Benefit-risk assessment of sirolimus in renal transplantation

scientific article

Benefit-risk assessment of sirolimus in renal transplantation is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1036892589
P356DOI10.2165/00002018-200528020-00006
P698PubMed publication ID15691225

P2093author name stringDirk R J Kuypers
P2860cites workIslet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimenQ28141785
Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cellsQ28191714
Sirolimus-Eluting Stents versus Standard Stents in Patients with Stenosis in a Native Coronary ArteryQ28206536
Drug points: Premature osteonecrosis and sirolimus treatment in renal transplantationQ28359700
Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TORQ28361576
Sirolimus (rapamycin)-based therapy in human renal transplantation: similar efficacy and different toxicity compared with cyclosporine. Sirolimus European Renal Transplant Study GroupQ28374428
Systemic toxicity following administration of sirolimus (formerly rapamycin) for psoriasis: association of capillary leak syndrome with apoptosis of lesional lymphocytesQ28376025
Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertilityQ30835829
Conversion to rapamycin immunosuppression in renal transplant recipients: report of an initial experienceQ31526307
Impaired phosphate handling of renal allografts is aggravated under rapamycin-based immunosuppressionQ31832634
Sirolimus interferes with the innate response to bacterial products in human whole blood by attenuation of IL-10 productionQ31908887
A worldwide, phase III, randomized, controlled, safety and efficacy study of a sirolimus/cyclosporine regimen for prevention of acute rejection in recipients of primary mismatched renal allograftsQ32048820
Therapeutic drug monitoring of sirolimus: correlations with efficacy and toxicityQ33332141
Sirolimus in association with mycophenolate mofetil induction for the prevention of acute graft rejection in renal allograft recipientsQ33332340
Toxicity and efficacy of sirolimus: relationship to whole-blood concentrationsQ33332540
Sirolimus-induced thrombocytopenia and leukopenia in renal transplant recipients: risk factors, incidence, progression, and managementQ33332820
Experience with the use of sirolimus in liver transplantation--use in patients for whom calcineurin inhibitors are contraindicatedQ33335178
A calcineurin inhibitor-sparing regimen with sirolimus, mycophenolate mofetil, and anti-CD25 mAb provides effective immunosuppression in kidney transplant recipients with delayed or impaired graft functionQ33335493
Rapamycin inhibits arterial intimal thickening caused by both alloimmune and mechanical injury. Its effect on cellular, growth factor, and cytokine response in injured vesselsQ70775037
Case report--sirolimus rescue therapy for refractory renal allograft rejectionQ71062331
Synergistic effects of cyclosporine and rapamycin in a chronic nephrotoxicity modelQ71463351
Inhibition by rapamycin of PDGF- and bFGF-induced human tenon fibroblast proliferation in vitroQ71508769
Cyclosporine induces high bone turnover and may contribute to bone loss after heart transplantationQ71669568
Effects of the pharmacokinetic interaction between orally administered sirolimus and cyclosporine on the synergistic prolongation of heart allograft survival in ratsQ71700461
Renal effects of rapamycin in the spontaneously hypertensive ratQ72412671
Reversal of ongoing heart, kidney, and pancreas allograft rejection and suppression of accelerated heart allograft rejection in the rat by rapamycinQ72537971
Effect of rapamycin on morphological and functional parameters in the kidney of the rabbitQ72580987
The efficacy and toxicity of rapamycin in murine islet transplantation. In vitro and in vivo studiesQ72628798
Lack of change of cancellous bone volume with short-term use of the new immunosuppressant rapamycin in ratsQ72872991
Effects of rapamycin on renal hemodynamics, water and sodium excretion, and plasma levels of angiotensin II, aldosterone, atrial natriuretic peptide, and vasopressin in pigsQ72887619
Sirolimus (rapamycin) halts and reverses progression of allograft vascular disease in non-human primatesQ73028842
Use of anti-CD25 monoclonal antibody in combination with rapamycin to eliminate cyclosporine treatment during the induction phase of immunosuppressionQ73044372
Sirolimus reduces the incidence of acute rejection episodes despite lower cyclosporine doses in caucasian recipients of mismatched primary renal allografts: a phase II trial. Rapamune Study GroupQ73253906
