Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity

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Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity is …
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scholarly articleQ13442814

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P356DOI10.1021/BI060217R
P8608Fatcat IDrelease_hkxf4whog5cvddelkzygt2dkri
P932PMC publication ID2796912
P698PubMed publication ID16669624
P5875ResearchGate publication ID7110254

P50authorMichel LazdunskiQ1930803
Christiane DeregnaucourtQ115583132
Joseph SchrévelQ115583756
Carole GuillaumeQ115583758
Morgane RouaultQ125197254
Lachlan D. RashQ52150344
Thomas MaurinQ58888402
Gérard LambeauQ63373800
José María GutiérrezQ42425503
Bruno LomonteQ43959570
P2093author name stringMichael H Gelb
Alain Doglio
Stéphane Canaan
Pierre Escoubas
Eric Boilard
James Bollinger
P2860cites workThe N-terminal amino group essential for the biological activity of notexin from Notechis scutatus scutatus venomQ68872076
Identification and properties of very high affinity brain membrane-binding sites for a neurotoxic phospholipase from the taipan venomQ69351278
Evidence that the anti-coagulant and lethal properties of a basic phospholipase A2 from snake venom are unrelatedQ69611046
The role of Asp-49 and other conserved amino acids in phospholipases A2 and their importance for enzymatic activityQ69613275
Nigexine, a phospholipase A2 from cobra venom with cytotoxic properties not related to esterase activity. Purification, amino acid sequence, and biological propertiesQ69666552
The role of aspartic acid-49 in the active site of phospholipase A2. A site-specific mutagenesis study of porcine pancreatic phospholipase A2 and the rationale of the enzymatic activity of [lysine49]phospholipase A2 from Agkistrodon piscivorus pisciQ70210923
Identification of functional involvement of tryptophan residues in phospholipase A2 from Naja naja atra (Taiwan cobra) snake venomQ70481032
Inhibition of ACh release at an Aplysia synapse by neurotoxic phospholipases A2: specific receptors and mechanisms of actionQ70956187
Effects on behaviour and EEG of single chain phospholipases A2 from snake and bee venoms injected into rat brain: search for a functional antagonismQ71340538
Presynaptic toxicity of the histidine-modified, phospholipase A2-inactive, β-bungarotoxin, crotoxin and notexinQ72542771
Structural elements of secretory phospholipases A2 involved in the binding to M-type receptorsQ72631444
Role of the AGA/AGG codons, the rarest codons in global gene expression in Escherichia coliQ72801102
Secretory phospholipase A2 potentiates glutamate-induced rat striatal neuronal cell death in vivoQ73149256
Secreted phospholipase A(2) induces vascular endothelial cell migrationQ73219921
Biological Functions of Group X Secretory PLA2Q73403503
Catalytic significance of the specificity of divalent cations as KS* and kcat* cofactors for secreted phospholipase A2Q77217000
Roles of Trp31 in high membrane binding and proinflammatory activity of human group V phospholipase A2Q77336155
Differential interfacial and substrate binding modes of mammalian pancreatic phospholipases A2: a comparison among human, bovine, and porcine enzymesQ77937486
Catalytic role of the active site histidine of porcine pancreatic phospholipase A2 probed by the variants H48Q, H48N and H48KQ77945079
Introduction of a C-terminal aromatic sequence from snake venom phospholipases A2 into the porcine pancreatic isozyme dramatically changes the interfacial kineticsQ78197325
Neuroprotection and peptide toxinsQ80093052
Basic amino acid residues in the beta-structure region contribute, but not critically, to presynaptic neurotoxicity of ammodytoxin AQ80871557
Structures of the catalytic site mutants D99A and H48Q and the calcium-loop mutant D49E of phospholipase A2Q27617644
The crystal structure of the H48Q active site mutant of human group IIA secreted phospholipase A2 at 1.5 A resolution provides an insight into the catalytic mechanismQ27640234
Enhanced activity and altered specificity of phospholipase A2 by deletion of a surface loopQ27704523
Phospholipase A2 engineering. Deletion of the C-terminus segment changes substrate specificity and uncouples calcium and substrate binding at the zwitterionic interfaceQ27733435
Structure of a snake venom phospholipase A2 modified by p-bromo-phenacyl-bromideQ27760646
Site-directed mutagenesis by overlap extension using the polymerase chain reactionQ27860503
Both group IB and group IIA secreted phospholipases A2 are natural ligands of the mouse 180-kDa M-type receptorQ28511678
The expanding superfamily of phospholipase A(2) enzymes: classification and characterizationQ28609761
Phospholipase A2 enzymesQ28609770
Anti-Plasmodium properties of group IA, IB, IIA and III secreted phospholipases A2 are serum-dependentQ30829154
Bee venom phospholipase A2 induces stage-specific growth arrest of the intraerythrocytic Plasmodium falciparum via modifications of human serum componentsQ30926042
Excitement ahead: structure, function and mechanism of snake venom phospholipase A2 enzymesQ33339804
