Myosin II motor proteins with different functions determine the fate of lamellipodia extension during cell spreading

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Myosin II motor proteins with different functions determine the fate of lamellipodia extension during cell spreading is …
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scholarly articleQ13442814

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P819ADS bibcode2010PLoSO...5.8560B
P356DOI10.1371/JOURNAL.PONE.0008560
P932PMC publication ID2797395
P698PubMed publication ID20052411
P5875ResearchGate publication ID40851227

P2093author name stringVenkaiah Betapudi
P2860cites workConditional expression of a truncated fragment of nonmuscle myosin II-A alters cell shape but not cytokinesis in HeLa cellsQ24290393
Vertebrate nonmuscle myosin II isoforms rescue small interfering RNA-induced defects in COS-7 cell cytokinesisQ24298237
Human nonmuscle myosin heavy chain mRNA: generation of diversity through alternative polyadenylylationQ24559682
Exchange of actin subunits at the leading edge of living fibroblasts: possible role of treadmillingQ24680491
Stress fibers are generated by two distinct actin assembly mechanisms in motile cellsQ24683694
Differential localization in cells of myosin II heavy chain kinases during cytokinesis and polarized migrationQ24799364
Structure of Ca 2+ -Bound S100A4 and Its Interaction with Peptides Derived from Nonmuscle Myosin-IIA †Q27650317
Cellular motility driven by assembly and disassembly of actin filamentsQ27860676
Cell migration: a physically integrated molecular processQ27860682
Cytokinesis depends on the motor domains of myosin-II in fission yeast but not in budding yeastQ27933611
The lamellipodium: where motility beginsQ28202993
Molecular mechanism of actin-dependent retrograde flow in lamellipodia of motile cellsQ28242574
Nonmuscle myosin II moves in new directionsQ28261837
Actin-based cell motility and cell locomotionQ28276582
Human nonmuscle myosin heavy chains are encoded by two genes located on different chromosomesQ28286152
Critical regions for assembly of vertebrate nonmuscle myosin IIQ28300801
Nonmuscle myosin IIA and IIB have distinct functions in the exocytosis-dependent process of cell membrane repairQ28512682
Cortical actin turnover during cytokinesis requires myosin II.Q46458346
Cytoplasmic dynamics of myosin IIA and IIB: spatial 'sorting' of isoforms in locomoting cells.Q47847401
A 29 residue region of the sarcomeric myosin rod is necessary for filament formation.Q52196141
Formation of focal adhesion-stress fibre complexes coordinated by adhesive and non-adhesive surface domainsQ56807383
Myosin IIA regulates cell motility and actomyosin–microtubule crosstalkQ58022519
Localization of myosin II A and B isoforms in cultured neuronsQ71290580
Myosin II is involved in transmitter release at synapses formed between rat sympathetic neurons in cultureQ72769775
Myosin IIB is required for growth cone motilityQ74316064
Myosin II functions in actin-bundle turnover in neuronal growth conesQ82661954
Localization of myosin II and V isoforms in cultured rat sympathetic neurones and their potential involvement in presynaptic functionQ28565854
Identification and characterization of nonmuscle myosin II-C, a new member of the myosin II familyQ28592899
Building the actin cytoskeleton: filopodia contribute to the construction of contractile bundles in the lamellaQ28755150
Molecular mechanism of actin-dependent retograde flow in lamellipodia of motile cellsQ29029756
Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent mannerQ29616027
Two distinct actin networks drive the protrusion of migrating cellsQ29617078
Activation of the interferon system by short-interfering RNAsQ29620341
Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cellsQ30311189
Regulation of protrusion, adhesion dynamics, and polarity by myosins IIA and IIB in migrating cellsQ30442995
Distinct pathways for the early recruitment of myosin II and actin to the cytokinetic furrowQ30480997
The role of myosin II in glioma invasion of the brainQ30482874
siRNA-mediated gene silencing: a global genome viewQ30500906
Lamellipodial actin mechanically links myosin activity with adhesion-site formationQ30834196
Retrograde flow rate is increased in growth cones from myosin IIB knockout miceQ30886604
MHC-IIB filament assembly and cellular localization are governed by the rod net chargeQ33317268
Pitx2a expression alters actin-myosin cytoskeleton and migration of HeLa cells through Rho GTPase signalingQ33953770
A novel myosin heavy chain gene in human chromosome 19q13.3.Q34221079
Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs).Q34365459
Spatiotemporal feedback between actomyosin and focal-adhesion systems optimizes rapid cell migrationQ34543645
Differential transmission of actin motion within focal adhesionsQ34598084
Mechanics and regulation of cytokinesisQ35804823
Myosin-IIA heavy-chain phosphorylation regulates the motility of MDA-MB-231 carcinoma cellsQ35942363
Regulation of myosin II during cytokinesis in higher eukaryotesQ36151437
Role of the COOH-terminal nonhelical tailpiece in the assembly of a vertebrate nonmuscle myosin rodQ36531810
Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cellsQ36603910
A conventional myosin motor drives neurite outgrowthQ36632367
Myosin II and mechanotransduction: a balancing act.Q36744365
Flux at focal adhesions: slippage clutch, mechanical gauge, or signal depotQ36758894
Myosin IIC: a third molecular motor driving neuronal dynamicsQ36854943
Multiple regulatory steps control mammalian nonmuscle myosin II assembly in live cellsQ37035180
Myosin IIA drives neurite retractionQ37155552
Myosin IIA is involved in the endocytosis of CXCR4 induced by SDF-1alphaQ40165747
Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migrationQ40223694
Distinct roles of nonmuscle myosin II isoforms in the regulation of MDA-MB-231 breast cancer cell spreading and migrationQ40285029
Periodic lamellipodial contractions correlate with rearward actin wavesQ40579490
Life at the leading edge: the formation of cell protrusionsQ40800590
Separate but linked functions of conventional myosins modulate adhesion and neurite outgrowthQ40833581
Myosin II activation promotes neurite retraction during the action of Rho and Rho-kinase.Q42829543
Differential localization of non-muscle myosin II isoforms and phosphorylated regulatory light chains in human MRC-5 fibroblastsQ43828057
Expression and characterization of a functional myosin head fragment in Dictyostelium discoideumQ44996597
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue1
P407language of work or nameEnglishQ1860
P304page(s)e8560
P577publication date2010-01-05
P1433published inPLOS OneQ564954
P1476titleMyosin II motor proteins with different functions determine the fate of lamellipodia extension during cell spreading
P478volume5