Apolipoprotein CIII is upregulated by anticalcineurins and rapamycin: implications in transplantation-induced dyslipidemiaQ73337974
Pharmacokinetics of sirolimus in stable renal transplant patients after multiple oral dose administrationQ73349035
Proinflammatory effects in experimental mesangial proliferative glomerulonephritis of the immunosuppressive agent SDZ RAD, a rapamycin derivativeQ73378576
Interstitial pneumonitis associated with sirolimus therapy in renal-transplant recipientsQ73456717
The trouble with kidneys derived from the non heart-beating donor: a single center 10-year experienceQ73648791
Acute effects of rapamycin on glomerular dynamics: a micropuncture study in the ratQ73832072
Living-donor kidney transplantation at Mayo Clinic--RochesterQ73935835
Interstitial pneumonitis associated with sirolimus therapy in renal-transplant recipientsQ74121152
Pediatric utilization of rapamycin for severe cardiac allograft rejectionQ74191605
Relative tissue distributions of cyclosporine and sirolimus after concomitant peroral administration to the rat: evidence for pharmacokinetic interactionsQ74477319
Effects of oral phosphorus supplementation on mineral metabolism of renal transplant recipientsQ77484646
Hypertriglyceridemia in renal transplant recipients treated with sirolimusQ77724864
Predictors of renal transplant histology at three monthsQ77793963
Rapamycin reverses chronic graft vascular disease in a novel cardiac allograft modelQ77960609
Sirolimus rescue therapy for refractory rejection in renal transplantationQ95721512
Effects of sirolimus on lipids in renal allograft recipients: an analysis using the Framingham risk modelQ44064646
Successful treatment of tacrolimus-associated thrombotic microangiopathy with sirolimus conversion and plasma exchangeQ44079044
Sirolimus-based immunosuppression for transplant-associated thrombotic microangiopathyQ44082739
Effects of sirolimus on plasma lipids, lipoprotein levels, and fatty acid metabolism in renal transplant patients.Q44102328
Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine.Q44106407
Sirolimus-induced leukocytoclastic vasculitisQ44157210
Incidence, therapy, and consequences of lymphocele after sirolimus-cyclosporine-prednisone immunosuppression in renal transplant recipientsQ44168474
New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs.Q44200460
Kidney transplantation without calcineurin inhibitor drugs: a prospective, randomized trial of sirolimus versus cyclosporineQ44221070
Kidney transplantation with rabbit antithymocyte globulin induction and sirolimus monotherapyQ44233380
Long-term results of a prospective randomized study comparing two immunosuppressive regimens, one with and one without CsA, in low-risk renal transplant recipientsQ44236018
Basiliximab-sirolimus-prednisone induction regimen followed by delayed low-dose cyclosporine in renal transplant recipients of living donorsQ44256933
Sirolimus rescue treatment in calcineurin-inhibitor nephrotoxicity after kidney transplantationQ44256950
Comparative effects of sirolimus and mycophenolate mofetil on erythropoiesis in kidney transplant patientsQ44261905
Sirolimus and lymphocele formation after kidney transplantation: an immunosuppressive medication as co-factor for a surgical problem?Q44288747
Bone mineral density changes within six months of renal transplantationQ44289403
Severe acute renal failure after exposure to sirolimus-tacrolimus in two living donor kidney recipientsQ44289430
Early experience with sirolimus in lung transplant recipients with chronic allograft rejectionQ44312072
Kidney function and morphology after short-term combination therapy with cyclosporine A, tacrolimus and sirolimus in the rat.Q44313379
Protocol core needle biopsy and histologic Chronic Allograft Damage Index (CADI) as surrogate end point for long-term graft survival in multicenter studiesQ44321472
Diabetes mellitus after kidney transplantation in the United StatesQ44326129
Sirolimus may promote thrombotic microangiopathyQ44326132
Post-renal transplant syndrome of transient lower limb joint pain: description under a tacrolimus-based immunosuppression.Q44330635
Delayed graft function and cast nephropathy associated with tacrolimus plus rapamycin use.Q44378937
The impact of cyclosporine dose reduction with or without the addition of rapamycin on functional, molecular, and histological markers of chronic allograft nephropathyQ44379119
Sirolimus Prolongs Recovery from Delayed Graft Function After Cadaveric Renal TransplantationQ44402537
Early withdrawal of cyclosporine A improves 1-year kidney graft structure and function in sirolimus-treated patients.Q44405395
