Effects of IkappaBalpha and its mutants on NF-kappaB and p53 signaling pathways

scientific article

Effects of IkappaBalpha and its mutants on NF-kappaB and p53 signaling pathways is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3748/WJG.V12.I41.6658
P932PMC publication ID4125672
P698PubMed publication ID17075980
P5875ResearchGate publication ID298735365

P2093author name stringLan Zhang
Da Xing
Ju Wang
Xian Li
An Hong
Xiao-Jia Chen
Fen-Yong Sun
De-Bin Zhu
P2860cites workStructure of an IkappaBalpha/NF-kappaB complexQ22008582
Multiple nuclear factors interact with the immunoglobulin enhancer sequencesQ24296245
Identification of a novel p53 functional domain that is necessary for efficient growth suppressionQ24311276
Coupling of a signal response domain in I kappa B alpha to multiple pathways for NF-kappa B activationQ24316905
A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa BQ24568234
A new mathematical model for relative quantification in real-time RT-PCRQ27860781
Ikappa Balpha functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-kappaBQ28282499
The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppressionQ28585698
Activators and target genes of Rel/NF-kappaB transcription factorsQ29547882
NF-kappaB in cancer: from innocent bystander to major culpritQ29614603
NF-kappaB and cell-cycle regulation: the cyclin connectionQ34225148
Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategiesQ34400583
Mechanisms by which IkappaB proteins control NF-kappaB activityQ34789958
NF-kappaB in cancer: a marked targetQ35091120
IkappaB kinases: key regulators of the NF-kappaB pathwayQ35753155
NF-kappaB: tumor promoter or suppressor?Q35753163
Nuclear factor kB activity in patients with acute severe cholangitisQ36316128
Role of NF-kB in multiple organ dysfunction during acute obstructive cholangitisQ36506343
Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasisQ38298694
Dynamics of NF kappa B and Ikappa Balpha studied with green fluorescent protein (GFP) fusion proteins. Investigation of GFP-p65 binding to DNa by fluorescence resonance energy transfer.Q38313667
Regulation of NF-kappaB activity by I kappaB-related proteins in adenocarcinoma cellsQ38324140
Signal-dependent degradation of IkappaBalpha is mediated by an inducible destruction box that can be transferred to NF-kappaB, bcl-3 or p53.Q38337239
Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB.Q40563919
Transfection of a dominant-negative mutant NF-kB inhibitor (IkBm) represses p53-dependent apoptosis in acute lymphoblastic leukemia cells: interaction of IkBm and p53Q40619108
Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesisQ40666413
Degradation of IkappaBalpha is limited by a postphosphorylation/ubiquitination eventQ40792626
Defective IkappaBalpha in Hodgkin cell lines with constitutively active NF-kappaB.Q41046169
mdm2 and bax, downstream mediators of the p53 response, are degraded by the ubiquitin-proteasome pathwayQ41070621
Rel/NF-kappa B and I kappa B proteins: an overviewQ41595423
I kappa B proteins: structure, function and regulationQ41595429
The phosphatidylinositol 3-kinase (PI3K)-Akt pathway suppresses Bax translocation to mitochondriaQ43884355
The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosisQ44134125
Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage.Q44814700
Nuclear localization of I kappa B alpha promotes active transport of NF-kappa B from the nucleus to the cytoplasmQ48964086
Rel/NF-kappa B transcription factors and I kappa B inhibitors: evolution from a unique common ancestor.Q52560877
Blockade of nuclear factor-kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8.Q54033436
Role of NF-κB in p53-mediated programmed cell deathQ57248006
Inducible NF-kappaB activation is permitted by simultaneous degradation of nuclear IkappaBalphaQ73789357
Stable inhibition of nuclear factor kappaB in cancer cells does not increase sensitivity to cytotoxic drugsQ74462119
The nuclear factor-kappa B RelA transcription factor is constitutively activated in human pancreatic adenocarcinoma cellsQ77904111
P433issue41
P407language of work or nameEnglishQ1860
P921main subjectNF-κBQ411114
P304page(s)6658-6664
P577publication date2006-11-01
P1433published inWorld Journal of GastroenterologyQ15708885
P1476titleEffects of IkappaBalpha and its mutants on NF-kappaB and p53 signaling pathways
P478volume12

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cites work (P2860)
Q43243801Enhancement of chemotherapeutic agent-induced apoptosis by inhibition of NF-kappaB using ursolic acid
Q39207728IκB-α: At the crossroad between oncogenic and tumor-suppressive signals.
Q46724722Leishmanial lipid suppresses tumor necrosis factor alpha, interleukin-1beta, and nitric oxide production by adherent synovial fluid mononuclear cells in rheumatoid arthritis patients and induces apoptosis through the mitochondrial-mediated pathway
Q39029101Mechanisms of p53 Functional De-Regulation: Role of the IκB-α/p53 Complex
Q41547633Non genomic loss of function of tumor suppressors in CML: BCR-ABL promotes IκBα mediated p53 nuclear exclusion
Q39651409Study on norcantharidin-induced apoptosis in SMMC-7721 cells through mitochondrial pathways
Q38937733The BCR-ABL/NF-κB signal transduction network: a long lasting relationship in Philadelphia positive Leukemias

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