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cites work (P2860)
Q34772579A proteomic study of myosin II motor proteins during tumor cell migration
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Q53311944Contribution of myosin II activity to cell spreading dynamics.
Q27303946Cyclic tensile strain controls cell shape and directs actin stress fiber formation and focal adhesion alignment in spreading cells
Q39053492Deciphering acute coronary syndrome biomarkers: High-resolution proteomics in platelets, thrombi and microparticles.
Q55358385Different contributions of nonmuscle myosin IIA and IIB to the organization of stress fiber subtypes in fibroblasts.
Q36452882Dose-dependent proteomic analysis of glioblastoma cancer stem cells upon treatment with γ-secretase inhibitor
Q29347015Endogenous species of mammalian nonmuscle myosin IIA and IIB include activated monomers and heteropolymers.
Q42257455Focal adhesion kinases in adhesion structures and disease
Q57788041Genomic approaches in the search for molecular biomarkers in chronic kidney disease
Q37665359Integrin β1, myosin light chain kinase and myosin IIA are required for activation of PI3K-AKT signaling following MEK inhibition in metastatic triple negative breast cancer
Q27315008Involvement of local lamellipodia in endothelial barrier function
Q33563355LIMCH1 regulates nonmuscle myosin-II activity and suppresses cell migration
Q43168051Label-Free Quantitative Proteomic Analysis of Differentially Expressed Membrane Proteins of Pulmonary Alveolar Macrophages Infected with Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus and Its Attenuated Strain
Q33852054Life without double-headed non-muscle myosin II motor proteins
Q52650595Mammalian nonmuscle myosin II comes in three flavors.
Q83229072Myosin II isoforms play distinct roles in junction biogenesis
Q42207770Myosin IIA is essential for Shigella flexneri cell-to-cell spread.
Q30591181Myosin light chain kinase (MLCK) regulates cell migration in a myosin regulatory light chain phosphorylation-independent mechanism.
Q52364597New insights into the formation and the function of lamellipodia and ruffles in mesenchymal cell migration.
Q89501822Non-diabetic end-stage renal disease in Saudis associated with polymorphism of MYH9 gene but not UMOD gene
Q30582026Regulation of nonmuscle myosin II by tropomyosin
Q38110508Roles of ion transport in control of cell motility
Q39177650S100A4 downregulates filopodia formation through increased dynamic instability
Q48136749Self-sorting of nonmuscle myosins IIA and IIB polarizes the cytoskeleton and modulates cell motility.
Q35809950Significance of filamin A in mTORC2 function in glioblastoma
Q43187995Supervillin binds the Rac/Rho-GEF Trio and increases Trio-mediated Rac1 activation
Q27309144The role of myosin-II in force generation of DRG filopodia and lamellipodia
Q42582162Unraveling the determinants of protrusion formation
Q42676978VP15R from infectious spleen and kidney necrosis virus is a non-muscle myosin-II-binding protein

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