Ten years of sirolimus therapy for human renal transplantation: the University of Texas at Houston experienceQ44437917
Sirolimus therapy without calcineurin inhibitors: Necker Hospital 8-year experienceQ44437921
Sirolimus in combination with tacrolimus or mycophenolate mofetil for minimizing acute rejection risk in renal transplant recipients—a single center experienceQ44437938
Reduced and standard target concentration tacrolimus with sirolimus in renal allograft recipientsQ44437948
Fixed-dose sirolimus with reduced dose calcineurin inhibitor: the University of Colorado experienceQ44437952
Kidney transplantation without calcineurin inhibitors using sirolimus.Q44437956
Conversion to sirolimus in solid organ transplantation: a Single-Center experienceQ44437963
Clinical use of rapamycin in renal allograft recipients identifies its relevant toxicity profile and raises unsolved questions: a Single-Center experienceQ44437966
Tubular function in patients with hypokalemia induced by sirolimus after renal transplantationQ44437975
De novo use of sirolimus in immunosuppression regimens in kidney and kidney-pancreas transplantation at the University of California, San FranciscoQ44437985
Rapamycin: signaling in vascular smooth muscleQ44437992
Pneumonitis associated with the use of mycophenolate mofetilQ44460475
Campath-1H induction plus rapamycin monotherapy for renal transplantation: results of a pilot study.Q44461489
Airway anastomotic dehiscence associated with use of sirolimus immediately after lung transplantationQ44469215
Morphological and biochemical effects of immunosuppressive drugs in a capillary tube assay for endothelial dysfunctionQ44471173
Rapid conversion to sirolimus for chronic progressive deterioration of the renal function in kidney allograft recipientsQ44491034
Interstitial granulomatous pneumonitis associated with sirolimus in a child after liver transplantationQ44491733
A prospective randomized multicenter study of tacrolimus in combination with sirolimus in renal-transplant recipientsQ44493612
Randomized trial of tacrolimus + mycophenolate mofetil or azathioprine versus cyclosporine + mycophenolate mofetil after cadaveric kidney transplantation: results at three years.Q44493644
Sirolimus-induced thrombotic microangiopathy in a renal transplant recipientQ44493997
The influence of the rapamycin-derivate SDZ RAD on the healing of airway anastomosesQ44508122
Results from a human renal allograft tolerance trial evaluating the humanized CD52-specific monoclonal antibody alemtuzumab (CAMPATH-1H).Q44514934
Sirolimus does not increase the risk for postoperative thromboembolic events among renal transplant recipientsQ44527258
Dyslipidemia in renal transplant recipients treated with a sirolimus and cyclosporine-based immunosuppressive regimen: incidence, risk factors, progression, and prognosisQ44527275
Efficacy of sirolimus (rapamycin) administered concomitantly with a subtherapeutic dose of cyclosporin in the treatment of severe psoriasis: a randomized controlled trialQ33338797
Sirolimus allows early cyclosporine withdrawal in renal transplantation resulting in improved renal function and lower blood pressureQ33339056
Characteristics of sirolimus-associated interstitial pneumonitis in renal transplant patientsQ33339059
De novo hemolytic uremic syndrome after kidney transplantation in patients treated with cyclosporine-sirolimus combinationQ33341564
Improved renal function in sirolimus-treated renal transplant patients after early cyclosporine eliminationQ33345776
Thrombotic micro-angiopathy with sirolimus-based immunosuppression: potentiation of calcineurin-inhibitor-induced endothelial damage?Q33346767
Bicêtre hospital experience with sirolimus-based therapy in human renal transplantation: the sirolimus European renal transplant studyQ33347960
Sirolimus: a single center experience in combination with calcineurin inhibitors.Q33347963
A pilot protocol of a calcineurin-inhibitor free regimen for kidney transplant recipients of marginal donor kidneys or with delayed graft functionQ33348393
Long-term improvement in renal function with sirolimus after early cyclosporine withdrawal in renal transplant recipients: 2-year results of the Rapamune Maintenance Regimen StudyQ33349178
De novo hemolytic-uremic syndrome/thrombotic microangiopathy in renal transplant patients receiving calcineurin inhibitors: role of sirolimusQ33349848
Thrombotic microangiopathy after renal transplantation in the United StatesQ33357327
Long-term benefits with sirolimus-based therapy after early cyclosporine withdrawalQ33359653
Enhancement of human platelet aggregation and secretion induced by rapamycinQ33504794
