Ombrabulin plus cisplatin versus placebo plus cisplatin in patients with advanced soft-tissue sarcomas after failure of anthracycline and ifosfamide chemotherapy: a randomised, double-blind, placebo-controlled, phase 3 trial

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Ombrabulin plus cisplatin versus placebo plus cisplatin in patients with advanced soft-tissue sarcomas after failure of anthracycline and ifosfamide chemotherapy: a randomised, double-blind, placebo-controlled, phase 3 trial is …
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scholarly articleQ13442814

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P356DOI10.1016/S1470-2045(15)70102-6
P698PubMed publication ID25864104

P50authorJean-Yves BlayQ37842284
Armando SantoroQ56335956
Nicolas PenelQ56381073
Emmanuelle BompasQ89340670
George D DemetriQ96229532
Nicolas IsambertQ114440231
Sant P ChawlaQ114447881
Didier CupissolQ114725572
Arthur P StaddonQ116794138
Zsuzsanna PápaiQ116794186
P2093author name stringAnthony W Tolcher
Fabio A Franke
Antonio López-Pousa
Antoine Italiano
Esma Saâda-Bouzid
Solenn Le-Guennec
Patrick Cohen
Nada Babovic
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DISRUPT: a randomised phase 2 trial of ombrabulin (AVE8062) plus a taxane-platinum regimen as first-line therapy for metastatic non-small cell lung cancer.Q52650698
A novel combretastatin A-4 derivative, AC-7700, shows marked antitumor activity against advanced solid tumors and orthotopically transplanted tumors.Q55241476
Cisplatin. A phase II evaluation in previously untreated patients with soft tissue sarcomasQ69745434
Phase II study of a combination of mitomycin, doxorubicin and cisplatin in advanced sarcomasQ70092359
Determination of vascular endothelial growth factor (VEGF) overexpression in soft tissue sarcomas and the role of overexpression in leiomyosarcomaQ79255416
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P433issue5
P921main subjectplaceboQ269829
cisplatinQ412415
ifosfamideQ418560
chemotherapyQ974135
phase III clinical trialQ42824827
P304page(s)531-540
P577publication date2015-04-08
P1433published inLancet Oncology CommissionQ13747613
P1476titleOmbrabulin plus cisplatin versus placebo plus cisplatin in patients with advanced soft-tissue sarcomas after failure of anthracycline and ifosfamide chemotherapy: a randomised, double-blind, placebo-controlled, phase 3 trial
P478volume16

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