scholarly article | Q13442814 |
P356 | DOI | 10.1021/BI060217R |
P8608 | Fatcat ID | release_hkxf4whog5cvddelkzygt2dkri |
P932 | PMC publication ID | 2796912 |
P698 | PubMed publication ID | 16669624 |
P5875 | ResearchGate publication ID | 7110254 |
P50 | author | Michel Lazdunski | Q1930803 |
Christiane Deregnaucourt | Q115583132 | ||
Joseph Schrével | Q115583756 | ||
Carole Guillaume | Q115583758 | ||
Morgane Rouault | Q125197254 | ||
Lachlan D. Rash | Q52150344 | ||
Thomas Maurin | Q58888402 | ||
Gérard Lambeau | Q63373800 | ||
José María Gutiérrez | Q42425503 | ||
Bruno Lomonte | Q43959570 | ||
P2093 | author name string | Michael H Gelb | |
Alain Doglio | |||
Stéphane Canaan | |||
Pierre Escoubas | |||
Eric Boilard | |||
James Bollinger | |||
P2860 | cites work | The N-terminal amino group essential for the biological activity of notexin from Notechis scutatus scutatus venom | Q68872076 |
Identification and properties of very high affinity brain membrane-binding sites for a neurotoxic phospholipase from the taipan venom | Q69351278 | ||
Evidence that the anti-coagulant and lethal properties of a basic phospholipase A2 from snake venom are unrelated | Q69611046 | ||
The role of Asp-49 and other conserved amino acids in phospholipases A2 and their importance for enzymatic activity | Q69613275 | ||
Nigexine, a phospholipase A2 from cobra venom with cytotoxic properties not related to esterase activity. Purification, amino acid sequence, and biological properties | Q69666552 | ||
The role of aspartic acid-49 in the active site of phospholipase A2. A site-specific mutagenesis study of porcine pancreatic phospholipase A2 and the rationale of the enzymatic activity of [lysine49]phospholipase A2 from Agkistrodon piscivorus pisci | Q70210923 | ||
Identification of functional involvement of tryptophan residues in phospholipase A2 from Naja naja atra (Taiwan cobra) snake venom | Q70481032 | ||
Inhibition of ACh release at an Aplysia synapse by neurotoxic phospholipases A2: specific receptors and mechanisms of action | Q70956187 | ||
Effects on behaviour and EEG of single chain phospholipases A2 from snake and bee venoms injected into rat brain: search for a functional antagonism | Q71340538 | ||
Presynaptic toxicity of the histidine-modified, phospholipase A2-inactive, β-bungarotoxin, crotoxin and notexin | Q72542771 | ||
Structural elements of secretory phospholipases A2 involved in the binding to M-type receptors | Q72631444 | ||
Role of the AGA/AGG codons, the rarest codons in global gene expression in Escherichia coli | Q72801102 | ||
Secretory phospholipase A2 potentiates glutamate-induced rat striatal neuronal cell death in vivo | Q73149256 | ||
Secreted phospholipase A(2) induces vascular endothelial cell migration | Q73219921 | ||
Biological Functions of Group X Secretory PLA2 | Q73403503 | ||
Catalytic significance of the specificity of divalent cations as KS* and kcat* cofactors for secreted phospholipase A2 | Q77217000 | ||
Roles of Trp31 in high membrane binding and proinflammatory activity of human group V phospholipase A2 | Q77336155 | ||
Differential interfacial and substrate binding modes of mammalian pancreatic phospholipases A2: a comparison among human, bovine, and porcine enzymes | Q77937486 | ||
Catalytic role of the active site histidine of porcine pancreatic phospholipase A2 probed by the variants H48Q, H48N and H48K | Q77945079 | ||
Introduction of a C-terminal aromatic sequence from snake venom phospholipases A2 into the porcine pancreatic isozyme dramatically changes the interfacial kinetics | Q78197325 | ||
Neuroprotection and peptide toxins | Q80093052 | ||
Basic amino acid residues in the beta-structure region contribute, but not critically, to presynaptic neurotoxicity of ammodytoxin A | Q80871557 | ||