Requirements for therapeutic drug monitoring of sirolimus, an immunosuppressive agent used in renal transplantationQ33925685
Clinical pharmacokinetics and therapeutic drug monitoring of sirolimusQ33925690
Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipientsQ33968031
A clinical pharmacokinetic study of tacrolimus and sirolimus combination immunosuppression comparing simultaneous to separated administrationQ34129460
Interstitial pneumonitis associated with sirolimus: a dilemma for lung transplantationQ34176754
Effects of rapamycin on cultured hepatocyte proliferation and gene expressionQ34240244
Sirolimus-associated pulmonary toxicityQ34317056
Clinical pharmacokinetics of sirolimusQ34347243
International standardization of criteria for the histologic diagnosis of renal allograft rejection: the Banff working classification of kidney transplant pathologyQ34354852
Death with functioning graft--a preventable cause of graft loss.Q34659898
Rapamycin inhibits GM-CSF-induced neutrophil migrationQ34781893
Sirolimus monotherapy in nephrotoxicity due to calcineurin inhibitors in liver transplant recipientsQ35053894
Clinical epidemiology of cardiac disease in renal transplant recipientsQ35086955
Pharmacokinetics of tacrolimus-based combination therapiesQ35124324
A retrospective review of sirolimus (Rapamune) therapy in orthotopic liver transplant recipients diagnosed with chronic rejectionQ35125083
Sirolimus: its discovery, biological properties, and mechanism of actionQ35125746
Therapeutic monitoring of sirolimus: its contribution to optimal prescription.Q35125770
Preclinical results of sirolimus treatment in transplant modelsQ35125793
Molecular actions of sirolimus: sirolimus and mTorQ35125798
Sirolimus-induced pneumonitis: three cases and a review of the literatureQ35608779
Conversion to sirolimus-based maintenance immunosuppression using daclizumab bridge therapy in renal transplant recipientsQ35817128
Effect of cyclosporine, mycophenolic acid, and rapamycin on the proliferation of rat aortic vascular smooth muscle cells: in vitro studyQ38525562
Calcineurin-inhibitor induced pain syndrome (CIPS): a severe disabling complication after organ transplantationQ39420730
A randomized long-term trial of tacrolimus and sirolimus versus tacrolimus and mycophenolate mofetil versus cyclosporine (NEORAL) and sirolimus in renal transplantation. I. Drug interactions and rejection at one yearQ40535785
Immunosuppressive TOR kinase inhibitor everolimus (RAD) suppresses growth of cells derived from posttransplant lymphoproliferative disorder at allograft-protecting dosesQ40643579
Rapamycin is an effective inhibitor of human renal cancer metastasis.Q40664831
The immunosuppressant rapamycin, alone or with transforming growth factor-beta, enhances osteoclast differentiation of RAW264.7 monocyte-macrophage cells in the presence of RANK-ligandQ40707638
Insulin release and suppression by tacrolimus, rapamycin and cyclosporin A are through regulation of the ATP-sensitive potassium channelQ40743752
Mechanism of action of the immunosuppressant rapamycinQ40965429
The immunosuppressant rapamycin blocks in vitro responses to hematopoietic cytokines and inhibits recovering but not steady-state hematopoiesis in vivoQ41447199
Tacrolimus and sirolimus decrease oxidative phosphorylation of isolated rat kidney mitochondriaQ41787336
Sirolimus/cyclosporine/tacrolimus interactions on bile flow and biliary excretion of immunosuppressants in a subchronic bile fistula rat modelQ41886213
The effect of rapamycin on kidney function in the Sprague-Dawley rat.Q41923533
A pilot trial of tacrolimus, sirolimus, and steroids in renal transplant recipientsQ42415027
Comparison of the effect of rapamycin and FK506 on release of prostacyclin and endothelin in vitroQ42475482
Pronounced renal vasoconstriction and systemic hypertension in renal transplant patients treated with cyclosporin A versus FK 506.Q42544482
Novel anti-Pneumocystis carinii effects of the immunosuppressant mycophenolate mofetil in contrast to provocative effects of tacrolimus, sirolimus, and dexamethasoneQ42550663
Comparison of acute rapamycin nephrotoxicity with cyclosporine and FK506.Q42552889
A phase III prospective, randomized study to evaluate concentration-controlled sirolimus (rapamune) with cyclosporine dose minimization or elimination at six months in de novo renal allograft recipients.Q42598004
Sirolimus does not exhibit nephrotoxicity compared to cyclosporine in renal transplant recipients.Q42680562
Immunosuppressive effects and safety of a sirolimus/cyclosporine combination regimen for renal transplantationQ43453547
