A highly active adipyl-cephalosporin acylase obtained via rational randomization

scientific article

A highly active adipyl-cephalosporin acylase obtained via rational randomization is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1742-4658.2007.06081.X
P698PubMed publication ID17922842
P5875ResearchGate publication ID5921917

P50authorCharles F SioQ56132221
Robbert H CoolQ41573282
P2093author name stringGudrun Koch
Wim J Quax
Carlos R Reis
Linda G Otten
P2860cites workProduction of cephalosporin intermediates by feeding adipic acid to recombinant Penicillium chrysogenum strains expressing ring expansion activityQ47948709
Detailed analysis of grid-based molecular docking: A case study of CDOCKER-A CHARMm-based MD docking algorithm.Q51638510
Lessons in molecular recognition: the effects of ligand and protein flexibility on molecular docking accuracy.Q52005770
CHARMM: A program for macromolecular energy, minimization, and dynamics calculationsQ53340989
The 2.0 A crystal structure of cephalosporin acylaseQ27628277
Structure of cephalosporin acylase in complex with glutaryl-7-aminocephalosporanic acid and glutarate: insight into the basis of its substrate specificityQ27637085
Crystal structures of glutaryl 7-aminocephalosporanic acid acylase: insight into autoproteolytic activationQ27640914
Evolution of an acylase active on cephalosporin CQ33226329
Improving the activity and stability of GL-7-ACA acylase CA130 by site-directed mutagenesisQ33995892
Improving enzyme properties: when are closer mutations better?Q36113206
Enzymatic modifications of cephalosporins by cephalosporin acylase and other enzymesQ36523466
Altering the substrate specificity of cephalosporin acylase by directed evolution of the Beta -subunit.Q44116156
Directed evolution of a glutaryl acylase into an adipyl acylaseQ44135941
Deacylation activity of cephalosporin acylase to cephalosporin C is improved by changing the side-chain conformations of active-site residuesQ44597638
A Bound Water Molecule Is Crucial in Initiating Autocatalytic Precursor Activation in an N-terminal HydrolaseQ44610979
Analysis of a substrate specificity switch residue of cephalosporin acylaseQ44697144
Mutational analysis of a key residue in the substrate specificity of a cephalosporin acylaseQ44918705
In vivo post-translational processing and subunit reconstitution of cephalosporin acylase from Pseudomonas sp. 130.Q47946017
P433issue21
P407language of work or nameEnglishQ1860
P304page(s)5600-5610
P577publication date2007-10-08
P1433published inFEBS JournalQ1388041
P1476titleA highly active adipyl-cephalosporin acylase obtained via rational randomization
P478volume274

Reverse relations

cites work (P2860)
Q40294313Alteration of substrate selection of antibiotic acylase from β-lactam to echinocandin
Q38082383Cephalosporin C acylase: dream and(/or) reality.
Q35251122Engineering of a CPC acylase using a facile pH indicator assay

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