Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors

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Phase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1030443771
P356DOI10.1007/S10637-016-0407-Y
P932PMC publication ID5893501
P698PubMed publication ID27917453

P2093author name stringAndrew J Brenner
Andreas G Bader
Susan Smith
David S Hong
Yoon-Koo Kang
Sinil Kim
Muhammad S Beg
Mitesh Borad
Jasgit Sachdev
Jay Stoudemire
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The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44Q24617130
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dsRNA-activation of TLR3 and RLR signaling: gene induction-dependent and independent effectsQ26864048
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The miR-34 family in cancer and apoptosisQ28245865
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MicroRNA profiling of BRCA1/2 mutation-carrying and non-mutation-carrying high-grade serous carcinomas of ovaryQ33508232
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MicroRNA-34a enhances T cell activation by targeting diacylglycerol kinase ζ.Q35023511
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Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in miceQ35086711
Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- and tissue-specific microRNAsQ35189998
Increased microRNA-34b and -34c predominantly expressed in stromal tissues is associated with poor prognosis in human colon cancerQ35496606
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TP53-independent function of miR-34a via HDAC1 and p21(CIP1/WAF1.).Q37181402
A phase 1 study of the BCL2-targeted deoxyribonucleic acid inhibitor (DNAi) PNT2258 in patients with advanced solid tumorsQ37539213
Developing therapeutic microRNAs for cancerQ37543146
Quantification of therapeutic miRNA mimics in whole blood from nonhuman primatesQ37696858
Activation of complement by therapeutic liposomes and other lipid excipient-based therapeutic products: prediction and preventionQ37905250
P433issue2
P304page(s)180-188
P577publication date2016-12-05
P1433published inInvestigational New DrugsQ2312231
P1476titlePhase I study of MRX34, a liposomal miR-34a mimic, administered twice weekly in patients with advanced solid tumors
P478volume35

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