The CNK2 scaffold interacts with vilse and modulates Rac cycling during spine morphogenesis in hippocampal neurons

scientific article

The CNK2 scaffold interacts with vilse and modulates Rac cycling during spine morphogenesis in hippocampal neurons is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.CUB.2014.02.036
P932PMC publication ID4006347
P698PubMed publication ID24656827
P5875ResearchGate publication ID261032961

P2093author name stringMing Zhou
Deborah K Morrison
Junghwa Lim
Daniel A Ritt
P2860cites workCNK, a RAF-binding multidomain protein required for RAS signalingQ22008001
Mutations in ARHGEF6, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardationQ24290357
Densin-180, a synaptic protein, links to PSD-95 through its direct interaction with MAGUIN-1Q24311820
Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsionQ24555752
Vilse, a conserved Rac/Cdc42 GAP mediating Robo repulsion in tracheal cells and axonsQ24562721
Synapse formation is regulated by the signaling adaptor GIT1Q24675182
CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signalingQ27649887
MAGUIN, a novel neuronal membrane-associated guanylate kinase-interacting proteinQ28141792
Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and RlfQ28181747
WW and SH3 domains, two different scaffolds to recognize proline-rich ligandsQ28209648
Synaptic localization of membrane-associated guanylate kinase-interacting protein mediated by the pleckstrin homology domainQ28218901
The GIT/PIX complex: an oligomeric assembly of GIT family ARF GTPase-activating proteins and PIX family Rac1/Cdc42 guanine nucleotide exchange factorsQ28268247
PAK3 mutation in nonsyndromic X-linked mental retardationQ28281729
A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLCQ28574525
The CNK1 scaffold binds cytohesins and promotes insulin pathway signalingQ33998868
Intracellular signaling pathways that regulate dendritic spine morphogenesisQ34081322
Molecular mechanisms of dendritic spine development and remodelingQ34417235
The role of Rho GTPases and associated kinases in regulating neurite outgrowthQ34598154
Development of an optimized backbone of FRET biosensors for kinases and GTPasesQ35579824
Loss-of-Function CNKSR2 Mutation Is a Likely Cause of Non-Syndromic X-Linked Intellectual DisabilityQ35888720
Non-syndromic X-linked mental retardation: from a molecular to a clinical point of view.Q36029403
Growth of dendritic spines: a continuing storyQ36049223
Dendritic pathology in mental retardation: from molecular genetics to neurobiology.Q36471799
Spatio-temporal regulation of Rac1 and Cdc42 activity during nerve growth factor-induced neurite outgrowth in PC12 cellsQ44626769
CNK2 couples NGF signal propagation to multiple regulatory cascades driving cell differentiationQ47933019
Association of membrane-associated guanylate kinase-interacting protein-1 with Raf-1.Q49082500
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectmorphogenesisQ815547
Rho GTPase activating protein 39Q21135379
postsynapse organizationQ47009192
P304page(s)786-792
P577publication date2014-03-20
P1433published inCurrent BiologyQ1144851
P1476titleThe CNK2 scaffold interacts with vilse and modulates Rac cycling during spine morphogenesis in hippocampal neurons
P478volume24

Reverse relations

cites work (P2860)
Q92633738A de novo variant in the X-linked gene CNKSR2 is associated with seizures and mild intellectual disability in a female patient
Q47833656Aging-dependent expression of synapse-related proteins in the mouse brain.
Q53589124CNKSR2 deletions: a novel cause of X-linked intellectual disability and seizures.
Q90814272Disease-associated synaptic scaffold protein CNK2 modulates PSD size and influences localisation of the regulatory kinase TNIK
Q47773456Frequency of CNKSR2 mutation in the X-linked epilepsy-aphasia spectrum
Q36790831GIT1 enhances neurite outgrowth by stimulating microtubule assembly
Q47312401Identification of a basidiomycete-specific Vilse-like GTPase activating proteins (GAPs) and its roles in the production of virulence factors in Cryptococcus neoformans
Q30843681Important roles of Vilse in dendritic architecture and synaptic plasticity
Q61124672In vivo proximity proteomics of nascent synapses reveals a novel regulator of cytoskeleton-mediated synaptic maturation
Q28081571Mechanisms for spatiotemporal regulation of Rho-GTPase signaling at synapses
Q99562086Molecular architecture of postsynaptic Interactomes
Q89228311Neuronal GAP-Porf-2 transduces EphB1 signaling to brake axon growth
Q58562155Porf-2 = Arhgap39 = Vilse: A Pivotal Role in Neurodevelopment, Learning and Memory
Q36747190Porf-2 Inhibits Neural Stem Cell Proliferation Through Wnt/β-Catenin Pathway by Its GAP Domain
Q33753167Rac1 Guides Porf-2 to Wnt Pathway to Mediate Neural Stem Cell Proliferation
Q39329885Regulating Rac in the nervous system: molecular function and disease implication of Rac GEFs and GAPs.
Q34442643Structural plasticity: mechanisms and contribution to developmental psychiatric disorders
Q33856549Synaptic Interactome Mining Reveals p140Cap as a New Hub for PSD Proteins Involved in Psychiatric and Neurological Disorders
Q28118573X-exome sequencing of 405 unresolved families identifies seven novel intellectual disability genes

Search more.