Toll-like receptors: structural pieces of a curve-shaped puzzle

scientific article

Toll-like receptors: structural pieces of a curve-shaped puzzle is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1038/SJ.ICB.7100089
P698PubMed publication ID17607319
P5875ResearchGate publication ID6230986

P50authorJamie RossjohnQ28036336
P2093author name stringTrevor Huyton
Matthew Wilce
P2860cites workMD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4Q22009943
Structural basis for signal transduction by the Toll/interleukin-1 receptor domainsQ24290524
A Toll-like receptor recognizes bacterial DNAQ24290668
Lipopolysaccharide is in close proximity to each of the proteins in its membrane receptor complex. transfer from CD14 to TLR4 and MD-2Q24290990
Discrimination of bacterial lipoproteins by Toll-like receptor 6Q24291383
Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signalingQ24299305
Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteinsQ24300005
Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domainQ24304907
A family of human receptors structurally related to Drosophila TollQ24321888
Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient miceQ24329114
Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophagesQ24609722
Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infectionQ24633526
Structure of the lnlB leucine-rich repeats, a domain that triggers host cell invasion by the bacterial pathogen L. monocytogenesQ27620987
RanGAP mediates GTP hydrolysis without an arginine fingerQ27637706
An extensively associated dimer in the structure of the C713S mutant of the TIR domain of human TLR2Q27639981
Structure and gating mechanism of the acetylcholine receptor poreQ27641514
Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopyQ27684426
A human homologue of the Drosophila Toll protein signals activation of adaptive immunityQ28131769
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathwayQ28216760
Structural model of MD-2 and functional role of its basic amino acid clusters involved in cellular lipopolysaccharide recognitionQ28258779
Approaching the asymptote? Evolution and revolution in immunologyQ28274344
The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adultsQ28289939
A toll-like receptor that prevents infection by uropathogenic bacteriaQ28504943
Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complexQ28588629
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signalingQ28590478
CD36 is a sensor of diacylglyceridesQ28591244
Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGEQ29620722
The smallest known non-avian theropod dinosaurQ30621543
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognitionQ33930537
Crystal structure of human toll-like receptor 3 (TLR3) ectodomainQ33987865
Direct binding of Toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A.Q34207380
Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL.Q34318269
Somatic diversification of variable lymphocyte receptors in the agnathan sea lampreyQ34331961
Genomic insights into the immune system of the sea urchinQ34580628
The dsRNA binding site of human Toll-like receptor 3.Q34695451
The Toll-IL-1 receptor adaptor family grows to five members.Q35155932
Recognition of bacterial peptidoglycan by the innate immune systemQ35549169
Leucine-rich repeats and pathogen recognition in Toll-like receptors.Q35557275
CD14 and apoptosis.Q35591578
Pathogen recognition: TLRs throw us a curveQ36287071
Manifold mechanisms of Toll-like receptor-ligand recognitionQ36354700
TLR signaling.Q36627105
Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors.Q36759549
Toll-like receptor 4 region Glu24-Lys47 is a site for MD-2 binding: importance of CYS29 and CYS40.Q40216944
Structural and functional analyses of the human Toll-like receptor 3. Role of glycosylationQ40305644
Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH.Q40376713
Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila toll pathway.Q40442019
Interaction of soluble form of recombinant extracellular TLR4 domain with MD-2 enables lipopolysaccharide binding and attenuates TLR4-mediated signalingQ40489306
Four N-linked glycosylation sites in human toll-like receptor 2 cooperate to direct efficient biosynthesis and secretion.Q40549942
HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathwayQ40751242
Activation of Toll-like receptor-2 by glycosylphosphatidylinositol anchors from a protozoan parasiteQ40797228
The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens.Q40919510
Cutting edge: Tlr5-/- mice are more susceptible to Escherichia coli urinary tract infectionQ43863628
CD14 is required for MyD88-independent LPS signaling.Q45990170
Double-stranded RNA-mediated TLR3 activation is enhanced by CD14.Q46094308
Domain exchange between human toll-like receptors 1 and 6 reveals a region required for lipopeptide discriminationQ46675904
Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene productQ47072878
The molecular structure of the TLR3 extracellular domain.Q52576529
Complex between bovine ribonuclease A and porcine ribonuclease inhibitor crystallizes in a similar unit cell as free ribonuclease inhibitorQ72122433
Crystal structure of CD14 and its implications for lipopolysaccharide signalingQ81255784
P433issue6
P921main subjecttoll-like receptorQ408004
P304page(s)406-410
P577publication date2007-07-03
P1433published inImmunology & Cell BiologyQ13731918
P1476titleToll-like receptors: structural pieces of a curve-shaped puzzle
P478volume85

Reverse relations

cites work (P2860)
Q89142855Blocking TIR Domain Interactions in TLR9 Signaling
Q37435038DIDS protects against neuronal injury by blocking Toll-like receptor 2 activated-mechanisms
Q47146788Danger of frustrated sensors: Role of Toll-like receptors and NOD-like receptors in aseptic and septic inflammations around total hip replacements
Q37809892Impact of Toll-like receptor 4 polymorphisms on risk of cancer
Q28383875Molecular mechanism of DNA damage induced by titanium dioxide nanoparticles in toll-like receptor 3 or 4 expressing human hepatocarcinoma cell lines
Q37386815Role of toll-like receptors 3, 4 and 7 in cellular uptake and response to titanium dioxide nanoparticles
Q37549926Sensors of the innate immune system: their mode of action
Q57476481TLR4 Polymorphisms and Expression in Solid Cancers
Q45038512TLR7 negatively regulates dendrite outgrowth through the Myd88-c-Fos-IL-6 pathway
Q34923415The N-terminus of CD14 acts to bind apoptotic cells and confers rapid-tethering capabilities on non-myeloid cells
Q51075145Toll-like receptor 8 deletion accelerates autoimmunity in a mouse model of lupus through a Toll-like receptor 7-dependent mechanism.

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