The adenylate cyclase toxins of Bacillus anthracis and Bordetella pertussis promote Th2 cell development by shaping T cell antigen receptor signaling

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The adenylate cyclase toxins of Bacillus anthracis and Bordetella pertussis promote Th2 cell development by shaping T cell antigen receptor signaling is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PPAT.1000325
P932PMC publication ID2643477
P698PubMed publication ID19266022
P5875ResearchGate publication ID24181807

P50authorCesare MontecuccoQ504278
Mario Milco D'EliosQ52868123
Daniel LadantQ56811517
P2093author name stringMarisa Benagiano
Cosima T Baldari
Silvia Rossi Paccani
Irene Zornetta
Nagaja Capitani
P2860cites workCalcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.Q24295132
Activation of the Interleukin-5 Promoter by cAMP in Murine EL-4 Cells Requires the GATA-3 and CLE0 ElementsQ24315620
The adenylate cyclase toxin of Bordetella pertussis binds to target cells via the alpha(M)beta(2) integrin (CD11b/CD18)Q24675699
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Anthrax toxin receptor 2-dependent lethal toxin killing in vivoQ28572283
Functional diversity of helper T lymphocytesQ29619415
Macrophage cytotoxicity produced by adenylate cyclase toxin from Bordetella pertussis: more than just making cyclic AMP!Q30439119
Adenylate cyclase toxin from Bordetella pertussis synergizes with lipopolysaccharide to promote innate interleukin-10 production and enhances the induction of Th2 and regulatory T cells.Q30449654
Anthrax edema toxin modulates PKA- and CREB-dependent signaling in two phases.Q33380169
Lineage commitment in the immune system: the T helper lymphocyte grows up.Q33970744
E-prostanoid (EP)2/EP4 receptor-dependent maturation of human monocyte-derived dendritic cells and induction of helper T2 polarization.Q51051385
The p38 mitogen-activated protein kinase regulates effector functions of primary human CD4 T cells.Q51987576
Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production.Q52547955
The molecular machinery for cAMP-dependent immunomodulation in T-cells: Figure 1Q57371064
Defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell helpQ63408332
cAMP up-regulates IL-4 and IL-5 production from activated CD4+ T cells while decreasing IL-2 release and NF-AT inductionQ72403439
Cyclic AMP inhibits extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/Akt pathways by inhibiting Rap1Q74293069
Adjuvant and protective properties of native and recombinant Bordetella pertussis adenylate cyclase toxin preparations in miceQ77391682
p38 alpha mitogen-activated protein kinase is activated by CD28-mediated signaling and is required for IL-4 production by human CD4+CD45RO+ T cells and Th2 effector cellsQ77841569
SAP regulates T(H)2 differentiation and PKC-theta-mediated activation of NF-kappaB1Q80991137
Direct inhibition of T-lymphocyte activation by anthrax toxins in vivoQ34194649
The neutrophil-activating protein of Helicobacter pylori promotes Th1 immune responsesQ34448375
Pore formation by the Bordetella adenylate cyclase toxin in lipid bilayer membranes: role of voltage and pH.Q34708490
Effect of different forms of adenylate cyclase toxin of Bordetella pertussis on protection afforded by an acellular pertussis vaccine in a murine modelQ35220336
Impaired IL-4 and c-Maf expression and enhanced Th1-cell development in Vav1-deficient mice.Q35848067
Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4Q36228702
Bordetella adenylate cyclase toxin: a swift saboteur of host defenseQ36365962
Anthrax toxins suppress T lymphocyte activation by disrupting antigen receptor signalingQ36403206
AKAP signaling complexes: getting to the heart of the matterQ36523453
The molecular machinery for cAMP-dependent immunomodulation in T-cellsQ36541993
Anthrax toxin: receptor binding, internalization, pore formation, and translocationQ36750138
Bordetella pertussis adenylate cyclase toxin modulates innate and adaptive immune responses: distinct roles for acylation and enzymatic activity in immunomodulation and cell death.Q38323912
Insertional mutagenesis of Bordetella pertussis adenylate cyclaseQ38330594
Cell entry and cAMP imaging of anthrax edema toxinQ39121575
Suppression of T-lymphocyte activation and chemotaxis by the adenylate cyclase toxin of Bordetella pertussisQ39758258
cAMP imaging of cells treated with pertussis toxin, cholera toxin, and anthrax edema toxinQ39939713
Regulation of Th2 cytokine genes by p38 MAPK-mediated phosphorylation of GATA-3.Q40174738
Protein kinase A regulates GATA-3-dependent activation of IL-5 gene expression in Th2 cellsQ40665498
cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1bQ40721660
Cyclic AMP activates p38 mitogen-activated protein kinase in Th2 cells: phosphorylation of GATA-3 and stimulation of Th2 cytokine gene expressionQ40843952
Bordetella pertussis inhibition of interleukin-12 (IL-12) p70 in human monocyte-derived dendritic cells blocks IL-12 p35 through adenylate cyclase toxin-dependent cyclic AMP inductionQ42047758
The Helicobacter pylori vacuolating toxin inhibits T cell activation by two independent mechanisms.Q42906330
Prostaglandin-E2 is a potent inhibitor of human interleukin 12 productionQ42942780
Cholera toxin indirectly activates human monocyte-derived dendritic cells in vitro through the production of soluble factors, including prostaglandin E(2) and nitric oxide.Q43192962
Multiple signals required for cyclic AMP-responsive element binding protein (CREB) binding protein interaction induced by CD3/CD28 costimulationQ43512765
Complement receptor 3 ligation of dendritic cells suppresses their stimulatory capacityQ44240882
Prostaglandin E2 synthesis in human monocyte-derived dendritic cellsQ44469414
Tyrosine-728 and glutamic acid-735 are essential for the metalloproteolytic activity of the lethal factor of Bacillus anthracis.Q44707224
Up-regulation of IL-4 production by the activated cAMP/cAMP-dependent protein kinase (protein kinase A) pathway in CD3/CD28-stimulated naive T cellsQ44851086
Immune responses to Bacillus anthracis protective antigen in patients with bioterrorism-related cutaneous or inhalation anthraxQ45043237
TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signalingQ45094763
Adjuvanticity of native and detoxified adenylate cyclase toxin of Bordetella pertussis towards co-administered antigensQ45098739
Nonsteroidal anti-inflammatory drugs inhibit a Fyn-dependent pathway coupled to Rac and stress kinase activation in TCR signaling.Q45129927
Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in T(H)2 cytokine regulation.Q45147807
Eradication of established tumors by vaccination with recombinant Bordetella pertussis adenylate cyclase carrying the human papillomavirus 16 E7 oncoprotein.Q45253754
Evaluation of serologic tests for diagnosis of anthrax after an outbreak of cutaneous anthrax in ParaguayQ45520319
Anthrax edema toxin cooperates with lethal toxin to impair cytokine secretion during infection of dendritic cellsQ46425895
Adenylate cycalse toxin of Bordetella pertussis inhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cellsQ46653871
Evidence for adjuvanticity of anthrax edema toxinQ46707928
Bacillus anthracis edema toxin acts as an adjuvant for mucosal immune responses to nasally administered vaccine antigensQ46902199
Bacterial toxins as mucosal adjuvants.Q50127978
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageQuantQ112270642
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectBordetella pertussisQ137103
Bacillus anthracisQ614156
P304page(s)e1000325
P577publication date2009-03-06
P1433published inPLOS PathogensQ283209
P1476titleThe adenylate cyclase toxins of Bacillus anthracis and Bordetella pertussis promote Th2 cell development by shaping T cell antigen receptor signaling
P478volume5