Receptors for a growing family of secreted phospholipases A2.Q33633078
Secreted phospholipases A(2), a new class of HIV inhibitors that block virus entry into host cellsQ33858057
Search for relationships among the hemolytic, phospholipolytic, and neurotoxic activities of snake venomsQ33959539
Conus venoms: a rich source of novel ion channel-targeted peptidesQ33975042
Localization of structural elements of bee venom phospholipase A2 involved in N-type receptor binding and neurotoxicityQ34064227
A nutrient-regulated, dual localization phospholipase A(2) in the symbiotic fungus Tuber borchiiQ34082264
Increasing molecular diversity of secreted phospholipases A(2) and their receptors and binding proteinsQ34083759
Neuronal receptors for phospholipases A(2 )and beta-neurotoxicity.Q34086613
What can venom phospholipases A(2) tell us about the functional diversity of mammalian secreted phospholipases A(2)?Q34086618
A viral phospholipase A2 is required for parvovirus infectivityQ34101246
Interfacial enzymology: the secreted phospholipase A(2)-paradigm.Q34105620
In vitro neuromuscular activity of snake venomsQ34143135
Structural effects of covalent inhibition of phospholipase A2 suggest allosteric coupling between membrane binding and catalytic sitesQ34180618
Phospholipase A(2).Q34219384
Novel Mammalian Group XII Secreted Phospholipase A2Lacking Enzymatic Activity,Q34265835
Cloning and expression of a membrane receptor for secretory phospholipases A2.Q34348680
Phospholipase A2 myotoxins from Bothrops snake venomsQ34391390
Equivalent effects of snake PLA2 neurotoxins and lysophospholipid-fatty acid mixturesQ34474542
Anticoagulant venom and mammalian secreted phospholipases A(2): protein- versus phospholipid-dependent mechanism of action.Q34574886
Interfacial binding of bee venom secreted phospholipase A2 to membranes occurs predominantly by a nonelectrostatic mechanismQ45112088
A molecular mechanism for Lys49-phospholipase A2 activity based on ligand-induced conformational change.Q45185592
Inflammatory events induced by Lys-49 and Asp-49 phospholipases A2 isolated from Bothrops asper snake venom: role of catalytic activityQ45246214
Crystallographic and biochemical studies of the (inactive) Lys-49 phospholipase A2 from the venom of Agkistridon piscivorus piscivorusQ45760670
Antimicrobial activity of myotoxic phospholipases A2 from crotalid snake venoms and synthetic peptide variants derived from their C-terminal regionQ46498997
Identification of vascular endothelial growth factor receptor-binding protein in the venom of eastern cottonmouth. A new role of snake venom myotoxic Lys49-phospholipase A2.Q46598590
Do chemical modifications dissociate between the enzymatic and pharmacological activities of beta bungarotoxin and notexin?Q46883839
Elapid venom toxins: multiple recruitments of ancient scaffoldsQ47730446
Tryptophan 110, a residue involved in the toxic activity but not in the enzymatic activity of notexinQ48282908
Tryptophan residues of phospholipase A2 from the venom of an Australian elapid snake (Pseudechis australis)Q50875285
Evidence for the regulatory role of the N-terminal helix of secretory phospholipase A(2) from studies on native and chimeric proteins.Q51371213
Structural analysis of phospholipase A2 from functional perspective. 2. Characterization of a molten globule-like state induced by site-specific mutagenesis.Q52534208
Unusual mode of binding of human group IIA secreted phospholipase A2 to anionic interfaces as studied by continuous wave and time domain electron paramagnetic resonance spectroscopy.Q53872788
Tyr→Trp-substituted peptide 115-129 of a Lys49 phospholipase A2 expresses enhanced membrane-damaging activities and reproduces its in vivo myotoxic effectQ57042082
Neuromuscular effects of nigexine, a basic phospholipase A2 from Naja nigricollis venomQ62900129
complete amino-acid sequence of a non-neurotoxic, non-enzymatic phospholipase A2 homolog from the venom of the Australian tiger snake Notechis scutatus scutatusQ67266276
IL-12: monoclonal antibodies specific for the 40-kDa subunit block receptor binding and biologic activity on activated human lymphoblastsQ67698484
An essential tryptophan in the active site of phospholipase A2 from the venom of Bitis gabonicaQ67783381
Crystal structure of bovine pancreatic phospholipase A2 covalently inhibited by p-bromo-phenacyl-bromideQ68394634
Identification and purification of a very high affinity binding protein for toxic phospholipases A2 in skeletal muscleQ68461520
Codon usage bias and tRNA abundance in DrosophilaQ34743363
Phospholipase A2 receptor: a regulator of biological functions of secretory phospholipase A2.Q34997924
Sodium channel toxins and neurotransmitter release.Q35564768
Chemical modifications of phospholipases A2 from snake venoms: effects on catalytic and pharmacological propertiesQ35690564
Mapping structural determinants of biological activities in snake venom phospholipases A2 by sequence analysis and site directed mutagenesis.Q35690569
An overview of lysine-49 phospholipase A2 myotoxins from crotalid snake venoms and their structural determinants of myotoxic actionQ35690573
