The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load

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The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load is …
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scholarly articleQ13442814

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P819ADS bibcode2009PLoSO...4.5872H
P356DOI10.1371/JOURNAL.PONE.0005872
P932PMC publication ID2689931
P698PubMed publication ID19516902
P5875ResearchGate publication ID26283041

P50authorAnnelli SandbaekQ100693264
Karina BanasikQ55754910
Charlotta PisingerQ67741218
Oluf Borbye PedersenQ29583849
Knut Borch-JohnsenQ30431778
Torsten LauritzenQ30435282
P2093author name stringShiro Maeda
Torben Hansen
Johan Holmkvist
Hiroyuki Unoki
Gitte Andersen
Sören Brunak
Thomas Skot Jensen
P2860cites workRequirement of a macromolecular signaling complex for beta adrenergic receptor modulation of the KCNQ1-KCNE1 potassium channelQ24292184
Mutation of an A-kinase-anchoring protein causes long-QT syndromeQ24304235
Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmiasQ24314905
Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11pQ77829278
Glucose-dependent regulation of rhythmic action potential firing in pancreatic beta-cells by K(ATP)-channel modulationQ44232785
Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetesQ44286433
A randomized non-pharmacological intervention study for prevention of ischaemic heart disease: baseline results Inter99.Q44685218
Studies of association of variants near the HHEX, CDKN2A/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies.Q50546010
The BIGTT test: a novel test for simultaneous measurement of pancreatic beta-cell function, insulin sensitivity, and glucose tolerance.Q51479764
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.Q53532459
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populationsQ57502502
A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndromeQ24318498
PLINK: a tool set for whole-genome association and population-based linkage analysesQ24677407
Action potentials and insulin secretion: new insights into the role of Kv channelsQ27865199
Polymorphisms in the gene encoding the voltage-dependent Ca(2+) channel Ca (V)2.3 (CACNA1E) are associated with type 2 diabetes and impaired insulin secretionQ28253128
A genome-wide association study identifies novel risk loci for type 2 diabetesQ28287727
Effects of I(Ks) channel inhibitors in insulin-secreting INS-1 cellsQ28575969
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetesQ28680760
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variantsQ29547210
Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levelsQ29547214
Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultationQ29547453
A human phenome-interactome network of protein complexes implicated in genetic disordersQ29614448
A variant in CDKAL1 influences insulin response and risk of type 2 diabetesQ29614878
The long QT syndrome. Prospective longitudinal study of 328 familiesQ33156679
Members of the Kv1 and Kv2 voltage-dependent K(+) channel families regulate insulin secretionQ34084555
Common variants at ten loci modulate the QT interval duration in the QTSCD StudyQ34289629
KCNQ potassium channels: physiology, pathophysiology, and pharmacologyQ34305841
hKCNE4 inhibits the hKCNQ1 potassium current without affecting the activation kineticsQ34393715
Expression and function of pancreatic beta-cell delayed rectifier K+ channels. Role in stimulus-secretion couplingQ34409327
QT interval, cardiovascular risk factors and risk of death in diabetesQ35765865
Pharmacological properties and functional role of Kslow current in mouse pancreatic beta-cells: SK channels contribute to Kslow tail current and modulate insulin secretionQ36493671
Anchoring of protein kinase A facilitates hormone-mediated insulin secretionQ36834213
Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: a study of 3,734 subjects comprising three ethnicities living in SingaporeQ37193658
Common variants at ten loci influence QT interval duration in the QTGEN StudyQ37240241
Studies of variations of the cyclin-dependent kinase inhibitor 1C and the cyclin-dependent kinase 4 genes in relation to type 2 diabetes mellitus and related quantitative traitsQ42476798
Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion.Q44149480
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjecttype 2 diabetesQ3025883
preproinsulinQ7240673
P304page(s)e5872
P577publication date2009-06-11
P1433published inPLOS OneQ564954
P1476titleThe type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load
P478volume4