Structures of the catalytic site mutants D99A and H48Q and the calcium-loop mutant D49E of phospholipase A2 | Q27617644 | ||
The crystal structure of the H48Q active site mutant of human group IIA secreted phospholipase A2 at 1.5 A resolution provides an insight into the catalytic mechanism | Q27640234 | ||
Enhanced activity and altered specificity of phospholipase A2 by deletion of a surface loop | Q27704523 | ||
Phospholipase A2 engineering. Deletion of the C-terminus segment changes substrate specificity and uncouples calcium and substrate binding at the zwitterionic interface | Q27733435 | ||
Structure of a snake venom phospholipase A2 modified by p-bromo-phenacyl-bromide | Q27760646 | ||
Site-directed mutagenesis by overlap extension using the polymerase chain reaction | Q27860503 | ||
Both group IB and group IIA secreted phospholipases A2 are natural ligands of the mouse 180-kDa M-type receptor | Q28511678 | ||
The expanding superfamily of phospholipase A(2) enzymes: classification and characterization | Q28609761 | ||
Phospholipase A2 enzymes | Q28609770 | ||
Anti-Plasmodium properties of group IA, IB, IIA and III secreted phospholipases A2 are serum-dependent | Q30829154 | ||
Bee venom phospholipase A2 induces stage-specific growth arrest of the intraerythrocytic Plasmodium falciparum via modifications of human serum components | Q30926042 | ||
Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymes | Q33339804 | ||
Receptors for a growing family of secreted phospholipases A2. | Q33633078 | ||
Secreted phospholipases A(2), a new class of HIV inhibitors that block virus entry into host cells | Q33858057 | ||
Search for relationships among the hemolytic, phospholipolytic, and neurotoxic activities of snake venoms | Q33959539 | ||
Conus venoms: a rich source of novel ion channel-targeted peptides | Q33975042 | ||
Localization of structural elements of bee venom phospholipase A2 involved in N-type receptor binding and neurotoxicity | Q34064227 | ||
A nutrient-regulated, dual localization phospholipase A(2) in the symbiotic fungus Tuber borchii | Q34082264 | ||
Increasing molecular diversity of secreted phospholipases A(2) and their receptors and binding proteins | Q34083759 | ||
Neuronal receptors for phospholipases A(2 )and beta-neurotoxicity. | Q34086613 | ||
What can venom phospholipases A(2) tell us about the functional diversity of mammalian secreted phospholipases A(2)? | Q34086618 | ||
A viral phospholipase A2 is required for parvovirus infectivity | Q34101246 | ||
Interfacial enzymology: the secreted phospholipase A(2)-paradigm. | Q34105620 | ||
In vitro neuromuscular activity of snake venoms | Q34143135 | ||
Structural effects of covalent inhibition of phospholipase A2 suggest allosteric coupling between membrane binding and catalytic sites | Q34180618 | ||
Phospholipase A(2). | Q34219384 | ||
Novel Mammalian Group XII Secreted Phospholipase A2Lacking Enzymatic Activity, | Q34265835 | ||
Cloning and expression of a membrane receptor for secretory phospholipases A2. | Q34348680 | ||
Phospholipase A2 myotoxins from Bothrops snake venoms | Q34391390 | ||
Equivalent effects of snake PLA2 neurotoxins and lysophospholipid-fatty acid mixtures | Q34474542 | ||
Anticoagulant venom and mammalian secreted phospholipases A(2): protein- versus phospholipid-dependent mechanism of action. | Q34574886 | ||
Interfacial binding of bee venom secreted phospholipase A2 to membranes occurs predominantly by a nonelectrostatic mechanism | Q45112088 | ||
A molecular mechanism for Lys49-phospholipase A2 activity based on ligand-induced conformational change. | Q45185592 | ||
Inflammatory events induced by Lys-49 and Asp-49 phospholipases A2 isolated from Bothrops asper snake venom: role of catalytic activity | Q45246214 | ||
Crystallographic and biochemical studies of the (inactive) Lys-49 phospholipase A2 from the venom of Agkistridon piscivorus piscivorus | Q45760670 | ||
