Phase Ib trial of the PI3K/mTOR inhibitor voxtalisib (SAR245409) in combination with chemoimmunotherapy in patients with relapsed or refractory B-cell malignancies

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Phase Ib trial of the PI3K/mTOR inhibitor voxtalisib (SAR245409) in combination with chemoimmunotherapy in patients with relapsed or refractory B-cell malignancies is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/BJH.14181
P698PubMed publication ID27293194

P2093author name stringLei Gao
Lia Gore
Jyoti Sharma
Luciano J Costa
Farrukh T Awan
Joanne Lager
P2860cites workA phase II trial of the oral mTOR inhibitor everolimus in relapsed aggressive lymphomaQ24607479
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MCL-1 and BCL-xL-dependent resistance to the BCL-2 inhibitor ABT-199 can be overcome by preventing PI3K/AKT/mTOR activation in lymphoid malignanciesQ33419789
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Integrative genomic analysis implicates gain of PIK3CA at 3q26 and MYC at 8q24 in chronic lymphocytic leukemiaQ37037294
PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphomaQ37049376
Molecular mechanisms of resistance to Rituximab and pharmacologic strategies for its circumventionQ37448352
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Dual PI3K/mTOR inhibition is required to effectively impair microenvironment survival signals in mantle cell lymphoma.Q38957093
The dual PI3K and mTOR inhibitor NVP-BEZ235 exhibits anti-proliferative activity and overcomes bortezomib resistance in mantle cell lymphoma cellsQ39353496
Activation of the PI3K/AKT/mTOR pathway in diffuse large B cell lymphoma: clinical significance and inhibitory effect of rituximabQ39426629
Activated phosphoinositide 3-kinase/AKT signaling confers resistance to trastuzumab but not lapatinibQ39700483
Phosphatidylinositol 3'-kinase catalytic subunit alpha gene amplification contributes to the pathogenesis of mantle cell lymphomaQ39805170
Preferential chemosensitization of PTEN-mutated prostate cells by silencing the Akt kinaseQ40156585
Selective inhibitors of phosphoinositide 3-kinase delta: modulators of B-cell function with potential for treating autoimmune inflammatory diseases and B-cell malignanciesQ42320922
High immunohistochemical expression of p-AKT predicts inferior survival in patients with diffuse large B-cell lymphoma treated with immunochemotherapyQ43143099
Revised response criteria for malignant lymphomaQ47582438
Efficacy, safety, pharmacokinetics and pharmacodynamics of SAR245409 (voxtalisib, XL765), an orally administered phosphoinositide 3-kinase/mammalian target of rapamycin inhibitor: a phase 1 expansion cohort in patients with relapsed or refractory lyQ54316519
Phase I Trial of the Pan-PI3K Inhibitor Pilaralisib (SAR245408/XL147) in Patients with Chronic Lymphocytic Leukemia (CLL) or Relapsed/Refractory Lymphoma.Q55062120
Phase I Safety, Pharmacokinetic, and Pharmacodynamic Study of SAR245409 (XL765), a Novel, Orally Administered PI3K/mTOR Inhibitor in Patients with Advanced Solid TumorsQ58614417
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)55-65
P577publication date2016-06-13
P1433published inBritish Journal of HaematologyQ4970200
P1476titlePhase Ib trial of the PI3K/mTOR inhibitor voxtalisib (SAR245409) in combination with chemoimmunotherapy in patients with relapsed or refractory B-cell malignancies
P478volume175

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cites work (P2860)
Q89599313Is There a Role for Dual PI3K/mTOR Inhibitors for Patients Affected with Lymphoma?
Q92258777Overview of Current Targeted Anti-Cancer Drugs for Therapy in Onco-Hematology
Q92035420PI3K/mTOR inhibition of IDH1 mutant glioma leads to reduced 2HG production that is associated with increased survival
Q55010628Pre-clinical activity of targeting the PI3K/Akt/mTOR pathway in Burkitt lymphoma.
Q46675870Rituximab in B-Cell Hematologic Malignancies: A Review of 20 Years of Clinical Experience

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