Sirolimus improves the two-year outcome of renal allografts in African-American patientsQ43493492
Immunosuppressant use without bone loss--implications for bone loss after transplantationQ43517225
Sirolimus-based immunosuppression with reduce dose cyclosporine or tacrolimus after renal transplantationQ43534748
Effect of histological damage on long-term kidney transplant outcomeQ43547328
Effect of rapamycin and FK506 on mesangial cell proliferationQ43552846
Pharmacokinetic interactions augment toxicities of sirolimus/cyclosporine combinations.Q43584947
Dyslipidemia during sirolimus therapy in liver transplant recipients occurs with concomitant cyclosporine but not tacrolimusQ43604915
Multicenter trial exploring calcineurin inhibitors avoidance in renal transplantationQ43633987
Dose optimization of mycophenolate mofetil when administered with a low dose of tacrolimus in cadaveric renal transplant recipientsQ43685021
Sirolimus-associated eyelid edema in kidney transplant recipientsQ43685041
Comparison of sirolimus-based calcineurin inhibitor-sparing and calcineurin inhibitor-free regimens in cadaveric renal transplantationQ43703063
Rapamycin impairs recovery from acute renal failure: role of cell-cycle arrest and apoptosis of tubular cellsQ43735102
Population pharmacokinetics of everolimus in de novo renal transplant patients: impact of ethnicity and comedicationsQ43738218
Sirolimus for rescue and primary immunosuppression in transplanted children receiving tacrolimusQ43747072
Oral ulcerations in a renal transplant recipient: a mycophenolate mofetil-induced complication?Q43747084
Interstitial pneumonitis associated with sirolimus (rapamycin) therapy after liver transplantationQ43752523
Cholestasis and regulation of genes related to drug metabolism and biliary transport in rat liver following treatment with cyclosporine A and sirolimus (Rapamycin).Q43758772
Effect of sirolimus on the metabolism of apoB100- containing lipoproteins in renal transplant patientsQ43768135
Conversion to rapamycin in renal allograft recipients with biopsy-proven calcineurin inhibitor-induced nephrotoxicityQ43828472
Are wound complications after a kidney transplant more common with modern immunosuppression?Q43843799
Combination therapy with low dose sirolimus and tacrolimus is synergistic in preventing spontaneous and recurrent autoimmune diabetes in non-obese diabetic miceQ43949026
The impact of novel immunosuppressive agents on infections in organ transplant recipients and the interactions of these agents with antimicrobialsQ44024985
Role of immunosuppressive drugs in the development of tissue-invasive cytomegalovirus infection in renal transplant recipients.Q44033366
European best practice guidelines for renal transplantation. Section IV: Long-term management of the transplant recipient. IV.10. Pregnancy in renal transplant recipientsQ44046247
Higher surgical wound complication rates with sirolimus immunosuppression after kidney transplantation: a matched-pair pilot studyQ44527287
Long-term pharmacokinetic study of the novel combination of tacrolimus and sirolimus in de novo renal allograft recipientsQ44527309
Comparison of sirolimus vs. mycophenolate mofetil on surgical complications and wound healing in adult kidney transplantationQ44549982
Rapamycin in lung transplantation: preliminary resultsQ44577658
Report from the National Transplantation Pregnancy Registry (NTPR): outcomes of pregnancy after transplantation.Q44583035
Risk factors for Pneumocystis carinii pneumonia in kidney transplant recipients: a case-control studyQ44585215
Rapamycin-induced oligospermiaQ44591465
Withdrawal of steroid therapy in African American kidney transplant recipients receiving sirolimus and tacrolimus.1Q44595688
Human herpesvirus-6 in renal transplant recipients: potential risk factors for the development of human herpesvirus-6 seroconversion.Q44608613
Sirolimus-Induced Interstitial Pneumonitis in an Islet Transplant RecipientQ44631791
The natural history of chronic allograft nephropathyQ44688416
Testosterone concentrations and sirolimus in male renal transplant patients.Q44695059
The impact of sirolimus, mycophenolate mofetil, cyclosporine, azathioprine, and steroids on wound healing in 513 kidney-transplant recipientsQ44701667
Sirolimus inhibits oxidative burst activity in transplant recipients.Q44701677
Sirolimus myopathyQ44701679
Addition of sirolimus to cyclosporine delays the recovery from delayed graft function but does not affect 1-year graft functionQ44705288
Sirolimus delays recovery of rat kidney transplants after ischemia-reperfusion injuryQ44711152