Antimicrobial activity of myotoxic phospholipases A2 from crotalid snake venoms and synthetic peptide variants derived from their C-terminal region | Q46498997 | ||
Identification of vascular endothelial growth factor receptor-binding protein in the venom of eastern cottonmouth. A new role of snake venom myotoxic Lys49-phospholipase A2. | Q46598590 | ||
Do chemical modifications dissociate between the enzymatic and pharmacological activities of beta bungarotoxin and notexin? | Q46883839 | ||
Elapid venom toxins: multiple recruitments of ancient scaffolds | Q47730446 | ||
Tryptophan 110, a residue involved in the toxic activity but not in the enzymatic activity of notexin | Q48282908 | ||
Tryptophan residues of phospholipase A2 from the venom of an Australian elapid snake (Pseudechis australis) | Q50875285 | ||
Evidence for the regulatory role of the N-terminal helix of secretory phospholipase A(2) from studies on native and chimeric proteins. | Q51371213 | ||
Structural analysis of phospholipase A2 from functional perspective. 2. Characterization of a molten globule-like state induced by site-specific mutagenesis. | Q52534208 | ||
Unusual mode of binding of human group IIA secreted phospholipase A2 to anionic interfaces as studied by continuous wave and time domain electron paramagnetic resonance spectroscopy. | Q53872788 | ||
Tyr→Trp-substituted peptide 115-129 of a Lys49 phospholipase A2 expresses enhanced membrane-damaging activities and reproduces its in vivo myotoxic effect | Q57042082 | ||
Neuromuscular effects of nigexine, a basic phospholipase A2 from Naja nigricollis venom | Q62900129 | ||
complete amino-acid sequence of a non-neurotoxic, non-enzymatic phospholipase A2 homolog from the venom of the Australian tiger snake Notechis scutatus scutatus | Q67266276 | ||
IL-12: monoclonal antibodies specific for the 40-kDa subunit block receptor binding and biologic activity on activated human lymphoblasts | Q67698484 | ||
An essential tryptophan in the active site of phospholipase A2 from the venom of Bitis gabonica | Q67783381 | ||
Crystal structure of bovine pancreatic phospholipase A2 covalently inhibited by p-bromo-phenacyl-bromide | Q68394634 | ||
Identification and purification of a very high affinity binding protein for toxic phospholipases A2 in skeletal muscle | Q68461520 | ||
Codon usage bias and tRNA abundance in Drosophila | Q34743363 | ||
Phospholipase A2 receptor: a regulator of biological functions of secretory phospholipase A2. | Q34997924 | ||
Sodium channel toxins and neurotransmitter release. | Q35564768 | ||
Chemical modifications of phospholipases A2 from snake venoms: effects on catalytic and pharmacological properties | Q35690564 | ||
Mapping structural determinants of biological activities in snake venom phospholipases A2 by sequence analysis and site directed mutagenesis. | Q35690569 | ||
An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic action | Q35690573 | ||
Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicity | Q35690578 | ||
Natural phospholipase A(2) myotoxin inhibitor proteins from snakes, mammals and plants | Q35690590 | ||
Structure-function relationships and mechanism of anticoagulant phospholipase A2 enzymes from snake venoms | Q36143088 | ||
Phospholipase A2 engineering. Probing the structural and functional roles of N-terminal residues with site-directed mutagenesis, X-ray, and NMR. | Q36707402 | ||
Phospholipase A2 engineering. Structural and functional roles of the highly conserved active site residue aspartate-49. | Q36730095 | ||
Molecular aspects of neuronal voltage-dependent K+ channels | Q36890828 | ||
Active-site mutagenesis of a Lys49-phospholipase A2: biological and membrane-disrupting activities in the absence of catalysis | Q38292301 | ||
