The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD).

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The uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD). is …
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scholarly articleQ13442814

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P356DOI10.1093/NAR/GKL277
P932PMC publication ID1458284
P698PubMed publication ID16679454
P5875ResearchGate publication ID7102556

P50authorMatthias HentzeQ99354
Niels H GehringQ41632975
Andreas E KulozikQ89170845
P2093author name stringNicole Echner
Stephen Breit
Gabriele Neu-Yilik
Clemens Stockklausner
P2860cites workAn analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAsQ22066003
Y14 and hUpf3b form an NMD-activating complexQ24300691
Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirementsQ24337735
The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctionsQ24595096
Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathwayQ24791079
The RNA binding protein Pub1 modulates the stability of transcripts containing upstream open reading framesQ27938420
Translational pathophysiology: a novel molecular mechanism of human diseaseQ28145229
The human intronless melanocortin 4-receptor gene is NMD insensitiveQ28217154
A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundanceQ29615731
A perfect message: RNA surveillance and nonsense-mediated decayQ29616125
When the message goes awry: disease-producing mutations that influence mRNA content and performance.Q30329218
Thrombopoietin in patients with congenital thrombocytopenia and absent radii: elevated serum levels, normal receptor expression, but defective reactivity to thrombopoietin.Q33499842
At least one intron is required for the nonsense-mediated decay of triosephosphate isomerase mRNA: a possible link between nuclear splicing and cytoplasmic translationQ33778146
Post-termination ribosome interactions with the 5'UTR modulate yeast mRNA stabilityQ33864041
Identifying the right stop: determining how the surveillance complex recognizes and degrades an aberrant mRNA.Q33888137
Abnormally spliced beta-globin mRNAs: a single point mutation generates transcripts sensitive and insensitive to nonsense-mediated mRNA decayQ33957567
cis- and trans-acting suppressors of a translation initiation defect at the cyc1 locus of Saccharomyces cerevisiaeQ33959896
Upstream open reading frames as regulators of mRNA translationQ33966388
Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcriptsQ34149373
Quality control of mRNA functionQ34156109
Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noiseQ34353133
Thrombopoietin: the novel hepatic hormone.Q34513015
SC35 autoregulates its expression by promoting splicing events that destabilize its mRNAsQ34583829
Utilizing the GCN4 leader region to investigate the role of the sequence determinants in nonsense-mediated mRNA decay.Q35851318
A splicing-dependent regulatory mechanism that detects translation signalsQ35913215
Genome-wide analysis of mRNAs regulated by the nonsense-mediated and 5' to 3' mRNA decay pathways in yeastQ38346636
Splicing and 3' end formation in the definition of nonsense-mediated decay-competent human beta-globin mRNPsQ39673514
The yeast transcription factor genes YAP1 and YAP2 are subject to differential control at the levels of both translation and mRNA stability.Q39723071
Nonsense mutations in close proximity to the initiation codon fail to trigger full nonsense-mediated mRNA decay.Q40552071
A regulatory mechanism that detects premature nonsense codons in T-cell receptor transcripts in vivo is reversed by protein synthesis inhibitors in vitroQ41267481
Binary specification of nonsense codons by splicing and cytoplasmic translationQ42647080
The relationship between eukaryotic translation and mRNA stability. A short upstream open reading frame strongly inhibits translational initiation and greatly accelerates mRNA degradation in the yeast Saccharomyces cerevisiaeQ50113260
An activating splice donor mutation in the thrombopoietin gene causes hereditary thrombocythaemia.Q55067329
Characterization of a General Stabilizer Element That Blocks Deadenylation-dependent mRNA DecayQ61735643
Hereditary thrombocythaemia in a Japanese family is caused by a novel point mutation in the thrombopoietin geneQ73231030
Translation is required to remove Y14 from mRNAs in the cytoplasmQ74471693
ThrombopoietinQ77218573
A single-base deletion in the thrombopoietin (TPO) gene causes familial essential thrombocythemia through a mechanism of more efficient translation of TPO mRNAQ78253579
The nonsense-mediated mRNA decay pathway triggers degradation of most BRCA1 mRNAs bearing premature termination codonsQ78410743
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)2355-2363
P577publication date2006-05-05
P1433published inNucleic Acids ResearchQ135122
P1476titleThe uORF-containing thrombopoietin mRNA escapes nonsense-mediated decay (NMD).
P478volume34