High-throughput screening for human galactokinase inhibitors

scientific article

High-throughput screening for human galactokinase inhibitors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1177/1087057108318331
P932PMC publication ID2705177
P698PubMed publication ID18490662
P5875ResearchGate publication ID5359087

P50authorPeter BuchwaldQ39967319
Klaas J. WierengaQ120869563
P2093author name stringKent Lai
Manshu Tang
P2860cites workFunctional analysis of disease‐causing mutations in human galactokinaseQ24299794
Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamilyQ27629750
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Congenital galactosemia, a single enzymatic block in galactose metabolismQ28212638
Virtual screening of chemical librariesQ33209939
Galactokinase: structure, function and role in type II galactosemiaQ33982846
Molecular structure of human galactokinase: implications for type II galactosemiaQ33983696
The enzymatic transformation of uridine diphosphate glucose into a galactose derivativeQ34297292
Galactose-1-phosphate in the pathophysiology of galactosemiaQ34721308
Clinical features of galactokinase deficiency:A review of the literatureQ35111155
High tolerance for oral galactose in classical galactosaemia: dietary implications.Q35277656
ChemBank: a small-molecule screening and cheminformatics resource databaseQ36454111
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Hidden sources of galactose in the environment.Q40480941
GALT deficiency causes UDP-hexose deficit in human galactosemic cellsQ40665629
Regulation of genes controlling synthesis of the galactose pathway enzymes in yeast.Q41821687
The effect of dietary fruits and vegetables on urinary galactitol excretion in galactose-1-phosphate uridyltransferase deficiencyQ42558448
Novel inhibitors of poly(ADP-ribose) polymerase/PARP1 and PARP2 identified using a cell-based screen in yeastQ43612292
The rate of de novo galactose synthesis in patients with galactose-1-phosphate uridyltransferase deficiencyQ44732112
Intracellular galactose-1-phosphate accumulation leads to environmental stress response in yeast modelQ46708765
Determining appropriate substrate conversion for enzymatic assays in high-throughput screeningQ47278992
Estimation of galactose-1-phosphate in erythrocytes: A rapid and simple enzymatic methodQ51685498
Long‐term prognosis in galactosaemia: Results of a survey of 350 casesQ52243798
Yeast as a screening tool.Q53668666
Endogenous synthesis of galactose in normal men and patients with hereditary galactosaemiaQ63644737
Galactose metabolism in a patient with hereditary galactokinase deficiencyQ68686360
Galactosemia: how does long-term treatment change the outcome?Q70617007
Galactitol and galactose-1-phosphate in the lens of a galactosemic infantQ72207756
P433issue5
P304page(s)415-423
P577publication date2008-05-19
P1433published inJournal of Biomolecular ScreeningQ6294856
P1476titleHigh-throughput screening for human galactokinase inhibitors
P478volume13

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cites work (P2860)
Q91927626Discovery of novel inhibitors of human galactokinase by virtual screening
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Q33669582Galactose and its Metabolites Deteriorate Metaphase II Mouse Oocyte Quality and Subsequent Embryo Development by Disrupting the Spindle Structure
Q24646350Galactose toxicity in animals
Q34014282Identification of novel small molecule inhibitors of 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) kinase of Gram-negative bacteria
Q54357270Increased promiscuity of human galactokinase following alteration of a single amino acid residue distant from the active site.
Q34054239Innovative therapy for Classic Galactosemia - tale of two HTS.
Q63644723Introduction to the Maastricht workshop: lessons from the past and new directions in galactosemia
Q28483059IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening
Q43252785Mechanistic studies on human N-acetylgalactosamine kinase
Q24607116Molecular and biochemical characterization of human galactokinase and its small molecule inhibitors
Q90661175Novel mRNA-Based Therapy Reduces Toxic Galactose Metabolites and Overcomes Galactose Sensitivity in a Mouse Model of Classic Galactosemia
Q34714428Ovarian function in girls and women with GALT-deficiency galactosemia
Q36486013Oxidative stress contributes to outcome severity in a Drosophila melanogaster model of classic galactosemia
Q43286013Small-molecule costimulatory blockade: organic dye inhibitors of the CD40-CD154 interaction
Q35572971Structure-activity analysis and cell-based optimization of human galactokinase inhibitors
Q33563888Sweet and sour: an update on classic galactosemia.
Q61800932The Distribution of Standard Deviations Applied to High Throughput Screening
Q45776629The hazardous effects of three natural food dyes on developmental stages and longevity of Drosophila melanogaster
Q37906514The structural and molecular biology of type I galactosemia: Enzymology of galactose 1-phosphate uridylyltransferase

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