A phase I trial of intravenously-administered recombinant tumor necrosis factor-alpha in cancer patients

scientific article published on August 1, 1988

A phase I trial of intravenously-administered recombinant tumor necrosis factor-alpha in cancer patients is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1200/JCO.1988.6.8.1328
P953full work available at URLhttp://intl.jco.org/cgi/content/abstract/6/8/1328
https://ascopubs.org/doi/pdfdirect/10.1200/JCO.1988.6.8.1328
P698PubMed publication ID3411344

P50authorMoshe TalpazQ87650933
P2093author name stringJ. U. Gutterman
R. Kurzrock
B. Feinberg
S. Saks
M. Blick
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectphase I clinical trialQ5452194
oncologyQ162555
P304page(s)1328-1334
P577publication date1988-08-01
P1433published inJournal of Clinical OncologyQ400292
P1476titleA phase I trial of intravenously-administered recombinant tumor necrosis factor-alpha in cancer patients
P478volume6

Reverse relations

cites work (P2860)
Q55001725A New Venue of TNF Targeting.
Q55241476A novel combretastatin A-4 derivative, AC-7700, shows marked antitumor activity against advanced solid tumors and orthotopically transplanted tumors.
Q38015061Biological response modifiers in the management of patients with breast cancer
Q42482850Cellular and cytokine responses of the human central nervous system to intracranial administration of tumor necrosis factor α for the treatment of malignant gliomas
Q36589103Central Nervous System Toxicity of Biological Response Modifiers
Q36081325Changes in endogenous cytokines, adhesion molecules and platelets during cytokine-induced tumour necrosis.
Q36363709Circadian dynamics of tumor necrosis factor alpha (cachectin) lethality
Q37068894Combination of Gold Nanoparticle-Conjugated Tumor Necrosis Factor-α and Radiation Therapy Results in a Synergistic Antitumor Response in Murine Carcinoma Models.
Q36422849Combinational adenovirus-mediated gene therapy and dendritic cell vaccine in combating well-established tumors
Q34479801Cytokine deregulation in cancer
Q67993236Differential sensitivity of renal cell carcinoma xenografts towards therapy with interferon-alpha, interferon-gamma, tumor necrosis factor and their combinations
Q39123611Dyslipidemia in systemic lupus erythematosus
Q84845719Early effect of hepatic artery TNF-alpha infusion on systemic hemodynamics and inflammation: a dose-response study in pigs
Q33356537Efficacy of monoclonal antibody against human recombinant tumor necrosis factor in E. coli-challenged swine
Q44586795Elevated triglycerides and low levels of high-density lipoprotein as markers of disease activity in association with up-regulation of the tumor necrosis factor alpha/tumor necrosis factor receptor system in systemic lupus erythematosus
Q40785400Gene delivery from the E3 region of replicating human adenovirus: evaluation of the 6.7 K/gp19 K region
Q43710400Gene delivery from the E3 region of replicating human adenovirus: evaluation of the ADP region
Q35925611Gene therapy strategies to improve the effectiveness of cancer radiotherapy
Q71988414High dose recombinant tumour necrosis factor (rTNFα) administered by isolation perfusion for advanced tumours of the limbs: a model for biochemotherapy of cancer
Q39227872High dose tumor necrosis factor-alpha and melphalan administered via isolated limb perfusion for advanced limb soft tissue sarcoma results in a >90% response rate and limb preservation
Q42150777High serum levels of TNF-α after its administration for isolation perfusion of the limb
Q38221692Immunotherapeutic and oncolytic viral therapeutic strategies in pancreatic cancer
Q33177384In vivo isolated kidney perfusion with tumour necrosis factor alpha (TNF-alpha) in tumour-bearing rats
Q40641645Induction of tumor necrosis factor-alpha as a cause of bleomycin-related toxicity
Q64906046Inflammatory Signaling in Hypertension: Regulation of Adrenal Catecholamine Biosynthesis.
Q41703227Inhibition of protein synthesis enhances the lytic effects of tumor necrosis factor alpha and interferon gamma in cell lines derived from gynecological malignancies