Thrombotic microangiopathy associated with combined sirolimus and tacrolimus immunosuppression after intestinal transplantationQ44728988
A randomized long-term trial of tacrolimus/sirolimus versus tacrolimus/mycophenolate mofetil versus cyclosporine (NEORAL)/sirolimus in renal transplantation. II. Survival, function, and protocol compliance at 1 yearQ44741819
Everolimus and mycophenolate mofetil are potent inhibitors of fibroblast proliferation after lung transplantation.Q44741825
Short- and long-term clinical benefit of sirolimus-eluting stents compared to conventional bare stents for patients with acute myocardial infarctionQ44771237
Combination therapy with sirolimus and mycophenolate mofetil: effects on the kidney and on transforming growth factor-beta1.Q44799975
Conversion to sirolimus: a successful treatment for posttransplantation Kaposi's sarcomaQ44799991
Mycophenolate mofetil and sirolimus as calcineurin inhibitor-free immunosuppression for late cardiac-transplant recipients with chronic renal failureQ44845167
Sirolimus increases transforming growth factor-beta1 expression and potentiates chronic cyclosporine nephrotoxicityQ44845957
Lymphedema associated with sirolimus in renal transplant recipients.Q44846974
Acute rapamycin nephrotoxicity in native kidneys of patients with chronic glomerulopathiesQ44854978
Observations regarding the use of sirolimus and tacrolimus in high-risk cadaveric renal transplantationQ44860714
Rapamycin-associated post-transplantation glomerulonephritis and its remission after reintroduction of calcineurin-inhibitor therapyQ44866395
Increased risk of thrombotic microangiopathy in patients receiving a cyclosporin-sirolimus combinationQ44899011
Sirolimus-based therapy following early cyclosporine withdrawal provides significantly improved renal histology and function at 3 yearsQ44899016
Sirolimus-induced angioedemaQ44899034
Should prophylaxis for Pneumocystis carinii pneumonia in solid organ transplant recipients ever be discontinued?Q44906768
Rapamycin protects allografts from rejection while simultaneously attacking tumors in immunosuppressed miceQ44913829
Sirolimus impairs gonadal function in heart transplant recipientsQ44935460
Acute respiratory failure and pulmonary fibrosis secondary to administration of mycophenolate mofetilQ44958299
Two-year incidence of malignancy in sirolimus-treated renal transplant recipients: results from five multicenter studiesQ44963400
Wound-healing complications after kidney transplantation: a prospective, randomized comparison of sirolimus and tacrolimusQ44967971
Pilot randomized study of early tacrolimus withdrawal from a regimen with sirolimus plus tacrolimus in kidney transplantationQ44989307
Sirolimus-induced leukocytoclastic vasculitis: the second case reportedQ45016050
Predictors of success in conversion from calcineurin inhibitor to sirolimus in chronic allograft dysfunctionQ45057604
De novo kidney transplantation without use of calcineurin inhibitors preserves renal structure and function at two years.Q45100299
Alterations of the female reproductive system in recipients of islet graftsQ45183364
Lovastatin induces fibroblast apoptosis in vitro and in vivo. A possible therapy for fibroproliferative disorders.Q46449145
Combined costimulation blockade plus rapamycin but not cyclosporine produces permanent engraftmentQ56907406
Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre studyQ57943257
Sirolimus-tacrolimus combination immunosuppressionQ60998185
Management of lymphoceles after kidney transplantationQ62517980
Functional and histopathologic effects of rapamycin on mouse kidneyQ70601660
P433issue2
P921main subjectsirolimusQ32089
P304page(s)153-181
P577publication date2005-01-01
P1433published inDrug SafetyQ15724462
P1476titleBenefit-risk assessment of sirolimus in renal transplantation
P478volume28

Reverse relations

cites work (P2860)
Q39024541A Systematic Literature Review Approach to Estimate the Therapeutic Index of Selected Immunosuppressant Drugs After Renal Transplantation
Q36003663Alleviating neurodegeneration in Drosophila models of PolyQ diseases
Q36769277Allogeneic hematopoietic stem-cell transplantation for sickle cell disease
Q36328854An engineered L-arginine sensor of Chlamydia pneumoniae enables arginine-adjustable transcription control in mammalian cells and mice
Q38038696An evaluation of sirolimus in renal transplantation
Q33253253Bloodstream infection following 217 consecutive systemic-enteric drained pancreas transplants
Q37821472Calcineurin inhibitor-free immunosuppression in pediatric renal transplantation: a viable option?
