| scholarly article | Q13442814 |
| P356 | DOI | 10.1038/NCHEMBIO.188 |
| P2888 | exact match | https://scigraph.springernature.com/pub.10.1038/nchembio.188 |
| P698 | PubMed publication ID | 19561619 |
| P5875 | ResearchGate publication ID | 26325714 |
| P50 | author | Herbert Waldmann | Q1609256 |
| Tudor I Oprea | Q38323677 | ||
| Luc Brunsveld | Q41551687 | ||
| Daniel Rauh | Q55447453 | ||
| Willem A. Van Otterlo | Q79881113 | ||
| Marta Dominguez Seoane | Q84136224 | ||
| Ansgar Schuffenhauer | Q101211547 | ||
| Peter Ertl | Q27768873 | ||
| P2093 | author name string | Sabine Möcklinghoff | |
| Stefan Wetzel | |||
| Steffen Renner | |||
| Dieter Steinhilber | |||
| Bettina Hofmann | |||
| P2860 | cites work | Chemistry and biology of the aeruginosin family of serine protease inhibitors | Q37030738 |
| Tetrahydroisoquinolines as subtype selective estrogen agonists/antagonists | Q40559457 | ||
| Detection and assignment of common scaffolds in project databases of lead molecules | Q45034619 | ||
| Discovery of a new class of inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase B by biology-oriented synthesis | Q46499033 | ||
| Virtual and biomolecular screening converge on a selective agonist for GPR30. | Q46978096 | ||
| Three-dimensional quantitative structure-activity relationship study of nonsteroidal estrogen receptor ligands using the comparative molecular field analysis/cross-validated r2-guided region selection approach | Q47956201 | ||
| The scaffold tree--visualization of the scaffold universe by hierarchical scaffold classification | Q48082132 | ||
| Prediction of biological targets for compounds using multiple-category Bayesian models trained on chemogenomics databases. | Q51941401 | ||
| Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl)thiazole and methoxytetrahydropyran hybrids. | Q54033516 | ||
| Clustering and Rule-Based Classifications of Chemical Structures Evaluated in the Biological Activity Space | Q56919019 | ||
| Refined structure of alpha beta-tubulin at 3.5 A resolution | Q27636088 | ||
| Nonlinear partial differential equations and applications: The mechanism of topoisomerase I poisoning by a camptothecin analog | Q27639935 | ||
| On the size of the active site in proteases. I. Papain | Q27860826 | ||
| Can we rationally design promiscuous drugs? | Q28294268 | ||
| Ligand efficiency: a useful metric for lead selection | Q29617403 | ||
| Molecular recognition: the fragment approach in lead generation. | Q30339034 | ||
| Charting biologically relevant chemical space: a structural classification of natural products (SCONP) | Q30351855 | ||
| Discovery of novel quinoline-based estrogen receptor ligands using peptide interaction profiling | Q31153963 | ||
| Biology-inspired synthesis of compound libraries | Q33314572 | ||
| Nuclear receptor ligand-binding domains: three-dimensional structures, molecular interactions and pharmacological implications | Q33922947 | ||
| Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis | Q34771016 | ||
| The shape of things to come: structural and synthetic studies of taxol and related compounds | Q35996314 | ||
| Drugs in other drugs: a new look at drugs as fragments | Q36697422 | ||
| A decade of fragment-based drug design: strategic advances and lessons learned | Q36732253 | ||
| P433 | issue | 8 | |
| P304 | page(s) | 585-592 | |
| P577 | publication date | 2009-06-28 | |
| P1433 | published in | Nature Chemical Biology | Q904026 |
| P1476 | title | Bioactivity-guided mapping and navigation of chemical space | |
| P478 | volume | 5 |
| Q57006878 | A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-Pyrones |
| Q38074314 | A conceptual framework for analysing and planning synthetic approaches to diverse lead-like scaffolds |
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| Q42238354 | Anti-infectious drug repurposing using an integrated chemical genomics and structural systems biology approach. |
| Q57006604 | Biology-Oriented Synthesis of a Withanolide-Inspired Compound Collection Reveals Novel Modulators of Hedgehog Signaling |
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| Q21994385 | Challenges and Perspectives of Chemical Biology, a Successful Multidisciplinary Field of Natural Sciences |
| Q38911197 | Chemoinformatics as a Theoretical Chemistry Discipline |
| Q38843130 | Counting on natural products for drug design |
| Q35580160 | De novo branching cascades for structural and functional diversity in small molecules |
| Q33702000 | Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules |
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| Q52838826 | Efficient discovery of bioactive scaffolds by activity-directed synthesis. |
| Q46980948 | Enantiomeric scaffolding of α-tetralone and related scaffolds by EKR (enzymatic kinetic resolution) and stereoselective ketoreduction with ketoreductases. |
| Q34646772 | Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it. |
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| Q37995087 | Fragment informatics and computational fragment-based drug design: an overview and update |
| Q47626065 | Harnessing the potential of natural products in drug discovery from a cheminformatics vantage point |
| Q30581583 | Many approved drugs have bioactive analogs with different target annotations |
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| Q62496001 | Natural Products for Drug Discovery in the 21st Century: Innovations for Novel Drug Discovery |
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| Q33520510 | Principles, implementation, and application of biology-oriented synthesis (BIOS). |
| Q28296738 | Recent advances in the search for novel 5-lipoxygenase inhibitors |
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| Q37903716 | Similar interactions of natural products with biosynthetic enzymes and therapeutic targets could explain why nature produces such a large proportion of existing drugs |
| Q42562538 | Staring off into chemical space |
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| Q47099492 | Synthesis and Demonstration of the Biological Relevance of sp3 -rich Scaffolds Distantly Related to Natural Product Frameworks. |
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| Q39915228 | Towards a more robust approach to selecting and prosecuting promising targets and compounds |
| Q34039203 | Towards the systematic exploration of chemical space |
| Q41226155 | Unveiling (-)-Englerin A as a Modulator of L-Type Calcium Channels |
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