ40939844
Complementation tagging of cooperating oncogenes in knockout miceQ41436944
Sustained expression of the pim-1 kinase is specifically induced in myeloid cells by cytokines whose receptors are structurally relatedQ41633524
Evidence implicating Gfi-1 and Pim-1 in pre-T-cell differentiation steps associated with beta-selectionQ42654229
Collaboration of pim-1 and bcl-2 in lymphomagenesisQ44678448
Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper siteQ44997396
Nomenclature for Runt-related (RUNX) proteinsQ47446478
Identification of the autophosphorylation sites of the Xenopus laevis Pim-1 proto-oncogene-encoded protein kinase.Q48050980
High-throughput retroviral tagging to identify components of specific signaling pathways in cancerQ48286997
Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors.Q52187583
Isolation of the Drosophila segmentation gene runt and analysis of its expression during embryogenesis.Q52455892
Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.Q52524249
Regulation of pim and myb mRNA accumulation by interleukin 2 and interleukin 3 in murine hematopoietic cell linesQ68099040
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P304page(s)21
P577publication date2006-05-09
P1433published inBMC Cell BiologyQ2020930
P1476titlePim-1 kinase phosphorylates RUNX family transcription factors and enhances their activity
P478volume7