Pediatric patients with refractory central nervous system tumors: experiences of a clinical trial combining bevacizumab and temsirolimus

scientific article

Pediatric patients with refractory central nervous system tumors: experiences of a clinical trial combining bevacizumab and temsirolimus is …
instance of (P31):
scholarly articleQ13442814

External links are
P932PMC publication ID5685166
P698PubMed publication ID24692729

P50authorNandita Guha-ThakurtaQ41599067
Razelle KurzrockQ56614941
P2093author name stringSang Joon Shin
Sarina A Piha-Paul
Michael Rytting
Tribhawan Vats
Joann Aaron
Eugenie Kleinerman
P2860cites workCharacterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinaseQ22009924
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.Q24540159
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapyQ29547379
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeuticsQ29617786
Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trialQ29618031
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinomaQ29618608
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesisQ29620559
Medical management of brain tumor patientsQ31134402
Treatment of children with recurrent high grade gliomas with a bevacizumab containing regimenQ33392585
The measurement of performance in childhood cancer patientsQ34050319
Pten signaling in gliomasQ34707865
Phase I study of temsirolimus in pediatric patients with recurrent/refractory solid tumorsQ35112340
Pathobiology, prognosis, and targeted therapy for renal cell carcinoma: exploiting the hypoxia-induced pathway.Q35569214
A phase II trial of bevacizumab plus everolimus for patients with refractory metastatic colorectal cancerQ35584707
VEGF as a key mediator of angiogenesis in cancerQ36319024
A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancerQ36509678
NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growthQ37275182
Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy.Q40821386
Annual report to the nation on the status of cancer, 1975-2001, with a special feature regarding survivalQ44407580
Randomized phase II study of multiple dose levels of CCI-779, a novel mammalian target of rapamycin kinase inhibitor, in patients with advanced refractory renal cell carcinomaQ44551425
Response criteria for phase II studies of supratentorial malignant gliomaQ44781447
Phase I/pharmacokinetic study of CCI-779 in patients with recurrent malignant glioma on enzyme-inducing antiepileptic drugs.Q45006311
Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme.Q46410598
Bevacizumab plus irinotecan in recurrent glioblastoma multiformeQ46942082
Expression of the ErbB-neuregulin signaling network during human cerebellar development: implications for the biology of medulloblastoma.Q48398636
Critical oncogenic mutations in newly diagnosed pediatric diffuse intrinsic pontine gliomaQ48761873
Trends in childhood cancer incidence in the U.S. (1992-2004).Q51111080
Activation of the IGF-IR system contributes to malignant growth of human and mouse medulloblastomas.Q55474277
The von Hippel-Lindau protein, vascular endothelial growth factor, and kidney cancerQ73734152
Possible molecular mechanisms involved in the toxicity of angiogenesis inhibitionQ80376810
Anti-VEGF therapies for malignant glioma: treatment effects and escape mechanismsQ83588875
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectbevacizumabQ413299
P304page(s)1939-1945
P577publication date2014-04-01
P1433published inAnticancer ResearchQ326290
P1476titlePediatric patients with refractory central nervous system tumors: experiences of a clinical trial combining bevacizumab and temsirolimus
P478volume34

Reverse relations

cites work (P2860)
Q5280168318F-FDOPA PET/MRI for monitoring early response to bevacizumab in children with recurrent brain tumors.
Q37058267Cancer prevention and therapy through the modulation of the tumor microenvironment
Q35788820Effective treatment of diverse medulloblastoma models with mebendazole and its impact on tumor angiogenesis
Q64923739Embryonal Tumors of the Central Nervous System in Children: The Era of Targeted Therapeutics.
Q47133403Medulloblastoma in children and adolescents: a systematic review of contemporary phase I and II clinical trials and biology update.
Q46155460The role of angiogenesis in Group 3 medulloblastoma pathogenesis and survival

Search more.