Safety evaluation of ruxolitinib for treating myelofibrosis

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Safety evaluation of ruxolitinib for treating myelofibrosis is …
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scholarly articleQ13442814

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P356DOI10.1517/14740338.2014.916273
P698PubMed publication ID24896661

P2093author name stringClaire Harrison
Donal McLornan
Sofia Galli
P2860cites workThe JAK-inhibitor ruxolitinib impairs dendritic cell function in vitro and in vivoQ43451422
Progressive multifocal leukoencephalopathy associated with ruxolitinibQ44509111
Bilateral toxoplasmosis retinitis associated with ruxolitinibQ44909357
Reactivation of hepatitis B virus infection following ruxolitinib treatment in a patient with myelofibrosis.Q45350105
Rapid and long-lasting decrease of T-regulatory cells in patients with myelofibrosis treated with ruxolitinib.Q46891342
Population pharmacokinetic analysis of orally-administered ruxolitinib (INCB018424 Phosphate) in patients with primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (PPV-MF) or post-essential thrombocythemia myelofibrosis (PET MF).Q50990686
Ruxolitinib is a potent immunosuppressive compound: is it time for anti-infective prophylaxis?Q54393708
The pharmacokinetics, pharmacodynamics, and safety of orally dosed INCB018424 phosphate in healthy volunteers.Q54618299
Somatic CALR mutations in myeloproliferative neoplasms with nonmutated JAK2Q24568313
Jakpot! New small molecules in autoimmune and inflammatory diseasesQ27001957
Constitutive activation of STAT transcription factors in acute myelogenous leukemiaQ28207618
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infectionQ29616521
Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosisQ33391880
Serious adverse events during ruxolitinib treatment discontinuation in patients with myelofibrosisQ33397838
JAK inhibition with ruxolitinib versus best available therapy for myelofibrosisQ33399977
A double-blind, placebo-controlled trial of ruxolitinib for myelofibrosisQ33399980
A phase I study of panobinostat (LBH589) in patients with primary myelofibrosis (PMF) and post-polycythaemia vera/essential thrombocythaemia myelofibrosis (post-PV/ET MF).Q33405372
Three-year efficacy, safety, and survival findings from COMFORT-II, a phase 3 study comparing ruxolitinib with best available therapy for myelofibrosisQ33411211
Romiplostim-induced myelofibrosisQ33411218
A phase 2 study of ruxolitinib, an oral JAK1 and JAK2 Inhibitor, in patients with advanced polycythemia vera who are refractory or intolerant to hydroxyureaQ33411637
Interim analysis of safety and efficacy of ruxolitinib in patients with myelofibrosis and low platelet countsQ33411755
Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: therapeutic implications for the treatment of myeloproliferative neoplasmsQ34021151
Kinase domain mutations confer resistance to novel inhibitors targeting JAK2V617F in myeloproliferative neoplasmsQ34021753
Metabolism, excretion, and pharmacokinetics of [14C]INCB018424, a selective Janus tyrosine kinase 1/2 inhibitor, in humansQ34023419
Somatic mutations of calreticulin in myeloproliferative neoplasmsQ34039270
An opportunistic infection associated with ruxolitinib, a novel janus kinase 1,2 inhibitorQ34343220
Safety and efficacy of everolimus, a mTOR inhibitor, as single agent in a phase 1/2 study in patients with myelofibrosis.Q36003480
Targeting JAK1/2 and mTOR in murine xenograft models of Ph-like acute lymphoblastic leukemiaQ36352535
Scouting out the neighborhood in AIDS-related lymphomaQ37026748
Establishing optimal quantitative-polymerase chain reaction assays for routine diagnosis and tracking of minimal residual disease in JAK2-V617F-associated myeloproliferative neoplasms: a joint European LeukemiaNet/MPN&MPNr-EuroNet (COST action BM090Q37250169
Comparison of placebo and best available therapy for the treatment of myelofibrosis in the phase 3 COMFORT studiesQ37552023
Genetic and epigenetic complexity in myeloproliferative neoplasmsQ37967274
Allogeneic stem cell transplantation for myelofibrosis in 2012.Q37998567
Ruxolitinib for the treatment of myelofibrosis: a NICE single technology appraisal.Q38133381
Therapeutic targeting of the Jak/STAT pathway.Q38155957
Resolution of bone marrow fibrosis in a patient receiving JAK1/JAK2 inhibitor treatment with ruxolitinibQ38444153
Heterodimeric JAK-STAT activation as a mechanism of persistence to JAK2 inhibitor therapyQ38824881
Revised response criteria for myelofibrosis: International Working Group-Myeloproliferative Neoplasms Research and Treatment (IWG-MRT) and European LeukemiaNet (ELN) consensus reportQ40045490
Health-related quality of life and symptoms in patients with myelofibrosis treated with ruxolitinib versus best available therapyQ40247865
Management of cytopenias in patients with myelofibrosis treated with ruxolitinib and effect of dose modifications on efficacy outcomesQ41836418
Phase 2 study of the JAK kinase inhibitor ruxolitinib in patients with refractory leukemias, including postmyeloproliferative neoplasm acute myeloid leukemiaQ42720284
A unified definition of clinical resistance and intolerance to hydroxycarbamide in polycythaemia vera and primary myelofibrosis: results of a European LeukemiaNet (ELN) consensus processQ43237567
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectmyelofibrosisQ1752571
ruxolitinibQ7383611
P304page(s)967-976
P577publication date2014-06-04
P1433published inExpert Opinion on Drug SafetyQ5421206
P1476titleSafety evaluation of ruxolitinib for treating myelofibrosis
P478volume13

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cites work (P2860)
Q38586421A comprehensive review of pacritinib in myelofibrosis
Q33605624Experience with ruxolitinib in the treatment of polycythaemia vera
Q90291421Fungal Infections with Ibrutinib and Other Small-Molecule Kinase Inhibitors
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Q36232824JAK2 inhibition has different therapeutic effects according to myeloproliferative neoplasm development in mice
Q92147338Life after ruxolitinib: Reasons for discontinuation, impact of disease phase, and outcomes in 218 patients with myelofibrosis
Q33438420Ruxolitinib for symptom control in patients with chronic lymphocytic leukaemia: a single-group, phase 2 trial
Q33419865Ruxolitinib: a review of its use in patients with myelofibrosis
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Q40085126Which patients with myelofibrosis should receive ruxolitinib therapy? ELN-SIE evidence-based recommendations.