Q41353348Inhibitory effects of tamoxifen and tumor necrosis factor alpha on human glioblastoma cells
Q36869456Interleukins. Clinical pharmacokinetics and practical implications
Q35711884Intralesional tumour necrosis factor combined with interferon gamma in metastatic melanoma
Q33180138Intrapleural administration of tumour necrosis factor-alpha (TNFalpha) in patients with mesothelioma: cytokine patterns and acute-phase protein response
Q41911282Isolated hepatic perfusion in the pig with TNF-alpha with and without melphalan
Q36838339Isolated limb perfusion with tumor necrosis factor and melphalan for limb salvage in 186 patients with locally advanced soft tissue extremity sarcomas. The cumulative multicenter European experience
Q41062002Isolated perfusion of the kidney with tumor necrosis factor for localized renal-cell carcinoma.
Q36421633Liver and tumour tissue concentrations of TNF-alpha in cancer patients treated with TNF-alpha and melphalan by isolated liver perfusion
Q33180936Low-dose tumor necrosis factor-alpha augments antitumor activity of stealth liposomal doxorubicin (DOXIL) in soft tissue sarcoma-bearing rats
Q54064832NF-kappaB determines between apoptosis and proliferation in hepatocytes during liver regeneration.
Q30832764NF-κB signalling and cell fate decisions in response to a short pulse of tumour necrosis factor.
Q43688712Novel tumor necrosis factor toxic effects. Pulmonary hemorrhage and severe hepatic dysfunction
Q33380199Phase 2 trial of recombinant tumor necrosis factor-alpha in combination with dactinomycin in children with recurrent Wilms tumor
Q40754298Phase I trial of recombinant human tumour necrosis factor α in patients with advanced malignancy
Q40582599Possible involvement of cytokines in diffuse intravascular coagulation and thrombosis
Q36764997Randomized phase III multi-institutional study of TNFerade biologic with fluorouracil and radiotherapy for locally advanced pancreatic cancer: final results
Q67720624Regional biologic therapy. Hepatic arterial infusion of recombinant human tumor necrosis factor in patients with liver metastases
Q37054005Role of Eicosanoids and the Cytokine Network in Transmembrane Signaling in Vascular Cells
Q40436403Signal Transduction in Atherosclerosis: Second Messengers and Regulation of Cellular Cholesterol Trafficking
Q29616428Signalling pathways of the TNF superfamily: a double-edged sword
Q60060706Squalene synthase: Structure and regulation
Q37167995Systemic lupus erythematosus and cardiovascular disease.
Q35640180Systemic use of tumor necrosis factor alpha as an anticancer agent
Q53923210TNF-alpha: a link between hypertriglyceridaemia and inflammation in SLE patients with cardiovascular disease.
Q39529070TNF-dependent signaling pathways in liver cancer: promising targets for therapeutic strategies?.
Q45855568TNFerade Biologic: preclinical toxicology of a novel adenovector with a radiation-inducible promoter, carrying the human tumor necrosis factor alpha gene
Q91709254Targeted enhancement of the therapeutic window of L19-TNF by transient and selective inhibition of RIPK1-signaling cascade
Q99557580Targeting co-stimulatory molecules in autoimmune disease
Q35196479The Therapeutic Potential of Interleukin-1 and Tumor Necrosis Factor on Hematopoietic Stem Cells
Q39439223The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress
Q45882007Transgene expression of alpha tumor necrosis factor with mutations D142N and A144R under control of human telomerase reverse transcriptase promoter eradicates well-established tumors and induces long-term antitumor immunity
Q40761921Treatment of cancer patients with recombinant interferon-gamma induces release of endogenous tumor necrosis factor-alpha
Q37965274Tumor necrosis factor: an update on basic research and clinical applications
Q40665218Tumour necrosis factor: the decline and fall of a biological agent and its resurrection
Q39345885Use of human MonoMac6 cells for development of in vitro assay predictive of adjuvant safety in vivo
Q44712586Use of soluble recombinant TNF receptor to improve detection of TNF secretion in cultures of tumor infiltrating lymphocytes

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