The importance of glycine-30 for enzymatic activity of phospholipase A2. | Q38336540 | ||
The C-terminal region of ammodytoxins is important but not sufficient for neurotoxicity | Q38360683 | ||
A model to explain the pharmacological effects of snake venom phospholipases A2. | Q38664430 | ||
A peptide derived from bee venom-secreted phospholipase A2 inhibits replication of T-cell tropic HIV-1 strains via interaction with the CXCR4 chemokine receptor. | Q39001849 | ||
Ammodytoxins, potent presynaptic neurotoxins, are also highly efficient phospholipase A2 enzymes | Q40374806 | ||
Cellular distribution, post-translational modification, and tumorigenic potential of human group III secreted phospholipase A(2). | Q40428682 | ||
Identification of the myotoxic site of the Lys49 phospholipase A(2) from Agkistrodon piscivorus piscivorus snake venom: synthetic C-terminal peptides from Lys49, but not from Asp49 myotoxins, exert membrane-damaging activities | Q40789423 | ||
Binding proteins on synaptic membranes for certain phospholipases A2 with presynaptic toxicity. | Q41049299 | ||
Proliferative effect of ammodytin L from the venom of Vipera ammodytes on 208F rat fibroblasts in culture | Q41148077 | ||
Chemical modification of taipoxin and the consequences for phospholipase activity, pathophysiology, and inhibition of high-affinity choline uptake | Q41491561 | ||
Dissociation of lethal toxicity and enzymic activity of notexin from Notechis scutatus scutatus (Australian-tiger-snake) venom by modification of tyrosine residues | Q41990885 | ||
Distinct sites for myotoxic and membrane-damaging activities in the C-terminal region of a Lys49-phospholipase A2. | Q42115492 | ||
Topology of the substrate-binding site of a Lys49-phospholipase A2 influences Ca2+-independent membrane-damaging activity. | Q42156718 | ||
Phenylalanine-24 in the N-terminal region of ammodytoxins is important for both enzymic activity and presynaptic toxicity | Q42198364 | ||
Cloning and recombinant expression of a novel mouse-secreted phospholipase A2. | Q42604316 | ||
Effects of chemical modifications of crotoxin B, the phospholipase A(2) subunit of crotoxin from Crotalus durissus terrificus snake venom, on its enzymatic and pharmacological activities | Q43680853 | ||
On the binding preference of human groups IIA and X phospholipases A2 for membranes with anionic phospholipids | Q44147123 | ||
Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2. | Q44164559 | ||
The neurotoxic phospholipase A2 associates, through a non-phosphorylated binding motif, with 14-3-3 protein gamma and epsilon isoforms | Q44368272 | ||
Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation. | Q44463039 | ||
Effect of tryptophan insertions on the properties of the human group IIA phospholipase A2: mutagenesis produces an enzyme with characteristics similar to those of the human group V phospholipase A2. | Q44479658 | ||
R25 is an intracellular membrane receptor for a snake venom secretory phospholipase A(2). | Q44627974 | ||
The X-ray structure of a snake venom Gln48 phospholipase A2 at 1.9A resolution reveals anion-binding sites | Q44788155 | ||
The basic phospholipase A2 from Naja nigricollis venom inhibits the prothrombinase complex by a novel nonenzymatic mechanism | Q44976548 | ||
Analysis of a novel prophage-encoded group A Streptococcus extracellular phospholipase A(2). | Q45013840 | ||
P433 | issue | 18 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | toxic encephalopathy | Q7830379 |
snake venom | Q424200 | ||
neurotoxicity | Q3338704 | ||
P304 | page(s) | 5800-5816 | |
P577 | publication date | 2006-05-01 | |
P1433 | published in | Biochemistry | Q764876 |
P1476 | title | Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity | |
P478 | volume | 45 |
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