Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio.

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Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio. is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1018181048
P356DOI10.1186/1471-2407-6-214
P932PMC publication ID1569857
P698PubMed publication ID16930472
P5875ResearchGate publication ID6858781

P50authorAnnick Mühlethaler-MottetQ60036047
P2093author name stringJean-Marc Joseph
Katia Balmas Bourloud
Katya Auderset
Marjorie Flahaut
Nicole Gross
Roland Meier
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Histone deacetylase inhibitors interact synergistically with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to induce apoptosis in carcinoma cell linesQ36060524
Persistent inhibition of FLIP(L) expression by lentiviral small hairpin RNA delivery restores death-receptor-induced apoptosis in neuroblastoma cells.Q40311361
Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies.Q40479108
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Synergistic induction of apoptosis in breast cancer cells by cotreatment with butyrate and TNF-alpha, TRAIL, or anti-Fas agonist antibody involves enhancement of death receptors' signaling and requires P21(waf1).Q40533297
Histone deacetylase inhibitors upregulate death receptor 5/TRAIL-R2 and sensitize apoptosis induced by TRAIL/APO2-L in human malignant tumor cellsQ40543132
Drug-mediated sensitization to TRAIL-induced apoptosis in caspase-8-complemented neuroblastoma cells proceeds via activation of intrinsic and extrinsic pathways and caspase-dependent cleavage of XIAP, Bcl-xL and RIP.Q40565103
Sensitization for tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by the chemopreventive agent resveratrolQ40598265
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Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression.Q43540223
Role of oxidant stress in the permeability transition induced in rat hepatic mitochondria by hydrophobic bile acidsQ43551171
Doxorubicin-induced death in neuroblastoma does not involve death receptors in S-type cells and is caspase-independent in N-type cellsQ44119535
Simultaneous activation of the intrinsic and extrinsic pathways by histone deacetylase (HDAC) inhibitors and tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) synergistically induces mitochondrial damage and apoptosis in human leukemiaQ44715109
Cisplatin activates Akt in small cell lung cancer cells and attenuates apoptosis by survivin upregulation.Q53668983
Induction of caspase 8 by interferon gamma renders some neuroblastoma (NB) cells sensitive to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) but reveals that a lack of membrane TR1/TR2 also contributes to TRAIL resistance in NB.Q53939117
The fundamental role of epigenetic events in cancerQ56421597
Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathwayQ58862256
Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cellsQ58862259
Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCNQ73766132
Loss of caspase-8 expression in highly malignant human neuroblastoma cells correlates with resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosisQ74256185
P407language of work or nameEnglishQ1860
P921main subjectapoptotic processQ14599311
neuroblastomaQ938205
P304page(s)214
P577publication date2006-08-24
P1433published inBMC CancerQ326300
P1476titleHistone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio
P478volume6