High doses of romiplostim induce proliferation and reduce proplatelet formation by human megakaryocytes

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High doses of romiplostim induce proliferation and reduce proplatelet formation by human megakaryocytes is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PLoSO...854723C
P356DOI10.1371/JOURNAL.PONE.0054723
P932PMC publication ID3554640
P698PubMed publication ID23359807
P5875ResearchGate publication ID235381224

P50authorAlessandra BalduiniQ56972276
P2093author name stringCarlo L Balduini
Manuela Currao
P2860cites workAdhesive receptors, extracellular proteins and myosin IIA orchestrate proplatelet formation by human megakaryocytes.Q53457979
Thrombopoietin, but not cytokines binding to gp130 protein-coupled receptors, activates MAPKp42/44, AKT, and STAT proteins in normal human CD34+ cells, megakaryocytes, and plateletsQ61942736
Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietinQ24316187
Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytesQ28142403
A senescence-like cell-cycle arrest occurs during megakaryocytic maturation: implications for physiological and pathological megakaryocytic proliferationQ28475435
AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP.Q33373031
Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trialQ33378523
Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP.Q33381893
Thrombopoietin agonists for the treatment of thrombocytopenia in liver disease and hepatitis C.Q33385482
Biology and chemistry of thrombopoietic agentsQ33390625
A randomized, double-blind study of romiplostim to determine its safety and efficacy in children with immune thrombocytopeniaQ33394959
Megakaryocytes and beyond: the birth of plateletsQ34215516
Constitutively released adenosine diphosphate regulates proplatelet formation by human megakaryocytesQ34280678
Roads to polyploidy: the megakaryocyte exampleQ34504475
The molecular and cellular biology of thrombopoietin: the primary regulator of platelet productionQ34658539
Blood platelets are assembled principally at the ends of proplatelet processes produced by differentiated megakaryocytesQ36313419
The mitogen-activated protein kinase signaling pathways: role in megakaryocyte differentiationQ37623945
PI3K/Akt/FOXO3a pathway contributes to thrombopoietin-induced proliferation of primary megakaryocytes in vitro and in vivo via modulation of p27(Kip1).Q40015626
Critical role for ERK1/2 in bone marrow and fetal liver-derived primary megakaryocyte differentiation, motility, and proplatelet formationQ42574292
AMG531 stimulates megakaryopoiesis in vitro by binding to Mpl.Q44704490
Megakaryocyte-matrix interaction within bone marrow: new roles for fibronectin and factor XIII-A.Q46501234
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectromiplostimQ1235195
P304page(s)e54723
P577publication date2013-01-24
P1433published inPLOS OneQ564954
P1476titleHigh doses of romiplostim induce proliferation and reduce proplatelet formation by human megakaryocytes
P478volume8

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cites work (P2860)
Q41480921A new path to platelet production through matrix sensing.
Q50091910A novel mode of stimulating platelet formation activity in megakaryocytes with peanut skin extract
Q36596892CCL5 derived from platelets increases megakaryocyte proplatelet formation
Q33442148Developmental differences between newborn and adult mice in response to romiplostim
Q47720114Effect of thrombopoietin receptor agonists on leukocyte and haematopoietic stem and progenitor cells in the peripheral blood of patients with immune thrombocytopenic purpura
Q33417148Effect of thrombopoietin receptor agonists on the apoptotic profile of platelets in patients with chronic immune thrombocytopenia
Q42335815Eltrombopag, a potent stimulator of megakaryopoiesis.
Q38187494Ex vivo production of platelets from stem cells
Q41510461Hyaluronan based hydrogels provide an improved model to study megakaryocyte-matrix interactions
Q33420441Immune thrombocytopenia: antiplatelet autoantibodies inhibit proplatelet formation by megakaryocytes and impair platelet production in vitro
Q90733820Induction of differentiation of human stem cells ex vivo: Toward large-scale platelet production
Q26745753Long-term safety and efficacy of romiplostim for treatment of immune thrombocytopenia
Q33434519Revealing eltrombopag's promotion of human megakaryopoiesis through AKT/ERK-dependent pathway activation
Q44643430Serotonin enhances megakaryopoiesis and proplatelet formation via p-Erk1/2 and F-actin reorganization
Q33440990Spotlight on romiplostim in the treatment of children with chronic immune thrombocytopenia: design, development, and potential place in therapy
Q28082685The secret life of a megakaryocyte: emerging roles in bone marrow homeostasis control
Q48320457Thrombopoietin receptor agonist switch in adult primary immune thrombocytopenia patients: A retrospective collaborative survey involving 4 Spanish centres.

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