Cleavage agents for soluble oligomers of human islet amyloid polypeptide

scientific article

Cleavage agents for soluble oligomers of human islet amyloid polypeptide is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00775-008-0354-Y
P698PubMed publication ID18320241

P50authorKeunhong JeongQ39438409
Junghun SuhQ112240041
P2093author name stringMin Gyum Kim
Sang Ho Yoo
Tae Yeon Lee
Woo Suk Chei
Jae Young Ahn
P2860cites workAmyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cellsQ24607640
Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patientsQ24631987
A specific amyloid-beta protein assembly in the brain impairs memoryQ28854597
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesisQ29547501
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetesQ29619192
Protein-cleaving catalyst selective for protein substrateQ31118066
Peptide-cleaving catalyst selective for peptide deformylaseQ31149040
A novel MALDI LIFT-TOF/TOF mass spectrometer for proteomicsQ33187567
Angiotensin-cleaving catalysts: conversion of N-terminal aspartate to pyruvate through oxidative decarboxylation catalyzed by Co(III)cyclenQ33214927
Peptide-cleaving catalyst selective for melanin-concentrating hormone: Oxidative decarboxylation of N-terminal aspartate catalyzed by Co(III)cyclenQ33250015
Therapeutic approaches to protein-misfolding diseasesQ34285075
Protein chemistry. In the footsteps of alchemistsQ34323404
In silico study of amyloid beta-protein folding and oligomerizationQ34374164
Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomersQ34396204
Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathwaysQ34468169
Toxic human islet amyloid polypeptide (h-IAPP) oligomers are intracellular, and vaccination to induce anti-toxic oligomer antibodies does not prevent h-IAPP-induced beta-cell apoptosis in h-IAPP transgenic miceQ34577455
Synthetic artificial peptidases and nucleases using macromolecular catalytic systemsQ35177330
Islet amyloid: a critical entity in the pathogenesis of type 2 diabetesQ35855088
Kinetics and thermodynamics of amyloid fibril assemblyQ36596626
Pancreatic amylin content in human diabetic subjects and its relation to diabetesQ42557258
Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseasesQ45072759
Inhibition of human IAPP fibril formation does not prevent beta-cell death: evidence for distinct actions of oligomers and fibrils of human IAPP.Q46081255
Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes.Q52490197
The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.Q52534249
Human islet amyloid polypeptide oligomers disrupt cell coupling, induce apoptosis, and impair insulin secretion in isolated human islets.Q52575906
Cleavage agents for soluble oligomers of amyloid beta peptides.Q53533591
Facile intramolecular hydrolysis of dipeptides and glycinamide.Q54528667
Fluorescamine: A Reagent for Assay of Amino Acids, Peptides, Proteins, and Primary Amines in the Picomole RangeQ70513064
High-frequency oscillations in circulating amylin concentrations in healthy humansQ73532668
Inhibition of amyloid fibril formation and cytotoxicity by hydroxyindole derivativesQ83131276
P433issue5
P304page(s)693-701
P577publication date2008-03-05
P1433published inJournal of Biological Inorganic ChemistryQ3186899
P1476titleCleavage agents for soluble oligomers of human islet amyloid polypeptide
P478volume13

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cites work (P2860)
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Q37387617Application of metal coordination chemistry to explore and manipulate cell biology
Q48157762Catalytic Metallodrugs: Substrate-Selective Metal Catalysts as Therapeutics.
Q35846078Catalytic metallodrugs based on the LaR2C peptide target HCV SLIV IRES RNA.
Q33698143Cyclen-hybrid compound captures copper to protect INS-1 cells from islet amyloid polypeptide cytotoxicity by inhibiting and lysing effects
Q89823393Degradation of proteins by PROTACs and other strategies
Q34775956Metallotherapeutics: novel strategies in drug design
Q33775775New chelating ligands for Co(III)-based peptide-cleaving catalysts selective for pathogenic proteins of amyloidoses
Q39437903Protective effects of cleavage agents on INS-1 cells against h-IAPP-induced apoptosis
Q46330675Proteolytic activity of Co(III) complex of 1-oxa-4,7,10-triazacyclododecane: a new catalytic center for peptide-cleavage agents
Q37371607Target-directed catalytic metallodrugs
Q36106851Targeted catalytic inactivation of angiotensin converting enzyme by lisinopril-coupled transition-metal chelates
Q35247064Transfer hydrogenation catalysis in cells as a new approach to anticancer drug design.

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