Q37517602Considerations in sirolimus use in the early and late post-transplant periods
Q36874564Effect of Sirolimus on Disease Progression in Patients with Autosomal Dominant Polycystic Kidney Disease and CKD Stages 3b-4.
Q27320627Effects of TORC1 Inhibition during the Early and Established Phases of Polycystic Kidney Disease
Q39820135Effects of rapamycin on gene expression, morphology, and electrophysiological properties of rat hippocampal neurons
Q35706983Efficacy and Safety of Low-Dose Cyclosporine with Everolimus and Steroids in de novo Heart Transplant Patients: A Multicentre, Randomized Trial
Q57792492Everolimus and Enteric-Coated Mycophenolate Sodium Ab Initio after Liver Transplantation: Midterm Results
Q33394235Everolimus-based, calcineurin-inhibitor-free regimen in recipients of de-novo kidney transplants: an open-label, randomised, controlled trial
Q36441466Everolimus: a review of its use in renal and cardiac transplantation
Q37992135Everolimus: preventing organ rejection in adult kidney transplant recipients
Q48097984Evidence of the immunomodulatory role of dual PI3K/mTOR inhibitors in transplantation: an experimental study in mice.
Q46449559Excellent long-term results in de novo renal transplant recipients treated with proliferation signal inhibitors and reduced calcineurin inhibitors exposure
Q27323092High-content chemical and RNAi screens for suppressors of neurotoxicity in a Huntington's disease model
Q35827879Immunosuppressive nano-therapeutic micelles downregulate endothelial cell inflammation and immunogenicity.
Q36938148Kidney transplantation: current issues and future prospects
Q51497219Kinetic nomograms assist individualization of drug regimens.
Q33513711Mechanisms of diabetes mellitus induced with FK506 in SD rats models
Q57817480Rapamycin Nano-Micelle Ophthalmic Solution Reduces Corneal Allograft Rejection by Potentiating Myeloid-Derived Suppressor Cells' Function
Q46755906Rapamycin decreases leukocyte migration in vivo and effectively reduces experimentally induced chronic colitis
Q83220038Side effects of sirolimus
Q34767143Sirolimus is associated with new-onset diabetes in kidney transplant recipients.
Q36936424Sirolimus-associated infertility: case report and literature review of possible mechanisms
Q36674174Sirolimus-associated proteinuria and renal dysfunction
Q33604754Surgical biology for the clinician: vascular effects of immunosuppression
Q46936587Tacrolimus combined with two different dosages of sirolimus in kidney transplantation: results of a multicenter study.
Q38946734The antiaging activity and cerebral protection of rapamycin at micro-doses.
Q35823680The food additive vanillic acid controls transgene expression in mammalian cells and mice
Q36652031The role and value of sirolimus administration in kidney and liver transplantation
Q41859603The use of everolimus in renal-transplant patients
Q33432698Therapeutic Drug Monitoring, Electronic Health Records, and Pharmacokinetic Modeling to Evaluate Sirolimus Drug Exposure-Response Relationships in Renal Transplant Patients
Q36985076Transporter-mediated uptake into cellular compartments
Q38161821What is the impact of immunosuppressive treatment on the post-transplant renal osteopathy?
Q80051902[Sirolimus-induced onychopathy in renal transplant recipients]

Search more.