Skeletal muscle degeneration induced by venom phospholipases A2: insights into the mechanisms of local and systemic myotoxicityQ35690578
Natural phospholipase A(2) myotoxin inhibitor proteins from snakes, mammals and plantsQ35690590
Structure-function relationships and mechanism of anticoagulant phospholipase A2 enzymes from snake venomsQ36143088
Phospholipase A2 engineering. Probing the structural and functional roles of N-terminal residues with site-directed mutagenesis, X-ray, and NMR.Q36707402
Phospholipase A2 engineering. Structural and functional roles of the highly conserved active site residue aspartate-49.Q36730095
Molecular aspects of neuronal voltage-dependent K+ channelsQ36890828
Active-site mutagenesis of a Lys49-phospholipase A2: biological and membrane-disrupting activities in the absence of catalysisQ38292301
The importance of glycine-30 for enzymatic activity of phospholipase A2.Q38336540
The C-terminal region of ammodytoxins is important but not sufficient for neurotoxicityQ38360683
A model to explain the pharmacological effects of snake venom phospholipases A2.Q38664430
A peptide derived from bee venom-secreted phospholipase A2 inhibits replication of T-cell tropic HIV-1 strains via interaction with the CXCR4 chemokine receptor.Q39001849
Ammodytoxins, potent presynaptic neurotoxins, are also highly efficient phospholipase A2 enzymesQ40374806
Cellular distribution, post-translational modification, and tumorigenic potential of human group III secreted phospholipase A(2).Q40428682
Identification of the myotoxic site of the Lys49 phospholipase A(2) from Agkistrodon piscivorus piscivorus snake venom: synthetic C-terminal peptides from Lys49, but not from Asp49 myotoxins, exert membrane-damaging activitiesQ40789423
Binding proteins on synaptic membranes for certain phospholipases A2 with presynaptic toxicity.Q41049299
Proliferative effect of ammodytin L from the venom of Vipera ammodytes on 208F rat fibroblasts in cultureQ41148077
Chemical modification of taipoxin and the consequences for phospholipase activity, pathophysiology, and inhibition of high-affinity choline uptakeQ41491561
Dissociation of lethal toxicity and enzymic activity of notexin from Notechis scutatus scutatus (Australian-tiger-snake) venom by modification of tyrosine residuesQ41990885
Distinct sites for myotoxic and membrane-damaging activities in the C-terminal region of a Lys49-phospholipase A2.Q42115492
Topology of the substrate-binding site of a Lys49-phospholipase A2 influences Ca2+-independent membrane-damaging activity.Q42156718
Phenylalanine-24 in the N-terminal region of ammodytoxins is important for both enzymic activity and presynaptic toxicityQ42198364
Cloning and recombinant expression of a novel mouse-secreted phospholipase A2.Q42604316
Effects of chemical modifications of crotoxin B, the phospholipase A(2) subunit of crotoxin from Crotalus durissus terrificus snake venom, on its enzymatic and pharmacological activitiesQ43680853
On the binding preference of human groups IIA and X phospholipases A2 for membranes with anionic phospholipidsQ44147123
Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X, and XII secreted phospholipases A2.Q44164559
The neurotoxic phospholipase A2 associates, through a non-phosphorylated binding motif, with 14-3-3 protein gamma and epsilon isoformsQ44368272
Potentiation of tumor necrosis factor alpha-induced secreted phospholipase A2 (sPLA2)-IIA expression in mesangial cells by an autocrine loop involving sPLA2 and peroxisome proliferator-activated receptor alpha activation.Q44463039
Effect of tryptophan insertions on the properties of the human group IIA phospholipase A2: mutagenesis produces an enzyme with characteristics similar to those of the human group V phospholipase A2.Q44479658
R25 is an intracellular membrane receptor for a snake venom secretory phospholipase A(2).Q44627974
The X-ray structure of a snake venom Gln48 phospholipase A2 at 1.9A resolution reveals anion-binding sitesQ44788155
The basic phospholipase A2 from Naja nigricollis venom inhibits the prothrombinase complex by a novel nonenzymatic mechanismQ44976548
Analysis of a novel prophage-encoded group A Streptococcus extracellular phospholipase A(2).Q45013840
P433issue18
P407language of work or nameEnglishQ1860
P921main subjecttoxic encephalopathyQ7830379
snake venomQ424200
neurotoxicityQ3338704
P304page(s)5800-5816
P577publication date2006-05-01
P1433published inBiochemistryQ764876
P1476titleNeurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity
P478volume45

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cites work (P2860)
Q92604374Activity of two key toxin groups in Australian elapid venoms show a strong correlation to phylogeny but not to diet
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Q37402769Group X phospholipase A2 stimulates the proliferation of colon cancer cells by producing various lipid mediators
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Q35097174Wound healing activity and mechanisms of action of an antibacterial protein from the venom of the eastern diamondback rattlesnake (Crotalus adamanteus)

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