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cites work (P2860)
Q37727941A Biologically-Based Computational Approach to Drug Repurposing for Anthrax Infection
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Q41012029Adenylate Cyclase Toxin promotes bacterial internalisation into non phagocytic cells.
Q40064017Anthrax Vaccine Precipitated induces Edema Toxin-neutralizing, Edema Factor-specific antibodies in human recipients
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Q38060730Anthrax lethal toxin and the induction of CD4 T cell immunity
Q27000357Bacillus anthracis edema factor substrate specificity: evidence for new modes of action
Q90419622Bioengineering of Bordetella pertussis Adenylate Cyclase Toxin for Antigen-Delivery and Immunotherapy
Q35217146Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells.
Q30360778Bordetella adenylate cyclase toxin is a unique ligand of the integrin complement receptor 3
Q34399010Both lethal and edema toxins of Bacillus anthracis disrupt the human dendritic cell chemokine network
Q34994573Ca2+ influx and tyrosine kinases trigger Bordetella adenylate cyclase toxin (ACT) endocytosis. Cell physiology and expression of the CD11b/CD18 integrin major determinants of the entry route
Q34807865Calpain-Mediated Processing of Adenylate Cyclase Toxin Generates a Cytosolic Soluble Catalytically Active N-Terminal Domain.
Q27010363Cellular and physiological effects of anthrax exotoxin and its relevance to disease
Q54979011Compartmentalized Cyclic AMP Production by the Bordetella pertussis and Bacillus anthracis Adenylate Cyclase Toxins Differentially Affects the Immune Synapse in T Lymphocytes.
Q64121539Edema Toxin Inhibits Efferocytosis in Human Macrophages and Alters Efferocytic Receptor Signaling
Q50041452Elevated cyclic AMP Inhibits Mycobacterium tuberculosis-stimulated T cell IFN-γ Secretion through type I Protein Kinase A.
Q35726627Natural cutaneous anthrax infection, but not vaccination, induces a CD4(+) T cell response involving diverse cytokines
Q37935265New insights into the biological effects of anthrax toxins: linking cellular to organismal responses
Q41649263Odorants specifically modulate chemotaxis and tissue retention of CD4+ T cells via cyclic adenosine monophosphate induction
Q28392599Passive Immunotherapy Protects against Enteric Invasion and Lethal Sepsis in a Murine Model of Gastrointestinal Anthrax
Q24602050Pertussis toxin and adenylate cyclase toxin: key virulence factors of Bordetella pertussis and cell biology tools
Q30416562Quantification of the adenylate cyclase toxin of Bordetella pertussis in vitro and during respiratory infection
Q30425735Role of CD11b/CD18 in the process of intoxication by the adenylate cyclase toxin of Bordetella pertussis
Q37954335T cell targeting by anthrax toxins: two faces of the same coin
Q30301113The Bordetella adenylate cyclase repeat-in-toxin (RTX) domain is immunodominant and elicits neutralizing antibodies
Q35213542The Bordetella pertussis adenylate cyclase toxin binds to T cells via LFA-1 and induces its disengagement from the immune synapse
Q37955761The myriad roles of cyclic AMP in microbial pathogens: from signal to sword
Q38129761The virulence factors of Bordetella pertussis: talented modulators of host immune response.
Q36540595Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection
Q37954284Toxins-useful biochemical tools for leukocyte research

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