Recombineering reveals a diverse collection of ribosomal proteins L4 and L22 that confer resistance to macrolide antibiotics

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Recombineering reveals a diverse collection of ribosomal proteins L4 and L22 that confer resistance to macrolide antibiotics is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JMB.2008.12.064
P932PMC publication ID2644216
P698PubMed publication ID19150357

P2093author name stringChristopher S Hayes
Elie J Diner
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Mutations in 23S rRNA and ribosomal protein L4 account for resistance in pneumococcal strains selected in vitro by macrolide passageQ33980212
The polypeptide tunnel system in the ribosome and its gating in erythromycin resistance mutants of L4 and L22.Q34087308
Diversity of ribosomal mutations conferring resistance to macrolides, clindamycin, streptogramin, and telithromycin in Streptococcus pneumoniaeQ34104600
Macrolide resistance conferred by base substitutions in 23S rRNA.Q34106180
The ribosomal exit tunnel functions as a discriminating gateQ34118341
The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosomeQ34214146
Escherichia coli ribosomal protein S8 feedback regulates part of spc operonQ34260850
Enhanced levels of lambda Red-mediated recombinants in mismatch repair mutantsQ34283357
Ribosomal protein gene sequence changes in erythromycin-resistant mutants of Escherichia coliQ34323549
The extended loops of ribosomal proteins L4 and L22 are not required for ribosome assembly or L4-mediated autogenous controlQ34365349
Mechanisms of bacterial resistance to macrolide antibioticsQ34647422
Recombineering: genetic engineering in bacteria using homologous recombinationQ34748892
Genetic engineering using homologous recombinationQ34995474
Bacterial ribosomal subunit synthesis: a novel antibiotic targetQ35010561
Synergy between efflux pump CmeABC and modifications in ribosomal proteins L4 and L22 in conferring macrolide resistance in Campylobacter jejuni and Campylobacter coliQ35127854
Macrolide resistance from the ribosome perspectiveQ35893106
Assembly map of the large subunit (50S) of Escherichia coli ribosomesQ36279594
Novel mutations in ribosomal proteins L4 and L22 that confer erythromycin resistance in Escherichia coliQ36437356
Forced extraction of targeted components from complex macromolecular assembliesQ36954399
Revisiting the mechanism of macrolide-antibiotic resistance mediated by ribosomal protein L22.Q36985091
In vitro selection of resistance in Haemophilus influenzae by amoxicillin-clavulanate, cefpodoxime, cefprozil, azithromycin, and clarithromycin.Q39652872
Effects of an efflux mechanism and ribosomal mutations on macrolide susceptibility of Haemophilus influenzae clinical isolatesQ39731976
Prevalence of erm gene classes in erythromycin-resistant Staphylococcus aureus strains isolated between 1959 and 1988.Q39779100
Erythromycin resistance by ribosome modificationQ39779280
Antipneumococcal activities of two novel macrolides, GW 773546 and GW 708408, compared with those of erythromycin, azithromycin, clarithromycin, clindamycin, and telithromycinQ40290408
In vitro selection and characterization of resistance to macrolides and related antibiotics in Mycoplasma pneumoniae.Q40469366
Binding site of the bridged macrolides in the Escherichia coli ribosomeQ40733620
Binding of [14C]erythromycin to Escherichia coli ribosomesQ41030687
In vitro activities of telithromycin, linezolid, and quinupristin-dalfopristin against Streptococcus pneumoniae with macrolide resistance due to ribosomal mutationsQ41269599
Effect of efflux on telithromycin and macrolide susceptibility in Haemophilus influenzaeQ41869629
Fluorescence polarization method to characterize macrolide-ribosome interactionsQ42000963
Proline residues at the C terminus of nascent chains induce SsrA tagging during translation terminationQ44053781
The synthesis of polyphenylalanine on ribosomes to which erythromycin is boundQ44512579
Chloramphenicol, erythromycin, carbomycin and vernamycin B protect overlapping sites in the peptidyl transferase region of 23S ribosomal RNA.Q46131638
Features of ribosome-peptidyl-tRNA interactions essential for tryptophan induction of tna operon expressionQ46227073
Mutation of L4 ribosomal protein conferring unusual macrolide resistance in two independent clinical isolates of Staphylococcus aureusQ46381452
Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistanceQ46455040
A set of recombineering plasmids for gram-negative bacteriaQ50080127
Erythromycin resistance mutations in ribosomal proteins L22 and L4 perturb the higher order structure of 23 S ribosomal RNA.Q54092195
Identification of a single base change in ribosomal RNA leading to erythromycin resistanceQ54271892
Characterisation of in vitro-selected mutants of Ureaplasma parvum resistant to macrolides and related antibiotics.Q54449271
An investigation of the molecular mechanisms contributing to high-level erythromycin resistance in Campylobacter.Q54474480
Biochemical and genetic studies on two different types of erythromycin resistant mutants of Escherichia coli with altered ribosomal proteinsQ54645205
Ribosomal protein L4 of Escherichia coli: in vitro analysis of L4-mediated attenuation controlQ54696361
Mismatch amplification mutation assay (MAMA): application to the c-H-ras geneQ67997592
Selective action of erythromycin on initiating ribosomesQ69359443
Three genes that affect Escherichia coli ribosomesQ69840639
Erythromycin inhibits the assembly of the large ribosomal subunit in growing Escherichia coli cellsQ72276357
Beta protein of bacteriophage lambda promotes renaturation of DNAQ72915291
Specific inhibition of 50S ribosomal subunit formation in Staphylococcus aureus cells by 16-membered macrolide, lincosamide, and streptogramin B antibioticsQ73901470
Protein secretion and possible roles for multiple signal peptidases for precursor processing in bacilliQ77584099
Cleavage of the A site mRNA codon during ribosome pausing provides a mechanism for translational quality controlQ79212374
P433issue2
P304page(s)300-315
P577publication date2009-01-03
P1433published inJournal of Molecular BiologyQ925779
P1476titleRecombineering reveals a diverse collection of ribosomal proteins L4 and L22 that confer resistance to macrolide antibiotics
P478volume386

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cites work (P2860)
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