Molecular and genetic characterizations of five pathogenic and two non-pathogenic monoclonal antiphospholipid antibodies

scientific article

Molecular and genetic characterizations of five pathogenic and two non-pathogenic monoclonal antiphospholipid antibodies is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0161-5890(02)00115-3
P698PubMed publication ID12220888

P2093author name stringMin Zhu
Anisur Rahman
Sudha Visvanathan
Pojen P Chen
Chul Soo Cho
Kwan K Hwang
Reginald U Chukwuocha
P2860cites workAnti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H)Q24558202
Basic local alignment search toolQ25938991
The V kappa genes of the L regions and the repertoire of V kappa gene sequences in the human germ lineQ28255655
Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosusQ28261335
The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loopsQ33191252
Characteristics and pathogenic role of anti-beta2-glycoprotein I single-chain Fv domains: induction of experimental antiphospholipid syndromeQ33330858
Antiphospholipid antibodies and the antiphospholipid syndrome in systemic lupus erythematosus. A prospective analysis of 500 consecutive patientsQ33438663
Anticardiolipin antibodies: isotype distribution and phospholipid specificityQ33456927
Activation of cultured vascular endothelial cells by antiphospholipid antibodies.Q33488617
The production, binding characteristics and sequence analysis of four human IgG monoclonal antiphospholipid antibodiesQ33498767
Immunological and molecular analysis of three monoclonal lupus anticoagulant antibodies from a patient with systemic lupus erythematosusQ33501756
Sequence and evolution of the human germline V lambda repertoireQ34410060
Selection of immunoglobulin variable regions in autoimmunity to DNAQ35499782
Sequence analyses of three immunoglobulin G anti-virus antibodies reveal their utilization of autoantibody-related immunoglobulin Vh genes, but not V lambda genesQ35612673
Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven responseQ36231063
Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutationQ36350233
Mutational analysis of an autoantibody: differential binding and pathogenicityQ36363653
A monoclonal IgG anticardiolipin antibody from a patient with the antiphospholipid syndrome is thrombogenic in miceQ37412204
The role of germline gene expression and somatic mutation in the generation of autoantibodies to DNA.Q37924462
The inference of antigen selection on Ig genesQ40742095
Sequences of monoclonal antiphospholipid antibodies: variations on an anti-DNA antibody themeQ41209320
A human monoclonal antiphospholipid antibody that is representative of serum antibodies and is germline encodedQ42277420
Structural repertoire of the human VH segmentsQ42603998
A directory of human germ-line V kappa segments reveals a strong bias in their usageQ42604123
Human anticardiolipin monoclonal autoantibodies cause placental necrosis and fetal loss in BALB/c miceQ47973524
Endothelial cells as target for antiphospholipid antibodies. Human Polyclonal and Monoclonal Anti-β2-Glycoprotein I Antibodies React In Vitro with Endothelial Cells Through Adherent β2-Glycoprotein I and Induce Endothelial ActivationQ62395215
Association of anti-beta 2 glycoprotein I antibodies with lupus-type circulating anticoagulant and thrombosis in systemic lupus erythematosusQ68008000
Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactorQ68090535
Binding of beta 2-glycoprotein I to platelets: effect of adenylate cyclase activityQ71417830
Anti-annexin antibody in the sera of patients with habitual fetal loss or preeclampsiaQ72157020
Placental thrombosis and fetal loss after passive transfer of mouse lupus monoclonal or human polyclonal anti-cardiolipin antibodies in pregnant naive BALB/c miceQ72177243
The clonal analysis of anticardiolipin antibodies in a single patient with primary antiphospholipid syndrome reveals an extreme antibody heterogeneityQ73963274
Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivoQ77342565
Serum anti-beta2-glycoprotein-I and anticardiolipin antibodies during thrombosis in systemic lupus erythematosus patientsQ77391585
P433issue5-6
P304page(s)299-311
P577publication date2002-10-01
P1433published inMolecular ImmunologyQ6895954
P1476titleMolecular and genetic characterizations of five pathogenic and two non-pathogenic monoclonal antiphospholipid antibodies
P478volume39

Reverse relations

cites work (P2860)
Q26999710Antiphospholipid antibodies and the placenta: a systematic review of their in vitro effects and modulation by treatment
Q37409260Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4/MyD88 pathway
Q35106998Autoantibodies: Focus on anti-DNA antibodies
Q37283017Examining the non-linear relationship between monoclonal antiphospholipid antibody sequence, structure and function
Q36843689Hydroxychloroquine directly reduces the binding of antiphospholipid antibody-beta2-glycoprotein I complexes to phospholipid bilayers
Q46373484Patient-derived monoclonal antibodies directed towards beta2 glycoprotein-1 display lupus anticoagulant activity
Q24798707The critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin
Q34610233The role of antibody polyspecificity and lipid reactivity in binding of broadly neutralizing anti-HIV-1 envelope human monoclonal antibodies 2F5 and 4E10 to glycoprotein 41 membrane proximal envelope epitopes
Q37721592Use of monoclonal antibodies to dissect specificity and pathogenesis of antiphospholipid antibodies

Search more.